EE200300145A - Asa- ja polüasanaftalenüülkarboksamiidid ja farmatseutiline kompositsioon - Google Patents

Asa- ja polüasanaftalenüülkarboksamiidid ja farmatseutiline kompositsioon

Info

Publication number
EE200300145A
EE200300145A EEP200300145A EEP200300145A EE200300145A EE 200300145 A EE200300145 A EE 200300145A EE P200300145 A EEP200300145 A EE P200300145A EE P200300145 A EEP200300145 A EE P200300145A EE 200300145 A EE200300145 A EE 200300145A
Authority
EE
Estonia
Prior art keywords
polyazanaphthalenylcarboxamides
aza
pharmaceutical composition
pharmaceutical
composition
Prior art date
Application number
EEP200300145A
Other languages
English (en)
Inventor
J. Anthony Neville
P. Gomez Robert
D. Young Steven
Egbertson Melissa
S. Wai John
Zhuang Linghang
Embrey Mark
Tran Lekhanh
Y. Melamed Jeffrey
Marie Langford H.
P. Guare James
E. Fisher Thorsten
M. Jolly Samson
S. Kuo Michelle
S. Perlow Debra
J. Bennett Jennifer
W. Funk Timothy
Original Assignee
Merck & Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co., Inc. filed Critical Merck & Co., Inc.
Publication of EE200300145A publication Critical patent/EE200300145A/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
EEP200300145A 2000-10-12 2001-10-09 Asa- ja polüasanaftalenüülkarboksamiidid ja farmatseutiline kompositsioon EE200300145A (et)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23970700P 2000-10-12 2000-10-12
US28165601P 2001-04-05 2001-04-05
PCT/US2001/042564 WO2002030931A2 (en) 2000-10-12 2001-10-09 Aza- and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors

Publications (1)

Publication Number Publication Date
EE200300145A true EE200300145A (et) 2003-06-16

Family

ID=26932782

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200300145A EE200300145A (et) 2000-10-12 2001-10-09 Asa- ja polüasanaftalenüülkarboksamiidid ja farmatseutiline kompositsioon

Country Status (26)

Country Link
US (2) US6921759B2 (et)
EP (1) EP1326865B1 (et)
JP (1) JP4252797B2 (et)
KR (1) KR20030036922A (et)
CN (1) CN1469878A (et)
AR (1) AR033845A1 (et)
AT (1) ATE430745T1 (et)
AU (3) AU1152702A (et)
BG (1) BG107677A (et)
BR (1) BR0114610A (et)
CA (1) CA2425440C (et)
CZ (1) CZ20031028A3 (et)
DE (1) DE60138635D1 (et)
EA (1) EA200300449A1 (et)
EE (1) EE200300145A (et)
HU (1) HUP0302367A2 (et)
IL (1) IL155089A0 (et)
IS (1) IS6760A (et)
MX (1) MXPA03003263A (et)
NO (1) NO20031672L (et)
NZ (1) NZ525088A (et)
PE (1) PE20020509A1 (et)
PL (1) PL360944A1 (et)
SK (1) SK4322003A3 (et)
WO (2) WO2002030931A2 (et)
YU (1) YU27903A (et)

