PE130999A1 - 4-oxo-naftiridin-3-carboxamidas sustituidas; ligandos de receptor cerebral gaba - Google Patents

4-oxo-naftiridin-3-carboxamidas sustituidas; ligandos de receptor cerebral gaba

Info

Publication number
PE130999A1
PE130999A1 PE1998001100A PE00110098A PE130999A1 PE 130999 A1 PE130999 A1 PE 130999A1 PE 1998001100 A PE1998001100 A PE 1998001100A PE 00110098 A PE00110098 A PE 00110098A PE 130999 A1 PE130999 A1 PE 130999A1
Authority
PE
Peru
Prior art keywords
alkyl
naftiridin
oxo
cycloalkyl
leaguards
Prior art date
Application number
PE1998001100A
Other languages
English (en)
Spanish (es)
Inventor
Pamela Albaugh
Robert W Desimone
Gang Liu
Original Assignee
Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp filed Critical Neurogen Corp
Publication of PE130999A1 publication Critical patent/PE130999A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Anesthesiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PE1998001100A 1997-08-25 1998-11-13 4-oxo-naftiridin-3-carboxamidas sustituidas; ligandos de receptor cerebral gaba PE130999A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US91818097A 1997-08-25 1997-08-25

Publications (1)

Publication Number Publication Date
PE130999A1 true PE130999A1 (es) 1999-12-16

Family

ID=25439933

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1998001100A PE130999A1 (es) 1997-08-25 1998-11-13 4-oxo-naftiridin-3-carboxamidas sustituidas; ligandos de receptor cerebral gaba

Country Status (24)

Country Link
EP (1) EP1007526A1 (pt)
JP (1) JP2001514181A (pt)
KR (1) KR20010023313A (pt)
CN (1) CN1268136A (pt)
AP (1) AP2000001742A0 (pt)
AU (1) AU753800B2 (pt)
BG (1) BG104192A (pt)
BR (1) BR9811362A (pt)
CA (1) CA2301599C (pt)
EG (1) EG21717A (pt)
HU (1) HUP0003258A3 (pt)
IL (1) IL134291A0 (pt)
IS (1) IS5382A (pt)
LV (1) LV12539B (pt)
NO (1) NO20000822L (pt)
NZ (1) NZ502548A (pt)
OA (1) OA11293A (pt)
PE (1) PE130999A1 (pt)
PL (1) PL338783A1 (pt)
SI (1) SI20270A (pt)
SK (1) SK2162000A3 (pt)
TW (1) TW574221B (pt)
WO (1) WO1999010347A1 (pt)
YU (1) YU10500A (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0010308A (pt) * 1999-05-06 2002-01-08 Neurogen Corp Composto, composição farmacêutica, uso de um composto, e, métodos para o tratamento de uma doença ou distúrbio associados com o agonismo patogênico, agonismo inverso ou antagonismo do receptor de gabaa, para localizar receptores de gabaa em uma amostra de tecido, para inibir a ligação de um composto de benzodiazepina a um receptor de gabaa e para alterar a atividade da transdução de sinal dos receptores de gabaa, e, composição farmacêutica embalada
WO2000071528A1 (en) * 1999-05-25 2000-11-30 Neurogen Corporation 4h-1,4-benzothiazine-2-carboxamides and their use as gaba brain receptor ligands
US6562822B2 (en) 2000-07-12 2003-05-13 Pharmacia & Upjohn Company Heterocyle carboxamides as antiviral agents
US6730682B2 (en) 2000-07-12 2004-05-04 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
US6559145B2 (en) 2000-07-12 2003-05-06 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
ATE364385T1 (de) 2000-10-12 2007-07-15 Merck & Co Inc Aza- und polyaza-naphthalenylcarbonsäureamide als hiv-integrase-hemmer
IL155089A0 (en) 2000-10-12 2003-10-31 Merck & Co Inc Aza and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors
EP1326610B1 (en) 2000-10-12 2006-11-15 Merck & Co., Inc. Aza-and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors
US20020151591A1 (en) * 2000-10-17 2002-10-17 Anabella Villalobos Combination use of acetylcholinesterase inhibitors and GABAa inverse agonists for the treatment of cognitive disorders
KR20030076717A (ko) * 2001-03-01 2003-09-26 화이자 프로덕츠 인크. 인지 장애의 치료를 위한 니코틴 수용체 부분 아고니스트,에스트로겐, 선택적 에스트로겐 조정자 또는 비타민 ｅ와함께, ｇａｂａａ 역아고니스트의 용도
AR036256A1 (es) 2001-08-17 2004-08-25 Merck & Co Inc Sal sodica de un inhibidor de integrasa del vih, procesos para su preparacion, composiciones farmaceuticas que lo contienen y su uso para la manufactura de un medicamento
ES2291642T3 (es) 2002-01-17 2008-03-01 MERCK & CO., INC. Hidroxinaftiridinoncarboxamidas utiles como inhibidores de la integrasa de vih.
JP4494020B2 (ja) 2002-03-15 2010-06-30 メルク・シャープ・エンド・ドーム・コーポレイション Ｈｉｖインテグラーゼ阻害剤として有用なｎ−（置換ベンジル）−８−ヒドロキシ−１，６−ナフチリジン−７−カルボキサミド
WO2004106336A1 (en) * 2003-05-27 2004-12-09 Pfizer Products Inc. Process for the preparation and purification of 1,5-naphthyridine-3-carboxyamides
WO2004106334A2 (en) * 2003-05-28 2004-12-09 Pfizer Products Inc. Process for the preparation of 1,5-naphthyridine-3-carboxy amides by direct ester amidation
WO2008046135A1 (en) * 2006-10-16 2008-04-24 Bionomics Limited Novel anxiolytic compounds
CA2670116C (en) * 2006-11-22 2015-03-10 Seaside Therapeutics, Llc Methods of treating mental retardation, down's syndrome, fragile x syndrome and autism

