BR0317282A - Derivados de 3h-quinazolin-4-ona - Google Patents

Derivados de 3h-quinazolin-4-ona

Info

Publication number
BR0317282A
BR0317282A BR0317282-1A BR0317282A BR0317282A BR 0317282 A BR0317282 A BR 0317282A BR 0317282 A BR0317282 A BR 0317282A BR 0317282 A BR0317282 A BR 0317282A
Authority
BR
Brazil
Prior art keywords
quinazolin
derivatives
inhibitors
preparation
pharmaceutical compositions
Prior art date
Application number
BR0317282-1A
Other languages
English (en)
Inventor
Rosa Maria Rodriguez Sarmiento
Andrew William Thomas
Rene Wyler
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR0317282A publication Critical patent/BR0317282A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms

Abstract

"DERIVADOS DE 3H-QUINAZOLIN-4-ONA". Esta invenção refere-se a derivados de 3H-quinazolin-4-ona, como definidos no relatório descritivo e nas reivindicações, a um processo para sua preparação, a composições farmacêuticas que os contêm, e a seu uso como inibidores seletivos de monoamina oxidase B.
BR0317282-1A 2002-12-13 2003-12-08 Derivados de 3h-quinazolin-4-ona BR0317282A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02027700 2002-12-13
PCT/EP2003/013888 WO2004054985A1 (en) 2002-12-13 2003-12-08 3h-quinazolin-4-one derivatives

Publications (1)

Publication Number Publication Date
BR0317282A true BR0317282A (pt) 2005-11-08

Family

ID=32524001

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0317282-1A BR0317282A (pt) 2002-12-13 2003-12-08 Derivados de 3h-quinazolin-4-ona

Country Status (23)

