RO84816B - Procedeu pentru prepararea unor 3-aminosidnonimine substituite - Google Patents

Procedeu pentru prepararea unor 3-aminosidnonimine substituite

Info

Publication number
RO84816B
RO84816B RO106750A RO10675082A RO84816B RO 84816 B RO84816 B RO 84816B RO 106750 A RO106750 A RO 106750A RO 10675082 A RO10675082 A RO 10675082A RO 84816 B RO84816 B RO 84816B
Authority
RO
Romania
Prior art keywords
acid
general formula
methanol
substituted
preparation
Prior art date
Application number
RO106750A
Other languages
English (en)
Other versions
RO84816A (ro
Inventor
Karl Schonefinger
Beyerle Rudi
Helmut Bohn
Mellita Just
Pierro A. Martorana
Nitz Rolf-Eberhard
Original Assignee
Cassella Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cassella Aktiengesellschaft filed Critical Cassella Aktiengesellschaft
Publication of RO84816A publication Critical patent/RO84816A/ro
Publication of RO84816B publication Critical patent/RO84816B/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/04—1,2,3-Oxadiazoles; Hydrogenated 1,2,3-oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Seasonings (AREA)
  • Epoxy Compounds (AREA)

Abstract

Inventia se refera la un procedeu de preparare a unor 3-amino-sidnonime substituite, cu activitate farmacologica, avînd formula generala I: (vezi formula) în care radicalul R2 reprezinta metil, etil, propil, izopropil, caracterizat prin aceea ca un compus cu formula generala III: (vezi formula) este ciclizat în prezenta unui agent de ciclizare, care mentine în solutie apoasa un pH sun 3, ales dintre acidul sulfuric, acidul clorhidric, acidul azotic trifloracetil sau acidul fosforic, de preferinta acidul clorhidric sau acidul trifluoracetic, la temperaturi între 0 si 40 degree C, de preferinta 0,,,20 degree C, într-un solvent organic sau anorganic, ales dintre apa, alcanol cu 1...4 atomi de carbon, un alchilester al unui acid carboxilic sau amestec apa-metanol, metanol-acetat de etil, dupa care compusii cu formula generala I obtinuti se pot acila în mod cunoscut la atomul de azot din pozitia 5 sau se transforma în saruri de aditie farmaceutic acceptabile, în mod cunoscut.
RO106750A 1981-03-02 1982-02-26 Procedeu pentru prepararea unor 3-aminosidnonimine substituite RO84816B (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813107933 DE3107933A1 (de) 1981-03-02 1981-03-02 Substituierte 3-amino-sydnonimine, verfahren zu ihrer herstellung und ihre verwendung

Publications (2)

Publication Number Publication Date
RO84816A RO84816A (ro) 1984-08-17
RO84816B true RO84816B (ro) 1984-09-30

Family

ID=6126174

Family Applications (1)

Application Number Title Priority Date Filing Date
RO106750A RO84816B (ro) 1981-03-02 1982-02-26 Procedeu pentru prepararea unor 3-aminosidnonimine substituite

Country Status (23)

