ES8303404A1 - Procedimiento para preparar 3-amino-sidnoniminas sustituidas. - Google Patents

Procedimiento para preparar 3-amino-sidnoniminas sustituidas.

Info

Publication number
ES8303404A1
ES8303404A1 ES510015A ES510015A ES8303404A1 ES 8303404 A1 ES8303404 A1 ES 8303404A1 ES 510015 A ES510015 A ES 510015A ES 510015 A ES510015 A ES 510015A ES 8303404 A1 ES8303404 A1 ES 8303404A1
Authority
ES
Spain
Prior art keywords
sydnonimine
substituted
amino
preparation
application
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES510015A
Other languages
English (en)
Other versions
ES510015A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Cassella Farbwerke Mainkur AG
Original Assignee
Cassella AG
Cassella Farbwerke Mainkur AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cassella AG, Cassella Farbwerke Mainkur AG filed Critical Cassella AG
Publication of ES510015A0 publication Critical patent/ES510015A0/es
Publication of ES8303404A1 publication Critical patent/ES8303404A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/04—1,2,3-Oxadiazoles; Hydrogenated 1,2,3-oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Seasonings (AREA)
  • Epoxy Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE 3-AMINO-SIDNONIMINAS SUSTITUIDAS Y DE SUS SALES DE ADICION DE ACIDO FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R Y R PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE CICLIZACION DE UN COMPUESTO DE FORMULA (II), EN LA QUE R TIENE EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), SEGUIDA DE ACILACION DEL COMPUESTO DE FORMULA (III), OBTENIDO, CON AGENTES DE ACILACION ADECUADOS. EL COMPUESTO OBTENIDO SE PUEDE TRANSFORMAR EN UNA SAL DE ADICION DE ACIDO. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU CAPACIDAD PARA DISMINUIR LA PRESION SANGUINEA, LA ARTERIAL Y LA ENDODIASTOLICA Y PARA ALIVIAR LA ACTIVIDAD CARDIACA.
ES510015A 1981-03-02 1982-03-01 Procedimiento para preparar 3-amino-sidnoniminas sustituidas. Expired ES8303404A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813107933 DE3107933A1 (de) 1981-03-02 1981-03-02 Substituierte 3-amino-sydnonimine, verfahren zu ihrer herstellung und ihre verwendung

Publications (2)

Publication Number Publication Date
ES510015A0 ES510015A0 (es) 1983-02-01
ES8303404A1 true ES8303404A1 (es) 1983-02-01

Family

ID=6126174

Family Applications (1)

Application Number Title Priority Date Filing Date
ES510015A Expired ES8303404A1 (es) 1981-03-02 1982-03-01 Procedimiento para preparar 3-amino-sidnoniminas sustituidas.

Country Status (23)

Country Link
US (2) US4436743A (es)
EP (1) EP0059356B1 (es)
JP (1) JPS57158768A (es)
KR (1) KR880001428B1 (es)
AT (1) ATE13055T1 (es)
AU (1) AU545292B2 (es)
CA (1) CA1192905A (es)
CS (1) CS224645B2 (es)
DD (1) DD208617A5 (es)
DE (2) DE3107933A1 (es)
DK (1) DK149852C (es)
ES (1) ES8303404A1 (es)
FI (1) FI820518L (es)
HU (1) HU190683B (es)
IL (1) IL65141A (es)
NO (1) NO820476L (es)
NZ (1) NZ199862A (es)
PH (1) PH18696A (es)
PL (1) PL136818B1 (es)
PT (1) PT74507B (es)
RO (1) RO84816B (es)
SU (1) SU1097197A3 (es)
ZA (1) ZA821327B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3107933A1 (de) * 1981-03-02 1982-09-16 Cassella Ag, 6000 Frankfurt Substituierte 3-amino-sydnonimine, verfahren zu ihrer herstellung und ihre verwendung
JPS5859977A (ja) * 1981-10-06 1983-04-09 Banyu Pharmaceut Co Ltd 新規なｎ−アシルシドノンイミン誘導体およびその製法
US4517179A (en) * 1983-04-29 1985-05-14 Pennwalt Corporation Rapid dissolving, uniform drug compositions and their preparation
DK243084A (da) * 1983-05-26 1984-11-27 Takeda Chemical Industries Ltd Perkutane farmaceutiske praeparater til udvortes brug
DE3526068A1 (de) * 1985-07-20 1987-01-22 Cassella Ag Substituierte 3-amino-sydnonimine, verfahren zu ihrer herstellung, ihre verwendung und sie enthaltende pharmazeutische praeparate
DE3702083A1 (de) * 1987-01-24 1988-08-04 Cassella Ag Allylmercaptoacetyl-sydnonimine, verfahren zu ihrer herstellung und ihre verwendung
DE3732174A1 (de) * 1987-09-24 1989-04-06 Cassella Ag Substituierte 3-aminosydnonimine, verfahren zu ihrer herstellung und ihre verwendung
US5221680A (en) * 1988-01-14 1993-06-22 Cassella Aktiengesellschaft Substituted 3-aminosydnonimines
FR2627696B1 (fr) * 1988-02-26 1991-09-13 Fournier Innovation Synergie Nouvelle forme galenique du fenofibrate
US5120732A (en) * 1988-06-14 1992-06-09 Cassella Aktiengesellschaft Substituted 3-aminosyndone imines, a process for their preparation and their use
DE4025604A1 (de) * 1990-08-13 1992-02-20 Cassella Ag 3-dicyclohexylamino-sydnonimine, verfahren zu ihrer herstellung und ihre verwendung
DE4028679A1 (de) * 1990-09-10 1992-03-19 Cassella Ag Substituierte 3-aminosydnonimine, verfahren zu ihrer herstellung und ihre verwendung
DE4031373A1 (de) * 1990-10-04 1992-04-09 Cassella Ag 3-piperazino-sydnonimine, verfahren zu ihrer herstellung und ihre verwendung
WO1997017334A1 (fr) * 1995-11-06 1997-05-15 Chugai Seiyaku Kabushiki Kaisha Derives d'imine de sydnone
FR2758459B1 (fr) * 1997-01-17 1999-05-07 Pharma Pass Composition pharmaceutique de fenofibrate presentant une biodisponibilite elevee et son procede de preparation
US6531158B1 (en) 2000-08-09 2003-03-11 Impax Laboratories, Inc. Drug delivery system for enhanced bioavailability of hydrophobic active ingredients

