HUP0401499A2 - Indolszármazékok, mint COX II inhibítorok - Google Patents
Indolszármazékok, mint COX II inhibítorokInfo
- Publication number
- HUP0401499A2 HUP0401499A2 HU0401499A HUP0401499A HUP0401499A2 HU P0401499 A2 HUP0401499 A2 HU P0401499A2 HU 0401499 A HU0401499 A HU 0401499A HU P0401499 A HUP0401499 A HU P0401499A HU P0401499 A2 HUP0401499 A2 HU P0401499A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- alkyl
- nr5r6
- hydrogen atom
- cox
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 229940054051 antipsychotic indole derivative Drugs 0.000 title 1
- 150000002475 indoles Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- -1 hydroxy- Chemical class 0.000 abstract 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/36—Oxygen atoms in position 3, e.g. adrenochrome
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
A találmány (I) általános képletű vegyületekre vonatkozik[melyképletben A jelentése -CH2-, -O-, -S- vagy -S(O)- ; Ar jelentése adottesetben helyettesített fenilcsoport vagy adott esetben helyettesítettnaftalenilcsoport; Rl jelentése hidrogénatom, alkil-, alkoxi-,hidroxi-, hidroxi-alkil-, alkil-tio-csoport, halogénatom,cianocsoport, -C(O)R5, -C(O)NR5R6, -NR5R6, -(CR'R'')0-3OC(O)R5-, -(CR'R'')0-3SO2R5, vagy -(CR'R'')0-3NSO2R5; ahol R5, R6, R' és R''jelentése egymástól függetlenül hidrogénatom vagy alkilcsoport, azzala feltétellel, hogy ha A jelentése -CH2-, úgy R1 -C(O)NR5R6 csoporttóleltérő jelentésű; R2 jelentése hidrogénatom, alkil-, alkoxi-,hidroxicsoport, halogénatom, halogén-alkil-, nitro-, ciano- vagy -NR5R6 csoport; ahol R5 és R6 jelentése a korábbiakban megadott; R3jelentése -SOR7, -SO2R7 vagy -SO2NR5R6; ahol R7 jelentése alkil-,hidroxi-alkil-, alkoxi-alkil- vagy alkoxikarbonil-alkil-csoport; és R5és R6 jelentése a korábbiakban megadott; R4 jelentése hidrogénatomvagy alkilcsoport]. A találmány szerinti vegyületek szelektív COX-IIinhibitorok és ezért COX-II által közvetített betegségek kezelésérealkalmazhatók. A találmány kiterjed a vegyületek előállítására és avegyületeket tartalmazó gyógyszerkészítményekre is. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32538901P | 2001-09-27 | 2001-09-27 | |
| PCT/EP2002/010557 WO2003029212A1 (en) | 2001-09-27 | 2002-09-20 | Indole derivatives as cox ii inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0401499A2 true HUP0401499A2 (hu) | 2004-12-28 |
| HUP0401499A3 HUP0401499A3 (en) | 2007-05-02 |
Family
ID=23267681
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0401499A HUP0401499A3 (en) | 2001-09-27 | 2002-09-20 | Indole derivatives as cox ii inhibitors, process for their preparation and pharmaceutical compositions containing them |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US6872744B2 (hu) |
| EP (1) | EP1438289B1 (hu) |
| JP (1) | JP4141954B2 (hu) |
| KR (1) | KR20040047862A (hu) |
| CN (1) | CN1261412C (hu) |
| AR (1) | AR036624A1 (hu) |
| AT (1) | ATE292115T1 (hu) |
| BR (1) | BR0212925A (hu) |
| CA (1) | CA2461670A1 (hu) |
| CO (1) | CO5560557A2 (hu) |