Families Citing this family (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ20031028A3 (cs) * 2000-10-12 2003-08-13 Merck & Co., Inc. Aza- a polyazanaftalenylkarboxamidy
TWI243164B (en) 2001-02-13 2005-11-11 Aventis Pharma Gmbh Acylated indanyl amines and their use as pharmaceuticals
EP2033952B1 (en) 2001-03-01 2012-08-29 Shionogi&Co., Ltd. Nitrogen-containing Heteroaryl compounds having HIV Integrase Inhibitory Activity
BR0211750A (pt) 2001-08-10 2004-10-13 Shionogi & Co Agente antiviral
AR036256A1 (es) 2001-08-17 2004-08-25 Merck & Co Inc Sal sodica de un inhibidor de integrasa del vih, procesos para su preparacion, composiciones farmaceuticas que lo contienen y su uso para la manufactura de un medicamento
US20040186093A1 (en) * 2001-08-17 2004-09-23 Jaemoon Lee Process for preparing sultams
CA2456155A1 (en) * 2001-08-17 2003-02-27 Merck & Co., Inc. Process for preparing 5-sulfonamido-8-hydroxy-1, 6-naphthyridine-7-carboxamides
CN1700918B (zh) * 2001-10-26 2011-06-08 P·安杰莱蒂分子生物学研究所 关于hiv整合酶的n-取代的羟基嘧啶酮甲酰胺抑制剂
EP1441734B1 (en) 2001-10-26 2007-02-28 Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. Dihydroxypyrimidine carboxamide inhibitors of hiv integrase
DE10155075A1 (de) 2001-11-09 2003-05-22 Merck Patent Gmbh Cyclische Sulfonamide
DE60315796T2 (de) 2002-01-17 2008-06-05 Merck & Co., Inc. Hydroxynaphthyridinoncarbonsäureamide, die sich als inhibitoren der hiv-integrase eignen
DE60323743D1 (en) * 2002-03-15 2008-11-06 Merck & Co Inc N-(substituierte benzyl)-8-hydroxy-1,6-naphthyridin-7- carbonsäureamide als hiv-integrase-hemmer
US20050165000A1 (en) * 2002-04-10 2005-07-28 Robertson Sandra K. Pharmaceutical compositions containing an hiv integrase inhibitor and a nonionic surfactant
EP1532115A4 (en) * 2002-05-22 2006-01-11 Smithkline Beecham Corp INHIBITORS OF PROTEASE
EP1388535A1 (en) * 2002-08-07 2004-02-11 Aventis Pharma Deutschland GmbH Acylated arylcycloalkylamines and their use as pharmaceuticals
WO2004024693A1 (ja) * 2002-08-13 2004-03-25 Shionogi & Co., Ltd. Ｈｉｖインテグラーゼ阻害活性を有するヘテロ環化合物
EP1539714B1 (en) 2002-09-11 2008-08-13 Merck & Co., Inc. 8-hydroxy-1-oxo-tetrahydropyrrolopyrazine compounds useful as hiv integrase inhibitors
WO2004024078A2 (en) 2002-09-11 2004-03-25 Merck & Co., Inc. Dihydroxypyridopyrazine-1,6-dione compounds useful as hiv integrase inhibitors
US7692011B2 (en) 2002-10-04 2010-04-06 Prana Biotechnology Limited 8-hydroxy and 8-mercapto quinazolinones
US7074810B2 (en) 2002-10-07 2006-07-11 Bristol-Myers Squibb Company Triazolone and triazolethione derivatives as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme
WO2004035577A2 (en) * 2002-10-16 2004-04-29 Gilead Sciences, Inc. Pre-organized tricyclic integrase inhibitor compounds
AU2003292437A1 (en) 2002-12-27 2004-07-22 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa Tetrahydro-4h-pyrido(1,2-a)pyrimidines and related compounds useful as hiv integrase inhibitors
US20040220273A1 (en) * 2003-03-12 2004-11-04 Jaemoon Lee Preparation of 2-aminomethyl-5-fluorobenzamides
US20060211687A1 (en) * 2003-03-12 2006-09-21 Michael Palucki Potassium salt of an hiv integrase inhibitor
US7812016B2 (en) 2003-05-13 2010-10-12 Smithkline Beecham Corporation Naphthyridine integrase inhibitors
CN100418948C (zh) * 2003-07-15 2008-09-17 麦克公司 羟基吡啶cgrp受体抗拮抗剂
TW200510425A (en) 2003-08-13 2005-03-16 Japan Tobacco Inc Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
AU2004274493A1 (en) 2003-09-19 2005-03-31 Gilead Sciences, Inc. Aza-quinolinol phosphonate integrase inhibitor compounds
