BR9811362A - Composto - Google Patents

Composto

Info

Publication number
BR9811362A
BR9811362A BR9811362-3A BR9811362A BR9811362A BR 9811362 A BR9811362 A BR 9811362A BR 9811362 A BR9811362 A BR 9811362A BR 9811362 A BR9811362 A BR 9811362A
Authority
BR
Brazil
Prior art keywords
substituted
agonists
antagonists
compounds
unsubstituted alkyl
Prior art date
Application number
BR9811362-3A
Other languages
English (en)
Inventor
Panela Albaugh
Robert W Desimone
Gang Liu
Original Assignee
Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp filed Critical Neurogen Corp
Publication of BR9811362A publication Critical patent/BR9811362A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"COMPOSTO". A presente invenção abrange estruturas da Fórmula (I) ou seus sais não tóxicos farmaceuticamente aceitáveis em que: X é hidrogênio, halogênio, alquila substituída ou não substituída, alcóxi substituído ou não substituído ou amino; e Y é alquila, arila ou heteroarila substituídas ou não substituídas, cujos compostos são agonistas, antagonistas ou agonistas inversos altamente seletivos quanto aos receptores cerebrais GABAa ou pró-medicamentos de agonistas, antagonistas ou agonistas inversos para os receptores cerebrais GABAa. Estes compostos são utilizáveis no diagnóstico e no tratamento da ansiedade, Síndrome de Down, distúrbios do sono, cognitivos e de convulsão e dose excessiva com medicamentos de benzodiazepina e para realce da agilidade.
BR9811362-3A 1997-08-25 1998-08-24 Composto BR9811362A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91818097A 1997-08-25 1997-08-25
PCT/US1998/017513 WO1999010347A1 (en) 1997-08-25 1998-08-24 Substituted 4-oxo-napthyridine-3-carboxamides as gaba brain receptor ligands

Publications (1)

Publication Number Publication Date
BR9811362A true BR9811362A (pt) 2000-08-22

Family

ID=25439933

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9811362-3A BR9811362A (pt) 1997-08-25 1998-08-24 Composto

Country Status (24)

Country Link
EP (1) EP1007526A1 (pt)
JP (1) JP2001514181A (pt)
KR (1) KR20010023313A (pt)
CN (1) CN1268136A (pt)
AP (1) AP2000001742A0 (pt)
AU (1) AU753800B2 (pt)
BG (1) BG104192A (pt)
BR (1) BR9811362A (pt)
CA (1) CA2301599C (pt)
EG (1) EG21717A (pt)
HU (1) HUP0003258A3 (pt)
IL (1) IL134291A0 (pt)
IS (1) IS5382A (pt)
LV (1) LV12539B (pt)
NO (1) NO20000822L (pt)
NZ (1) NZ502548A (pt)
OA (1) OA11293A (pt)
PE (1) PE130999A1 (pt)
PL (1) PL338783A1 (pt)
SI (1) SI20270A (pt)
SK (1) SK2162000A3 (pt)
TW (1) TW574221B (pt)
WO (1) WO1999010347A1 (pt)
YU (1) YU10500A (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6413956B1 (en) * 1999-05-06 2002-07-02 Neurogen Corporation Substituted 4-oxo-quinoline-3-carboxamides
WO2000071528A1 (en) * 1999-05-25 2000-11-30 Neurogen Corporation 4h-1,4-benzothiazine-2-carboxamides and their use as gaba brain receptor ligands
US6562822B2 (en) 2000-07-12 2003-05-13 Pharmacia & Upjohn Company Heterocyle carboxamides as antiviral agents
US6559145B2 (en) 2000-07-12 2003-05-06 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
US6730682B2 (en) 2000-07-12 2004-05-04 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
IL155089A0 (en) 2000-10-12 2003-10-31 Merck & Co Inc Aza and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors
DE60128936T2 (de) 2000-10-12 2008-04-10 Merck & Co, Inc. Aza- und polyaza-naphthalenylcarbonsäureamide als hiv-integrase-hemmer
US6841558B2 (en) 2000-10-12 2005-01-11 Merck & Co., Inc. Aza-and polyaza-naphthalenyl carboxamides useful as HIV intergrase inhibitors
US20020151591A1 (en) * 2000-10-17 2002-10-17 Anabella Villalobos Combination use of acetylcholinesterase inhibitors and GABAa inverse agonists for the treatment of cognitive disorders
CN1494422A (zh) * 2001-03-01 2004-05-05 �Ʒ� Gabaa反相激动剂与烟碱受体不完全激动剂、雌激素、选择性雌激素调节剂、或维生素e联合用于认知障碍的用途
AR036256A1 (es) 2001-08-17 2004-08-25 Merck & Co Inc Sal sodica de un inhibidor de integrasa del vih, procesos para su preparacion, composiciones farmaceuticas que lo contienen y su uso para la manufactura de un medicamento
AU2003216049B2 (en) 2002-01-17 2008-07-17 Merck Sharp & Dohme Corp. Hydroxynaphthyridinone carboxamides useful as HIV integrase inhibitors
US7323460B2 (en) 2002-03-15 2008-01-29 Merck & Co., Inc. N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamides useful as HIV integrase inhibitors
WO2004106336A1 (en) * 2003-05-27 2004-12-09 Pfizer Products Inc. Process for the preparation and purification of 1,5-naphthyridine-3-carboxyamides
WO2004106334A2 (en) * 2003-05-28 2004-12-09 Pfizer Products Inc. Process for the preparation of 1,5-naphthyridine-3-carboxy amides by direct ester amidation
CA2666219C (en) * 2006-10-16 2017-02-07 Bionomics Limited Novel anxiolytic compounds
CA2670116C (en) * 2006-11-22 2015-03-10 Seaside Therapeutics, Llc Methods of treating mental retardation, down's syndrome, fragile x syndrome and autism

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR204162A1 (es) * 1972-05-08 1975-11-28 Yamanouchi Pharma Co Ltd Proceso para la preparacion de derivados de ampicilina
GB1433774A (en) * 1973-02-26 1976-04-28 Allen & Hanburys Ltd Heterocyclic compounds apparatus for conveying articles
US4374138A (en) * 1981-11-13 1983-02-15 Warner-Lambert Company Antibacterial amide compounds, compositions, and methods of use
DD279887A1 (de) * 1987-07-03 1990-06-20 Inst Pharmakologische Forschun Verfahren zur herstellung von d-alpha-(4(1h)-1,5-naphthyridon-3-carboxamido)-benzylpenicillin und anderen beta-lactamantibiotika
DD279875A1 (de) * 1987-07-03 1990-06-20 Inst Pharmakologische Forschun Verfahren zur herstellung von aktivierten carbonsaeureestern
DD295360A5 (de) * 1987-07-03 1991-10-31 Akad Wissenschaften Verfahren zur Herstellung von aktivierten Carbonsäureestern
JPS6461461A (en) * 1987-09-01 1989-03-08 Otsuka Pharma Co Ltd Benzohetero ring derivative

Also Published As

Publication number Publication date
YU10500A (sh) 2002-10-18
NO20000822D0 (no) 2000-02-18
JP2001514181A (ja) 2001-09-11
NO20000822L (no) 2000-04-13
AP2000001742A0 (en) 2000-02-24
NZ502548A (en) 2002-06-28
EP1007526A1 (en) 2000-06-14
HUP0003258A3 (en) 2001-05-28
HUP0003258A2 (en) 2001-03-28
AU753800B2 (en) 2002-10-31
AU9117398A (en) 1999-03-16
IL134291A0 (en) 2001-04-30
SI20270A (sl) 2000-12-31
LV12539B (en) 2001-01-20
PL338783A1 (en) 2000-11-20
IS5382A (is) 2000-02-22
SK2162000A3 (en) 2001-03-12
OA11293A (en) 2002-11-19
WO1999010347A1 (en) 1999-03-04
CA2301599C (en) 2003-03-25
LV12539A (en) 2000-10-20
CN1268136A (zh) 2000-09-27
TW574221B (en) 2004-02-01
BG104192A (en) 2001-05-31
CA2301599A1 (en) 1999-03-04
PE130999A1 (es) 1999-12-16
EG21717A (en) 2002-02-27
KR20010023313A (ko) 2001-03-26

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Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements