PE20040828A1 - Benzoxazinonas como modulares de 5-hidroxitriptamina (5-ht) - Google Patents
Benzoxazinonas como modulares de 5-hidroxitriptamina (5-ht)Info
- Publication number
- PE20040828A1 PE20040828A1 PE2003001114A PE2003001114A PE20040828A1 PE 20040828 A1 PE20040828 A1 PE 20040828A1 PE 2003001114 A PE2003001114 A PE 2003001114A PE 2003001114 A PE2003001114 A PE 2003001114A PE 20040828 A1 PE20040828 A1 PE 20040828A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- oxazin
- ona
- piperazin
- benzo
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D291/00—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms
- C07D291/08—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
- C07D419/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D419/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A DERIVADOS DE BENZOXAZINONAS DE FORMULA I DONDE Y ES C o S; m ES 1 CUANDO Y ES C y m ES 2 CUANDO Y ES S; n ES 1 o 2; p ES 0-3; q ES 1-3; Z ES (CRaRb)r, o SO2; Ra Y Rb SON H o ALQUILO; r ES 0-2; X ES CH o N; R1 ES H, HALOGENO, ALQUILO, HALOALQUILO, HETEROALQUILO, ALCOXI, CIANO, ENTRE OTROS; R2 ES ARILO O HETEROARILO, AMBOS OPCIONALMENTE SUSTITUIDOS; R3 Y R4 SON H o ALQUILO, o AMBOS JUNTO CON SUS CARBONOS COMPARTIDOS FORMAN UN ANILLO CICLOALQUILO DE 3-6 MIEMBROS; R5, R6, R7, R8 Y R9 SON H o ALQUILO, O UNO DE R5 Y R6 JUNTO CON UNO DE R7, R8 Y R9 Y LOS ATOMOS DE EN MEDIO PUEDEN FORMAR UN ANILLO DE 5-7 MIEMBROS. SON COMPUESTOS PREFERIDOS: 4-BENCIL-6-METIL-8-PIPERAZIN-1-IL-4H-BENZO[1,4]OXAZIN-3-ONA; 4-BENCIL-6-METOXI-8-PIPERAZIN-1-IL-4H-BENZO[1,4]-OXAZIN-3-ONA; 4-(2-FLUORO-BENCIL)-6-METOXI-8-PIPERAZIN-1-IL-4H-BENZO[1,4]OXAZIN-3-ONA; ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCESO PARA PRODUCIR DICHOS COMPUESTOS Y UNA COMPOSICION FARMACEUTICA. ESTOS COMPUESTOS SON MODULARES DE 5-HIDROXITRIPTAMINA (5-HT) Y SON UTILES PARA TRATAR O PREVENIR TRASTORNOS DEL SISTEMA NERVIOSO CENTRAL Y DEL TRACTO GASTROINTESTINAL
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42494602P | 2002-11-08 | 2002-11-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20040828A1 true PE20040828A1 (es) | 2004-11-25 |
Family
ID=32312902
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2003001114A PE20040828A1 (es) | 2002-11-08 | 2003-11-05 | Benzoxazinonas como modulares de 5-hidroxitriptamina (5-ht) |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US7141562B2 (es) |
| EP (1) | EP1562918B1 (es) |
| JP (1) | JP4401297B2 (es) |
| KR (1) | KR100683361B1 (es) |
| CN (1) | CN100390157C (es) |
| AR (1) | AR042002A1 (es) |
| AT (1) | ATE384054T1 (es) |
| AU (1) | AU2003293653B2 (es) |
| BR (1) | BR0315302A (es) |
| CA (1) | CA2505334A1 (es) |
| DE (1) | DE60318733T2 (es) |
| DK (1) | DK1562918T3 (es) |
| ES (1) | ES2298609T3 (es) |
| GT (1) | GT200300241A (es) |
| HR (1) | HRP20050390A2 (es) |
| IL (1) | IL168343A (es) |
| MX (1) | MXPA05004758A (es) |
| MY (1) | MY136824A (es) |
| NO (1) | NO20052074L (es) |
| NZ (1) | NZ539508A (es) |
| PA (1) | PA8587501A1 (es) |
| PE (1) | PE20040828A1 (es) |
| PL (1) | PL377770A1 (es) |
| PT (1) | PT1562918E (es) |
| RU (1) | RU2328490C2 (es) |
| TW (1) | TWI285639B (es) |
| WO (1) | WO2004041792A1 (es) |
| ZA (1) | ZA200503248B (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7504395B2 (en) * | 2001-07-20 | 2009-03-17 | Psychogenics, Inc. | Treatment for attention-deficit hyperactivity disorder |