AU2004285449A1 (en) 2003-10-20 2005-05-12 Merck & Co., Inc. Hydroxy pyridopyrrolopyrazine dione compounds useful as HIV integrase inhibitors
TW200533357A (en) 2004-01-08 2005-10-16 Millennium Pharm Inc 2-(amino-substituted)-4-aryl pyrimidines and related compounds useful for treating inflammatory diseases
AU2005211349A1 (en) * 2004-01-30 2005-08-18 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. N-benzyl-3,4-dihyroxypyridine-2-carboxamide and N-benzyl-2,3-dihydroxypyridine-4-carboxamide compounds useful as HIV integrase inhibitors
EP1714966A4 (en) * 2004-02-04 2008-01-02 Shionogi & Co NAPHTHYLIDINE DERIVATIVE HAVING HIGH INTEGRASE HIV INHIBITING ACTIVITY
BRPI0507628A (pt) 2004-02-11 2007-07-03 Smithkline Beecham Corp composto ou sal farmaceuticamente aceitável do mesmo, método de tratamento de uma infecção viral em um ser humano, uso de um composto composição farmacêutica, e, processo para a preparação de um composto
EA200601654A1 (ru) * 2004-03-09 2007-02-27 Мерк Энд Ко., Инк. Ингибиторы интегразы вич
US7619086B2 (en) * 2004-03-09 2009-11-17 Merck & Co., Inc. HIV integrase inhibitors
US7820680B2 (en) * 2004-03-09 2010-10-26 Merck & Co., Inc. HIV integrase inhibitors
CN1930161A (zh) * 2004-03-09 2007-03-14 P·安杰莱蒂分子生物学研究所 Hiv整合酶抑制剂
WO2005110415A1 (en) 2004-05-07 2005-11-24 Merck & Co., Inc. Hiv integrase inhibitors
CN101146540A (zh) * 2004-06-09 2008-03-19 默克公司 Hiv整合酶抑制剂
UA87884C2 (uk) 2004-12-03 2009-08-25 Мерк Энд Ко., Инк. Безводна кристалічна калієва сіль інгібітора віл-інтегрази
NZ555215A (en) * 2004-12-03 2010-08-27 Merck Sharp & Dohme Use of atazanavir for improving the pharmacokinetics of raltegravir
US7858788B2 (en) * 2005-02-21 2010-12-28 Shionogi & Co., Ltd. Bicyclic carbamoylpyridone derivative having HIV integrase inhibitory activity
WO2006103399A1 (en) * 2005-03-31 2006-10-05 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa Hiv integrase inhibitors
EP1881825B1 (en) * 2005-05-10 2013-07-24 Merck Sharp & Dohme Corp. Hiv integrase inhibitors
AR057023A1 (es) * 2005-05-16 2007-11-14 Gilead Sciences Inc Compuestos heterociclicos con propiedades inhibidoras de hiv-integrasa
WO2007019100A2 (en) * 2005-08-04 2007-02-15 Smithkline Beecham Corporation Hiv integrase inhibitors
US20080214503A1 (en) * 2005-08-04 2008-09-04 Smithkline Beecham Corporation Hiv Integrase Inhibitors
JP2009503081A (ja) * 2005-08-04 2009-01-29 スミスクライン ビーチャム コーポレーション Ｈｉｖインテグラーゼ阻害薬
EP1909578A4 (en) * 2005-08-04 2010-07-14 Glaxosmithkline Llc INHIBITORS OF HIV INTEGRASE
CA2622639C (en) * 2005-10-04 2012-01-03 Istituto Di Recerche Di Biologia Molecolare P. Angeletti S.P.A. Hiv integrase inhibitors
JP2009513640A (ja) * 2005-10-27 2009-04-02 メルク エンド カムパニー インコーポレーテッド Ｈｉｖインテグラーゼインヒビター
KR20080064182A (ko) * 2005-10-27 2008-07-08 시오노기세야쿠 가부시키가이샤 Ｈｉｖ 인테그라아제 억제활성을 가지는 다환성카르바모일피리돈 유도체
WO2007076035A2 (en) * 2005-12-21 2007-07-05 Abbott Laboratories Anti-viral compounds
WO2007136714A2 (en) * 2006-05-16 2007-11-29 Gilead Sciences, Inc. Integrase inhibitors
CA2657287A1 (en) * 2006-07-17 2008-01-24 Merck & Co., Inc. 1-hydroxy naphthyridine compounds as anti-hiv agents
EP2079699A1 (en) * 2006-07-25 2009-07-22 Envivo Pharmaceuticals, Inc. Quinoline derivatives
AU2007292387A1 (en) * 2006-09-05 2008-03-13 Bipar Sciences, Inc. Treatment of cancer
ES2488922T3 (es) 2006-09-29 2014-09-01 Idenix Pharmaceuticals, Inc. Fosfoindoles enantiómeramente puros como inhibidores del HIV