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1695897C3 (de) 1966-07-04 1979-02-15 Takeda Chemical Industries Ltd N-Acyl-sydnonimine, deren Salze, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US3833580A (en) 1966-08-09 1974-09-03 Boehringer Sohn Ingelheim 3-morpholino-n6-cyclohexylcarbonyl sydnonimine
BE788052A (fr) * 1971-08-26 1973-02-26 Science Union & Cie Societe Fr Nouveaux derives de la sydnone imine
US3833589A (en) * 1972-07-31 1974-09-03 Sandoz Ag Substituted sydnonimine nitrate esters
DE2930736A1 (de) * 1979-07-28 1981-02-12 Cassella Ag Pharmakologisch wirksame, substituierte 3-amino-sydnonimine, verfahren zu ihrer herstellung und ihre verwendung
DE3107933A1 (de) * 1981-03-02 1982-09-16 Cassella Ag, 6000 Frankfurt Substituierte 3-amino-sydnonimine, verfahren zu ihrer herstellung und ihre verwendung
JPS5832870A (ja) * 1981-08-24 1983-02-25 Hiroyoshi Hidaka 新規なシドノンイミン誘導体及びその製法
JPS5859977A (ja) * 1981-10-06 1983-04-09 Banyu Pharmaceut Co Ltd 新規なｎ−アシルシドノンイミン誘導体およびその製法

Also Published As

Publication number Publication date
EP0059356B1 (de) 1985-05-02
KR880001428B1 (ko) 1988-08-08
ES510015A0 (es) 1983-02-01
DK67682A (da) 1982-09-03
ATE13055T1 (de) 1985-05-15
ZA821327B (en) 1983-01-26
AU545292B2 (en) 1985-07-11
PL136818B1 (en) 1986-03-31
HU190683B (en) 1986-10-28
DD208617A5 (de) 1984-04-04
DE3263342D1 (en) 1985-06-05
PL235274A1 (es) 1982-10-25
RO84816B (ro) 1984-09-30
KR830009062A (ko) 1983-12-17
JPS57158768A (en) 1982-09-30
EP0059356A1 (de) 1982-09-08
PT74507B (de) 1983-11-08
PH18696A (en) 1985-09-05
DK149852B (da) 1986-10-13
PT74507A (de) 1982-04-01
SU1097197A3 (ru) 1984-06-07
NZ199862A (en) 1985-04-30
RO84816A (ro) 1984-08-17
CS224645B2 (en) 1984-01-16
IL65141A0 (en) 1982-05-31
IL65141A (en) 1984-10-31
NO820476L (no) 1982-09-03
FI820518L (fi) 1982-09-03
DK149852C (da) 1987-06-01
CA1192905A (en) 1985-09-03
US4551454A (en) 1985-11-05
US4436743A (en) 1984-03-13
AU8096682A (en) 1982-09-16
DE3107933A1 (de) 1982-09-16

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