TNSN97158A1 - Certains pyrrolecarboxanilide fondus ; une nouvelle classe de ligands recepteurs du cerveau (acide gamma -aminobutyrique). - Google Patents

Certains pyrrolecarboxanilide fondus ; une nouvelle classe de ligands recepteurs du cerveau (acide gamma -aminobutyrique).

Info

Publication number
TNSN97158A1
TNSN97158A1 TNTNSN97158A TNSN97158A TNSN97158A1 TN SN97158 A1 TNSN97158 A1 TN SN97158A1 TN TNSN97158 A TNTNSN97158 A TN TNSN97158A TN SN97158 A TNSN97158 A TN SN97158A TN SN97158 A1 TNSN97158 A1 TN SN97158A1
Authority
TN
Tunisia
Prior art keywords
hydrogen
agonists
pyrrolecarboxanilide
aminobutyric
melted
Prior art date
Application number
TNTNSN97158A
Other languages
English (en)
Inventor
Pamela Albaugh
Alan Hutchison
Original Assignee
Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp filed Critical Neurogen Corp
Publication of TNSN97158A1 publication Critical patent/TNSN97158A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'INVENTION ACTUELLE ENGLOBE LES STRUCTURE DE LA FORMUEL I OU LES SELS NON-TOXIQUES ACCEPTABLES PHARMACEUTIQUEMENT EN DECOULANT...... OU W REPRESENTE DU PHENYLE SUBSTITUE OU NON-SUBSTITUE ; X EST DE L'HYDROGENE, HYDROXY OU ALKYLE LEGER ; T EST DE L'HYDROGENE, HALOGENE, HYDROXY, NITRO, AMINO OU ALKYLE ; R3 EST DE L'HYDROGENE OU UN GROUPE ORGANIQUE ; R4 EST DE L'HYDROGENE OU UN SUBSTITUANT ORGANIQUE SUBSTITUE OU NON ; R5 ET R6 REPRESENTENT DES SUBSTITUANTS ORGANIQUES ET INORGANIQUES ; ET n EST 1,2, 3 ET 4 DONT LES COMPOSES SONT DES AGONISTES, ANTAGONISTES OU AGONISTES INVERSES TRES SELECTIFS POUR LES RECEPTEURS DU CERVEAU GABAa OU DES PRODOGUES D'AGONISTES, D'ANTAGONISTES OU D'AGONISTES INVERSES POUR LES RECEPTEURS DU CERVEAU GABAa. CES COMPOSES SONT UTILES POUR LE DIAGNOSTIC ET LE TRAITEMENT DE L'ANXIETE, DES TROUBLES DU SOMMEIL ET EPILEPTIQUE, DES SURDOSES DE DROGUES AU BENZODIAZEPINE ET POUR AMELIORER LA MEMOIRE.
TNTNSN97158A 1996-03-22 1997-09-19 Certains pyrrolecarboxanilide fondus ; une nouvelle classe de ligands recepteurs du cerveau (acide gamma -aminobutyrique). TNSN97158A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62093996A 1996-03-22 1996-03-22
PCT/US1997/004623 WO1997034870A1 (fr) 1996-03-22 1997-03-20 Certains pyrrolecarboxamides fusionnes utilises comme ligands de recepteurs cerebraux gaba

Publications (1)

Publication Number Publication Date
TNSN97158A1 true TNSN97158A1 (fr) 2005-03-15

Family

ID=24488030

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN97158A TNSN97158A1 (fr) 1996-03-22 1997-09-19 Certains pyrrolecarboxanilide fondus ; une nouvelle classe de ligands recepteurs du cerveau (acide gamma -aminobutyrique).

Country Status (7)