JP2010506913A (ja) * 2006-10-18 2010-03-04 メルク エンド カムパニー インコーポレーテッド Ｈｉｖインテグラーゼ阻害剤
US20090291921A1 (en) * 2007-11-20 2009-11-26 Gilead Sciences, Inc. Integrase inhibitors
US8993542B2 (en) 2008-01-25 2015-03-31 Chimerix Inc. Methods of treating viral infections
EP2318406B1 (en) 2008-07-17 2016-01-27 Critical Outcome Technologies, Inc. Thiosemicarbazone inhibitor compounds and cancer treatment methods
EP2379076B1 (en) 2008-12-23 2014-11-12 The Trustees of Columbia University in the City of New York Phosphodiesterase inhibitors and uses thereof
EP2435037B1 (en) 2009-05-27 2014-11-12 Merck Sharp & Dohme Corp. Hiv protease inhibitors
MX2012004426A (es) * 2009-10-13 2012-07-30 Elanco Animal Health Ireland Inhibidores macrociclicos de integrasa.
CN102655752A (zh) 2009-10-26 2012-09-05 默沙东公司 包含整合酶抑制剂的固体药物组合物
EP2345641A1 (en) 2009-12-29 2011-07-20 Polichem S.A. New secondary 8-hydroxyquinoline-7-carboxamide derivatives
EP2345643A1 (en) 2009-12-29 2011-07-20 Polichem S.A. New tertiary 8-hydroxyquinoline-7-carboxamide derivatives and uses thereof
EP2345642A1 (en) * 2009-12-29 2011-07-20 Polichem S.A. Secondary 8-hydroxyquinoline-7-carboxamide derivatives for use as antifungal agents
US9006218B2 (en) 2010-02-12 2015-04-14 Chimerix Inc. Nucleoside phosphonate salts
CA2999435A1 (en) 2010-04-01 2011-10-06 Critical Outcome Technologies Inc. Compounds and method for treatment of hiv
CN102958935B (zh) 2010-04-02 2015-12-09 爱尔兰詹森科学公司 大环整合酶抑制剂
US9079834B2 (en) 2010-10-28 2015-07-14 Merck Canada Inc. HIV protease inhibitors
CA2818597A1 (en) 2010-12-23 2012-06-28 Merck Sharp & Dohme Corp. Quinoxalines and aza-quinoxalines as crth2 receptor modulators
EP2661265B1 (en) * 2010-12-23 2017-03-08 Merck Sharp & Dohme Corp. Quinolines and aza-quinolines as crth2 receptor modulators
EP2487176A1 (en) * 2011-02-14 2012-08-15 Elanco Animal Health Ireland Limited Macrocyclic integrase inhibitors for use in the treatment of feline immunodeficiency virus
MX348961B (es) 2011-02-18 2017-07-04 Asana Biosciences Llc Compuestos de aminoindano y su uso en el tratamiento del dolor.
EP2771332B1 (en) 2011-10-26 2016-06-29 Merck Canada Inc. Thiophen and thiazol sulfonamid derivatives as HIV protease inhibitors for the treatment of AIDS
US9044482B2 (en) 2012-08-15 2015-06-02 Asana Biosciences, Llc Use of aminoindane compounds in treating overactive bladder and interstitial cystitis
AR092489A1 (es) 2012-09-11 2015-04-22 Merck Sharp & Dohme Inhibidores de proteasa del vih
CN103709162B (zh) * 2012-09-29 2016-12-07 中国科学院上海药物研究所 三取代咪唑并二氮杂萘酮化合物及其制备方法和用途
CN104003986B (zh) * 2013-02-22 2016-06-08 中国科学院上海药物研究所 吡啶骈环类化合物及其制备方法、其药物组合物和用途
WO2015013835A1 (en) 2013-07-31 2015-02-05 Merck Sharp & Dohme Corp. Piperazine derivatives as hiv protease inhibitors
EP3083609B1 (en) 2013-12-19 2018-08-15 Merck Sharp & Dohme Corp. Hiv protease inhibitors
EP3082822B1 (en) 2013-12-19 2020-01-15 Merck Sharp & Dohme Corp. Hiv protease inhibitors
WO2015134366A1 (en) 2014-03-06 2015-09-11 Merck Sharp & Dohme Corp. Hiv protease inhibitors
US10138255B2 (en) 2014-03-10 2018-11-27 Merck Sharp & Dohme Corp. Piperazine derivatives as HIV protease inhibitors
EP3423044A4 (en) 2016-03-02 2019-11-20 The Board of Regents of The University of Texas System STING-ACTIVATING NANO VACCINE FOR IMMUNOTHERAPY
CN106588922B (zh) * 2017-01-17 2018-04-27 北京工业大学 二取代八氢-1,6-萘啶类化合物及其制备方法和应用
EP4248968A3 (en) * 2017-07-18 2023-12-06 Merck Patent GmbH Tlr7/8 antagonists and uses thereof
CN109776415B (zh) * 2019-03-07 2020-11-17 福建南方制药股份有限公司 一种Roxadustat中间体的制备方法