| PL209872B1 (pl) | 2002-03-27 | 2011-10-31 | Glaxo Group Ltd | Pochodna chinolinowa, sposób jej wytwarzania i jej zastosowanie oraz zawierająca ją farmaceutyczna kompozycja |
| DE602004000260T2 (de) | 2003-07-22 | 2006-08-24 | Arena Pharmaceuticals, Inc., San Diego | Diaryl- und arylheteroarylharnstoffderivate als modulatoren des 5-ht2a-serotoninrezeptors, die sich zur prophylaxe und behandlung von damit im zusammenhang stehenden erkrankungen eignen |
| WO2005058847A1 (en) * | 2003-12-09 | 2005-06-30 | F. Hoffmann-La Roche Ag | Benzoxazine derivatives and uses thereof |
| ES2643615T3 (es) * | 2004-09-30 | 2017-11-23 | F. Hoffmann-La Roche Ag | Composiciones y métodos para el tratamiento de trastornos cognitivos |
| US7713954B2 (en) * | 2004-09-30 | 2010-05-11 | Roche Palo Alto Llc | Compositions and methods for treating cognitive disorders |
| EP1904483A1 (en) | 2005-07-13 | 2008-04-02 | F. Hoffmann-Roche AG | Benzimidazole derivatives as 5-ht6,5-ht24 |
| WO2007032572A1 (en) * | 2005-09-15 | 2007-03-22 | Korea Reserach Institute Of Chemical Technology | N-substituted-1h-quinoline-2, 4-diones, preparation method thereof, and pharmaceutical composition containing the same |
| US20100120747A1 (en) * | 2006-06-23 | 2010-05-13 | Laboratorios Del Dr. Esteve, S.A. | Combination of a cholinesterase inhibitor and a compound with 5-ht6 receptor affinity |
| EP2508177A1 (en) | 2007-12-12 | 2012-10-10 | Glaxo Group Limited | Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline |
| US20110021538A1 (en) | 2008-04-02 | 2011-01-27 | Arena Pharmaceuticals, Inc. | Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor |
| WO2010062321A1 (en) | 2008-10-28 | 2010-06-03 | Arena Pharmaceuticals, Inc. | Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea and crystalline forms related thereto |
| ITMI20131782A1 (it) * | 2013-10-25 | 2015-04-26 | Dipharma Francis Srl | Procedimento per la preparazione di un agonista della trombopoietina |
| JP2018516992A (ja) | 2015-06-12 | 2018-06-28 | アクソファント サイエンシーズ ゲーエムベーハーＡｘｏｖａｎｔ Ｓｃｉｅｎｃｅｓ Ｇｍｂｈ | レム睡眠行動障害の予防および処置のために有用なジアリールおよびアリールヘテロアリール尿素誘導体 |
| RU2018103338A (ru) | 2015-07-15 | 2019-08-15 | Аксовант Сайенсиз Гмбх | Производные диарил- и арилгетероарилмочевины для профилактики и лечения галлюцинаций, ассоциированных с нейродегенеративным заболеванием |
| RU2624978C2 (ru) * | 2015-07-27 | 2017-07-11 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Воронежский государственный медицинский университет им. Н.Н. Бурденко" Министерства здравоохранения Российской Федерации | Способ лечения умеренного когнитивного снижения |
| CN111051302B (zh) * | 2017-08-07 | 2021-04-09 | 苏文生命科学有限公司 | 作为纯5-ht6受体拮抗剂的氟哌啶化合物 |
| CN111559990B (zh) * | 2020-05-29 | 2021-03-09 | 四川大学华西医院 | 一种小分子噁噻嗪类衍生物及其应用 |
| CN112047898A (zh) * | 2020-10-14 | 2020-12-08 | 兰州大学 | 一种苯并[c][1,2]噁嗪骨架类新化合物及其制备方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE81975T1 (de) * | 1984-12-21 | 1992-11-15 | Duphar Int Res | Arzneimittel mit psychotroper wirkung. |
| AU605304B2 (en) * | 1987-06-22 | 1991-01-10 | Nihon Tokushu Nayaku Seizo K.K. | Benzo-fused cyclic compounds |
| FR2667068B1 (fr) * | 1990-09-26 | 1994-09-09 | Adir | Nouvelles amines alkyl heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| US5955470A (en) * | 1991-06-11 | 1999-09-21 | Merrell Pharmaceuticals, Inc. | Derivatives of amide analogs of certain methano bridged quinolizines |
