PE20001029A1 - Derivados de dihidrobenzodioxina carboxamida y acetona - Google Patents

Derivados de dihidrobenzodioxina carboxamida y acetona

Info

Publication number
PE20001029A1
PE20001029A1 PE1999000897A PE00089799A PE20001029A1 PE 20001029 A1 PE20001029 A1 PE 20001029A1 PE 1999000897 A PE1999000897 A PE 1999000897A PE 00089799 A PE00089799 A PE 00089799A PE 20001029 A1 PE20001029 A1 PE 20001029A1
Authority
PE
Peru
Prior art keywords
alkyl
disorders
piperidin
amide
propyl
Prior art date
Application number
PE1999000897A
Other languages
English (en)
Inventor
Robin Douglas Clark
Alam Jahangir
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20001029A1 publication Critical patent/PE20001029A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE A COMPUESTOS DE DIHIDROBENZODIOXINA DE FORMULA I, DONDE R1 Y R2 SON H, ALQUILO C1-C6, ALCOXI C1-C6, HALOGENO, AMINO, OH; X ES NH2, CH2; m ES 2-4; Y ES SO2; Z ES UN GRUPO DE FORMULA a o b; R3, R4 Y R5 SON H, ALQUILO C1-C6; Q ES O, S, NR6, CR7R8; n ES 1-2; R6 ES H, ALQUILO C1-C6, COR9, SO2R9, CONR10R11, ENTRE OTROS; R7 ES H, ALQUILO C1-C6; R8 ES H, ALQUILO C1-C6, ALCOXI C1-C6, -(CH2)pCONR10R11, -(CH2)pSO2NR10R11, ENTRE OTROS; R7 Y R8 JUNTO AL CARBONO FORMAN UN ANILLO DE 5-6 MIEMBROS; p ES 0-4; R9 ES ALQUILO C1-C6, HETEROARILO, HETEROCICLILO, ARILO; R10 Y R11 SON H, ALQUILO C1-C6. SON COMPUESTOS PREFERIDOS ACIDO 2,3-DIHIDROBENZO-[1,4]DIOXINA-5-CARBOXILICO {1-[3-(4-METILPIPERAZINA-1-SULFONIL)PROPIL]PIPERIDIN-4-ILMETIL}AMIDA, ACIDO 2,3-DIHIDROBENZO-[1,4]DIOXINA-5-CARBOXILICO{1-[3-(4-PROPILPIPERIDINA-1-SULFONIL)PROPIL]PIPERIDIN-4-ILMETIL}AMIDA, ACIDO 2,3-DIHIDROBENZO-[1,4]DIOXINA-5-CARBOXILICO{1-[3-(4-PROPILPIPERAZINA-1-SULFONIL)PROPIL]PIPERIDIN-4-ILMETIL}AMIDA, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO I ES UN ANTAGONISTA DEL RECEPTOR 5-HIDROXITRIPTAMINA O SEROTONINA (5-HT4) POR LO QUE PUEDE SER UTIL PARA EL TRATAMIENTO DE TRASTORNOS DE LAS VIAS URINARIAS, TRASTORNOS DEL SISTEMA NERVIOSO CENTRAL, TRASTORNOS CARDIOVASCULARES, TRASTORNOS GASTROINTESTINALES
PE1999000897A 1998-09-10 1999-09-07 Derivados de dihidrobenzodioxina carboxamida y acetona PE20001029A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9974098P 1998-09-10 1998-09-10
US13846899P 1999-06-10 1999-06-10

Publications (1)

Publication Number Publication Date
PE20001029A1 true PE20001029A1 (es) 2000-10-12

Family

ID=26796436

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1999000897A PE20001029A1 (es) 1998-09-10 1999-09-07 Derivados de dihidrobenzodioxina carboxamida y acetona

Country Status (17)

Country Link
US (1) US6172062B1 (es)
EP (1) EP1112270B1 (es)
JP (1) JP3366323B2 (es)
KR (1) KR100413150B1 (es)
CN (1) CN1142161C (es)
AR (1) AR035153A1 (es)
AT (1) ATE357443T1 (es)
AU (1) AU758807B2 (es)
BR (1) BRPI9913542B8 (es)
CA (1) CA2340952C (es)
CO (1) CO5130016A1 (es)
DE (1) DE69935600T2 (es)
ES (1) ES2283132T3 (es)
MA (1) MA26684A1 (es)
PE (1) PE20001029A1 (es)
TR (1) TR200100698T2 (es)
WO (1) WO2000015636A1 (es)

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US20060287335A1 (en) * 2000-11-28 2006-12-21 Wyeth Serotonergic agents for treating sexual dysfunction
US20060223824A1 (en) * 2000-11-28 2006-10-05 Wyeth Serotonergic agents
US6559169B2 (en) 2001-04-24 2003-05-06 Wyeth Antidepressant azaheterocyclymethyl derivatives of 2,3-dihydro-1,4-benzodioxan
US7041683B2 (en) 2001-04-24 2006-05-09 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1, 4-benzodiozan
US7089924B2 (en) * 2001-12-14 2006-08-15 Diamond Innovations, Inc. Granite slabs cut with frame saw employing blades with diamond-containing segments and method of cutting thereof
EA009259B1 (ru) * 2003-06-19 2007-12-28 Янссен Фармацевтика Н.В. Аминосульфонилзамещенные 4-(аминометил)пиперидинбензамиды в качестве 5ht-антагонистов
JP4767844B2 (ja) * 2003-06-19 2011-09-07 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ５ｈｔ４−アンタゴニストとしての複素環式置換４−（アミノメチル）−ピペリジンベンズアミド
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TWI351282B (en) 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
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ATE469897T1 (de) * 2004-12-22 2010-06-15 Theravance Inc Indazolcarbonsäureamidverbindungen
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ES2523851T3 (es) * 2005-03-02 2014-12-02 Theravance Biopharma R&D Ip, Llc Compuestos de quinolinona como agonistas de los receptores 5-HT4
WO2009079011A1 (en) * 2007-12-19 2009-06-25 The Scripps Research Institute Benzimidazoles and analogs as rho kinase inhibitors
US20110038835A1 (en) * 2007-12-21 2011-02-17 The Scripps Research Institute Anilides and analogs as rho kinase inhibitors
CA2709918A1 (en) * 2007-12-21 2009-06-25 The Scripps Research Institute Benzopyrans and analogs as rho kinase inhibitors
JP2012526133A (ja) 2009-05-05 2012-10-25 ベイポジェニックス インコーポレイテッド 炎症を低減させるための新規揮発性麻酔薬製剤およびその使用法
US8476221B2 (en) 2011-03-18 2013-07-02 Halimed Pharmaceuticals, Inc. Methods and compositions for the treatment of metabolic disorders
MA41629A (fr) 2015-03-04 2018-01-09 Center For Human Reproduction Compositions et méthodes d'utilisation de l'hormone anti-müllérienne pour le traitement de l'infertilité
US20210330599A1 (en) 2016-08-01 2021-10-28 University Of Rochester Nanoparticles for Controlled Release of Anti-Biofilm Agents and Methods of Use
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Also Published As

Publication number Publication date
DE69935600T2 (de) 2007-12-06
TR200100698T2 (tr) 2001-07-23
ATE357443T1 (de) 2007-04-15
AU5857299A (en) 2000-04-03
CO5130016A1 (es) 2002-02-27
BRPI9913542B8 (pt) 2021-05-25
KR20010085777A (ko) 2001-09-07
AR035153A1 (es) 2004-05-05
CN1142161C (zh) 2004-03-17
DE69935600D1 (de) 2007-05-03
EP1112270A1 (en) 2001-07-04
MA26684A1 (fr) 2004-12-20
WO2000015636A1 (en) 2000-03-23
CA2340952C (en) 2009-12-08
US6172062B1 (en) 2001-01-09
EP1112270B1 (en) 2007-03-21
BR9913542A (pt) 2001-06-05
ES2283132T3 (es) 2007-10-16
BRPI9913542B1 (pt) 2016-04-19
JP3366323B2 (ja) 2003-01-14
KR100413150B1 (ko) 2003-12-31
CN1315950A (zh) 2001-10-03
CA2340952A1 (en) 2000-03-23
AU758807B2 (en) 2003-03-27
JP2002524561A (ja) 2002-08-06

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