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5751837B2 (et) * 1973-04-05 1982-11-04
US4416884A (en) 1978-04-12 1983-11-22 Otsuka Pharmaceutical Co., Ltd. Piperazinylbenzoheterocyclic compounds
FR2632639B1 (fr) 1988-06-09 1990-10-05 Sanofi Sa Derives d'amino-4 carboxy-3 naphtyridines, leur preparation et compositions pharmaceutiques qui les contiennent
AU1625192A (en) 1991-05-31 1992-12-03 Zeneca Limited Heterocyclic derivatives
US5681832A (en) * 1995-02-17 1997-10-28 The United States Of America As Represented By The Department Of Health And Human Services Aroylaniline compounds, pharmaceutical compositions, and methods of using same to inhibit viral activity
US5633362A (en) * 1995-05-12 1997-05-27 E. I. Du Pont De Nemours And Company Production of 1,3-propanediol from glycerol by recombinant bacteria expressing recombinant diol dehydratase
EP0841927B1 (en) * 1995-08-02 2004-01-28 Darwin Discovery Limited Quinolones and their therapeutic use
US5945431A (en) 1996-03-15 1999-08-31 Biochem Therapeutics Incorporated Cytomegalovirus inhibiting compounds
WO1998011073A1 (en) * 1996-09-10 1998-03-19 Pharmacia & Upjohn Company 8-hydroxy-7-substituted quinolines as anti-viral agents
AU733551B2 (en) 1996-09-25 2001-05-17 Astrazeneca Ab Qinoline derivatives inhibiting the effect of growth factors such as VEGF
US5766944A (en) * 1996-12-31 1998-06-16 Ruiz; Margaret Eileen T cell differentiation of CD34+ stem cells in cultured thymic epithelial fragments
AU729995B2 (en) 1997-06-30 2001-02-22 Nippon Kayaku Kabushiki Kaisha Novel naphthyridine derivatives or salts thereof
CA2301599C (en) 1997-08-25 2003-03-25 Neurogen Corporation Substituted 4-oxo-napthyridine-3-carboxamides as gaba brain receptor ligands
GB9720052D0 (en) 1997-09-19 1997-11-19 Smithkline Beecham Plc Novel compounds
ES2255733T3 (es) 1997-09-30 2006-07-01 Daiichi Pharmaceutical Co., Ltd. Derivados sulfonilo.
CA2309882A1 (en) 1997-12-22 1999-07-01 Pharmacia & Upjohn Company 4-hydroxyquinoline-3-carboxamides and hydrazides as antiviral agents
US6262055B1 (en) 1998-06-03 2001-07-17 Merck & Co., Inc. HIV integrase inhibitors
US6380249B1 (en) 1998-06-03 2002-04-30 Merck & Co., Inc. HIV integrase inhibitors
US6306891B1 (en) 1998-06-03 2001-10-23 Merck & Co., Inc. HIV integrase inhibitors
SE9802550D0 (sv) 1998-07-15 1998-07-15 Active Biotech Ab Quinoline derivatives
AU5880600A (en) 1999-06-25 2001-01-31 Merck & Co., Inc. 1-(aromatic- or heteroaromatic-substituted)-3-(heteroaromatic substituted)-1,3-propanediones and uses thereof
US6730682B2 (en) 2000-07-12 2004-05-04 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
GB0017676D0 (en) 2000-07-19 2000-09-06 Angeletti P Ist Richerche Bio Inhibitors of viral polymerase
CZ20031028A3 (cs) * 2000-10-12 2003-08-13 Merck & Co., Inc. Aza- a polyazanaftalenylkarboxamidy
CN1336363A (zh) 2001-07-25 2002-02-20 张元宾 乙酰磺胺酸钾的合成制备方法
CA2456155A1 (en) 2001-08-17 2003-02-27 Merck & Co., Inc. Process for preparing 5-sulfonamido-8-hydroxy-1, 6-naphthyridine-7-carboxamides
AR036256A1 (es) * 2001-08-17 2004-08-25 Merck & Co Inc Sal sodica de un inhibidor de integrasa del vih, procesos para su preparacion, composiciones farmaceuticas que lo contienen y su uso para la manufactura de un medicamento
CN1700918B (zh) 2001-10-26 2011-06-08 P·安杰莱蒂分子生物学研究所 关于hiv整合酶的n-取代的羟基嘧啶酮甲酰胺抑制剂
EP1441734B1 (en) 2001-10-26 2007-02-28 Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. Dihydroxypyrimidine carboxamide inhibitors of hiv integrase
US20050165000A1 (en) * 2002-04-10 2005-07-28 Robertson Sandra K. Pharmaceutical compositions containing an hiv integrase inhibitor and a nonionic surfactant