| DE (1) | DE60203529T2 (hu) |
| DK (1) | DK1438289T3 (hu) |
| ES (1) | ES2238616T3 (hu) |
| HR (1) | HRPK20040271B3 (hu) |
| HU (1) | HUP0401499A3 (hu) |
| IL (1) | IL160752A0 (hu) |
| MX (1) | MXPA04002824A (hu) |
| NO (1) | NO20041237L (hu) |
| NZ (1) | NZ531577A (hu) |
| PL (1) | PL370342A1 (hu) |
| PT (1) | PT1438289E (hu) |
| RU (1) | RU2004113111A (hu) |
| SI (1) | SI1438289T1 (hu) |
| WO (1) | WO2003029212A1 (hu) |
| ZA (1) | ZA200402360B (hu) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL370342A1 (en) * | 2001-09-27 | 2005-05-16 | F.Hoffmann-La Roche Ag | Indole derivatives as cox ii inhibitors |
| SE0202241D0 (sv) * | 2002-07-17 | 2002-07-17 | Astrazeneca Ab | Novel Compounds |
| US7365090B2 (en) * | 2002-08-07 | 2008-04-29 | Idenix Pharmaceuticals, Inc. | Substituted phenylindoles for the treatment of HIV |
| US20050250794A1 (en) * | 2003-12-19 | 2005-11-10 | Andrew Napper | Methods of treating a disorder |
| US7119214B2 (en) * | 2004-04-13 | 2006-10-10 | Cephalon France | Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives |
| EP1589016A1 (en) * | 2004-04-13 | 2005-10-26 | Cephalon France | Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives |
| US7423176B2 (en) | 2004-04-13 | 2008-09-09 | Cephalon, Inc. | Bicyclic aromatic sulfinyl derivatives |
| BRPI0512252A (pt) | 2004-06-18 | 2008-02-19 | Biolipox Ab | composto ou um sal farmaceuticamente aceitável do mesmo, formulação farmacêutica, uso de um composto, método de tratamento de uma doença, produto combinado, e, processo para a preparação de um composto |
| WO2006041961A1 (en) * | 2004-10-05 | 2006-04-20 | GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTHAND HUMAN SERVICES | Arylthioindole tubulin polymerization inhibitors and methods of treating or preventing cancer using same |
| KR20070114123A (ko) | 2005-01-19 | 2007-11-29 | 바이올리폭스 에이비 | 염증 치료에 유용한 인돌 |
| US7622495B2 (en) * | 2006-10-03 | 2009-11-24 | Neurim Pharmaceuticals (1991) Ltd. | Substituted aryl-indole compounds and their kynurenine/kynuramine-like metabolites as therapeutic agents |
| CA2668959A1 (en) | 2006-11-09 | 2008-05-15 | F. Hoffmann-La Roche Ag | Indole and benzofuran 2-carboxamide derivatives |
| WO2012024620A2 (en) | 2010-08-20 | 2012-02-23 | Amira Pharmaceuticals, Inc. | Autotaxin inhibitors and uses thereof |
| WO2012166415A1 (en) | 2011-05-27 | 2012-12-06 | Amira Pharmaceuticals, Inc. | Heterocyclic autotaxin inhibitors and uses thereof |
| US9714240B2 (en) | 2013-09-17 | 2017-07-25 | Pharmakea, Inc. | Vinyl autotaxin inhibitor compounds |
| JP2016530210A (ja) | 2013-09-17 | 2016-09-29 | ファーマケア，インク． | ヘテロ環式ビニルオートタキシン阻害剤化合物 |
| EP3049405A4 (en) | 2013-09-26 | 2017-03-08 | Pharmakea Inc. | Autotaxin inhibitor compounds |
| HUE055213T2 (hu) | 2013-11-22 | 2021-11-29 | Sabre Therapeutics Llc | Autotaxin inhibitor vegyületek |
| JP6873919B2 (ja) | 2015-05-27 | 2021-05-19 | セイバー セラピューティクス エルエルシー | オートタキシン阻害剤とその使用 |
| KR102241064B1 (ko) | 2019-07-30 | 2021-04-16 | 부산대학교 산학협력단 | 신규한 인돌 유도체 및 이를 포함하는 염증성 질환 예방 또는 치료용 조성물 |