Country Link
US (2) US4436743A (ro)
EP (1) EP0059356B1 (ro)
JP (1) JPS57158768A (ro)
KR (1) KR880001428B1 (ro)
AT (1) ATE13055T1 (ro)
AU (1) AU545292B2 (ro)
CA (1) CA1192905A (ro)
CS (1) CS224645B2 (ro)
DD (1) DD208617A5 (ro)
DE (2) DE3107933A1 (ro)
DK (1) DK149852C (ro)
ES (1) ES510015A0 (ro)
FI (1) FI820518A7 (ro)
HU (1) HU190683B (ro)
IL (1) IL65141A (ro)
NO (1) NO820476L (ro)
NZ (1) NZ199862A (ro)
PH (1) PH18696A (ro)
PL (1) PL136818B1 (ro)
PT (1) PT74507B (ro)
RO (1) RO84816B (ro)
SU (1) SU1097197A3 (ro)
ZA (1) ZA821327B (ro)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3107933A1 (de) * 1981-03-02 1982-09-16 Cassella Ag, 6000 Frankfurt Substituierte 3-amino-sydnonimine, verfahren zu ihrer herstellung und ihre verwendung
JPS5859977A (ja) * 1981-10-06 1983-04-09 Banyu Pharmaceut Co Ltd 新規なｎ−アシルシドノンイミン誘導体およびその製法
US4517179A (en) * 1983-04-29 1985-05-14 Pennwalt Corporation Rapid dissolving, uniform drug compositions and their preparation
DK243084A (da) * 1983-05-26 1984-11-27 Takeda Chemical Industries Ltd Perkutane farmaceutiske praeparater til udvortes brug
DE3526068A1 (de) * 1985-07-20 1987-01-22 Cassella Ag Substituierte 3-amino-sydnonimine, verfahren zu ihrer herstellung, ihre verwendung und sie enthaltende pharmazeutische praeparate
DE3702083A1 (de) * 1987-01-24 1988-08-04 Cassella Ag Allylmercaptoacetyl-sydnonimine, verfahren zu ihrer herstellung und ihre verwendung
DE3732174A1 (de) * 1987-09-24 1989-04-06 Cassella Ag Substituierte 3-aminosydnonimine, verfahren zu ihrer herstellung und ihre verwendung
US5221680A (en) * 1988-01-14 1993-06-22 Cassella Aktiengesellschaft Substituted 3-aminosydnonimines
FR2627696B1 (fr) * 1988-02-26 1991-09-13 Fournier Innovation Synergie Nouvelle forme galenique du fenofibrate
US5120732A (en) * 1988-06-14 1992-06-09 Cassella Aktiengesellschaft Substituted 3-aminosyndone imines, a process for their preparation and their use
DE4025604A1 (de) * 1990-08-13 1992-02-20 Cassella Ag 3-dicyclohexylamino-sydnonimine, verfahren zu ihrer herstellung und ihre verwendung
DE4028679A1 (de) * 1990-09-10 1992-03-19 Cassella Ag Substituierte 3-aminosydnonimine, verfahren zu ihrer herstellung und ihre verwendung
DE4031373A1 (de) * 1990-10-04 1992-04-09 Cassella Ag 3-piperazino-sydnonimine, verfahren zu ihrer herstellung und ihre verwendung
EP0903346A1 (en) * 1995-11-06 1999-03-24 Chugai Seiyaku Kabushiki Kaisha Sydnone imine derivatives
FR2758459B1 (fr) * 1997-01-17 1999-05-07 Pharma Pass Composition pharmaceutique de fenofibrate presentant une biodisponibilite elevee et son procede de preparation
US6531158B1 (en) 2000-08-09 2003-03-11 Impax Laboratories, Inc. Drug delivery system for enhanced bioavailability of hydrophobic active ingredients

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1695897C3 (de) 1966-07-04 1979-02-15 Takeda Chemical Industries Ltd N-Acyl-sydnonimine, deren Salze, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US3833580A (en) 1966-08-09 1974-09-03 Boehringer Sohn Ingelheim 3-morpholino-n6-cyclohexylcarbonyl sydnonimine
BE788052A (fr) * 1971-08-26 1973-02-26 Science Union & Cie Societe Fr Nouveaux derives de la sydnone imine
US3833589A (en) * 1972-07-31 1974-09-03 Sandoz Ag Substituted sydnonimine nitrate esters
DE2930736A1 (de) * 1979-07-28 1981-02-12 Cassella Ag Pharmakologisch wirksame, substituierte 3-amino-sydnonimine, verfahren zu ihrer herstellung und ihre verwendung
DE3107933A1 (de) * 1981-03-02 1982-09-16 Cassella Ag, 6000 Frankfurt Substituierte 3-amino-sydnonimine, verfahren zu ihrer herstellung und ihre verwendung
JPS5832870A (ja) * 1981-08-24 1983-02-25 Hiroyoshi Hidaka 新規なシドノンイミン誘導体及びその製法
JPS5859977A (ja) * 1981-10-06 1983-04-09 Banyu Pharmaceut Co Ltd 新規なｎ−アシルシドノンイミン誘導体およびその製法

Also Published As

Publication number Publication date
DK149852B (da) 1986-10-13
ES8303404A1 (es) 1983-02-01
ES510015A0 (es) 1983-02-01
CS224645B2 (en) 1984-01-16
PT74507A (de) 1982-04-01
PL235274A1 (ro) 1982-10-25
EP0059356A1 (de) 1982-09-08
CA1192905A (en) 1985-09-03
EP0059356B1 (de) 1985-05-02
ATE13055T1 (de) 1985-05-15
US4436743A (en) 1984-03-13
IL65141A0 (en) 1982-05-31
DE3107933A1 (de) 1982-09-16
JPS57158768A (en) 1982-09-30
PL136818B1 (en) 1986-03-31
FI820518L (fi) 1982-09-03
KR830009062A (ko) 1983-12-17
DE3263342D1 (en) 1985-06-05
FI820518A7 (fi) 1982-09-03
NZ199862A (en) 1985-04-30
DK149852C (da) 1987-06-01
RO84816A (ro) 1984-08-17
ZA821327B (en) 1983-01-26
US4551454A (en) 1985-11-05
DK67682A (da) 1982-09-03
NO820476L (no) 1982-09-03
HU190683B (en) 1986-10-28
IL65141A (en) 1984-10-31
DD208617A5 (de) 1984-04-04
PT74507B (de) 1983-11-08
KR880001428B1 (ko) 1988-08-08
PH18696A (en) 1985-09-05
AU545292B2 (en) 1985-07-11
SU1097197A3 (ru) 1984-06-07
AU8096682A (en) 1982-09-16

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