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR204813A1 (es) * 1972-05-08 1976-03-05 Yamanouchi Pharma Co Ltd Proceso para la preparacion de derivados de ampilicina
GB1433774A (en) * 1973-02-26 1976-04-28 Allen & Hanburys Ltd Heterocyclic compounds apparatus for conveying articles
US4374138A (en) * 1981-11-13 1983-02-15 Warner-Lambert Company Antibacterial amide compounds, compositions, and methods of use
DD279875A1 (de) * 1987-07-03 1990-06-20 Inst Pharmakologische Forschun Verfahren zur herstellung von aktivierten carbonsaeureestern
DD279887A1 (de) * 1987-07-03 1990-06-20 Inst Pharmakologische Forschun Verfahren zur herstellung von d-alpha-(4(1h)-1,5-naphthyridon-3-carboxamido)-benzylpenicillin und anderen beta-lactamantibiotika
DD295360A5 (de) * 1987-07-03 1991-10-31 Akad Wissenschaften Verfahren zur Herstellung von aktivierten Carbonsäureestern
JPS6461461A (en) * 1987-09-01 1989-03-08 Otsuka Pharma Co Ltd Benzohetero ring derivative

Also Published As

Publication number Publication date
CN1268136A (zh) 2000-09-27
CA2301599C (en) 2003-03-25
JP2001514181A (ja) 2001-09-11
SK2162000A3 (en) 2001-03-12
IS5382A (is) 2000-02-22
WO1999010347A1 (en) 1999-03-04
BG104192A (en) 2001-05-31
IL134291A0 (en) 2001-04-30
EP1007526A1 (en) 2000-06-14
NZ502548A (en) 2002-06-28
AP2000001742A0 (en) 2000-02-24
AU753800B2 (en) 2002-10-31
AU9117398A (en) 1999-03-16
NO20000822L (no) 2000-04-13
TW574221B (en) 2004-02-01
NO20000822D0 (no) 2000-02-18
BR9811362A (pt) 2000-08-22
CA2301599A1 (en) 1999-03-04
LV12539B (en) 2001-01-20
SI20270A (sl) 2000-12-31
PL338783A1 (en) 2000-11-20
OA11293A (en) 2002-11-19
KR20010023313A (ko) 2001-03-26
YU10500A (sh) 2002-10-18
HUP0003258A3 (en) 2001-05-28
EG21717A (en) 2002-02-27
HUP0003258A2 (en) 2001-03-28
LV12539A (en) 2000-10-20

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FD Application declared void or lapsed