ES8400404A1 - Un procedimiento para la preparacion de derivados de fenilpiperidina sustituidos. - Google Patents

Un procedimiento para la preparacion de derivados de fenilpiperidina sustituidos.

Info

Publication number
ES8400404A1
ES8400404A1 ES515739A ES515739A ES8400404A1 ES 8400404 A1 ES8400404 A1 ES 8400404A1 ES 515739 A ES515739 A ES 515739A ES 515739 A ES515739 A ES 515739A ES 8400404 A1 ES8400404 A1 ES 8400404A1
Authority
ES
Spain
Prior art keywords
alkoxy
hydroxy
derivatives
substituted
vivo hydrolysable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES515739A
Other languages
English (en)
Other versions
ES515739A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES515739A0 publication Critical patent/ES515739A0/es
Publication of ES8400404A1 publication Critical patent/ES8400404A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

UN PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE FENILPIPERIDINA SUSTITUIDOS.SE HACE REACCIONAR EL COMPUESTO (II) CON Q-L-R4 SIENDO L UN ENLACE ALQUILENO C1-6 O 1-OXOALQUILENO C1-6; Q ES UN GRUPO FACILMENTE DESPLAZABLE POR UN NUCLEOFILO. SE OBTIENE EL COMPUESTO (I) SIENDO: R1 HIDROXI, ALCOXI C1-4 O UN GRUPO ACILOXI HIDROLIZABLE IN VIVO; R2 ES HIDROGENO, ALQUILO C1-4, HIDROXI, ALCOXI C1-4 O ACILOXI HIDROLIZABLE IN VIVO; R4 ES BENZOFURILO, BENZOTIENILO, INDOLILO, QUINOLILO, ISOQUINOLILO; 2K3 DIHIDROBENZOFURILO U OTROS. A ES UN ENLACE O ALQUILENO C1-6.
ES515739A 1981-09-17 1982-09-15 Un procedimiento para la preparacion de derivados de fenilpiperidina sustituidos. Expired ES8400404A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8128090 1981-09-17
GB8128091 1981-09-17

Publications (2)

Publication Number Publication Date
ES515739A0 ES515739A0 (es) 1983-10-16
ES8400404A1 true ES8400404A1 (es) 1983-10-16

Family

ID=26280730

Family Applications (1)

Application Number Title Priority Date Filing Date
ES515739A Expired ES8400404A1 (es) 1981-09-17 1982-09-15 Un procedimiento para la preparacion de derivados de fenilpiperidina sustituidos.

Country Status (4)

Country Link
US (1) US4460594A (es)
EP (1) EP0077607A1 (es)
AU (1) AU8846782A (es)
ES (1) ES8400404A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0115607A1 (de) * 1983-01-04 1984-08-15 MERCK PATENT GmbH Tetrahydrocarbazolderivate
DE3301758A1 (de) * 1983-01-20 1984-07-26 Merck Patent Gmbh, 6100 Darmstadt Indolderivate
US5256673A (en) * 1983-11-25 1993-10-26 Merck Patent Gesellschaft Mit Beschrankter Haftung Indole-3-yl-A-tetrahydropyridyl or piperidyl compounds
US5231104A (en) * 1988-07-08 1993-07-27 Pfizer Inc. 1-arylethyl-3-substituted piperidines
GB8929331D0 (en) * 1989-12-29 1990-02-28 Shell Int Research Piperidine derivatives
NZ243065A (en) 1991-06-13 1995-07-26 Lundbeck & Co As H Piperidine derivatives and pharmaceutical compositions
CA2188949A1 (en) * 1994-04-28 1995-11-09 Janusz Jozef Kulagowski Benzofuran derivatives as d4 receptor antagonists
GB9521347D0 (en) * 1995-10-18 1995-12-20 Merck Sharp & Dohme Therapeutic agents
US6107313A (en) * 1998-10-02 2000-08-22 Combichem, Inc. Dopamine receptor antagonists
WO2004048334A1 (en) * 2002-11-26 2004-06-10 Pfizer Products Inc. Phenyl substituted piperidine compounds for use as ppar activators
DE102004036349A1 (de) * 2004-07-27 2006-03-23 Grünenthal GmbH Substituierte 3-Phenylpiperidin-Derivate

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3476760A (en) * 1967-03-06 1969-11-04 Smithkline Corp Substituted piperidinoalkylthianaphthenes and benzofurans
US3686188A (en) * 1970-06-30 1972-08-22 Ciba Geigy Corp N-benzofurylmethyl-arylalkyleneimines
US3936464A (en) * 1974-10-25 1976-02-03 American Cyanamid Company 1-Acyl-3-[2-(4-phenyl-1-piperidinyl)ethyl]indolines
CA1147339A (en) * 1979-12-05 1983-05-31 Folke L. Arvidsson Phenyl-azacykloalkanes
US4358456A (en) * 1980-05-03 1982-11-09 John Wyeth & Brother Limited Antipsychotic piperidinomethyl-indole derivatives

Also Published As

Publication number Publication date
AU8846782A (en) 1983-03-24
EP0077607A1 (en) 1983-04-27
ES515739A0 (es) 1983-10-16
US4460594A (en) 1984-07-17

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