Country Link
US (1) US7087612B2 (pt)
EP (1) EP1572666B1 (pt)
JP (1) JP4384053B2 (pt)
KR (1) KR100707532B1 (pt)
CN (1) CN100418954C (pt)
AR (1) AR042362A1 (pt)
AT (1) ATE335729T1 (pt)
AU (1) AU2003293798B8 (pt)
BR (1) BR0317282A (pt)
CA (1) CA2509633A1 (pt)
CL (1) CL2003002565A1 (pt)
DE (1) DE60307512T2 (pt)
ES (1) ES2270154T3 (pt)
GT (1) GT200300284A (pt)
MX (1) MXPA05006124A (pt)
MY (1) MY141743A (pt)
PA (1) PA8591901A1 (pt)
PE (1) PE20040911A1 (pt)
PL (1) PL377474A1 (pt)
RU (1) RU2340604C2 (pt)
TW (1) TW200424180A (pt)
UY (1) UY28120A1 (pt)
WO (1) WO2004054985A1 (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7846915B2 (en) 2004-10-20 2010-12-07 Resverlogix Corporation Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases
RU2007129642A (ru) 2005-02-25 2009-03-27 Ф.Хоффманн-Ля Рош Аг (Ch) Таблетки с улучшенным распределением лекарственного вещества
CA2617213C (en) 2005-07-29 2014-01-28 Resverlogix Corp. Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices
GB0525068D0 (en) * 2005-12-08 2006-01-18 Novartis Ag Organic compounds
JP4876690B2 (ja) * 2006-04-21 2012-02-15 三菱瓦斯化学株式会社 キナゾリン−４−オン誘導体の製造法
EP2123627B1 (en) * 2007-01-19 2013-11-20 Ube Industries, Ltd. Process for producing aromatic amine having aralkyloxy or heteroaralkyloxy group
NZ579355A (en) 2007-02-01 2012-03-30 Resverlogix Corp 2-(Aryl)-4-oxo-quinazoline derivatives
EP2346837B8 (en) 2008-06-26 2015-04-15 Resverlogix Corporation Methods of preparing quinazolinone derivatives
EP2660238B1 (en) 2009-01-08 2015-05-06 Resverlogix Corporation Compounds for the prevention and treatment of cardiovascular disease
KR101803259B1 (ko) 2009-03-18 2017-11-30 리스버로직스 코퍼레이션 신규한 소염제
BRPI1014956B8 (pt) 2009-04-22 2021-05-25 Resverlogix Corp agentes anti-inflamatórios
LT2773354T (lt) 2011-11-01 2019-08-12 Resverlogix Corp. Geriamosios greitai atsipalaiduojančios pakeistų chinozolinų vaisto formos
WO2014080290A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Cyclic amines as bromodomain inhibitors
WO2014080291A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Biaryl derivatives as bromodomain inhibitors
MX2015007921A (es) 2012-12-21 2016-03-03 Zenith Epigenetics Corp Compuestos heterociclicos novedosos como inhibidores de bromodominio.
EP3268007B1 (en) 2015-03-13 2022-11-09 Resverlogix Corp. Compositions and therapeutic methods for the treatment of complement-associated diseases
CN106146410B (zh) * 2015-04-03 2018-10-12 中南大学 6-氨基-4(3h)-喹唑啉酮衍生物及其合成方法和用途
CN108191667B (zh) * 2018-01-04 2021-03-26 利尔化学股份有限公司 2-硝基-4-三氟甲基苯甲酸甲酯的制备方法
CN109553534A (zh) * 2018-11-27 2019-04-02 常州大学 一种2-硝基-4-甲氧基苯甲酸的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6136273A (ja) * 1984-07-26 1986-02-20 Mitsubishi Yuka Yakuhin Kk ２−フエニルアルキル−４（３ｈ）−キナゾリノン誘導体
US5679715A (en) 1995-06-07 1997-10-21 Harris; Richard Y. Method for treating multiple sclerosis
US5783577A (en) * 1995-09-15 1998-07-21 Trega Biosciences, Inc. Synthesis of quinazolinone libraries and derivatives thereof
JP3258027B2 (ja) 1996-03-15 2002-02-18 サマーセット・ファーマシューティカルズ・インコーポレイテッド セレジリン投与による末梢ニューロパシーの予防および治療方法
DE69838172T2 (de) * 1997-08-22 2008-04-10 Astrazeneca Ab Oxindolylchinazolinderivate als angiogenesehemmer
US6890930B1 (en) * 1999-09-28 2005-05-10 3-Dimensional Pharmaceuticals, Inc. Quinazolinones
AU1359801A (en) 1999-11-05 2001-06-06 Vela Pharmaceuticals Inc. Methods and compositions for treating reward deficiency syndrome

Also Published As

Publication number Publication date
MY141743A (en) 2010-06-30
US20040142951A1 (en) 2004-07-22
KR100707532B1 (ko) 2007-04-12
PA8591901A1 (es) 2004-11-26
US7087612B2 (en) 2006-08-08
JP4384053B2 (ja) 2009-12-16
GT200300284A (es) 2004-07-14
DE60307512D1 (de) 2006-09-21
ES2270154T3 (es) 2007-04-01
UY28120A1 (es) 2004-06-30
AU2003293798B2 (en) 2009-01-15
RU2340604C2 (ru) 2008-12-10
KR20050085587A (ko) 2005-08-29
AU2003293798B8 (en) 2009-02-12
CN100418954C (zh) 2008-09-17
PE20040911A1 (es) 2004-12-11
WO2004054985A1 (en) 2004-07-01
EP1572666A1 (en) 2005-09-14
RU2005121908A (ru) 2006-01-27
CA2509633A1 (en) 2004-07-01
AU2003293798A1 (en) 2004-07-09
CN1720237A (zh) 2006-01-11
JP2006513177A (ja) 2006-04-20
CL2003002565A1 (es) 2005-01-07
AR042362A1 (es) 2005-06-15
ATE335729T1 (de) 2006-09-15
MXPA05006124A (es) 2005-08-16
EP1572666B1 (en) 2006-08-09
TW200424180A (en) 2004-11-16
PL377474A1 (pl) 2006-02-06
DE60307512T2 (de) 2007-02-08

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2160 DE 29/05/2012.