MX9306311A - Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen - Google Patents

Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen

Info

Publication number
MX9306311A
MX9306311A MX9306311A MX9306311A MX9306311A MX 9306311 A MX9306311 A MX 9306311A MX 9306311 A MX9306311 A MX 9306311A MX 9306311 A MX9306311 A MX 9306311A MX 9306311 A MX9306311 A MX 9306311A
Authority
MX
Mexico
Prior art keywords
receptor
procedure
contain
preparation
pharmaceutical compositions
Prior art date
Application number
MX9306311A
Other languages
English (en)
Inventor
Laramie Mary Gaster
Keith Raymond Mulholland
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929221482A external-priority patent/GB9221482D0/en
Priority claimed from GB929221769A external-priority patent/GB9221769D0/en
Priority claimed from GB929223139A external-priority patent/GB9223139D0/en
Priority claimed from GB929223137A external-priority patent/GB9223137D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of MX9306311A publication Critical patent/MX9306311A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención proporciona compuestos de la fórmula (I) en la que la fórmula (I) consiste de las fórmulas (I-1) a (I-4) y sus sales farmacéuticamente aceptables, el uso de un compuesto de la fórmula (I) o una sal del mismo farmacéuticamente aceptable: y con su uso como agentes farmacéuticos en el tratamiento de desórdenes gastrointestinales, desórdenes cardiovasculares y desórdenes del SNC.
MX9306311A 1992-10-13 1993-10-11 Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen MX9306311A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB929221482A GB9221482D0 (en) 1992-10-13 1992-10-13 Pharmaceuticals
GB929221769A GB9221769D0 (en) 1992-10-16 1992-10-16 Pharmaceuticals
GB929223139A GB9223139D0 (en) 1992-11-05 1992-11-05 Pharmaceuticals
GB929223137A GB9223137D0 (en) 1992-11-05 1992-11-05 Pharmaceuticals

Publications (1)

Publication Number Publication Date
MX9306311A true MX9306311A (es) 1994-04-29

Family

ID=27450944

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9306311A MX9306311A (es) 1992-10-13 1993-10-11 Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen

Country Status (5)

Country Link
EP (1) EP0664806A1 (es)
AU (1) AU5369594A (es)
CA (1) CA2146923A1 (es)
MX (1) MX9306311A (es)
WO (1) WO1994008995A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5852014A (en) * 1992-03-12 1998-12-22 Smithkline Beecham P.L.C. Condensed indole derivatives as 5HT4 -receptor antagonists
US5998409A (en) * 1992-03-12 1999-12-07 Smithkline Beecham Plc Condensed indole derivatives as 5HT4 -receptor antagonists
WO1994008965A1 (en) * 1992-10-16 1994-04-28 Smithkline Beecham Plc N-alkylpiperidinyl-4-methyl carboxylic esters/amides of condensed ring systems as 5-ht4 receptor antagonists
MX9700557A (es) * 1994-07-22 1997-12-31 Byk Gulden Lomberg Chem Fab Dihidrobenzofuranos.
BR9509035A (pt) * 1994-09-27 1997-10-14 Janssen Pharmaceutica Nv Derivados de benzoato de fenil-oxo-alquíl-(4-peperidinila)
NZ293605A (en) * 1994-09-27 1998-07-28 Janssen Pharmaceutica Nv N-substituted piperidinyl bicyclic benzoate derivatives, 3-alkoxy-4-hydroxy-piperidine intermediates, and pharmaceutical compositions
TW360653B (en) * 1995-03-01 1999-06-11 Janssen Pharmaceutica Nv A oxadiazole compound having colon motility stimulating properties, its preparation process and its pharmaceutical composition
US5710274A (en) * 1996-02-28 1998-01-20 Neurogen Corporation N-aminoalkyldibenzofurancarboxamides; new dopamine receptor subtype specific ligands
TW445263B (en) * 1996-02-29 2001-07-11 Janssen Pharmaceutica Nv Novel esters of 1,4-disubstituted piperidine derivatives
TW402591B (en) 1997-07-11 2000-08-21 Janssen Pharmaceutica Nv Monocyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives
CN1142161C (zh) * 1998-09-10 2004-03-17 弗·哈夫曼-拉罗切有限公司 作为5－ht4受体拮抗剂的二氢苯并二噁烯羧酰胺与酮衍生物
TW570920B (en) 1998-12-22 2004-01-11 Janssen Pharmaceutica Nv 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders
GB0211230D0 (en) 2002-05-16 2002-06-26 Medinnova Sf Treatment of heart failure
ATE380185T1 (de) * 2002-10-23 2007-12-15 Glenmark Pharmaceuticals Ltd Tricyclische verbindungen zur behandlung von entzündlichen- und allergischen erkrankungen: verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen
WO2004069831A1 (en) * 2003-02-10 2004-08-19 Glenmark Pharmaceuticals Ltd. Tricyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation
JP2006522789A (ja) 2003-04-11 2006-10-05 グレンマーク・ファーマシューティカルズ・エス・エー 炎症性およびアレルギー性障害の治療に有用な新規な複素環式化合物；それらの調製方法および医薬組成物
WO2004111044A1 (en) * 2003-06-17 2004-12-23 Glenmark Pharmaceuticals Ltd. Tricyclic compounds useful for the treatment of inflammatory and allergic disorders:process for their preparation
EP1799632A2 (en) 2004-10-13 2007-06-27 Glenmark Pharmaceuticals S.A. Process for the preparation of n-(3,5-dichloropyrid-4-yl)-4-difluoromethoxy-8-methanesulfonamido-dibenzo[b,d]furan-1-carboxamide
CN101124229B (zh) 2004-12-17 2012-07-18 格兰马克药品股份有限公司 用于治疗炎性和过敏性障碍的新杂环化合物
BRPI0517211B8 (pt) 2004-12-17 2021-05-25 Glenmark Pharmaceuticals Sa composto, composição farmacêutica e seu uso.

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4888353A (en) * 1986-02-28 1989-12-19 Erbamont, Inc. Carboxamides useful as antiemetic or antipsychotic agents
JPS63139180A (ja) * 1986-12-02 1988-06-10 Tanabe Seiyaku Co Ltd カルボン酸誘導体
KR920011020B1 (ko) * 1989-07-03 1992-12-26 요시또미세이야꾸 가부시끼가이샤 벤즈아진 화합물 및 그의 의약용도
GB9005014D0 (en) * 1990-03-06 1990-05-02 Janssen Pharmaceutica Nv N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives
GB9028105D0 (en) * 1990-12-27 1991-02-13 Erba Carlo Spa Process for the preparation of substituted benzofuran derivatives
US5114947A (en) * 1990-12-27 1992-05-19 Erbamont Inc. Method for alleviating anxiety using benzobicyclic carboxamides
GB9103862D0 (en) * 1991-02-25 1991-04-10 Glaxo Group Ltd Chemical compounds
WO1993002677A1 (en) * 1991-08-03 1993-02-18 Smithkline Beecham Plc 5-ht4 receptor antagonists
JP3294611B2 (ja) * 1991-09-12 2002-06-24 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー ５−ｈｔ４レセプター・アンタゴニスト
JPH07503480A (ja) * 1992-02-06 1995-04-13 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー ５−ｈｔ４拮抗薬としてのベンゾピラン，ベンゾチオピランおよびベンゾフラン誘導体

Also Published As

Publication number Publication date
CA2146923A1 (en) 1994-04-28
WO1994008995A1 (en) 1994-04-28
EP0664806A1 (en) 1995-08-02
AU5369594A (en) 1994-05-09

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