FR2771741B1 - Variants d'epissage du recepteur serotoninergique 5-ht4 humain et leurs applications, notamment pour le criblage - Google Patents

Variants d'epissage du recepteur serotoninergique 5-ht4 humain et leurs applications, notamment pour le criblage

Info

Publication number
FR2771741B1
FR2771741B1 FR9715037A FR9715037A FR2771741B1 FR 2771741 B1 FR2771741 B1 FR 2771741B1 FR 9715037 A FR9715037 A FR 9715037A FR 9715037 A FR9715037 A FR 9715037A FR 2771741 B1 FR2771741 B1 FR 2771741B1
Authority
FR
France
Prior art keywords
screening
human
applications
splice variants
serotoninergic receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9715037A
Other languages
English (en)
Other versions
FR2771741A1 (fr
Inventor
Rodolphe Fischmeister
Michel Langlois
Yamina Dahmoune
Monique Gastineau
Olivier Blondel
Johan Hoebeke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut National de la Sante et de la Recherche Medicale INSERM
Original Assignee
Institut National de la Sante et de la Recherche Medicale INSERM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut National de la Sante et de la Recherche Medicale INSERM filed Critical Institut National de la Sante et de la Recherche Medicale INSERM
Priority to FR9715037A priority Critical patent/FR2771741B1/fr
Priority to EP98958279A priority patent/EP1034264A1/fr
Priority to JP2000523333A priority patent/JP2002507385A/ja
Priority to PCT/FR1998/002560 priority patent/WO1999028456A1/fr
Priority to CA002310541A priority patent/CA2310541A1/fr
Priority to US09/555,313 priority patent/US6506580B1/en
Publication of FR2771741A1 publication Critical patent/FR2771741A1/fr
Application granted granted Critical
Publication of FR2771741B1 publication Critical patent/FR2771741B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR9715037A 1997-11-28 1997-11-28 Variants d'epissage du recepteur serotoninergique 5-ht4 humain et leurs applications, notamment pour le criblage Expired - Fee Related FR2771741B1 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
FR9715037A FR2771741B1 (fr) 1997-11-28 1997-11-28 Variants d'epissage du recepteur serotoninergique 5-ht4 humain et leurs applications, notamment pour le criblage
EP98958279A EP1034264A1 (fr) 1997-11-28 1998-11-27 Variants d'epissage du recepteur serotoninergique 5-ht4 humain et leurs applications, notamment pour le criblage
JP2000523333A JP2002507385A (ja) 1997-11-28 1998-11-27 ヒトの５−ｈｔ４セロトニン作動性受容体のスプライシングバリアント、及び、特にスクリーニングのためのその利用
PCT/FR1998/002560 WO1999028456A1 (fr) 1997-11-28 1998-11-27 Variants d'epissage du recepteur serotoninergique 5-ht4 humain et leurs applications, notamment pour le criblage
CA002310541A CA2310541A1 (fr) 1997-11-28 1998-11-27 Variants d'epissage du recepteur serotoninergique 5-ht4 humain et leurs applications, notamment pour le criblage
US09/555,313 US6506580B1 (en) 1997-11-28 1998-11-27 Splice variants for human 5-HT4 serotonin receptor and their applications, in particular for screening

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9715037A FR2771741B1 (fr) 1997-11-28 1997-11-28 Variants d'epissage du recepteur serotoninergique 5-ht4 humain et leurs applications, notamment pour le criblage

Publications (2)

Publication Number Publication Date
FR2771741A1 FR2771741A1 (fr) 1999-06-04
FR2771741B1 true FR2771741B1 (fr) 2001-07-13

Family

ID=9513961

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9715037A Expired - Fee Related FR2771741B1 (fr) 1997-11-28 1997-11-28 Variants d'epissage du recepteur serotoninergique 5-ht4 humain et leurs applications, notamment pour le criblage

Country Status (6)

Country Link
US (1) US6506580B1 (fr)
EP (1) EP1034264A1 (fr)
JP (1) JP2002507385A (fr)
CA (1) CA2310541A1 (fr)
FR (1) FR2771741B1 (fr)
WO (1) WO1999028456A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6531230B1 (en) * 1998-01-13 2003-03-11 3M Innovative Properties Company Color shifting film
AU758807B2 (en) * 1998-09-10 2003-03-27 F. Hoffmann-La Roche Ag Dihydrobenzodioxine carboxamide and ketone derivatives as 5-HT4 receptor antagonists
US20070065801A1 (en) * 2003-05-21 2007-03-22 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with 5-hydroxytryptamine (seotonin) receptor 4 (5-ht4)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE192490T1 (de) * 1992-11-03 2000-05-15 Synaptic Pharma Corp Für einen humanen serotoninrezeptor (5-ht4b) kodierende dns und ihre verwendung
US5472866A (en) * 1992-12-24 1995-12-05 Synaptic Pharmaceutical Corporation DNA encoding 5-HT4A serotonin receptors
EP0683161A1 (fr) * 1994-05-17 1995-11-22 MIDY S.p.A. Nouvel ester de l'acide 4-amino-5-chloro-2-méthoxybenzoique, procédé pour sa préparation et compositions pharmaceutiques le contenant

Also Published As

Publication number Publication date
CA2310541A1 (fr) 1999-06-10
FR2771741A1 (fr) 1999-06-04
JP2002507385A (ja) 2002-03-12
EP1034264A1 (fr) 2000-09-13
WO1999028456A1 (fr) 1999-06-10
US6506580B1 (en) 2003-01-14

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Legal Events

Date Code Title Description
ST Notification of lapse

Effective date: 20060731