MX9700557A - Dihidrobenzofuranos. - Google Patents

Dihidrobenzofuranos.

Info

Publication number
MX9700557A
MX9700557A MX9700557A MX9700557A MX9700557A MX 9700557 A MX9700557 A MX 9700557A MX 9700557 A MX9700557 A MX 9700557A MX 9700557 A MX9700557 A MX 9700557A MX 9700557 A MX9700557 A MX 9700557A
Authority
MX
Mexico
Prior art keywords
dihydrobenzofuranes
compounds
inhibitors
novel
formula
Prior art date
Application number
MX9700557A
Other languages
English (en)
Inventor
Hermann Amschler
Dieter Flockerzi
Beate Gutterer
Armin Hatzelmann
Chritian Schudt
Rolf Beume
Dietrich Hafner
Hans-Peter Kley
Wolf-Rudiger Ulrich
Original Assignee
Byk Gulden Lomberg Chem Fab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chem Fab filed Critical Byk Gulden Lomberg Chem Fab
Publication of MX9700557A publication Critical patent/MX9700557A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems

Abstract

Los compuestos de la formula (I), en donde R1, R2, R3 y R4 tienen los significados indicados en la descripcion, son inhibidores PDE efectivos novedosos.
MX9700557A 1994-07-22 1995-07-19 Dihidrobenzofuranos. MX9700557A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH232394 1994-07-22
PCT/EP1995/002841 WO1996003399A1 (de) 1994-07-22 1995-07-19 Dihydrobenzofurane

Publications (1)

Publication Number Publication Date
MX9700557A true MX9700557A (es) 1997-12-31

Family

ID=4231132

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9700557A MX9700557A (es) 1994-07-22 1995-07-19 Dihidrobenzofuranos.

Country Status (22)

Country Link
US (1) US6121274A (es)
EP (1) EP0772610B9 (es)
JP (1) JP4146894B2 (es)
KR (1) KR100381584B1 (es)
CN (1) CN1068879C (es)
AT (1) ATE196765T1 (es)
AU (1) AU702346B2 (es)
CZ (1) CZ291758B6 (es)
DE (1) DE59508773D1 (es)
DK (1) DK0772610T3 (es)
ES (1) ES2152414T3 (es)
FI (1) FI970246A0 (es)
GR (1) GR3034991T3 (es)
HU (1) HU221504B (es)
MX (1) MX9700557A (es)
NO (1) NO311221B1 (es)
NZ (1) NZ290420A (es)
PL (1) PL185683B1 (es)
PT (1) PT772610E (es)
RU (1) RU2138498C1 (es)
SK (1) SK281857B6 (es)
WO (1) WO1996003399A1 (es)

Families Citing this family (37)

