RU1819260C - Способ получени аминоалкоксифенильных производных или их фармацевтически приемлемых солей - Google Patents

Способ получени аминоалкоксифенильных производных или их фармацевтически приемлемых солей

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Publication number
RU1819260C
RU1819260C SU884356350A SU4356350A RU1819260C RU 1819260 C RU1819260 C RU 1819260C SU 884356350 A SU884356350 A SU 884356350A SU 4356350 A SU4356350 A SU 4356350A RU 1819260 C RU1819260 C RU 1819260C
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RU
Russia
Prior art keywords
phenyl
alkylene
benzo
pyridyl
reagent
Prior art date
Application number
SU884356350A
Other languages
English (en)
Inventor
Гюбэн Жан
Шатлэн Пьер
Иньон Анри
Люкшетти Жан
Маокс Жан-Мари
Валла Жан-Ноэль
Original Assignee
Санофи
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Publication date
Priority claimed from US07/082,554 external-priority patent/US4957925A/en
Application filed by Санофи filed Critical Санофи
Application granted granted Critical
Publication of RU1819260C publication Critical patent/RU1819260C/ru

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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
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    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Hematology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Indole Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Furan Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Использование: в качестве антиадре- нэргических средств в медицине. Сущность изобретени : продукт аминоалкоксифе- нильные производные общей формулы Су- B-fcC°C-C-C C-0-A-NRiR2, где В - S- или SOa-rpynna; A - линейный или разветвленный алкиленовый радикал, содержащий 2-5 атомов углерода; RI - Ci-Ci-алкил или AlkАг , где Alk - одинарна  св зь или Ci-Cs-ал- килен; Аг-- пиридил, фенил, 2,3-метиленди- оксифенил или фенил, замещенный одним или несколькими заместител ми, которые могут быть как одинаковыми, так и различными , выбранными из атомов галогена, низших алкильных или алкоксильных групп; R2 - водород или Ст-С алкил, или Rt и R2 вместе образуют Сз-Се-алкилен; Су- инодо- линин-3-ил, индолил, бёнзофурил, бензоти- енил, хинолинил, пирроло (1,2-а) пиридил, 4,5-дигидрофуранил или фенил, при условии , что когда Су - бензо(Ь) фурил или бензо (Ь) тиенил, то В  вл етс  502-гру.ппой, а RI - Afk-Ar или же фармацевтически приемлемые соли. Реагент 1: 4-оксифенил формулы Су-В-СбН4ОН. Реагент 2: X-A-NRiRa, где Х- галоген, С|-С4-алкилсульфонилокси, или С1 С4-арилсульфонилоксигруппа. Услови  реакции:- в присутствии щелочного агента в среде пол рного растворител  при температуре от комнатной до температуры кипени  реакционной смеси. 3 табл. i .- , о ел G

Description

Cy-so2- -o-(CH2)3-te
Таблица 1
39;
1819260
40
Продолжение табл.1
45
1819260
Cy-S02- -0-(СН2)п-Аш
46
Продолжение тэбл.1
47
1819260
48
Продолжение табл.1
49
181926050
Продолжение табл.I
Пример
Су
;
0
п
-S02- :-ННС(СН3)3
-S02- s-N-( t
г
К«f „ осн 
« 3 i
I
ч
: -S02- :
В сравнении с известными соединени ми получены следующие результаты
(CH2)2(c2H5)a
Амин
от максимального сокращени  I 1СГ7П Т J
32.0 :83.3 :
it
:i
:t
79.3 90.4 :
: t:
ti:
19.2 :73.1 s86.6 i
: .
ttt
iit
« от максимального сокращени 
Т
-0-(СН2)3-Аш
2 .
% от максимального собращени 
2-этил-1-4-/3-Саи-и-бутиламйно)пропилокси/ бензоилиндолйзин,
Таблица 2
Таблица 3
SU884356350A 1987-08-07 1988-08-05 Способ получени аминоалкоксифенильных производных или их фармацевтически приемлемых солей RU1819260C (ru)

Applications Claiming Priority (1)

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US07/082,554 US4957925A (en) 1986-02-14 1987-08-07 Aminoalkoxyphenyl derivatives, process of preparation and compositions containing the same

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SU904830121A RU2032669C1 (ru) 1987-08-07 1990-06-15 Способ получения аминофеноксипроизводных

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FR2594438B1 (fr) * 1986-02-14 1990-01-26 Labaz Sanofi Nv Derives d'indolizine, leur procede de preparation ainsi que les compositions en contenant
IL87181A (en) * 1987-08-07 1993-08-18 Sanofi Sa Aminoalkoxyphenyl derivatives, their preparation and pharmaceutical and veterinary compositions containing them
FR2633622B1 (fr) * 1988-07-04 1991-05-17 Sanofi Sa Derives de sulfonyl indolizine, leur procede de preparation et leur utilisation comme intermediaires de synthese
CA2008985A1 (en) * 1989-02-06 1990-08-06 Jean Gubin Aminoalkoxyphenyl derivatives, process of preparation and compositions containing the same
FR2642756B1 (fr) * 1989-02-07 1994-03-04 Sanofi Derives cycloaminoalkoxyphenyle, leur procede de preparation ainsi que les compositions pharmaceutiques ou veterinaires en contenant
FR2642755B1 (ru) * 1989-02-07 1993-11-05 Sanofi
FR2692574B1 (fr) * 1992-06-23 1995-06-23 Sanofi Elf Derives hydroxy-4 benzenethio, leur preparation ainsi que leur utilisation pour la preparation de derives aminoalkoxybenzenesulfonyles.
FR2692578B1 (fr) * 1992-06-23 1995-06-30 Sanofi Elf Derives d'indolizines, procede de preparation et utilisation pour la preparation de composes aminoalkoxybenzenesulfonyl-indolizines a activite pharmaceutique.
FR2708604B1 (fr) * 1993-07-30 1995-10-20 Sanofi Elf Utilisation de dérivés de benzènesulfonyl-indole pour la préparation de médicaments.
GB9321811D0 (en) * 1993-10-22 1993-12-15 Smithkline Beecham Plc Pharmaceuticals
FR2725133B1 (fr) * 1994-09-30 1996-12-20 Sanofi Sa Composition pharmaceutique de fantofarone pour administration orale
US6514971B1 (en) 1996-03-15 2003-02-04 Zeneca Limited Cinnoline derivatives and use as medicine
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PL274094A1 (en) 1989-05-02
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PT88181A (pt) 1989-06-30
YU152188A (en) 1990-04-30
IL87181A0 (en) 1988-12-30
SG58994G (en) 1994-10-28
AU620040B2 (en) 1992-02-13
EP0302793A3 (en) 1990-11-28
IE882274L (en) 1989-02-07
PL160574B1 (pl) 1993-03-31
DE3886298T2 (de) 1994-06-09
JPS6470458A (en) 1989-03-15
AU2061988A (en) 1989-02-09
TNSN88080A1 (fr) 1990-07-10
DK435588A (da) 1989-02-08
NO883503L (no) 1989-02-08
ATE98643T1 (de) 1994-01-15
EP0302792B1 (en) 1994-10-26
IE61731B1 (en) 1994-11-30
AU2024388A (en) 1989-02-09
RU2032669C1 (ru) 1995-04-10
DK438788A (da) 1989-02-08
HUT48870A (en) 1989-07-28
MA21348A1 (fr) 1989-04-01
FI93215B (fi) 1994-11-30
DK435588D0 (da) 1988-08-04
DE3851925T2 (de) 1995-06-08
NZ225642A (en) 1990-03-27
DE3886298D1 (de) 1994-01-27
EP0302793B1 (en) 1993-12-15
CA1335378C (en) 1995-04-25
PT88181B (pt) 1995-03-01
HU207990B (en) 1993-07-28
DD278792A5 (de) 1990-05-16
NO176142C (no) 1995-02-08
MY103905A (en) 1993-10-30
PL163114B1 (pl) 1994-02-28
PT88180A (pt) 1989-06-30
ES2060667T3 (es) 1994-12-01
EP0302793A2 (en) 1989-02-08
PT88180B (pt) 1995-03-01
AR246250A1 (es) 1994-07-29
FI883672A0 (fi) 1988-08-05
ZA885782B (en) 1990-04-25
NO176142B (no) 1994-10-31
ZA885781B (en) 1990-04-25
AU608873B2 (en) 1991-04-18
OA09013A (en) 1991-03-31
NZ225625A (en) 1990-09-26
JPH01104038A (ja) 1989-04-21
DK438788D0 (da) 1988-08-05
NO883503D0 (no) 1988-08-05
ATE113274T1 (de) 1994-11-15
SG59866G (en) 1995-09-18
FI883672A (fi) 1989-02-08
CA1335379C (en) 1995-04-25
IL87181A (en) 1993-08-18
FI93215C (fi) 1995-03-10
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