Country Link
US (2) US6353109B2 (fr)
EP (1) EP0888300A1 (fr)
AU (1) AU2218997A (fr)
PA (1) PA8438301A1 (fr)
PE (1) PE109598A1 (fr)
TN (1) TNSN97158A1 (fr)
WO (1) WO1997034870A1 (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0888300A1 (fr) * 1996-03-22 1999-01-07 Neurogen Corporation Certains pyrrolecarboxamides fusionnes utilises comme ligands de recepteurs cerebraux gaba
ID24135A (id) 1997-11-13 2000-07-06 Pfizer Prod Inc Metode sintesa pirol amida
GT199800179A (es) * 1997-11-13 2000-05-02 Procedimiento de sintesis de pirrol amidas.
AU2881199A (en) * 1998-02-26 1999-09-15 Neurogen Corporation Substituted 1,4-dihydro-4-oxonicotinic carboxamides: gaba brain receptor ligands
ES2243046T3 (es) 1998-02-26 2005-11-16 Neurogen Corporation Carboxamidas cicloalquil-4-oxonicotinicas sustituidas; ligandos de receptores gaba del cerebro.
GB9812038D0 (en) * 1998-06-04 1998-07-29 Merck Sharp & Dohme Therapeutic compound
GB9900222D0 (en) * 1999-01-06 1999-02-24 Merck Sharp & Dohme Therapeutic compounds
CA2364652A1 (fr) 1999-02-22 2000-08-31 Benoit Bachand Derives de naphthyridine ¢1,8! a activite antivirale
OA12015A (en) 1999-08-31 2006-04-19 Neurogen Corp Fused pyrrolecarboxamides: gaba brain receptor ligands.
US6723332B2 (en) 2000-05-26 2004-04-20 Neurogen Corporation Oxomidazopyridine-carboxamides
CA2430841A1 (fr) * 2000-12-04 2002-06-13 Pfizer Products Inc. Synthese de pyrrolescarboxamides fusionnes
US6861529B2 (en) 2001-07-06 2005-03-01 Pfizer Inc Cycloalkypyrrole-3-carboxylic acid derivatives and heterocycloalkylpyrrole-3-carboxylic acid derivatives
WO2003066634A1 (fr) * 2002-02-07 2003-08-14 Neurogen Corporation Arylamides d'acide pyrazolecarboxylique substitues, fusionnes, et composes associes
FR2863169B1 (fr) * 2003-12-08 2006-02-10 Air Liquide Sante Int Medicament gazeux inhalable a base d'argon pour le traitement des neuro-intoxications
CA2620333A1 (fr) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenese par modulation du recepteur muscarinique
EP2258359A3 (fr) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenèse par modulation des récepteurs muscariniques avec sabcomeline
EP2377530A3 (fr) 2005-10-21 2012-06-20 Braincells, Inc. Modulation de neurogénèse par inhibition PDE
WO2007053596A1 (fr) * 2005-10-31 2007-05-10 Braincells, Inc. Modulation de la neurogenese dont la mediation est assuree par recepteur gaba
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
JP2009536669A (ja) 2006-05-09 2009-10-15 ブレインセルス，インコーポレイティド アンジオテンシン調節による神経新生
EP2026813A2 (fr) 2006-05-09 2009-02-25 Braincells, Inc. Neurogenèse induite par le récepteur 5ht
KR20090064418A (ko) 2006-09-08 2009-06-18 브레인셀즈 인코퍼레이션 4-아실아미노피리딘 유도체 포함 조합물
JP5373613B2 (ja) 2006-10-16 2013-12-18 バイオノミクス リミテッド 新規な抗不安薬化合物
US10954231B2 (en) 2006-10-16 2021-03-23 Bionomics Limited Anxiolytic compounds
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
JP2014510065A (ja) 2011-03-02 2014-04-24 バイオノミックス リミテッド 治療薬としての新規な小分子
CN103649086A (zh) 2011-05-12 2014-03-19 生态学有限公司 制备萘啶的方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3455943A (en) 1966-10-21 1969-07-15 American Cyanamid Co Certain 5,8-dihydro-beta-carbolines
US4075343A (en) 1976-09-13 1978-02-21 Pfizer Inc. Anti-allergenic 5-alkoxyimidazo[1,2-A]quinoline-2-carboxylic acids and derivatives thereof
DE3029980A1 (de) 1980-08-08 1982-03-11 Boehringer Mannheim Gmbh, 6800 Mannheim Indolderivate und verfahren zu ihrer herstellung
JPS57123180A (en) 1980-12-17 1982-07-31 Schering Ag 3-substituted beta-carboline, manufacture and psychotropic drug containing same
DE3147276A1 (de) 1981-11-28 1983-06-09 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur herstellung von indolderivaten, deren verwendung als wertvolle zwischenprodukte und neue 4-hydroxyindole
DE3246932A1 (de) 1982-12-16 1984-06-20 Schering AG, 1000 Berlin und 4709 Bergkamen Substituierte 5h-pyrimido(5,4-b)indole
DE3335323A1 (de) 1983-09-27 1985-04-04 Schering AG, 1000 Berlin und 4709 Bergkamen Substituierte ss-carboline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3535927A1 (de) 1985-10-04 1987-04-09 Schering Ag 3-vinyl- und 3-ethinyl-ss-carbolinderivate, ihre herstellung und ihre verwendung als arzneimittel
AU652968B2 (en) 1990-10-09 1994-09-15 Neurogen Corporation Certain cycloalkyl and azacycloalkyl pyrrolopyrimidines; a new class of gaba brain receptor ligands
US5243049A (en) 1992-01-22 1993-09-07 Neurogen Corporation Certain pyrroloquinolinones: a new class of GABA brain receptor ligands
WO1993017025A1 (fr) 1992-02-19 1993-09-02 The Upjohn Company IMIDAZO(1,5-a)QUINOXALINES ET QUINAZOLINES SUBSTITUEES EN POSITION 3, ACTIVES PAR RAPPORT AU SYSTEME NERVEUX CENTRAL
US5266698A (en) 1992-04-30 1993-11-30 Neurogen Corporation Certain aryl and cycloalkyl fused imidazopyrazinediones; a new class of GABA brain receptor ligands
AU6098194A (en) 1993-01-29 1994-08-15 Ariad Pharmaceuticals, Inc. Analogs of receptor tyrosine activation motifs and therapeutic uses thereof
US5750702A (en) 1993-10-27 1998-05-12 Neurogen Corporation Certain pyrrolo pyridine-3-carboxamides; a new class of GABA brain receptor ligands
US5484944A (en) * 1993-10-27 1996-01-16 Neurogen Corporation Certain fused pyrrolecarboxanilides and their use as GABA brain receptor ligands
US5804686A (en) * 1996-01-19 1998-09-08 Neurogen Corporation fused pyrrolecarboxamides; a new class of GABA brain receptor ligands
EP0888300A1 (fr) * 1996-03-22 1999-01-07 Neurogen Corporation Certains pyrrolecarboxamides fusionnes utilises comme ligands de recepteurs cerebraux gaba

Also Published As

Publication number Publication date
AU2218997A (en) 1997-10-10
US20010020035A1 (en) 2001-09-06
PE109598A1 (es) 1999-01-16
WO1997034870A1 (fr) 1997-09-25
US6353109B2 (en) 2002-03-05
US6720339B2 (en) 2004-04-13
EP0888300A1 (fr) 1999-01-07
US20020198204A1 (en) 2002-12-26
PA8438301A1 (es) 2000-05-24

Similar Documents

Publication Publication Date Title
TNSN97158A1 (fr) Certains pyrrolecarboxanilide fondus ; une nouvelle classe de ligands recepteurs du cerveau (acide gamma -aminobutyrique).
MA27120A1 (fr) Des pyrrolecarboxanilides fusionnes, une nouvelle classe de gaba (acide aminobutyrique) pour tissus recepteurs de cerveau
CA2175204A1 (fr) Pyrrolecarboxanilides fusionnes constituant une nouvelle classe de ligands des recepteurs gaba du cerveau
ES2111650T3 (es) Derivados aciclicos de etilenodiamina como antagonistas de receptores de la sustancia p.
OA09579A (en) Certain imidazoquinoxalines a new class of gaba brain receptor ligands
EA199700156A1 (ru) Производные индола как антагонисты рецептора 5-нт
DK0641328T3 (da) Broforbundne, azabicykliske derivater som substans P-antagonister
BG102634A (en) New condensated pyrolocarboxamides, a new class gaba receptor ligands in the brain
ES2174836T3 (es) Heterrociclos nitrogenados triciclicos condesados como antagonistas de receptor de la sustancia p.
PT98393A (pt) Processo para a preparacao de derivados de quinuclidina
PE46899A1 (es) Derivados de n-fenil-sulfonamida
HUP0000079A2 (hu) Indán- és dihidroindolszármazékok
PE20001029A1 (es) Derivados de dihidrobenzodioxina carboxamida y acetona
GB9210400D0 (en) Therapeutic agents
PE130999A1 (es) 4-oxo-naftiridin-3-carboxamidas sustituidas; ligandos de receptor cerebral gaba
ATE296290T1 (de) Substituierte cycloalkyl-4-oxonicotinische karboxamide; gaba gehirn-rezeptorligande
BR0009539A (pt) composto, composição farmacêutica, método para tratamento ou prevenção de uma doença ou distúrbio associado com agonismo patogênico, agonismo inverso ou antagonismo do receptor gaba a, uso de um composto, método para localizar receptores gaba a em uma amostra de tecido, método para alterar a atividade transdutora de sinal de receptores gaba a, método para o tratamento ou prevenção de distúrbios psicológicos associados com modulação do complexo receptor gaba a, e, processo para a preparação de um composto
US4880826A (en) Melatonin antagonist
DE69912419D1 (de) Phenylsulfonamid-phenylethylamine nützlich als dopamin-rezeptoren
EP0585206B1 (fr) Tryptamines pour traitement des troubles du rythme circadien
BR9916189A (pt) Derivados de amida arilpiperidina e aril-1,2,5,6-tetraidropiridina tendo atividade receptora 5ht1a
CA2223936A1 (fr) Nouvelles imidazolones d'aryle et de cycloalkyle substituees; nouvelle classe de ligands du recepteur gaba du cerveau
MY107732A (en) Certain imidazoquinoxalines; a new class of gaba brain receptor ligands.
HU193083B (en) Process for preparing diazepinoindole derivatives further pharmaceutical compositions containing such compounds
DE59103080D1 (de) 9-Amino-2-phenylbicyclo[3.3.1]nonane und 9-Amino-2-phenylbicyclo[3.3.1]-non-2-ene und diese enthaltende therapeutische Mittel.