ATE253058T1 - Piperidin- und piperazin derivate als 5-ht1- rezeptor-agonisten - Google Patents
Piperidin- und piperazin derivate als 5-ht1- rezeptor-agonistenInfo
- Publication number
- ATE253058T1 ATE253058T1 AT98202832T AT98202832T ATE253058T1 AT E253058 T1 ATE253058 T1 AT E253058T1 AT 98202832 T AT98202832 T AT 98202832T AT 98202832 T AT98202832 T AT 98202832T AT E253058 T1 ATE253058 T1 AT E253058T1
- Authority
- AT
- Austria
- Prior art keywords
- piperidine
- receptor agonists
- piperazine derivatives
- compounds
- receptors
- Prior art date
Links
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical class C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title abstract 3
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title 2
- 102000035038 5-HT1 receptors Human genes 0.000 title 1
- 108091005478 5-HT1 receptors Proteins 0.000 title 1
- 239000000018 receptor agonist Substances 0.000 title 1
- 229940044601 receptor agonist Drugs 0.000 title 1
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 102000004980 Dopamine D2 Receptors Human genes 0.000 abstract 1
- 108090001111 Dopamine D2 Receptors Proteins 0.000 abstract 1
- 102000017911 HTR1A Human genes 0.000 abstract 1
- 101150015707 HTR1A gene Proteins 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- -1 piperidine derivative compounds Chemical class 0.000 abstract 1
- 238000009877 rendering Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Indole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97202704 | 1997-09-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE253058T1 true ATE253058T1 (de) | 2003-11-15 |
Family
ID=8228697
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98202832T ATE253058T1 (de) | 1997-09-02 | 1998-08-24 | Piperidin- und piperazin derivate als 5-ht1- rezeptor-agonisten |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US6214829B1 (de) |
| JP (1) | JP4221084B2 (de) |
| AT (1) | ATE253058T1 (de) |
| CA (1) | CA2246126C (de) |
| DE (1) | DE69819266T2 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE299142T1 (de) * | 1999-08-23 | 2005-07-15 | Solvay Pharm Bv | Phenylpiperazin-derivate als inhibitoren der serotonin-wiederaufnahme |
| UA73981C2 (en) * | 2000-03-10 | 2005-10-17 | Merck Patent Gmbh | (r)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane for treatment of extrapyramidal movement disorders (variants), pharmaceutical composition and kit |
| BR0115297A (pt) * | 2000-11-14 | 2003-08-26 | Merck Patent Ges Mit Beschonkt | Usos de antagonistas seletivos do receptor de dopamina d2 e agonistas do receptor 5-ht1a combinados |
| AR032712A1 (es) * | 2001-02-21 | 2003-11-19 | Solvay Pharm Bv | Un mesilato de derivados de fenilpiperazina y composiciones farmaceuticas que lo contienen |
| DK1408976T5 (da) * | 2001-07-20 | 2011-01-10 | Psychogenics Inc | Behandling af ADHD (Attention deficit hyperactivity disorder) |
| EP1408964B1 (de) * | 2001-07-26 | 2007-01-24 | MERCK PATENT GmbH | Verwendung von 2- 5-(4-fluorphenyl)-3-pyridylmethylaminomethyl-chroman und seiner physiologisch annehmbaren salze |
| PT1562918E (pt) * | 2002-11-08 | 2008-03-12 | Hoffmann La Roche | Benzoxazinonas substituídas e as suas utilizações |
| GB0227240D0 (en) * | 2002-11-21 | 2002-12-31 | Glaxo Group Ltd | Compounds |
| GB0316915D0 (en) * | 2003-07-18 | 2003-08-20 | Glaxo Group Ltd | Compounds |
| TWI320783B (en) | 2005-04-14 | 2010-02-21 | Otsuka Pharma Co Ltd | Heterocyclic compound |
| JP4315393B2 (ja) * | 2005-04-14 | 2009-08-19 | 大塚製薬株式会社 | 複素環化合物 |
| JP2019516682A (ja) * | 2016-05-04 | 2019-06-20 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | インドールアミン２，３−ジオキシゲナーゼ阻害剤およびその使用方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ209876A (en) | 1983-10-17 | 1988-03-30 | Duphar Int Res | Piperazines and pharmaceutical compositions |
| FR2567884B1 (fr) | 1984-07-19 | 1987-03-06 | Roussel Uclaf | Nouveaux derives de l'indole, leur preparation, leur application comme medicaments et les compositions les renfermant |
| IL92544A0 (en) | 1988-12-08 | 1990-08-31 | Duphar Int Res | Piperazine derivatives,their preparation and pharmaceutical compositions containing them |
| AU645681B2 (en) | 1991-05-02 | 1994-01-20 | John Wyeth & Brother Limited | Piperazine derivatives |
| DK148392D0 (da) | 1992-12-09 | 1992-12-09 | Lundbeck & Co As H | Heterocykliske forbindelser |
| GB9300195D0 (en) | 1993-01-06 | 1993-03-03 | Wyeth John & Brother Ltd | Piperazine derivatives |
| EP0650964A1 (de) | 1993-11-02 | 1995-05-03 | Duphar International Research B.V | 1- 2H-1-Benzopyran-2-on-8-yl -Piperazin Derivate |
| US5519025A (en) | 1995-04-10 | 1996-05-21 | American Home Products Corporation | 4-indolylpiperazinyl derivatives |
| US5486518A (en) | 1995-04-10 | 1996-01-23 | American Home Products Corporation | 4-indolylpiperazinyl derivatives |
| CZ8197A3 (en) | 1996-01-16 | 1997-10-15 | American Home Prod | (1h-indol-4-yl)-piperidine- or tetrahydropyridine ethyl amines and -ethyl carboxamides and pharmaceutical composition containing thereof |
-
1998
- 1998-08-24 DE DE69819266T patent/DE69819266T2/de not_active Expired - Lifetime
- 1998-08-24 AT AT98202832T patent/ATE253058T1/de not_active IP Right Cessation
- 1998-08-28 CA CA002246126A patent/CA2246126C/en not_active Expired - Fee Related
- 1998-08-31 US US09/144,076 patent/US6214829B1/en not_active Expired - Lifetime
- 1998-08-31 JP JP25910598A patent/JP4221084B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP4221084B2 (ja) | 2009-02-12 |
| US6214829B1 (en) | 2001-04-10 |
| DE69819266D1 (de) | 2003-12-04 |
| CA2246126A1 (en) | 1999-03-02 |
| CA2246126C (en) | 2006-10-31 |
| JPH11147871A (ja) | 1999-06-02 |
| DE69819266T2 (de) | 2004-07-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE245636T1 (de) | Benzofurylpiperazine: 5-ht2c serotoninrezeptor agonisten | |
| DE69819266D1 (de) | Piperidin- und Piperazin Derivate als 5-HT1-Rezeptor-Agonisten | |
| DE69736704D1 (de) | Piperazin- und piperidin- derivate | |
| PA8467101A1 (es) | Compuestos 4-(2-ceto-1-benzilimidazolinil)piperidina como agonistas del receptor orli | |
| CH1175401H1 (de) | Piperazin Derivate verwendbar als CCR5 Antagonisten | |
| DE60032780D1 (de) | Tetrahydroquinolin-derivate | |
| DE69129009D1 (de) | Indole Derivate als Serotonin-Antagonisten | |
| DK0957099T3 (da) | Heterocykliske carboxamider | |
| DE60008262D1 (de) | Piperazinderivate als 5-ht1b antagonisten | |
| ATE284853T1 (de) | Ureido-thiobuttersäurederivate als ppar-agonisten | |
| DE50001729D1 (de) | N-(indolcarbonyl-)piperazinderivate als 5-ht2a-rezeptor liganden | |
| ATE210649T1 (de) | Arylacrylamidderivate als 5ht1 agoniste oder antagoniste | |
| ATE252575T1 (de) | Indole und 2,3-dihydroindolderivate, ihre herstellung und verwendung | |
| BR0115609A (pt) | Agentes serotonérgicos | |
| EA200000023A1 (ru) | Производные 2-(-4-арил или гетероарил-пиперазин-1-илметил) -1h-индола | |
| BG105136A (en) | 4,5,6 and 7-indole and indoline derivatives, their preparation and use | |
| TR200400645T4 (tr) | İkameli Fenil Piperazin türevleri, Bunların Hazırlanması ve kullanımları | |
| TR200200125T2 (tr) | Yeni aminotiyazol türevleri, bunların hazırlanması ve bunları içeren farmasötik kompozisyonlar. | |
| MXPA05009988A (es) | Derivados de 6-sulfonamida quinolina y cromeno como antagonistas de los receptores de androgenos. | |
| ATE395333T1 (de) | 4-phenylpiperazinyl, -piperidinyl und - tetrahydropyridyl-derivate als dopamin d4- antagonisten | |
| DE60131001D1 (de) | Oxazolylarylpropionsäure derivate und ihre verwendung als ppar agonisten | |
| EA200200727A1 (ru) | Новые производные индола | |
| HRP20090143T3 (hr) | N-oksidi kao predlijekovi derivata piperazina i piperidina | |
| MX9700080A (es) | Derivados de aril y heteroaril alcoxinaftaleno. | |
| YU78100A (sh) | 4,5,6 i 7-indol i indolin derivati, njihova izrada i upotreba |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |