AR246250A1 - Un procedimiento para preparar nuevos derivados carboxilicos o heteroxiclicos. - Google Patents

Un procedimiento para preparar nuevos derivados carboxilicos o heteroxiclicos.

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Publication number
AR246250A1
AR246250A1 AR88311592A AR31159288A AR246250A1 AR 246250 A1 AR246250 A1 AR 246250A1 AR 88311592 A AR88311592 A AR 88311592A AR 31159288 A AR31159288 A AR 31159288A AR 246250 A1 AR246250 A1 AR 246250A1
Authority
AR
Argentina
Prior art keywords
alkyl
radical
phenyl
subst
formula
Prior art date
Application number
AR88311592A
Other languages
English (en)
Original Assignee
Sanofi Sa
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Publication date
Priority claimed from US07/082,554 external-priority patent/US4957925A/en
Application filed by Sanofi Sa filed Critical Sanofi Sa
Application granted granted Critical
Publication of AR246250A1 publication Critical patent/AR246250A1/es

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    • C07—ORGANIC CHEMISTRY
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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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    • C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D209/04—Indoles; Hydrogenated indoles
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
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    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
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    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
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    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
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    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

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  • General Chemical & Material Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Indole Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Furan Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

PREPARACION DE UN DERIVADO DE AMINOALCOXIFENILO DE FORMULA(I),SU N-OXIDO Y SALES DONDE B ES -S- O -SO2-,A ES ALQUILENO,R3 ES ALQUILO O -ALK-AR EN LA CUAL ALK ES UN ENLACE SIMPLE O ALQUILENO Y ARES PIRIDILO,FENILO,1,3- BENZODIOXOLANILO O FENILO SUSTITUIDO CON 1 O MAS SUSTITUYENTES,COMO HALOGENO,ALQUILO,ALCOXI;R4 ES H O ALQUILO;CY ES:A)UN HETEROCICLICO SUBSTITUIDO POR ALQUILO O UN CICLOPROPILO EN LA POSICION CON RESPECTO AL GRUPO METINO DIRECTAMENTE LIGADO A B,SIENDO EL HETEROCICLICO 3- INDOLIZINILO,3-BENZOFURILO,3-BENZOTIENILO,3-PIRAZOLO¡1,5-A¿PIRIDILO,3- QUINOLI LO,5-PIRROLO¡1,2-B¿PIRIDAZINILO,4,5-DIHIDRO-3-PIRROLILO,4,5-DIHIDRO 3-FURILO,3- FURILO,5-(2-HALOGENO-FENIL-ALQUILO C1-C4)-4,5,6,7-TETRAHIDRO- TIENO¡3,2-C¿-3-PIRIDILO,1-BENZIMIDAZOLILO,4-PIRAZOLIL O Y 2-O 3-INDOLILO N- SUBSTITUIDO POR ALQUILO O NO;B) UN GRUPO PIRIDILO,CINNOLINILO,PIRIMIDILO,2- INDENILO O NAFTILO;C) UN FENILO O CICLOHEXENILO SUBSTITUIDO O NO POR UN ALQUILO EN LA POSICION CON RESPECTO AL GRUPO METINO DIRECTAMENTE L IGADO A B;D)UN RADICAL 2-IMIDAZOLILO N-SUBST.POR BENCILO O ALQUILO;E)UN RADICAL 2-BENZIMIDAZOLILO N-SUBST.POR ALQUILO; F)UN RADICAL 4-IMIDAZOLILO SUBST.1 Y 5 POR FENILO;G)UN RADICAL 4-TIAZOLILO SUBST.EN 5 POR FENILO;Y H)UN RADICAL 4-ISOXAZOLILO SUBST.EN 5 POR UN ALQUILO Y OPCIONALMENTE EN 3 POR FENILO,CUANDO CY ES BENZO(B)FURILO O BENZO(B)TIENILO Y B ES -SO2-,R3 REPRESENTA UN RADICAL-ALK-AR,POR A)CONDENSACION DE UN 4-ALCOXIFENIL DE FORMULA (II)EN LA CUAL B'REPRESENTA UN GRUPO -S- O -SO2-,X ES HALOGENO,ALQUILSULFONILOXI O ARILSULFONILOXI CON UNA AMINA DE FORMULA (III) O B)REACCION DE 4-HIDROXIFENILO DE FORMULA (IV)EN LA CUAL B'REPRESENTA UN GRUPO -S- O -SO2- Y CON UN COMPUESTO DE FORMULA (V),DONDE X ES HALOGENO,ALQUILSULFONILOXI,ARILSULFOXIDO.
AR88311592A 1987-08-07 1988-08-04 Un procedimiento para preparar nuevos derivados carboxilicos o heteroxiclicos. AR246250A1 (es)