| CN113004187B (zh) * | 2021-03-16 | 2022-09-20 | 沈阳药科大学 | 一种具有抑制有机阴离子转运体1活性的化合物及制备方法和应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4654360A (en) | 1984-06-01 | 1987-03-31 | Syntex (U.S.A.) Inc. | 1,2,3-trisubstituted indoles for treatment of inflammation |
| JPH0347123A (ja) | 1989-05-05 | 1991-02-28 | G D Searle & Co | インドール―２―カルボキシレート化合物類を含有するｃｎｓ疾患治療用組成物 |
| DE4338770A1 (de) | 1993-11-12 | 1995-05-18 | Matthias Dr Lehr | Indol-2-alkansäuren und ihre Derivate als Hemmstoffe der Phospholipase A¶2¶ |
| CA2264020A1 (en) | 1996-08-26 | 1998-03-05 | Jean Bemis | Inhibitors of phospholipase enzymes |
| AU7237998A (en) * | 1997-05-16 | 1998-12-08 | Chugai Seiyaku Kabushiki Kaisha | Indole derivatives and mono- and diazaindole derivatives |
| CN1298404A (zh) | 1998-02-25 | 2001-06-06 | 遗传研究所有限公司 | 磷脂酶a2的抑制剂 |
| MXPA00006605A (es) * | 1999-07-02 | 2004-12-09 | Pfizer | Compuestos de carbonil-indol biciclicos como agentes antiinflamatorios/analgesicos. |
| US6306890B1 (en) * | 1999-08-30 | 2001-10-23 | Vanderbilt University | Esters derived from indolealkanols and novel amides derived from indolealkylamides that are selective COX-2 inhibitors |
| US6376708B1 (en) * | 2000-04-11 | 2002-04-23 | Monsanto Technology Llc | Process and catalyst for dehydrogenating primary alcohols to make carboxylic acid salts |
| PL370342A1 (en) * | 2001-09-27 | 2005-05-16 | F.Hoffmann-La Roche Ag | Indole derivatives as cox ii inhibitors |
| TW200400177A (en) * | 2002-06-04 | 2004-01-01 | Wyeth Corp | 1-(Aminoalkyl)-3-sulfonylindole and-indazole derivatives as 5-hydroxytryptamine-6 ligands |
-
2002
- 2002-09-20 PL PL02370342A patent/PL370342A1/xx not_active Application Discontinuation
- 2002-09-20 EP EP02779382A patent/EP1438289B1/en not_active Expired - Lifetime
- 2002-09-20 KR KR10-2004-7004428A patent/KR20040047862A/ko not_active Application Discontinuation
- 2002-09-20 WO PCT/EP2002/010557 patent/WO2003029212A1/en active IP Right Grant
- 2002-09-20 PT PT02779382T patent/PT1438289E/pt unknown
- 2002-09-20 AT AT02779382T patent/ATE292115T1/de not_active IP Right Cessation
- 2002-09-20 MX MXPA04002824A patent/MXPA04002824A/es unknown
- 2002-09-20 BR BR0212925-6A patent/BR0212925A/pt not_active IP Right Cessation
- 2002-09-20 SI SI200230116T patent/SI1438289T1/xx unknown
- 2002-09-20 RU RU2004113111/04A patent/RU2004113111A/ru not_active Application Discontinuation
- 2002-09-20 HU HU0401499A patent/HUP0401499A3/hu unknown
- 2002-09-20 JP JP2003532462A patent/JP4141954B2/ja not_active Expired - Fee Related
- 2002-09-20 IL IL16075202A patent/IL160752A0/xx unknown
- 2002-09-20 ES ES02779382T patent/ES2238616T3/es not_active Expired - Lifetime
- 2002-09-20 DE DE60203529T patent/DE60203529T2/de not_active Expired - Fee Related
- 2002-09-20 CN CNB028191900A patent/CN1261412C/zh not_active Expired - Fee Related
- 2002-09-20 DK DK02779382T patent/DK1438289T3/da active
- 2002-09-20 NZ NZ531577A patent/NZ531577A/en unknown
- 2002-09-20 CA CA002461670A patent/CA2461670A1/en not_active Abandoned