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Publication number Priority date Publication date Assignee Title
US6514996B2 (en) 1995-05-19 2003-02-04 Kyowa Hakko Kogyo Co., Ltd. Derivatives of benzofuran or benzodioxole
JP4172817B2 (ja) * 1995-05-19 2008-10-29 協和醗酵工業株式会社 含酸素複素環化合物
EP0873331B1 (en) * 1995-12-05 2002-04-03 Darwin Discovery Limited Benzofuran carboxamides and sulphonamides
AU2892397A (en) * 1996-05-15 1997-12-05 Byk Gulden Novel imidazopyridines
TR199802386T2 (xx) * 1996-05-20 1999-02-22 Darwin Discovery Limited Benzofuran karboksamidler ve bunlar�n terap�tik kullan�m�.
DE19628622A1 (de) * 1996-07-16 1998-01-22 Byk Gulden Lomberg Chem Fab Neue 5-substituierte [2H] Chromene
DE19628621A1 (de) * 1996-07-16 1998-01-22 Byk Gulden Lomberg Chem Fab Neue 4-substituierte Benzofurane
WO1998007715A1 (en) * 1996-08-19 1998-02-26 Byk Gulden Lomberg Chemische Fabrik Gmbh Novel benzofuran-4-carboxamides
US6043263A (en) * 1996-11-12 2000-03-28 Byk Gulden Lomberg Chemische Fabrik Gmbh (2,3-dihydrobenzofuranyl)-thiazoles as phosphodiesterase inhibitors
JP2001505198A (ja) * 1996-11-20 2001-04-17 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング Ｐｄｅ阻害剤としての置換ジヒドロベンゾフラン
EP1042319B1 (en) 1997-12-15 2004-02-04 ALTANA Pharma AG Dihydrobenzofurans
GB2333041A (en) * 1998-01-13 1999-07-14 Johnson & Johnson Medical Ltd Wound Composition
EE04641B1 (et) * 1998-05-05 2006-06-15 Byk Gulden Lomberg Chemische Fabrik Gmbh Bensimidasoolid ja bensoksasoolid, nende kasutamine hingamisteede ja dermatooside raviks ette nähtud ravimite valmistamiseks ning neid sisaldav ravim
ATE245642T1 (de) * 1998-06-10 2003-08-15 Altana Pharma Ag Benzamide mit tetrahydrofuranyloxy-substituenten als inhibitoren der phosphodiesterase 4
SK287231B6 (sk) 1999-08-21 2010-04-07 Nycomed Gmbh Liečivo zahŕňajúce PDE inhibítor a agonistu beta2 adrenoreceptora
GB0003257D0 (en) 2000-02-11 2000-04-05 Darwin Discovery Ltd Heterocyclic compounds and their therapeutic use
JP2005521711A (ja) * 2002-03-29 2005-07-21 中外製薬株式会社 呼吸器疾病の予防または治療のための医薬組成物
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
JPWO2007052794A1 (ja) * 2005-11-04 2009-04-30 日本曹達株式会社 オルト置換アニリン誘導体及び抗酸化薬
US7842713B2 (en) * 2006-04-20 2010-11-30 Pfizer Inc Fused phenyl amido heterocyclic compounds
US8304436B2 (en) 2007-05-16 2012-11-06 Nycomed Gmbh Pyrazolone derivatives as PDE4 inhibitors
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CA2688161C (en) 2007-06-04 2020-10-20 Kunwar Shailubhai Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
ES2522968T3 (es) 2008-06-04 2014-11-19 Synergy Pharmaceuticals Inc. Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
NZ591366A (en) 2008-09-11 2012-05-25 Pfizer Heteroaryls amide derivatives and their use as glucokinase activators
EP2406253B1 (en) 2009-03-11 2013-07-03 Pfizer Inc. Benzofuranyl derivatives used as glucokinase inhibitors
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN108676076A (zh) 2011-03-01 2018-10-19 辛纳吉制药公司 制备鸟苷酸环化酶c激动剂的方法
RU2621039C1 (ru) * 2012-01-12 2017-05-31 Цзянсу Хэнжуй Медсин Ко., Лтд. Полициклические производные, способ их получения и их фармацевтическое применение
WO2014131024A2 (en) 2013-02-25 2014-08-28 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
EP2970384A1 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
US9486494B2 (en) 2013-03-15 2016-11-08 Synergy Pharmaceuticals, Inc. Compositions useful for the treatment of gastrointestinal disorders
JP6606491B2 (ja) 2013-06-05 2019-11-13 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼｃの超高純度アゴニスト、その作成および使用方法
MX2016001714A (es) 2013-08-09 2016-10-03 Ardelyx Inc Compuestos y metodos para inhibir el transporte de fosfato.
TW202400564A (zh) 2015-06-05 2024-01-01 美商艾佛艾姆希公司 作為除草劑之嘧啶氧基苯衍生物
WO2020237096A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Combination for lowering serum phosphate in a patient

Family Cites Families (3)

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IE71647B1 (en) * 1991-01-28 1997-02-26 Rhone Poulenc Rorer Ltd Benzamide derivatives
ES2102036T3 (es) * 1992-06-15 1997-07-16 Celltech Therapeutics Ltd Derivados con grupo fenilo trisustituido utilizados como inhibidores selectivos de la fosfodiesterasa iv.
GB9212693D0 (en) * 1992-06-15 1992-07-29 Celltech Ltd Chemical compounds

Also Published As

Publication number Publication date
PT772610E (pt) 2001-03-30
KR100381584B1 (ko) 2003-08-21
EP0772610B9 (de) 2001-07-25
WO1996003399A1 (de) 1996-02-08
NO311221B1 (no) 2001-10-29
CZ18897A3 (en) 1997-09-17
FI970246A (fi) 1997-01-21
JP4146894B2 (ja) 2008-09-10
DK0772610T3 (da) 2001-01-29
AU3115395A (en) 1996-02-22
NZ290420A (en) 1999-01-28
CZ291758B6 (cs) 2003-05-14
DE59508773D1 (de) 2000-11-09
HUT77925A (hu) 1998-11-30
CN1068879C (zh) 2001-07-25
RU2138498C1 (ru) 1999-09-27
HU9700022D0 (en) 1997-02-28
AU702346B2 (en) 1999-02-18
US6121274A (en) 2000-09-19
EP0772610A1 (de) 1997-05-14
SK281857B6 (sk) 2001-08-06
NO970092D0 (no) 1997-01-09
PL318297A1 (en) 1997-06-09
GR3034991T3 (en) 2001-03-30
ATE196765T1 (de) 2000-10-15
CN1159804A (zh) 1997-09-17
ES2152414T3 (es) 2001-02-01
NO970092L (no) 1997-01-09
EP0772610B1 (de) 2000-10-04
FI970246A0 (fi) 1997-01-21
PL185683B1 (pl) 2003-07-31
SK297A3 (en) 1997-08-06
JPH10503484A (ja) 1998-03-31
HU221504B (en) 2002-10-28

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Legal Events

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HC Change of company name or juridical status

Owner name: ABBOTT GMBH & CO. KG

MM Annulment or lapse due to non-payment of fees