Also Published As

Publication number Publication date
EA200300449A1 (ru) 2003-10-30
KR20030036922A (ko) 2003-05-09
WO2002030930A2 (en) 2002-04-18
CN1469878A (zh) 2004-01-21
AU1152702A (en) 2002-04-22
AU2002211527B2 (en) 2006-08-24
MXPA03003263A (es) 2003-06-06
WO2002030931A2 (en) 2002-04-18
EP1326865A2 (en) 2003-07-16
CZ20031028A3 (cs) 2003-08-13
BG107677A (bg) 2003-11-28
AU2002211874A1 (en) 2002-04-22
US6921759B2 (en) 2005-07-26
JP2004511483A (ja) 2004-04-15
BR0114610A (pt) 2005-12-13
JP4252797B2 (ja) 2009-04-08
PE20020509A1 (es) 2002-06-20
EP1326865B1 (en) 2009-05-06
US20050176718A1 (en) 2005-08-11
NO20031672D0 (no) 2003-04-11
NZ525088A (en) 2004-11-26
AR033845A1 (es) 2004-01-07
WO2002030930A3 (en) 2002-08-29
ATE430745T1 (de) 2009-05-15
IS6760A (is) 2003-03-27
SK4322003A3 (en) 2003-09-11
WO2002030931A3 (en) 2002-10-24
US20030055071A1 (en) 2003-03-20
CA2425440C (en) 2010-04-13
HUP0302367A2 (hu) 2003-11-28
PL360944A1 (en) 2004-09-20
CA2425440A1 (en) 2002-04-18
YU27903A (sh) 2006-05-25
NO20031672L (no) 2003-06-05
DE60138635D1 (de) 2009-06-18
IL155089A0 (en) 2003-10-31

Similar Documents

Publication Publication Date Title
EE200300145A (et) Asa- ja polüasanaftalenüülkarboksamiidid ja farmatseutiline kompositsioon
NO20025450L (no) Ny farmasöytisk sammensetning
DK1524266T3 (da) Farmaceutisk sammensætning
FI991485A0 (fi) Uusi farmaseuttinen koostumus
DK1353919T3 (da) Hidtil ukendte quinuclidinderivater og medicinale sammensætninger indeholdende samme
NO20015175D0 (no) Farmasöytisk sammensetning
EE200100391A (et) Peptidüül-heterotsüklilised ketoonid, nende kasutamine ja farmatseutiline kompositsioon
EE200200251A (et) Uued N-asabitsükloamiidi derivaadid ja nende kasutamine
EE200200487A (et) Asetidiini derivaadid, nende valmistamismeetodid ja farmatseutiline kompositsioon
DK1329456T3 (da) Glucopyranosyloxybenzylbenzenderivater og medicinske sammensætninger indeholdende samme
EE200300207A (et) Heterotsüklüülalküülpiperidiini derivaadid, nendevalmistamismeetodid ja farmatseutiline kompositsioon
EE05475B1 (et) Superantigeeni sisaldav konjugaat, konjugaadi kasutamine ja konjugaati sisaldav farmatseutiline kompositsioon
NO20005913L (no) Legemiddelsammensetning
ITTO20010008A0 (it) Formulazione farmaceutica
EE200000468A (et) Ühendid, nende kasutamine ja farmatseutiline kompositsioon
EE04464B1 (et) Indalüülasendatud benseenkarboksamiidid, nende valmistamismeetod, kasutamine ja farmatseutilised kompositsioonid
EE200200626A (et) Antraniilamiidid ja nende kasutamine ravimitena
EE05020B1 (et) Glburiidi ravimkoostis
EE200200607A (et) 2-atsüülindoolderivaadid ja nende kasutamine kasvajavastaste ravimitena
IL152094A0 (en) Ecteinascidin derivatives and pharmaceutical compositions containing the same
NO20032614D0 (no) Farmasöytisk sammensetning med forbedret absorbabilitet
ATE366128T1 (de) Pharmazeutische zusammensetzung
NO20030156L (no) Farmasöytiske sammensetninger og fremgangsmåter for anvendelse derav
FI4488U1 (fi) Farmaseuttinen koostumus
PT1227817E (pt) Composicao farmaceutica aquosa contendo ciclesonida