AR042002A1 - Benzoxazinonas sustituidas, proceso de obtencion y usos para tratamiento de enfermedades del sistema nervioso central. - Google Patents
Benzoxazinonas sustituidas, proceso de obtencion y usos para tratamiento de enfermedades del sistema nervioso central.Info
- Publication number
- AR042002A1 AR042002A1 ARP030104100A ARP030104100A AR042002A1 AR 042002 A1 AR042002 A1 AR 042002A1 AR P030104100 A ARP030104100 A AR P030104100A AR P030104100 A ARP030104100 A AR P030104100A AR 042002 A1 AR042002 A1 AR 042002A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- independently
- nervous system
- central nervous
- benzoxazinonas
- Prior art date
Links
- 208000015114 central nervous system disease Diseases 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000004404 heteroalkyl group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D291/00—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms
- C07D291/08—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
- C07D419/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D419/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Se proporciona un compuesto de fórmula (1). También se proporciona métodos para la preparación, composiciones que lo comprenden, y métodos para el uso de compuestos para enfermedades del sistema nervioso central. Reivindicación 1: Un compuesto de la fórmula (1) o una sal o pro-fármaco aceptable farmacéuticamente del mismo, en donde: Y es C o S; m es 1 cuando Y es C y m es 2 cuando Y es S; n es 1 o 2; p es de 0 a 3; q es de 1 a 3; Z es -(CRaRb)x-, o -SO2-, donde cada Ra y Rb son H o alquilo independientemente; r es de 0 a 2; X es CH o N; cada R1 es independientemente halógeno, alquilo, haloalquilo, heteroalquilo, alcoxilo, ciano, -S(O)s-Rc, -C(=O)-NRcRd, -SO2-NRcRd, -N(Rc)-C(=O)-Rd, o -C(=O)-Rc, donde cada Rc y Rd es independientemente H o alquilo; s es de 0 a 2; R2 es arilo opcionalmente sustituido o heteroarilo opcionalmente sustituido; cada uno de R3 y R4 es independientemente H o alquilo, o R3 y R4 junto con sus carbonos compartidos pueden formar un anillo cicloalquilo de 3 a 6 miembros; y cada uno de R5, R6, R7. R8, y R9 son independientemente H o alquilo, o uno de R5 y R6 junto con uno de R7, R8, y R9 y los átomos de en medio pueden formar un anillo de 5 a 7 miembros.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42494602P | 2002-11-08 | 2002-11-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR042002A1 true AR042002A1 (es) | 2005-06-08 |
Family
ID=32312902
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030104100A AR042002A1 (es) | 2002-11-08 | 2003-11-07 | Benzoxazinonas sustituidas, proceso de obtencion y usos para tratamiento de enfermedades del sistema nervioso central. |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US7141562B2 (es) |
| EP (1) | EP1562918B1 (es) |
| JP (1) | JP4401297B2 (es) |
| KR (1) | KR100683361B1 (es) |
| CN (1) | CN100390157C (es) |
| AR (1) | AR042002A1 (es) |
| AT (1) | ATE384054T1 (es) |
| AU (1) | AU2003293653B2 (es) |
| BR (1) | BR0315302A (es) |
| CA (1) | CA2505334A1 (es) |
| DE (1) | DE60318733T2 (es) |
| DK (1) | DK1562918T3 (es) |
| ES (1) | ES2298609T3 (es) |
| GT (1) | GT200300241A (es) |
| HR (1) | HRP20050390A2 (es) |
| IL (1) | IL168343A (es) |
| MX (1) | MXPA05004758A (es) |
| MY (1) | MY136824A (es) |
| NO (1) | NO20052074L (es) |
| NZ (1) | NZ539508A (es) |
| PA (1) | PA8587501A1 (es) |
| PE (1) | PE20040828A1 (es) |
| PL (1) | PL377770A1 (es) |
| PT (1) | PT1562918E (es) |
| RU (1) | RU2328490C2 (es) |
| TW (1) | TWI285639B (es) |