| PT889889E (pt) * | 1996-03-29 | 2007-01-31 | Duphar Int Res | Composto de piperazina e piperidina |
| DE69819266T2 (de) * | 1997-09-02 | 2004-07-29 | Duphar International Research B.V. | Piperidin- und Piperazin Derivate als 5-HT1-Rezeptor-Agonisten |
| SK287018B6 (sk) * | 1999-08-23 | 2009-09-07 | Solvay Pharmaceuticals B. V. | Deriváty fenylpiperazínov, spôsob ich prípravy, farmaceutická kompozícia s ich obsahom a ich použitie |
| WO2001057003A1 (en) | 2000-02-01 | 2001-08-09 | Cor Therapeutics, Inc. | 3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE INHIBITORS OF FACTOR Xa |
| US20020019394A1 (en) | 2000-03-24 | 2002-02-14 | Wenhao Li | Bicyclic sulfonyl amino inhibitors of factor Xa |
| DE10031391A1 (de) | 2000-07-03 | 2002-02-07 | Knoll Ag | Bicyclische Verbindungen und ihre Verwendung zur Prophylaxe und Therapie der zerebralen Ischämie |
| CA2426706A1 (en) * | 2000-10-26 | 2002-05-02 | Smithkline Beecham P.L.C. | Benzoxazinone derivatives, their preparation and use |
| DE60230424D1 (en) * | 2001-08-10 | 2009-01-29 | Hoffmann La Roche | Arylsulfonyl-derivate mit 5-ht 6-rezeptor-affinität |
| DE60303376T2 (de) * | 2002-05-13 | 2006-11-16 | F. Hoffmann-La Roche Ag | Benzoxazinderivate als 5-ht6-modulatoren und deren verwendungen |
-
2003
- 2003-11-04 DK DK03789002T patent/DK1562918T3/da active
- 2003-11-04 PT PT03789002T patent/PT1562918E/pt unknown
- 2003-11-04 AU AU2003293653A patent/AU2003293653B2/en not_active Ceased
- 2003-11-04 KR KR1020057008044A patent/KR100683361B1/ko not_active IP Right Cessation
- 2003-11-04 ES ES03789002T patent/ES2298609T3/es not_active Expired - Lifetime
- 2003-11-04 RU RU2005117965/04A patent/RU2328490C2/ru not_active IP Right Cessation
- 2003-11-04 BR BR0315302-9A patent/BR0315302A/pt not_active Application Discontinuation
- 2003-11-04 DE DE60318733T patent/DE60318733T2/de not_active Expired - Lifetime
- 2003-11-04 MX MXPA05004758A patent/MXPA05004758A/es active IP Right Grant
- 2003-11-04 EP EP03789002A patent/EP1562918B1/en not_active Expired - Lifetime
- 2003-11-04 NZ NZ539508A patent/NZ539508A/en not_active IP Right Cessation
- 2003-11-04 PL PL377770A patent/PL377770A1/pl unknown
- 2003-11-04 CA CA002505334A patent/CA2505334A1/en not_active Abandoned
- 2003-11-04 JP JP2004549101A patent/JP4401297B2/ja not_active Expired - Fee Related
- 2003-11-04 TW TW092130842A patent/TWI285639B/zh active
- 2003-11-04 CN CNB2003801053862A patent/CN100390157C/zh not_active Expired - Fee Related
- 2003-11-04 WO PCT/EP2003/012278 patent/WO2004041792A1/en active IP Right Grant
- 2003-11-04 AT AT03789002T patent/ATE384054T1/de active
- 2003-11-05 PA PA20038587501A patent/PA8587501A1/es unknown
- 2003-11-05 PE PE2003001114A patent/PE20040828A1/es not_active Application Discontinuation
- 2003-11-06 GT GT200300241A patent/GT200300241A/es unknown
- 2003-11-06 US US10/702,302 patent/US7141562B2/en not_active Expired - Fee Related
- 2003-11-07 AR ARP030104100A patent/AR042002A1/es unknown
- 2003-11-07 MY MYPI20034282A patent/MY136824A/en unknown
-
2005
- 2005-04-21 ZA ZA200503248A patent/ZA200503248B/en unknown
- 2005-04-27 NO NO20052074A patent/NO20052074L/no not_active Application Discontinuation
- 2005-05-02 IL IL168343A patent/IL168343A/en not_active IP Right Cessation
- 2005-05-02 HR HR20050390A patent/HRP20050390A2/xx not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
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| FC | Refusal |