ATE335729T1 - 3h-chinazoline -4-on derivaten - Google Patents

3h-chinazoline -4-on derivaten

Info

Publication number
ATE335729T1
ATE335729T1 AT03789170T AT03789170T ATE335729T1 AT E335729 T1 ATE335729 T1 AT E335729T1 AT 03789170 T AT03789170 T AT 03789170T AT 03789170 T AT03789170 T AT 03789170T AT E335729 T1 ATE335729 T1 AT E335729T1
Authority
AT
Austria
Prior art keywords
chinazoline
derivatives
Prior art date
Application number
AT03789170T
Other languages
English (en)
Inventor
Sarmiento Rosa Maria Rodriguez
Andrew William Thomas
Rene Wyler
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE335729T1 publication Critical patent/ATE335729T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/86Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88Oxygen atoms
    • C07D239/90Oxygen atoms with acyclic radicals attached in position 2 or 3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/86Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT03789170T 2002-12-13 2003-12-08 3h-chinazoline -4-on derivaten ATE335729T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02027700 2002-12-13

Publications (1)

Publication Number Publication Date
ATE335729T1 true ATE335729T1 (de) 2006-09-15

Family

ID=32524001

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03789170T ATE335729T1 (de) 2002-12-13 2003-12-08 3h-chinazoline -4-on derivaten

Country Status (23)

Country Link
US (1) US7087612B2 (de)
EP (1) EP1572666B1 (de)
JP (1) JP4384053B2 (de)
KR (1) KR100707532B1 (de)
CN (1) CN100418954C (de)
AR (1) AR042362A1 (de)
AT (1) ATE335729T1 (de)
AU (1) AU2003293798B8 (de)
BR (1) BR0317282A (de)
CA (1) CA2509633A1 (de)
CL (1) CL2003002565A1 (de)
DE (1) DE60307512T2 (de)
ES (1) ES2270154T3 (de)
GT (1) GT200300284A (de)
MX (1) MXPA05006124A (de)
MY (1) MY141743A (de)
PA (1) PA8591901A1 (de)
PE (1) PE20040911A1 (de)
PL (1) PL377474A1 (de)
RU (1) RU2340604C2 (de)
TW (1) TW200424180A (de)
UY (1) UY28120A1 (de)
WO (1) WO2004054985A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7846915B2 (en) 2004-10-20 2010-12-07 Resverlogix Corporation Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases
CN101128189A (zh) 2005-02-25 2008-02-20 弗·哈夫曼-拉罗切有限公司 药物物质分散性改善的片剂
US8410109B2 (en) 2005-07-29 2013-04-02 Resverlogix Corp. Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices
GB0525068D0 (en) * 2005-12-08 2006-01-18 Novartis Ag Organic compounds
JP4876690B2 (ja) * 2006-04-21 2012-02-15 三菱瓦斯化学株式会社 キナゾリン−4−オン誘導体の製造法
JPWO2008087736A1 (ja) * 2007-01-19 2010-05-06 宇部興産株式会社 アラルキルオキシ又はヘテロアラルキルオキシ基を有する芳香族アミンの製法
MX2009008099A (es) 2007-02-01 2009-12-14 Resverlogix Corp Compuestos para la prevencion y tratamiento de enfermedades cardiovasculares.
KR101629356B1 (ko) 2008-06-26 2016-06-13 리스버로직스 코퍼레이션 퀴나졸리논 유도체의 제조방법
CA2747417C (en) 2009-01-08 2017-01-03 Resverlogix Corp. Compounds for the prevention and treatment of cardiovascular disease
KR101913109B1 (ko) 2009-03-18 2018-10-31 리스버로직스 코퍼레이션 신규한 소염제
DK2421533T3 (en) 2009-04-22 2019-01-07 Resverlogix Corp Hitherto unknown anti-inflammatory agents
LT2773354T (lt) 2011-11-01 2019-08-12 Resverlogix Corp. Geriamosios greitai atsipalaiduojančios pakeistų chinozolinų vaisto formos
US9073878B2 (en) 2012-11-21 2015-07-07 Zenith Epigenetics Corp. Cyclic amines as bromodomain inhibitors
WO2014080291A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Biaryl derivatives as bromodomain inhibitors
WO2014096965A2 (en) 2012-12-21 2014-06-26 Rvx Therapeutics Inc. Novel heterocyclic compounds as bromodomain inhibitors
JP6903585B2 (ja) 2015-03-13 2021-07-14 レスバーロジックス コーポレイション 補体関連疾患の治療のための組成物および治療方法
CN106146410B (zh) * 2015-04-03 2018-10-12 中南大学 6-氨基-4(3h)-喹唑啉酮衍生物及其合成方法和用途
CN108191667B (zh) * 2018-01-04 2021-03-26 利尔化学股份有限公司 2-硝基-4-三氟甲基苯甲酸甲酯的制备方法
CN109553534A (zh) * 2018-11-27 2019-04-02 常州大学 一种2-硝基-4-甲氧基苯甲酸的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6136273A (ja) * 1984-07-26 1986-02-20 Mitsubishi Yuka Yakuhin Kk 2−フエニルアルキル−4(3h)−キナゾリノン誘導体
JP3194963B2 (ja) * 1995-03-14 2001-08-06 ノバルティス・アクチエンゲゼルシャフト 三置換フェニル誘導体
IL117659A (en) * 1995-04-13 2000-12-06 Dainippon Pharmaceutical Co Substituted 2-phenyl pyrimidino amino acetamide derivative process for preparing the same and a pharmaceutical composition containing same
US5679715A (en) 1995-06-07 1997-10-21 Harris; Richard Y. Method for treating multiple sclerosis
US5783577A (en) * 1995-09-15 1998-07-21 Trega Biosciences, Inc. Synthesis of quinazolinone libraries and derivatives thereof
WO1997033572A1 (en) 1996-03-15 1997-09-18 Somerset Pharmaceuticals, Inc. Method for preventing and treating peripheral neurophathy by administering selegiline
ATE368665T1 (de) * 1997-08-22 2007-08-15 Astrazeneca Ab Oxindolylchinazolinderivate als angiogenesehemmer
US6890930B1 (en) * 1999-09-28 2005-05-10 3-Dimensional Pharmaceuticals, Inc. Quinazolinones
WO2001034172A2 (en) 1999-11-05 2001-05-17 Vela Pharmaceuticals Inc. Methods and compositions for treating reward deficiency syndrome

Also Published As

Publication number Publication date
EP1572666A1 (de) 2005-09-14
BR0317282A (pt) 2005-11-08
TW200424180A (en) 2004-11-16
US7087612B2 (en) 2006-08-08
EP1572666B1 (de) 2006-08-09
RU2005121908A (ru) 2006-01-27
WO2004054985A1 (en) 2004-07-01
UY28120A1 (es) 2004-06-30
US20040142951A1 (en) 2004-07-22
DE60307512T2 (de) 2007-02-08
CA2509633A1 (en) 2004-07-01
CL2003002565A1 (es) 2005-01-07
PA8591901A1 (es) 2004-11-26
MY141743A (en) 2010-06-30
AU2003293798B8 (en) 2009-02-12
RU2340604C2 (ru) 2008-12-10
JP2006513177A (ja) 2006-04-20
CN100418954C (zh) 2008-09-17
KR100707532B1 (ko) 2007-04-12
PE20040911A1 (es) 2004-12-11
MXPA05006124A (es) 2005-08-16
JP4384053B2 (ja) 2009-12-16
ES2270154T3 (es) 2007-04-01
PL377474A1 (pl) 2006-02-06
KR20050085587A (ko) 2005-08-29
AU2003293798B2 (en) 2009-01-15
AR042362A1 (es) 2005-06-15
DE60307512D1 (de) 2006-09-21
AU2003293798A1 (en) 2004-07-09
CN1720237A (zh) 2006-01-11
GT200300284A (es) 2004-07-14

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