ATE292115T1 - Indolderivate als cox-ii-inhibitoren - Google Patents

Indolderivate als cox-ii-inhibitoren

Info

Publication number
ATE292115T1
ATE292115T1 AT02779382T AT02779382T ATE292115T1 AT E292115 T1 ATE292115 T1 AT E292115T1 AT 02779382 T AT02779382 T AT 02779382T AT 02779382 T AT02779382 T AT 02779382T AT E292115 T1 ATE292115 T1 AT E292115T1
Authority
AT
Austria
Prior art keywords
cox
inhibitors
indole derivatives
indole
derivatives
Prior art date
Application number
AT02779382T
Other languages
English (en)
Inventor
Chris Allen Broka
Jeffrey Allen Campbell
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE292115T1 publication Critical patent/ATE292115T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/36—Oxygen atoms in position 3, e.g. adrenochrome
AT02779382T 2001-09-27 2002-09-20 Indolderivate als cox-ii-inhibitoren ATE292115T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32538901P 2001-09-27 2001-09-27
PCT/EP2002/010557 WO2003029212A1 (en) 2001-09-27 2002-09-20 Indole derivatives as cox ii inhibitors

Publications (1)

Publication Number Publication Date
ATE292115T1 true ATE292115T1 (de) 2005-04-15

Family

ID=23267681

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02779382T ATE292115T1 (de) 2001-09-27 2002-09-20 Indolderivate als cox-ii-inhibitoren

Country Status (25)

Country Link
US (3) US6872744B2 (de)
EP (1) EP1438289B1 (de)
JP (1) JP4141954B2 (de)
KR (1) KR20040047862A (de)
CN (1) CN1261412C (de)
AR (1) AR036624A1 (de)
AT (1) ATE292115T1 (de)
BR (1) BR0212925A (de)
CA (1) CA2461670A1 (de)
CO (1) CO5560557A2 (de)
DE (1) DE60203529T2 (de)
DK (1) DK1438289T3 (de)
ES (1) ES2238616T3 (de)
HR (1) HRPK20040271B3 (de)
HU (1) HUP0401499A3 (de)
IL (1) IL160752A0 (de)
MX (1) MXPA04002824A (de)
NO (1) NO20041237L (de)
NZ (1) NZ531577A (de)
PL (1) PL370342A1 (de)
PT (1) PT1438289E (de)
RU (1) RU2004113111A (de)
SI (1) SI1438289T1 (de)
WO (1) WO2003029212A1 (de)
ZA (1) ZA200402360B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4141954B2 (ja) * 2001-09-27 2008-08-27 エフ．ホフマン−ラ ロシュ アーゲー Ｃｏｘｉｉインヒビターとしてのインドール誘導体
SE0202241D0 (sv) * 2002-07-17 2002-07-17 Astrazeneca Ab Novel Compounds
EP1545510A4 (de) * 2002-08-07 2006-11-15 Idenix Cayman Ltd Substituierte phenylindole zur behandlung von hiv
MXPA06007054A (es) * 2003-12-19 2007-04-17 Elixir Pharmaceuticals Inc Metodos para tratar una enfermedad.
US7119214B2 (en) 2004-04-13 2006-10-10 Cephalon France Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives
EP1589016A1 (de) * 2004-04-13 2005-10-26 Cephalon France Thiosubstituierte tricyclische und bicyclische aromatische Methansulfinylderivate
US7423176B2 (en) 2004-04-13 2008-09-09 Cephalon, Inc. Bicyclic aromatic sulfinyl derivatives
AU2005254782A1 (en) 2004-06-18 2005-12-29 Biolipox Ab Indoles useful in the treatment of inflammation
WO2006041961A1 (en) * 2004-10-05 2006-04-20 GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTHAND HUMAN SERVICES Arylthioindole tubulin polymerization inhibitors and methods of treating or preventing cancer using same
DE602005026867D1 (de) 2005-01-19 2011-04-21 Biolipox Ab Entzündungshemmende indol-derivate
US7622495B2 (en) * 2006-10-03 2009-11-24 Neurim Pharmaceuticals (1991) Ltd. Substituted aryl-indole compounds and their kynurenine/kynuramine-like metabolites as therapeutic agents
MX2009004898A (es) 2006-11-09 2009-05-19 Hoffmann La Roche Derivados de indol y de benzofurano-2-carboxamida.
EP2606031B1 (de) * 2010-08-20 2017-09-27 Amira Pharmaceuticals, Inc. Autotaxin-hemmer und anwendungen davon
US9260416B2 (en) 2011-05-27 2016-02-16 Amira Pharmaceuticals, Inc. Heterocyclic autotaxin inhibitors and uses thereof
EP3046905A4 (de) 2013-09-17 2017-03-22 Pharmakea Inc. Vinylautotaxinhemmende verbindungen
EP3046909A4 (de) 2013-09-17 2017-03-29 Pharmakea, Inc. Heterocyclische vinyl-autotaxin-hemmerverbindungen
EP3049405A4 (de) 2013-09-26 2017-03-08 Pharmakea Inc. Autotaxin-inhibitorverbindungen
CN105793253B (zh) * 2013-11-22 2019-08-23 法玛克亚公司 自分泌运动因子抑制剂化合物
AU2016268250B2 (en) 2015-05-27 2020-08-27 Sabre Therapeutics Llc Autotaxin inhibitors and uses thereof
KR102241064B1 (ko) 2019-07-30 2021-04-16 부산대학교 산학협력단 신규한 인돌 유도체 및 이를 포함하는 염증성 질환 예방 또는 치료용 조성물
CN113004187B (zh) * 2021-03-16 2022-09-20 沈阳药科大学 一种具有抑制有机阴离子转运体1活性的化合物及制备方法和应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4654360A (en) 1984-06-01 1987-03-31 Syntex (U.S.A.) Inc. 1,2,3-trisubstituted indoles for treatment of inflammation
PT93943A (pt) 1989-05-05 1991-02-08 Searle & Co Processo para a preparacao de composicoes contendo compostos indole-2-carboxilato para tratamento de perturbacoes do snc
DE4338770A1 (de) 1993-11-12 1995-05-18 Matthias Dr Lehr Indol-2-alkansäuren und ihre Derivate als Hemmstoffe der Phospholipase A¶2¶
AU717430B2 (en) 1996-08-26 2000-03-23 Genetics Institute, Llc Inhibitors of phospholipase enzymes
AU7237998A (en) * 1997-05-16 1998-12-08 Chugai Seiyaku Kabushiki Kaisha Indole derivatives and mono- and diazaindole derivatives
CN1298404A (zh) 1998-02-25 2001-06-06 遗传研究所有限公司 磷脂酶a2的抑制剂
MXPA00006605A (es) * 1999-07-02 2004-12-09 Pfizer Compuestos de carbonil-indol biciclicos como agentes antiinflamatorios/analgesicos.
US6306890B1 (en) * 1999-08-30 2001-10-23 Vanderbilt University Esters derived from indolealkanols and novel amides derived from indolealkylamides that are selective COX-2 inhibitors
US6376708B1 (en) * 2000-04-11 2002-04-23 Monsanto Technology Llc Process and catalyst for dehydrogenating primary alcohols to make carboxylic acid salts
JP4141954B2 (ja) * 2001-09-27 2008-08-27 エフ．ホフマン−ラ ロシュ アーゲー Ｃｏｘｉｉインヒビターとしてのインドール誘導体
TW200400177A (en) * 2002-06-04 2004-01-01 Wyeth Corp 1-(Aminoalkyl)-3-sulfonylindole and-indazole derivatives as 5-hydroxytryptamine-6 ligands

Also Published As

Publication number Publication date
IL160752A0 (en) 2004-08-31
CA2461670A1 (en) 2003-04-10
EP1438289B1 (de) 2005-03-30
MXPA04002824A (es) 2004-07-05
US7074939B2 (en) 2006-07-11
DE60203529D1 (de) 2005-05-04
US7410994B2 (en) 2008-08-12
JP2005510474A (ja) 2005-04-21
CN1261412C (zh) 2006-06-28
US6872744B2 (en) 2005-03-29
HUP0401499A3 (en) 2007-05-02
DE60203529T2 (de) 2006-03-16
ZA200402360B (en) 2005-04-26
HRPK20040271B3 (en) 2006-02-28
KR20040047862A (ko) 2004-06-05
CO5560557A2 (es) 2005-09-30
PT1438289E (pt) 2005-06-30
NO20041237L (no) 2004-03-24
PL370342A1 (en) 2005-05-16
EP1438289A1 (de) 2004-07-21
DK1438289T3 (da) 2005-08-08
WO2003029212A1 (en) 2003-04-10
US20030130337A1 (en) 2003-07-10
SI1438289T1 (de) 2005-08-31
US20060178420A1 (en) 2006-08-10
US20050176803A1 (en) 2005-08-11
CN1561334A (zh) 2005-01-05
RU2004113111A (ru) 2005-06-27
HUP0401499A2 (hu) 2004-12-28
ES2238616T3 (es) 2005-09-01
BR0212925A (pt) 2004-10-13
NZ531577A (en) 2005-09-30
AR036624A1 (es) 2004-09-22
JP4141954B2 (ja) 2008-08-27
HRP20040271A2 (en) 2004-08-31

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