- 2002-09-25 AR ARP020103595A patent/AR036624A1/es not_active Application Discontinuation
- 2002-09-26 US US10/255,891 patent/US6872744B2/en not_active Expired - Fee Related
-
2004
- 2004-03-19 HR HR20040271A patent/HRPK20040271B3/xx not_active IP Right Cessation
- 2004-03-24 NO NO20041237A patent/NO20041237L/no unknown
- 2004-03-24 CO CO04027740A patent/CO5560557A2/es not_active Application Discontinuation
- 2004-03-25 ZA ZA200402360A patent/ZA200402360B/en unknown
-
2005
- 2005-02-25 US US11/065,841 patent/US7074939B2/en not_active Expired - Fee Related
-
2006
- 2006-03-02 US US11/391,655 patent/US7410994B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUP0401499A2 (hu) | Indolszármazékok, mint COX II inhibítorok | |
| WO2005013892A3 (en) | Hydrolytically-resistant boron-containing therapeutics and methods of use | |
| HUP0301431A2 (hu) | 3-Indolil-4-fenil-1H-pirrol-2,5-dion-származékok, mint glikogén szintáz kináz-3béta inhibitorok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
| MXPA05012466A (es) | Derivados de quinolina como inhibidores de fosfodiesterasa. | |
| MXPA05012061A (es) | Preparacion y uso de derivados alquilarilo para el tratamiento de la obesidad. | |
| TW200612936A (en) | Indole derivatives | |
| NO20054905L (no) | 2-acylamino-4-fenyltiazolderivater, fremgangsmate for deres fremstilling og anvendelse av de samme som i terapeutika | |
| ATE517882T1 (de) | Chinolinderivate | |
| TW200606162A (en) | Pyrazolopyridine derivatives | |
| CY1107747T1 (el) | Υποκατεστημενα τετρακυκλικα παραγωγα πυρρολοκινολονης χρησιμα ως αναστολεις της φωσφοδιεστερασης | |
| DK1678166T3 (da) | Proteinkinaseinhibitorer | |
| CY1109558T1 (el) | Παραγωγα βενζο[d]αζεπινης για την θεραπεια νευρολογικων διαταραχων | |
| DE60218194D1 (de) | Verwendung von indol- und indolin-derivaten bei der behandlung von adipositas oder zur reduzierung der nahrungsaufnahme | |
| NO20053748L (no) | Pyrrolopyridazinderivater. | |
| NO20063137L (no) | Tricykliske indolhydroksyetylaminderivater og deres anvendelse i behandlingen av Alzheimers sykdom | |
| NO20093464L (no) | Nye medikamentblandinger basert pa anti-cholinergisk effektive forbindelser og beta-mimetika | |
| EA200601350A1 (ru) | Азотсодержащие гетероциклические производные и их фармацевтические применения | |
| MXPA02011426A (es) | Derivados de b-carbolina utiles como inhibidores de fosfodiesterasa. | |
| EA200700099A1 (ru) | Производные пиридина | |
| MX2007007027A (es) | Derivados piperazinilpiridina como agentes anti-obesidad. | |
| UY29239A1 (es) | Nuevos derivados de piridotienopirimidina | |
| ATE452896T1 (de) | C3-cyanoepothilonderivate | |
| NO20072165L (no) | Metabolitter av visse (1,4)diazepino(6,7,1-IJ)kinolinderivater og fremgangsmater for fremstilling og anvendelse derav | |
| WO2003024976A3 (en) | Tricyclic indole derivatives as 5-ht ligands | |
| DE69814473D1 (de) | Neue allythiopyridazinderivate und verfahren zu ihrer herstellung |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |