HRPK20040271B3 - Indole derivatives as cox ii inhibitors - Google Patents

Indole derivatives as cox ii inhibitors

Info

Publication number
HRPK20040271B3
HRPK20040271B3 HR20040271A HRP20040271A HRPK20040271B3 HR PK20040271 B3 HRPK20040271 B3 HR PK20040271B3 HR 20040271 A HR20040271 A HR 20040271A HR P20040271 A HRP20040271 A HR P20040271A HR PK20040271 B3 HRPK20040271 B3 HR PK20040271B3
Authority
HR
Croatia
Prior art keywords
alkyl
hydroxy
hydrogen
halo
alkoxy
Prior art date
Application number
HR20040271A
Other languages
English (en)
Croatian (hr)
Inventor
Allen Broka Chris
Allen Campbell Jeffrey
Original Assignee
F. Hoffmann - La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann - La Roche Ag filed Critical F. Hoffmann - La Roche Ag
Publication of HRP20040271A2 publication Critical patent/HRP20040271A2/hr
Publication of HRPK20040271B3 publication Critical patent/HRPK20040271B3/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/36—Oxygen atoms in position 3, e.g. adrenochrome
HR20040271A 2001-09-27 2004-03-19 Indole derivatives as cox ii inhibitors HRPK20040271B3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32538901P 2001-09-27 2001-09-27
PCT/EP2002/010557 WO2003029212A1 (en) 2001-09-27 2002-09-20 Indole derivatives as cox ii inhibitors

Publications (2)

Publication Number Publication Date
HRP20040271A2 HRP20040271A2 (en) 2004-08-31
HRPK20040271B3 true HRPK20040271B3 (en) 2006-02-28

Family

ID=23267681

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20040271A HRPK20040271B3 (en) 2001-09-27 2004-03-19 Indole derivatives as cox ii inhibitors

Country Status (25)

Country Link
US (3) US6872744B2 (xx)
EP (1) EP1438289B1 (xx)
JP (1) JP4141954B2 (xx)
KR (1) KR20040047862A (xx)
CN (1) CN1261412C (xx)
AR (1) AR036624A1 (xx)
AT (1) ATE292115T1 (xx)
BR (1) BR0212925A (xx)
CA (1) CA2461670A1 (xx)
CO (1) CO5560557A2 (xx)
DE (1) DE60203529T2 (xx)
DK (1) DK1438289T3 (xx)
ES (1) ES2238616T3 (xx)
HR (1) HRPK20040271B3 (xx)
HU (1) HUP0401499A3 (xx)
IL (1) IL160752A0 (xx)
MX (1) MXPA04002824A (xx)
NO (1) NO20041237L (xx)
NZ (1) NZ531577A (xx)
PL (1) PL370342A1 (xx)
PT (1) PT1438289E (xx)
RU (1) RU2004113111A (xx)
SI (1) SI1438289T1 (xx)
WO (1) WO2003029212A1 (xx)
ZA (1) ZA200402360B (xx)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL370342A1 (en) * 2001-09-27 2005-05-16 F.Hoffmann-La Roche Ag Indole derivatives as cox ii inhibitors
SE0202241D0 (sv) * 2002-07-17 2002-07-17 Astrazeneca Ab Novel Compounds
US7365090B2 (en) * 2002-08-07 2008-04-29 Idenix Pharmaceuticals, Inc. Substituted phenylindoles for the treatment of HIV
CA2550091A1 (en) * 2003-12-19 2005-07-07 Elixir Pharmaceuticals, Inc. Methods of treating a disorder
EP1589016A1 (en) * 2004-04-13 2005-10-26 Cephalon France Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives
US7119214B2 (en) 2004-04-13 2006-10-10 Cephalon France Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives
US7423176B2 (en) 2004-04-13 2008-09-09 Cephalon, Inc. Bicyclic aromatic sulfinyl derivatives
CA2570363A1 (en) 2004-06-18 2005-12-29 Biolipox Ab Indoles useful in the treatment of inflammation
WO2006041961A1 (en) * 2004-10-05 2006-04-20 GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTHAND HUMAN SERVICES Arylthioindole tubulin polymerization inhibitors and methods of treating or preventing cancer using same
US8097623B2 (en) 2005-01-19 2012-01-17 Biolipox Ab Indoles useful in the treatment of inflammation
US7622495B2 (en) * 2006-10-03 2009-11-24 Neurim Pharmaceuticals (1991) Ltd. Substituted aryl-indole compounds and their kynurenine/kynuramine-like metabolites as therapeutic agents
JP2010509259A (ja) 2006-11-09 2010-03-25 エフ．ホフマン−ラ ロシュ アーゲー インドール及びベンゾフラン２−カルボキサミド誘導体
CN103201262B (zh) * 2010-08-20 2016-06-01 艾米拉医药股份有限公司 自分泌运动因子抑制剂及其用途
US9260416B2 (en) 2011-05-27 2016-02-16 Amira Pharmaceuticals, Inc. Heterocyclic autotaxin inhibitors and uses thereof
JP2016530209A (ja) 2013-09-17 2016-09-29 ファーマケア，インク． ビニルオートタキシン阻害剤化合物
EP3046909A4 (en) 2013-09-17 2017-03-29 Pharmakea, Inc. Heterocyclic vinyl autotaxin inhibitor compounds
JP2016531874A (ja) 2013-09-26 2016-10-13 ファーマケア，インク． オートタキシン阻害剤化合物
PT3071561T (pt) 2013-11-22 2021-06-25 Sabre Therapeutics Llc Compostos inibidores de autotaxina
EP4026549A1 (en) 2015-05-27 2022-07-13 Sabre Therapeutics LLC Autotaxin inhibitors and uses thereof
KR102241064B1 (ko) 2019-07-30 2021-04-16 부산대학교 산학협력단 신규한 인돌 유도체 및 이를 포함하는 염증성 질환 예방 또는 치료용 조성물
CN113004187B (zh) * 2021-03-16 2022-09-20 沈阳药科大学 一种具有抑制有机阴离子转运体1活性的化合物及制备方法和应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4654360A (en) 1984-06-01 1987-03-31 Syntex (U.S.A.) Inc. 1,2,3-trisubstituted indoles for treatment of inflammation
JPH0347123A (ja) 1989-05-05 1991-02-28 G D Searle & Co インドール―２―カルボキシレート化合物類を含有するｃｎｓ疾患治療用組成物
DE4338770A1 (de) 1993-11-12 1995-05-18 Matthias Dr Lehr Indol-2-alkansäuren und ihre Derivate als Hemmstoffe der Phospholipase A¶2¶
JP2000516958A (ja) 1996-08-26 2000-12-19 ジェネティックス・インスチチュート・インコーポレーテッド ホスホリパーゼ酵素の阻害剤
WO1998051667A1 (fr) * 1997-05-16 1998-11-19 Chugai Seiyaku Kabushiki Kaisha Derives d'indole et derives de mono- et diazaindole
CA2322163A1 (en) 1998-02-25 1999-09-02 John Mckew Inhibitors of phospholipase a2
MXPA00006605A (es) * 1999-07-02 2004-12-09 Pfizer Compuestos de carbonil-indol biciclicos como agentes antiinflamatorios/analgesicos.
US6306890B1 (en) * 1999-08-30 2001-10-23 Vanderbilt University Esters derived from indolealkanols and novel amides derived from indolealkylamides that are selective COX-2 inhibitors
US6376708B1 (en) * 2000-04-11 2002-04-23 Monsanto Technology Llc Process and catalyst for dehydrogenating primary alcohols to make carboxylic acid salts
PL370342A1 (en) * 2001-09-27 2005-05-16 F.Hoffmann-La Roche Ag Indole derivatives as cox ii inhibitors
TW200400177A (en) * 2002-06-04 2004-01-01 Wyeth Corp 1-(Aminoalkyl)-3-sulfonylindole and-indazole derivatives as 5-hydroxytryptamine-6 ligands

Also Published As

Publication number Publication date
CN1261412C (zh) 2006-06-28
DK1438289T3 (da) 2005-08-08
RU2004113111A (ru) 2005-06-27
US7074939B2 (en) 2006-07-11
CN1561334A (zh) 2005-01-05
DE60203529T2 (de) 2006-03-16
IL160752A0 (en) 2004-08-31
SI1438289T1 (xx) 2005-08-31
US6872744B2 (en) 2005-03-29
CA2461670A1 (en) 2003-04-10
KR20040047862A (ko) 2004-06-05
ES2238616T3 (es) 2005-09-01
PL370342A1 (en) 2005-05-16
EP1438289B1 (en) 2005-03-30
NO20041237L (no) 2004-03-24
MXPA04002824A (es) 2004-07-05
PT1438289E (pt) 2005-06-30
US7410994B2 (en) 2008-08-12
NZ531577A (en) 2005-09-30
EP1438289A1 (en) 2004-07-21
HRP20040271A2 (en) 2004-08-31
US20030130337A1 (en) 2003-07-10
WO2003029212A1 (en) 2003-04-10
DE60203529D1 (de) 2005-05-04
HUP0401499A3 (en) 2007-05-02
ATE292115T1 (de) 2005-04-15
CO5560557A2 (es) 2005-09-30
AR036624A1 (es) 2004-09-22
US20050176803A1 (en) 2005-08-11
US20060178420A1 (en) 2006-08-10
JP4141954B2 (ja) 2008-08-27
BR0212925A (pt) 2004-10-13
HUP0401499A2 (hu) 2004-12-28
JP2005510474A (ja) 2005-04-21
ZA200402360B (en) 2005-04-26

Similar Documents

Publication Publication Date Title
HRPK20040271B3 (en) Indole derivatives as cox ii inhibitors
DK1104760T3 (da) Sulfamoylheteroarylpyrazolforbindelser som anti-inflammatoriske/analgetiske midler
ATE261960T1 (de) Sulfonamide mit elastase inhibierender wirkung
EA200300531A1 (ru) Производные фталазинона
ME00411B (me) Nova jedinjenja koja imaju inhibitorno dejstvo na transporter glukoze zavistan od natrijuma
FI953968A (fi) Antraniiliset happojohdannaiset
UY26512A1 (es) Inhibidores no peptídicos de la unión celúlar dependiente de vla - 4 útiles en el tratamiento de enfermedades inflamatorias, autoinmunes y respiratorias
MX9804457A (es) Inhibidores de las metaloproteinasas, composiciones farmaceuticas que los contienen y sus usos farmaceuticos y metodos y compuestos intermedios utiles para su preparacion.
DK0791006T3 (da) Polyanioniske benzylglylcosider som inhibitorer af proliferation af glatte muskelceller
TR200302047T4 (tr) Anti-iltihabik / analjezik maddeler olarak heteroaril fenil pirazol bileşikleri.
EP0765865A4 (en) 2-ACYLAMINOPROPANOL COMPOUND AND MEDICINAL COMPOSITION
HRP20000508B1 (en) Substituted 2-benzylamino-2-phenyl-acetamide compounds
WO2003048134A1 (fr) Compose de triazole et son utilisation therapeutique
YU51498A (en) 2,4-diaminopyrimidine derivatives
PT1216245E (pt) Derivados sulfonil-hidrazida farmaceuticamente activos
DK0791005T3 (da) Inhibitorer af proliferation af glatte muskelceller
WO2002096886A8 (en) Pyrimidine derivatives
PT1140925E (pt) 3,4-di-hidro-2h-benzo¬1,4|oxazinil-metil-¬3-(1h-indol-3il)-alquil|-aminas
RS50449B (sr) Supstituisani bisindolilmaleimidi za inhibiciju proliferacije ćelija
AU4507989A (en) Aryloxy-, arylthio-, heteroaryloxy-, heteroarylthio- alkenylene derivatives of amines
PE62299A1 (es) Derivados terapeuticos de naftaleno
DE69806411T2 (de) Neue antiarrythmische verbindungen
DE69714303T2 (de) N,n-disubstituierte carbonsaureamid-derivate
DE69528984T2 (de) Hemmung der leukotrienbiosynthese mittels harnstoffderivaten
GB2316944A (en) New catechol derivatives

Legal Events

Date Code Title Description
A1OB Publication of a patent application
AKOB Publication of a request for the grant of a patent not including a substantive examination of a patent application (a consensual patent)
ODRP Renewal fee for the maintenance of a patent

Payment date: 20050713

Year of fee payment: 4

PKB1 Consensual patent granted
PBKO Lapse due to non-payment of renewal fee for consensual patent

Effective date: 20060921