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US07/082,554 US4957925A (en) 1986-02-14 1987-08-07 Aminoalkoxyphenyl derivatives, process of preparation and compositions containing the same

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JP (2) JPS6470458A (es)
AR (1) AR246250A1 (es)
AT (2) ATE113274T1 (es)
AU (2) AU608873B2 (es)
CA (2) CA1335378C (es)
DD (1) DD278792A5 (es)
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ES (1) ES2060667T3 (es)
FI (1) FI93215C (es)
HU (1) HU207990B (es)
IE (1) IE61731B1 (es)
IL (1) IL87181A (es)
MA (1) MA21348A1 (es)
MY (1) MY103905A (es)
NO (1) NO176142C (es)
NZ (2) NZ225625A (es)
OA (1) OA09013A (es)
PL (2) PL160574B1 (es)
PT (2) PT88180B (es)
RU (2) RU1819260C (es)
SG (2) SG59866G (es)
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Publication number Priority date Publication date Assignee Title
FR2594438B1 (fr) * 1986-02-14 1990-01-26 Labaz Sanofi Nv Derives d'indolizine, leur procede de preparation ainsi que les compositions en contenant
IL87181A (en) * 1987-08-07 1993-08-18 Sanofi Sa Aminoalkoxyphenyl derivatives, their preparation and pharmaceutical and veterinary compositions containing them
FR2633622B1 (fr) * 1988-07-04 1991-05-17 Sanofi Sa Derives de sulfonyl indolizine, leur procede de preparation et leur utilisation comme intermediaires de synthese
CA2008985A1 (en) * 1989-02-06 1990-08-06 Jean Gubin Aminoalkoxyphenyl derivatives, process of preparation and compositions containing the same
FR2642756B1 (fr) * 1989-02-07 1994-03-04 Sanofi Derives cycloaminoalkoxyphenyle, leur procede de preparation ainsi que les compositions pharmaceutiques ou veterinaires en contenant
FR2642755B1 (es) * 1989-02-07 1993-11-05 Sanofi
FR2692574B1 (fr) * 1992-06-23 1995-06-23 Sanofi Elf Derives hydroxy-4 benzenethio, leur preparation ainsi que leur utilisation pour la preparation de derives aminoalkoxybenzenesulfonyles.
FR2692578B1 (fr) * 1992-06-23 1995-06-30 Sanofi Elf Derives d'indolizines, procede de preparation et utilisation pour la preparation de composes aminoalkoxybenzenesulfonyl-indolizines a activite pharmaceutique.
FR2708604B1 (fr) * 1993-07-30 1995-10-20 Sanofi Elf Utilisation de dérivés de benzènesulfonyl-indole pour la préparation de médicaments.
GB9321811D0 (en) * 1993-10-22 1993-12-15 Smithkline Beecham Plc Pharmaceuticals
FR2725133B1 (fr) * 1994-09-30 1996-12-20 Sanofi Sa Composition pharmaceutique de fantofarone pour administration orale
US6514971B1 (en) 1996-03-15 2003-02-04 Zeneca Limited Cinnoline derivatives and use as medicine
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ES2388138T3 (es) 2003-08-27 2012-10-09 Ophthotech Corporation Terapia de combinación para tratamiento de trastornos neovasculares oculares
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FI61030C (fi) * 1976-02-19 1982-05-10 Sanofi Sa Foerfarande foer framstaellning av terapeutiskt verkande 2-substituerade-1- eller 3-benzoyl-indolizinderivat
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FR2376145A1 (fr) * 1977-01-03 1978-07-28 Thea Therapeutiques Applic Sa Nouveaux derives de chromones a activite medicamenteuse et leur preparation
GB1560006A (en) * 1977-08-18 1980-01-30 Laroche Navarron Sa Benzoyl furan derivatives process for their preparation and therapeutic applications thereof
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AU8165582A (en) * 1981-04-02 1982-10-07 Ici Australia Limited Quinolin derivatives
FR2594438B1 (fr) * 1986-02-14 1990-01-26 Labaz Sanofi Nv Derives d'indolizine, leur procede de preparation ainsi que les compositions en contenant
IL87181A (en) * 1987-08-07 1993-08-18 Sanofi Sa Aminoalkoxyphenyl derivatives, their preparation and pharmaceutical and veterinary compositions containing them

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EP0302792A3 (en) 1990-11-28
PL274094A1 (en) 1989-05-02
DE3851925D1 (de) 1994-12-01
PT88181A (pt) 1989-06-30
YU152188A (en) 1990-04-30
IL87181A0 (en) 1988-12-30
SG58994G (en) 1994-10-28
AU620040B2 (en) 1992-02-13
EP0302793A3 (en) 1990-11-28
IE882274L (en) 1989-02-07
PL160574B1 (pl) 1993-03-31
DE3886298T2 (de) 1994-06-09
JPS6470458A (en) 1989-03-15
AU2061988A (en) 1989-02-09
TNSN88080A1 (fr) 1990-07-10
DK435588A (da) 1989-02-08
NO883503L (no) 1989-02-08
RU1819260C (ru) 1993-05-30
ATE98643T1 (de) 1994-01-15
EP0302792B1 (en) 1994-10-26
IE61731B1 (en) 1994-11-30
AU2024388A (en) 1989-02-09
RU2032669C1 (ru) 1995-04-10
DK438788A (da) 1989-02-08
HUT48870A (en) 1989-07-28
MA21348A1 (fr) 1989-04-01
FI93215B (fi) 1994-11-30
DK435588D0 (da) 1988-08-04
DE3851925T2 (de) 1995-06-08
NZ225642A (en) 1990-03-27
DE3886298D1 (de) 1994-01-27
EP0302793B1 (en) 1993-12-15
CA1335378C (en) 1995-04-25
PT88181B (pt) 1995-03-01
HU207990B (en) 1993-07-28
DD278792A5 (de) 1990-05-16
NO176142C (no) 1995-02-08
MY103905A (en) 1993-10-30
PL163114B1 (pl) 1994-02-28
PT88180A (pt) 1989-06-30
ES2060667T3 (es) 1994-12-01
EP0302793A2 (en) 1989-02-08
PT88180B (pt) 1995-03-01
FI883672A0 (fi) 1988-08-05
ZA885782B (en) 1990-04-25
NO176142B (no) 1994-10-31
ZA885781B (en) 1990-04-25
AU608873B2 (en) 1991-04-18
OA09013A (en) 1991-03-31
NZ225625A (en) 1990-09-26
JPH01104038A (ja) 1989-04-21
DK438788D0 (da) 1988-08-05
NO883503D0 (no) 1988-08-05
ATE113274T1 (de) 1994-11-15
SG59866G (en) 1995-09-18
FI883672A (fi) 1989-02-08
CA1335379C (en) 1995-04-25
IL87181A (en) 1993-08-18
FI93215C (fi) 1995-03-10
EP0302792A2 (en) 1989-02-08

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