| WO (1) | WO2004041792A1 (es) |
| ZA (1) | ZA200503248B (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002322539B2 (en) | 2001-07-20 | 2007-09-27 | Psychogenics Inc. | Treatment for attention-deficit hyperactivity disorder |
| BRPI0308696B8 (pt) | 2002-03-27 | 2021-05-25 | Axovant Sciences Gmbh | composto derivado de quinolina, seu processo de preparação, sua composição farmacêutica e seus usos |
| BRPI0412263B1 (pt) | 2003-07-22 | 2019-10-15 | Arena Pharmaceuticals, Inc. | Derivados de diaril e aril heteroaril uréia, uso e composição farmacêutica contendo os mesmos, bem como processo para preparação da dita composição |
| WO2005058847A1 (en) | 2003-12-09 | 2005-06-30 | F. Hoffmann-La Roche Ag | Benzoxazine derivatives and uses thereof |
| WO2006037482A2 (en) * | 2004-09-30 | 2006-04-13 | F. Hoffmann-La Roche Ag | Compositions and methods for treating cognitive disorders |
| US7713954B2 (en) * | 2004-09-30 | 2010-05-11 | Roche Palo Alto Llc | Compositions and methods for treating cognitive disorders |
| CN101263136A (zh) | 2005-07-13 | 2008-09-10 | 弗·哈夫曼-拉罗切有限公司 | 作为5-ht6、5-ht24的苯并咪唑衍生物 |
| WO2007032572A1 (en) * | 2005-09-15 | 2007-03-22 | Korea Reserach Institute Of Chemical Technology | N-substituted-1h-quinoline-2, 4-diones, preparation method thereof, and pharmaceutical composition containing the same |
| TWI385161B (zh) * | 2006-02-02 | 2013-02-11 | Mitsubishi Tanabe Pharma Corp | 含氮雜雙環化合物 |
| PT2040755E (pt) * | 2006-06-23 | 2011-07-08 | Esteve Labor Dr | Combinação de um inibidor de colinesterase e um composto com afinidade para o receptor 5-ht6 |
| WO2009074607A1 (en) | 2007-12-12 | 2009-06-18 | Glaxo Group Limited | Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline |
| WO2009123714A2 (en) | 2008-04-02 | 2009-10-08 | Arena Pharmaceuticals, Inc. | Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor |
| US9126946B2 (en) | 2008-10-28 | 2015-09-08 | Arena Pharmaceuticals, Inc. | Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto |
| ITMI20131782A1 (it) * | 2013-10-25 | 2015-04-26 | Dipharma Francis Srl | Procedimento per la preparazione di un agonista della trombopoietina |
| EP4119141A1 (en) | 2015-06-12 | 2023-01-18 | Axovant Sciences GmbH | Nelotanserin for the prophylaxis and treatment of rem sleep behavior disorder |
| EP3322415A4 (en) | 2015-07-15 | 2019-03-13 | Axovant Sciences GmbH | DIARYL AND ARYLHETEROARYL UREA DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR FOR PROPHYLAXIS AND TREATMENT OF HALLUCINATIONS RELATED TO A NEUROGENERATIVE DISEASE |
| RU2624978C2 (ru) * | 2015-07-27 | 2017-07-11 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Воронежский государственный медицинский университет им. Н.Н. Бурденко" Министерства здравоохранения Российской Федерации | Способ лечения умеренного когнитивного снижения |
| SMT202100305T1 (it) * | 2017-08-07 | 2021-07-12 | Suven Life Sciences Ltd | Composti di fluoropiperidina come antagonisti dei recettori 5–ht6 puri |
| CN111559990B (zh) * | 2020-05-29 | 2021-03-09 | 四川大学华西医院 | 一种小分子噁噻嗪类衍生物及其应用 |
| CN112047898A (zh) * | 2020-10-14 | 2020-12-08 | 兰州大学 | 一种苯并[c][1,2]噁嗪骨架类新化合物及其制备方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU784769A3 (ru) * | 1977-03-17 | 1980-11-30 | Шел Интернэшнл Рисерч Маатсхаппии Б.В. (Фирма) | Способ получени бензоксазинкарбоксамидов |
| ATE81975T1 (de) | 1984-12-21 | 1992-11-15 | Duphar Int Res | Arzneimittel mit psychotroper wirkung. |
| AU605304B2 (en) * | 1987-06-22 | 1991-01-10 | Nihon Tokushu Nayaku Seizo K.K. | Benzo-fused cyclic compounds |
| FR2667068B1 (fr) * | 1990-09-26 | 1994-09-09 | Adir | Nouvelles amines alkyl heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| US5955470A (en) * | 1991-06-11 | 1999-09-21 | Merrell Pharmaceuticals, Inc. | Derivatives of amide analogs of certain methano bridged quinolizines |
| US6225312B1 (en) | 1996-03-29 | 2001-05-01 | Duphar International Research B.V. | Piperazine and piperidine compounds |
| ATE253058T1 (de) | 1997-09-02 | 2003-11-15 | Duphar Int Res | Piperidin- und piperazin derivate als 5-ht1- rezeptor-agonisten |
| ES2244469T3 (es) * | 1999-08-23 | 2005-12-16 | Solvay Pharmaceuticals B.V. | Fenilpiperazinas como inhibidores de la recaptacion de serotonina. |
| US20020013314A1 (en) | 2000-02-01 | 2002-01-31 | Bing-Yan Zhu | 3,4-dihydro-2H-benzo[1,4]oxazine inhibitors of factor Xa |
| US20020019394A1 (en) | 2000-03-24 | 2002-02-14 | Wenhao Li | Bicyclic sulfonyl amino inhibitors of factor Xa |
| DE10031391A1 (de) | 2000-07-03 | 2002-02-07 | Knoll Ag | Bicyclische Verbindungen und ihre Verwendung zur Prophylaxe und Therapie der zerebralen Ischämie |
| CN1478092A (zh) * | 2000-10-26 | 2004-02-25 | ʷ | 苯并噁嗪酮衍生物及其制备和应用 |
| MXPA04001250A (es) * | 2001-08-10 | 2004-05-27 | Hoffmann La Roche | Derivados de arilsulfonilo con afinidad receptora de 5-hidroxitriptamina6 (5-ht6). |
| CA2485136C (en) * | 2002-05-13 | 2011-12-20 | F. Hoffmann-La Roche Ag | Benzoxazine derivatives as 5-ht6 modulators and uses thereof |
-
2003
- 2003-11-04 JP JP2004549101A patent/JP4401297B2/ja not_active Expired - Fee Related
- 2003-11-04 CN CNB2003801053862A patent/CN100390157C/zh not_active Expired - Fee Related
- 2003-11-04 AT AT03789002T patent/ATE384054T1/de active
- 2003-11-04 CA CA002505334A patent/CA2505334A1/en not_active Abandoned
- 2003-11-04 NZ NZ539508A patent/NZ539508A/en not_active IP Right Cessation
- 2003-11-04 PL PL377770A patent/PL377770A1/pl unknown
- 2003-11-04 DK DK03789002T patent/DK1562918T3/da active
- 2003-11-04 MX MXPA05004758A patent/MXPA05004758A/es active IP Right Grant
- 2003-11-04 HR HR20050390A patent/HRP20050390A2/xx not_active Application Discontinuation
- 2003-11-04 RU RU2005117965/04A patent/RU2328490C2/ru not_active IP Right Cessation
- 2003-11-04 KR KR1020057008044A patent/KR100683361B1/ko not_active Expired - Fee Related
- 2003-11-04 DE DE60318733T patent/DE60318733T2/de not_active Expired - Lifetime
- 2003-11-04 WO PCT/EP2003/012278 patent/WO2004041792A1/en not_active Ceased
- 2003-11-04 TW TW092130842A patent/TWI285639B/zh active
- 2003-11-04 BR BR0315302-9A patent/BR0315302A/pt not_active Application Discontinuation
- 2003-11-04 ES ES03789002T patent/ES2298609T3/es not_active Expired - Lifetime
- 2003-11-04 PT PT03789002T patent/PT1562918E/pt unknown
- 2003-11-04 EP EP03789002A patent/EP1562918B1/en not_active Expired - Lifetime
- 2003-11-04 AU AU2003293653A patent/AU2003293653B2/en not_active Ceased
- 2003-11-05 PA PA20038587501A patent/PA8587501A1/es unknown
- 2003-11-05 PE PE2003001114A patent/PE20040828A1/es not_active Application Discontinuation
- 2003-11-06 US US10/702,302 patent/US7141562B2/en not_active Expired - Fee Related
- 2003-11-06 GT GT200300241A patent/GT200300241A/es unknown
- 2003-11-07 AR ARP030104100A patent/AR042002A1/es unknown
- 2003-11-07 MY MYPI20034282A patent/MY136824A/en unknown
-
2005
- 2005-04-21 ZA ZA200503248A patent/ZA200503248B/en unknown
- 2005-04-27 NO NO20052074A patent/NO20052074L/no not_active Application Discontinuation
- 2005-05-02 IL IL168343A patent/IL168343A/en not_active IP Right Cessation
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| FB | Suspension of granting procedure |