ATE299142T1 - Phenylpiperazin-derivate als inhibitoren der serotonin-wiederaufnahme - Google Patents
Phenylpiperazin-derivate als inhibitoren der serotonin-wiederaufnahmeInfo
- Publication number
- ATE299142T1 ATE299142T1 AT00962355T AT00962355T ATE299142T1 AT E299142 T1 ATE299142 T1 AT E299142T1 AT 00962355 T AT00962355 T AT 00962355T AT 00962355 T AT00962355 T AT 00962355T AT E299142 T1 ATE299142 T1 AT E299142T1
- Authority
- AT
- Austria
- Prior art keywords
- reuppost
- serotonin
- inhibitors
- phenylpiperazine derivatives
- phenylpiperazine
- Prior art date
Links
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 title 2
- 239000003112 inhibitor Substances 0.000 title 1
- YZTJYBJCZXZGCT-UHFFFAOYSA-N phenylpiperazine Chemical class C1CNCCN1C1=CC=CC=C1 YZTJYBJCZXZGCT-UHFFFAOYSA-N 0.000 title 1
- 229940076279 serotonin Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99202710 | 1999-08-23 | ||
| NL1012888 | 1999-08-23 | ||
| PCT/EP2000/008190 WO2001014330A2 (en) | 1999-08-23 | 2000-08-22 | Phenylpiperazines as serotonin reuptake inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE299142T1 true ATE299142T1 (de) | 2005-07-15 |
Family
ID=26153354
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00962355T ATE299142T1 (de) | 1999-08-23 | 2000-08-22 | Phenylpiperazin-derivate als inhibitoren der serotonin-wiederaufnahme |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US7067513B1 (de) |
| EP (1) | EP1212320B1 (de) |
| JP (1) | JP4919565B2 (de) |
| KR (1) | KR100634039B1 (de) |
| CN (1) | CN1155596C (de) |
| AR (1) | AR031526A1 (de) |
| AT (1) | ATE299142T1 (de) |
| AU (1) | AU772189B2 (de) |
| BR (1) | BR0013498A (de) |
| CA (1) | CA2379021C (de) |
| CZ (1) | CZ298533B6 (de) |
| DE (1) | DE60021194T2 (de) |
| DK (1) | DK1212320T3 (de) |
| ES (1) | ES2244469T3 (de) |
| HU (1) | HUP0203194A3 (de) |
| IL (2) | IL148218A0 (de) |
| MX (1) | MXPA02001919A (de) |
| NO (1) | NO321887B1 (de) |
| NZ (1) | NZ517900A (de) |
| PL (1) | PL201178B1 (de) |
| PT (1) | PT1212320E (de) |
| RU (1) | RU2246494C2 (de) |
| SI (1) | SI1212320T1 (de) |
| SK (1) | SK287018B6 (de) |
| TR (1) | TR200200460T2 (de) |
| TW (1) | TWI286136B (de) |
| UA (1) | UA74160C2 (de) |
| WO (1) | WO2001014330A2 (de) |
| ZA (1) | ZA200201829B (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0203194A3 (en) | 1999-08-23 | 2004-01-28 | Solvay Pharm Bv | Phenylpiperazines, pharmaceutical compositions containing them and their use |
| AR032711A1 (es) | 2001-02-21 | 2003-11-19 | Solvay Pharm Bv | Derivados de fenilpiperazina, un metodo para la preparacion de los mismos y una composicion farmaceutica que los contiene |
| AR032712A1 (es) * | 2001-02-21 | 2003-11-19 | Solvay Pharm Bv | Un mesilato de derivados de fenilpiperazina y composiciones farmaceuticas que lo contienen |
| WO2002085896A1 (en) * | 2001-04-24 | 2002-10-31 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-benzodioxan |
| US7041683B2 (en) | 2001-04-24 | 2006-05-09 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1, 4-benzodiozan |
| US6656950B2 (en) | 2001-04-25 | 2003-12-02 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of 1,4-dioxino[2,3-b]pyridine |
| EP1408976B3 (de) | 2001-07-20 | 2010-08-25 | Psychogenics Inc. | Behandlung von hyperaktivitätsstörungen und aufmerksamkeitsdefiziten |
| EP1336406A1 (de) * | 2002-02-14 | 2003-08-20 | Solvay Pharmaceuticals B.V. | Partieller Dopamin-D2 Rezeptoragonist plus Substanzen mit Serotonin- und/oder Noradrenalin inhibitorischer Aktivität |
| NZ536230A (en) * | 2002-05-13 | 2007-05-31 | Hoffmann La Roche | Benzoxazine derivatives as 5-hydroxytryptamine-6 (5-HT6) modulatory neurotransmitter in the brain |
| DE10233500A1 (de) * | 2002-07-24 | 2004-02-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 3-Z-[1-(4-(N-((4-Methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylen]-6-methoxycarbonyl-2-indolinon-Monoethansulfonat und dessen Verwendung als Arzneimittel |
| WO2004041792A1 (en) | 2002-11-08 | 2004-05-21 | F. Hoffmann-La Roche Ag | Substituted benzoxazinones and uses thereof |
| US7276603B2 (en) * | 2003-05-02 | 2007-10-02 | Wyeth | Benzofuranyl-and benzothienyl-piperazinyl quinolines and methods of their use |
| WO2004108671A1 (en) * | 2003-06-06 | 2004-12-16 | Suven Life Sciences Limited | Substituted indoles with serotonin receptor affinity, process for their preparation and pharmaceutical compositions containing them |
| AR052332A1 (es) * | 2004-12-07 | 2007-03-14 | Solvay Pharm Bv | Derivados de benzdioxanpiperazina con una afinidad combinada para receptores de dopamina-d2 y sitios de reabsorcion de serotonina, composiciones farmaceuticas que los contienen y su empleo como medicamentos para el tratamiento de enfermedades del snc |
| TW200633987A (en) * | 2004-12-07 | 2006-10-01 | Solvay Pharm Bv | Phenylpiperazines with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites |
| US7371769B2 (en) | 2004-12-07 | 2008-05-13 | Solvay Pharmaceuticals B.V. | Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites |
| US20060122247A1 (en) | 2004-12-08 | 2006-06-08 | Solvay Pharmaceuticals B.V. | Aryloxyethylamine and phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition |
| PT1824479E (pt) * | 2004-12-08 | 2009-01-30 | Solvay Pharm Bv | Derivados de fenilpiperazina com uma combinação de agonismo de receptor de dopamina d2 parcial e inibição da reabsorção de serotonina |
| PE20070523A1 (es) | 2005-09-12 | 2007-06-28 | Wyeth Corp | Formulacion de liberacion sostenida del glucuronato de (8-{4-[3-(5-fluoro-1h-indol-3-il)-propil]-piperazin-1-il}-2-metil-4h-benzo[1,4]oxazin-3-ona |
| GT200600414A (es) * | 2005-09-12 | 2007-09-20 | Sal de glucuranato de compuesto de piperazine | |
| GT200600416A (es) | 2005-09-12 | 2007-09-20 | Sales salicilato y gentisato de un compuesto de piperazina | |
| US9066903B2 (en) | 2006-02-28 | 2015-06-30 | The United States Of America As Represented By The Department Of Veterans Affairs | Pharmacological treatment of Parkinson's disease |
| FR2941946B1 (fr) * | 2009-02-12 | 2011-03-25 | Sanofi Aventis | Derives de 3-benzofuranyl-indol-2-one-3-acetamidopiperazines substitues, leur preparation et leur application en therapeutique |
| JP5732453B2 (ja) * | 2009-06-25 | 2015-06-10 | アルカーメス ファーマ アイルランド リミテッド | Nh酸性化合物のプロドラッグ |
| WO2015014256A1 (en) | 2013-07-29 | 2015-02-05 | Sunshine Lake Pharma Co., Ltd. | Substituted heteroaryl compounds and methods of use thereof |
| US10316025B2 (en) | 2015-06-03 | 2019-06-11 | Sunshine Lake Pharma Co., Ltd. | Substituted piperazine compounds and methods of use and use thereof |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1075156A (en) | 1963-08-27 | 1967-07-12 | Luso Farmaco Inst | Substituted piperazines |
| GB8830312D0 (en) | 1988-12-28 | 1989-02-22 | Lundbeck & Co As H | Heterocyclic compounds |
| DE4127849A1 (de) * | 1991-08-22 | 1993-02-25 | Merck Patent Gmbh | Benzodioxanderivate |
| US5314896A (en) | 1991-11-20 | 1994-05-24 | Warner-Lambert Company | 1,3-substituted cycloalkenes and cycloalkanes as central nervous system agents |
| DE4333254A1 (de) * | 1993-09-30 | 1995-04-06 | Merck Patent Gmbh | Piperidine und Piperazine |
| DE4414113A1 (de) | 1994-04-22 | 1995-10-26 | Merck Patent Gmbh | 3-Indolylpiperidine |
| US5576321A (en) | 1995-01-17 | 1996-11-19 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
| AR004229A1 (es) | 1995-11-06 | 1998-11-04 | Wyeth Corp | Derivados indolalquilo de benzodioxanmetilamina y su uso para preparar medicamentos |
| ZA9711376B (en) | 1996-12-20 | 1998-07-21 | Lundbeck & Co As H | Indole or dihydroindole derivatives |
| DE19730989A1 (de) * | 1997-07-18 | 1999-01-21 | Merck Patent Gmbh | Piperazin-Derivate |
| ATE252575T1 (de) * | 1997-07-25 | 2003-11-15 | Lundbeck & Co As H | Indole und 2,3-dihydroindolderivate, ihre herstellung und verwendung |
| ATE253058T1 (de) * | 1997-09-02 | 2003-11-15 | Duphar Int Res | Piperidin- und piperazin derivate als 5-ht1- rezeptor-agonisten |
| EP0900792B1 (de) | 1997-09-02 | 2003-10-29 | Duphar International Research B.V | Piperidin- und Piperazin Derivate als 5-HT1-Rezeptor-Agonisten |
| ID27976A (id) * | 1998-06-19 | 2001-05-03 | Lundbeck & Co As H | 4,5,6 dan 7-indol dan turunan-turunan indolin, pembuatan dan penggunaannya |
| EP1089997A1 (de) * | 1998-06-19 | 2001-04-11 | H.Lundbeck A/S | 4,5,6 und 7-indol- und indolin-derivate, ihre herstellung und anwendung |
| AR020773A1 (es) | 1998-10-16 | 2002-05-29 | Duphar Int Res | Compuesto derivados de 3-(tetrahidropiridin-4-il)indol, metodo para prepararlo, una composicion farmaceutica que los contiene, metodo para preparar dicha composicion y uso del compuesto |
| AR022303A1 (es) * | 1999-01-22 | 2002-09-04 | Lundbeck & Co As H | Derivados de piperidina, tetrahidropiridina y piperazina, su preparacion y utilizacion |
| HUP0203194A3 (en) | 1999-08-23 | 2004-01-28 | Solvay Pharm Bv | Phenylpiperazines, pharmaceutical compositions containing them and their use |
| AR032711A1 (es) | 2001-02-21 | 2003-11-19 | Solvay Pharm Bv | Derivados de fenilpiperazina, un metodo para la preparacion de los mismos y una composicion farmaceutica que los contiene |
| AR032712A1 (es) * | 2001-02-21 | 2003-11-19 | Solvay Pharm Bv | Un mesilato de derivados de fenilpiperazina y composiciones farmaceuticas que lo contienen |
| EP1336406A1 (de) | 2002-02-14 | 2003-08-20 | Solvay Pharmaceuticals B.V. | Partieller Dopamin-D2 Rezeptoragonist plus Substanzen mit Serotonin- und/oder Noradrenalin inhibitorischer Aktivität |
-
2000
- 2000-08-22 HU HU0203194A patent/HUP0203194A3/hu unknown
- 2000-08-22 UA UA2002032313A patent/UA74160C2/uk unknown
- 2000-08-22 CA CA002379021A patent/CA2379021C/en not_active Expired - Fee Related
- 2000-08-22 DK DK00962355T patent/DK1212320T3/da active
- 2000-08-22 JP JP2001518420A patent/JP4919565B2/ja not_active Expired - Fee Related
- 2000-08-22 WO PCT/EP2000/008190 patent/WO2001014330A2/en not_active Ceased
- 2000-08-22 PL PL364821A patent/PL201178B1/pl not_active IP Right Cessation
- 2000-08-22 AT AT00962355T patent/ATE299142T1/de active
- 2000-08-22 AU AU74118/00A patent/AU772189B2/en not_active Ceased
- 2000-08-22 NZ NZ517900A patent/NZ517900A/en not_active IP Right Cessation
- 2000-08-22 CN CNB008118655A patent/CN1155596C/zh not_active Expired - Fee Related
- 2000-08-22 MX MXPA02001919A patent/MXPA02001919A/es active IP Right Grant
- 2000-08-22 US US10/069,256 patent/US7067513B1/en not_active Expired - Fee Related
- 2000-08-22 RU RU2002107318/04A patent/RU2246494C2/ru not_active IP Right Cessation
- 2000-08-22 EP EP00962355A patent/EP1212320B1/de not_active Expired - Lifetime
- 2000-08-22 ES ES00962355T patent/ES2244469T3/es not_active Expired - Lifetime
- 2000-08-22 SK SK249-2002A patent/SK287018B6/sk not_active IP Right Cessation
- 2000-08-22 PT PT00962355T patent/PT1212320E/pt unknown
- 2000-08-22 DE DE60021194T patent/DE60021194T2/de not_active Expired - Lifetime
- 2000-08-22 TR TR2002/00460T patent/TR200200460T2/xx unknown
- 2000-08-22 AR ARP000104326A patent/AR031526A1/es active IP Right Grant
- 2000-08-22 SI SI200030720T patent/SI1212320T1/xx unknown
- 2000-08-22 KR KR1020027002242A patent/KR100634039B1/ko not_active Expired - Fee Related
- 2000-08-22 BR BR0013498-8A patent/BR0013498A/pt active Search and Examination
- 2000-08-22 IL IL14821800A patent/IL148218A0/xx active IP Right Grant
- 2000-08-22 CZ CZ20020619A patent/CZ298533B6/cs not_active IP Right Cessation
- 2000-09-01 TW TW089117890A patent/TWI286136B/zh not_active IP Right Cessation
-
2002
- 2002-02-18 IL IL148218A patent/IL148218A/en not_active IP Right Cessation
- 2002-02-19 NO NO20020810A patent/NO321887B1/no not_active IP Right Cessation
- 2002-03-05 ZA ZA200201829A patent/ZA200201829B/xx unknown
-
2006
- 2006-06-12 US US11/450,323 patent/US7456182B2/en not_active Expired - Fee Related
-
2008
- 2008-10-27 US US12/258,591 patent/US7605162B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE299142T1 (de) | Phenylpiperazin-derivate als inhibitoren der serotonin-wiederaufnahme | |
| ATE386730T1 (de) | Phenylpiperazinderivate als serotonin wiederaufnahmehemmer | |
| DE60032601D1 (de) | Als antikrebsmittel verwendbare heterocyklische derivate | |
| ATE437862T1 (de) | Pyrimidin-5-onderivate als ldl-pla2 inhibitoren | |
| ATE236877T1 (de) | N-(indolcarbonyl-)piperazinderivate als 5-ht2a- rezeptor liganden | |
| DK1244647T3 (da) | Quinzolinderivater som VIGF-inhibitorer | |
| EE200100486A (et) | Amiinderivaadid proteaasi inhibiitoritena | |
| DE50005155D1 (de) | Bicyclische imidazo-3-yl-aminderivate | |
| DE60008262D1 (de) | Piperazinderivate als 5-ht1b antagonisten | |
| ATE339403T1 (de) | Pyrrolderivate als phosphodiesterase vii-hemmer | |
| ATE413403T1 (de) | Bicyclische imidazo-5-yl-aminderivate | |
| DK1237857T3 (da) | Nye Phenalkyloxyphenylderivater | |
| IS6413A (is) | Setnir 8-arýkínólín fosfódíesterasa-4 latar | |
| NO20023001D0 (no) | Substituerte piperazinderivater som MTP inhibitorer | |
| DE60021384D1 (de) | Indolderivate | |
| DE60003072D1 (de) | Thiazolidindion-derivate als antidiabetika | |
| NO20023148D0 (no) | Nye indolderivater | |
| NO20020306D0 (no) | Indolderivater | |
| NO20022682L (no) | Heterosykliske derivater | |
| DE60012953D1 (de) | 3-amino-2-phenylpiperidinderivate als substanz p antagonisten | |
| IS2431B (is) | Nýjar indólafleiður | |
| NO20021310D0 (no) | Aminderivater |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1212320 Country of ref document: EP |