PT1438289E - Derivados de indole como inibidores de cox ii - Google Patents
Derivados de indole como inibidores de cox iiInfo
- Publication number
- PT1438289E PT1438289E PT02779382T PT02779382T PT1438289E PT 1438289 E PT1438289 E PT 1438289E PT 02779382 T PT02779382 T PT 02779382T PT 02779382 T PT02779382 T PT 02779382T PT 1438289 E PT1438289 E PT 1438289E
- Authority
- PT
- Portugal
- Prior art keywords
- cox
- inhibitors
- indole derivatives
- indole
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/36—Oxygen atoms in position 3, e.g. adrenochrome
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pregnancy & Childbirth (AREA)
- Psychiatry (AREA)
- Gynecology & Obstetrics (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32538901P | 2001-09-27 | 2001-09-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1438289E true PT1438289E (pt) | 2005-06-30 |
Family
ID=23267681
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT02779382T PT1438289E (pt) | 2001-09-27 | 2002-09-20 | Derivados de indole como inibidores de cox ii |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US6872744B2 (pt) |
| EP (1) | EP1438289B1 (pt) |
| JP (1) | JP4141954B2 (pt) |
| KR (1) | KR20040047862A (pt) |
| CN (1) | CN1261412C (pt) |
| AR (1) | AR036624A1 (pt) |
| AT (1) | ATE292115T1 (pt) |
| BR (1) | BR0212925A (pt) |
| CA (1) | CA2461670A1 (pt) |
| CO (1) | CO5560557A2 (pt) |
| DE (1) | DE60203529T2 (pt) |
| DK (1) | DK1438289T3 (pt) |
| ES (1) | ES2238616T3 (pt) |
| HR (1) | HRPK20040271B3 (pt) |
| HU (1) | HUP0401499A3 (pt) |
| IL (1) | IL160752A0 (pt) |
| MX (1) | MXPA04002824A (pt) |
| NO (1) | NO20041237L (pt) |
| NZ (1) | NZ531577A (pt) |
| PL (1) | PL370342A1 (pt) |
| PT (1) | PT1438289E (pt) |
| RU (1) | RU2004113111A (pt) |
| SI (1) | SI1438289T1 (pt) |
| WO (1) | WO2003029212A1 (pt) |
| ZA (1) | ZA200402360B (pt) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA04002824A (es) * | 2001-09-27 | 2004-07-05 | Hoffmann La Roche | Derivados de indol como inhibidores de cox ii. |
| SE0202241D0 (sv) * | 2002-07-17 | 2002-07-17 | Astrazeneca Ab | Novel Compounds |
| WO2004014364A1 (en) * | 2002-08-07 | 2004-02-19 | Idenix (Cayman) Limited | Substituted phenylindoles for the treatment of hiv |
| CA2550091A1 (en) * | 2003-12-19 | 2005-07-07 | Elixir Pharmaceuticals, Inc. | Methods of treating a disorder |
| US7423176B2 (en) | 2004-04-13 | 2008-09-09 | Cephalon, Inc. | Bicyclic aromatic sulfinyl derivatives |
| EP1589016A1 (en) * | 2004-04-13 | 2005-10-26 | Cephalon France | Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives |
| US7119214B2 (en) | 2004-04-13 | 2006-10-10 | Cephalon France | Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives |
| ES2315877T3 (es) | 2004-06-18 | 2009-04-01 | Biolipox Ab | Indoles utiles en el tratamiento de inflamaciones. |
| WO2006041961A1 (en) * | 2004-10-05 | 2006-04-20 | GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTHAND HUMAN SERVICES | Arylthioindole tubulin polymerization inhibitors and methods of treating or preventing cancer using same |
| EA200701504A1 (ru) | 2005-01-19 | 2008-02-28 | Биолипокс Аб | Индолы, пригодные для лечения воспалений |
| US7622495B2 (en) * | 2006-10-03 | 2009-11-24 | Neurim Pharmaceuticals (1991) Ltd. | Substituted aryl-indole compounds and their kynurenine/kynuramine-like metabolites as therapeutic agents |
| BRPI0718776A2 (pt) | 2006-11-09 | 2013-12-03 | Hoffmann La Roche | Derivados de indol e benzofurano 2-carboxamida |
| ES2646834T3 (es) | 2010-08-20 | 2017-12-18 | Amira Pharmaceuticals, Inc. | Inhibidores de autotaxina y usos de los mismos |
| US9260416B2 (en) | 2011-05-27 | 2016-02-16 | Amira Pharmaceuticals, Inc. | Heterocyclic autotaxin inhibitors and uses thereof |
| WO2015042052A1 (en) | 2013-09-17 | 2015-03-26 | Pharmakea, Inc. | Heterocyclic vinyl autotaxin inhibitor compounds |
| US9714240B2 (en) | 2013-09-17 | 2017-07-25 | Pharmakea, Inc. | Vinyl autotaxin inhibitor compounds |
| US9850203B2 (en) | 2013-09-26 | 2017-12-26 | Pharmakea, Inc. | Autotaxin inhibitor compounds |
| CA2930737C (en) | 2013-11-22 | 2023-02-21 | Pharmakea, Inc. | Autotaxin inhibitor compounds |
| KR20240060887A (ko) | 2015-05-27 | 2024-05-08 | 사브레 테라퓨틱스 엘엘씨 | 오토탁신 억제제 및 이의 용도 |
| KR102241064B1 (ko) | 2019-07-30 | 2021-04-16 | 부산대학교 산학협력단 | 신규한 인돌 유도체 및 이를 포함하는 염증성 질환 예방 또는 치료용 조성물 |
| CN113004187B (zh) * | 2021-03-16 | 2022-09-20 | 沈阳药科大学 | 一种具有抑制有机阴离子转运体1活性的化合物及制备方法和应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4654360A (en) | 1984-06-01 | 1987-03-31 | Syntex (U.S.A.) Inc. | 1,2,3-trisubstituted indoles for treatment of inflammation |
| JPH0347123A (ja) | 1989-05-05 | 1991-02-28 | G D Searle & Co | インドール―２―カルボキシレート化合物類を含有するｃｎｓ疾患治療用組成物 |
| DE4338770A1 (de) | 1993-11-12 | 1995-05-18 | Matthias Dr Lehr | Indol-2-alkansäuren und ihre Derivate als Hemmstoffe der Phospholipase A¶2¶ |
| CA2264020A1 (en) | 1996-08-26 | 1998-03-05 | Jean Bemis | Inhibitors of phospholipase enzymes |
| WO1998051667A1 (fr) * | 1997-05-16 | 1998-11-19 | Chugai Seiyaku Kabushiki Kaisha | Derives d'indole et derives de mono- et diazaindole |
| EE200000522A (et) | 1998-02-25 | 2002-02-15 | Genetics Institute, Inc. | Fosfolipaas A2 ensüümi inhibiitor, seda sisaldav farmatseutiline kompositsioon ning meetod fosfolipaasensüümi toime pärssimiseks |
| MXPA00006605A (es) * | 1999-07-02 | 2004-12-09 | Pfizer | Compuestos de carbonil-indol biciclicos como agentes antiinflamatorios/analgesicos. |
| US6306890B1 (en) * | 1999-08-30 | 2001-10-23 | Vanderbilt University | Esters derived from indolealkanols and novel amides derived from indolealkylamides that are selective COX-2 inhibitors |
| US6376708B1 (en) * | 2000-04-11 | 2002-04-23 | Monsanto Technology Llc | Process and catalyst for dehydrogenating primary alcohols to make carboxylic acid salts |
| MXPA04002824A (es) * | 2001-09-27 | 2004-07-05 | Hoffmann La Roche | Derivados de indol como inhibidores de cox ii. |
| TW200400177A (en) * | 2002-06-04 | 2004-01-01 | Wyeth Corp | 1-(Aminoalkyl)-3-sulfonylindole and-indazole derivatives as 5-hydroxytryptamine-6 ligands |
-
2002
- 2002-09-20 MX MXPA04002824A patent/MXPA04002824A/es unknown
- 2002-09-20 CN CNB028191900A patent/CN1261412C/zh not_active Expired - Fee Related
- 2002-09-20 IL IL16075202A patent/IL160752A0/xx unknown
- 2002-09-20 DE DE60203529T patent/DE60203529T2/de not_active Expired - Fee Related
- 2002-09-20 CA CA002461670A patent/CA2461670A1/en not_active Abandoned
- 2002-09-20 PL PL02370342A patent/PL370342A1/xx not_active Application Discontinuation
- 2002-09-20 DK DK02779382T patent/DK1438289T3/da active
- 2002-09-20 HU HU0401499A patent/HUP0401499A3/hu unknown
- 2002-09-20 WO PCT/EP2002/010557 patent/WO2003029212A1/en active IP Right Grant
- 2002-09-20 EP EP02779382A patent/EP1438289B1/en not_active Expired - Lifetime
- 2002-09-20 RU RU2004113111/04A patent/RU2004113111A/ru not_active Application Discontinuation
- 2002-09-20 JP JP2003532462A patent/JP4141954B2/ja not_active Expired - Fee Related
- 2002-09-20 PT PT02779382T patent/PT1438289E/pt unknown
- 2002-09-20 SI SI200230116T patent/SI1438289T1/xx unknown
- 2002-09-20 AT AT02779382T patent/ATE292115T1/de not_active IP Right Cessation
- 2002-09-20 BR BR0212925-6A patent/BR0212925A/pt not_active IP Right Cessation
- 2002-09-20 KR KR10-2004-7004428A patent/KR20040047862A/ko not_active Application Discontinuation
- 2002-09-20 NZ NZ531577A patent/NZ531577A/en unknown
- 2002-09-20 ES ES02779382T patent/ES2238616T3/es not_active Expired - Lifetime
- 2002-09-25 AR ARP020103595A patent/AR036624A1/es not_active Application Discontinuation
- 2002-09-26 US US10/255,891 patent/US6872744B2/en not_active Expired - Fee Related
-
2004
- 2004-03-19 HR HR20040271A patent/HRPK20040271B3/xx not_active IP Right Cessation
- 2004-03-24 NO NO20041237A patent/NO20041237L/no unknown
- 2004-03-24 CO CO04027740A patent/CO5560557A2/es not_active Application Discontinuation
- 2004-03-25 ZA ZA200402360A patent/ZA200402360B/en unknown
-
2005
- 2005-02-25 US US11/065,841 patent/US7074939B2/en not_active Expired - Fee Related
-
2006
- 2006-03-02 US US11/391,655 patent/US7410994B2/en not_active Expired - Fee Related
Also Published As
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