WO2003048134A1 - Compose de triazole et son utilisation therapeutique - Google Patents

Compose de triazole et son utilisation therapeutique Download PDF

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Publication number
WO2003048134A1
WO2003048134A1 PCT/JP2002/012735 JP0212735W WO03048134A1 WO 2003048134 A1 WO2003048134 A1 WO 2003048134A1 JP 0212735 W JP0212735 W JP 0212735W WO 03048134 A1 WO03048134 A1 WO 03048134A1
Authority
WO
WIPO (PCT)
Prior art keywords
haloalkyl
alkyl
triazole compound
halogeno
nitro
Prior art date
Application number
PCT/JP2002/012735
Other languages
English (en)
Japanese (ja)
Inventor
Yuki Kitao
Hiroshi Kawakami
Akira Matsuo
Original Assignee
Japan Tobacco Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Tobacco Inc. filed Critical Japan Tobacco Inc.
Priority to AU2002354410A priority Critical patent/AU2002354410A1/en
Priority to JP2003549326A priority patent/JPWO2003048134A1/ja
Publication of WO2003048134A1 publication Critical patent/WO2003048134A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

L'invention concerne un inhibiteur du cotransporteur sodium-phosphate, contenant un composé de triazole représenté par la formule générale (I), où : R1, R2 et R3 sont identiques ou différents et représentent chacun hydrogène, haloalkyle C1-6, halogéno, nitro, amino, cyano, alkyle C1-7, alcoxy C1-6, etc. ; R4 représente haloalkyle C1-6, alkyle C1-7, etc. ; R5, R6, R7 et R8 sont identiques ou différents et représentent chacun hydrogène, halogéno, haloalkyle C1-6, alkyle C1-7, alcoxy C1-6, ou nitro ; et l'anneau A représente aryle ou un groupe hétérocyclique aromatique. L'invention a également trait à un promédicament et à un sel pharmaceutiquement acceptable dudit inhibiteur. Ledit inhibiteur, qui présente une activité inhibitrice du cotransporteur sodium-phosphate, sert d'agent thérapeutique dans le traitement de l'hyperphosphatémie.
PCT/JP2002/012735 2001-12-05 2002-12-04 Compose de triazole et son utilisation therapeutique WO2003048134A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2002354410A AU2002354410A1 (en) 2001-12-05 2002-12-04 Triazole compound and medicinal use thereof
JP2003549326A JPWO2003048134A1 (ja) 2001-12-05 2002-12-04 トリアゾール化合物及びその医薬用途

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001/371687 2001-12-05
JP2001371687 2001-12-05

Publications (1)

Publication Number Publication Date
WO2003048134A1 true WO2003048134A1 (fr) 2003-06-12

Family

ID=19180699

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/012735 WO2003048134A1 (fr) 2001-12-05 2002-12-04 Compose de triazole et son utilisation therapeutique

Country Status (3)

Country Link
JP (1) JPWO2003048134A1 (fr)
AU (1) AU2002354410A1 (fr)
WO (1) WO2003048134A1 (fr)

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2862060A1 (fr) * 2003-11-06 2005-05-13 Galderma Res & Dev Procede de synthese en phase solide de composes de types sulfures de diaryle.
WO2007015809A2 (fr) * 2005-07-22 2007-02-08 Merck & Co., Inc. Inhibiteurs de la transcriptase inverse du vih
WO2011136269A1 (fr) 2010-04-28 2011-11-03 アステラス製薬株式会社 Composé de tétrahydrobenzothiophène
WO2013062065A1 (fr) 2011-10-27 2013-05-02 アステラス製薬株式会社 Dérivé de n-thiényl benzamide substitué avec un aminoalkyle
WO2014029983A1 (fr) 2012-08-21 2014-02-27 Ardelyx, Inc. Composés et procédés d'inhibition d'un antiport à médiation par nhe dans le traitement de troubles associés à une rétention de fluide ou à une surcharge de sel et de troubles du tractus gastro-intestinal
US8722695B2 (en) 2009-12-11 2014-05-13 Autifony Therapeutics Limited Imidazolidinedione derivatives
US9133175B2 (en) 2010-12-06 2015-09-15 Autifony Therapeutics Limited Compounds
US9193704B2 (en) 2011-06-07 2015-11-24 Autifony Therapeutics Limited Hydantoin derivatives as KV3 inhibitors
US9198923B2 (en) 2009-01-26 2015-12-01 Opko Ireland Global Holdings, Ltd. Phosphate management with small molecules
US9422252B2 (en) 2012-05-22 2016-08-23 Autifony Therapeutics Limited Triazoles as Kv3 inhibitors
US9669030B2 (en) 2012-05-22 2017-06-06 Autifony Therapeutics Limited Hydantoin derivatives as Kv3 inhibitors
WO2018129557A1 (fr) 2017-01-09 2018-07-12 Ardelyx, Inc. Inhibiteurs d'antiport à médiation par nhe
WO2018129552A1 (fr) 2017-01-09 2018-07-12 Ardelyx, Inc. Composés utiles pour le traitement de troubles du tractus digestif
WO2018129556A1 (fr) 2017-01-09 2018-07-12 Ardelyx, Inc. Composés et procédés pour l'inhibition d'un antiport à médiation par échangeur sodium/proton (nhe) dans le traitement de troubles associés à une rétention d'eau ou à une surcharge en sel et de troubles du tractus gastro-intestinal
EP3351248A1 (fr) 2008-12-31 2018-07-25 Ardelyx, Inc. Composés et procédés d'inhibition d'un antiport à médiation par nhe dans le traitement de troubles associés à une rétention de fluide ou à une surcharge de sel et de troubles du tractus gastro-intestinal
RU2662817C2 (ru) * 2013-04-24 2018-07-31 Дайити Санкио Компани, Лимитед Соединение дикарбоновой кислоты
US10272079B2 (en) 2013-04-12 2019-04-30 Ardelyx, Inc. NHE3-binding compounds and methods for inhibiting phosphate transport
US10376481B2 (en) 2012-08-21 2019-08-13 Ardelyx, Inc. Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
WO2023219127A1 (fr) * 2022-05-11 2023-11-16 中外製薬株式会社 Composition pharmaceutique pour le traitement ou la prévention d'une maladie kystique

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3769411A (en) * 1968-09-04 1973-10-30 Rohm & Haas Fungicidal 1,2,4-4h-triazole derivatives
US4372953A (en) * 1980-02-29 1983-02-08 Otsuka Pharmaceutical Company, Limited Tetrazole derivatives, and anti-ulcer composition containing the same
US4820625A (en) * 1986-09-19 1989-04-11 Fuji Photo Film Co., Ltd. Direct positive silver halide photographic material
WO1999002503A1 (fr) * 1997-07-07 1999-01-21 Basf Aktiengesellschaft Composes de triazole et leur utilisation comme ligands de la dopamine d¿3?

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3769411A (en) * 1968-09-04 1973-10-30 Rohm & Haas Fungicidal 1,2,4-4h-triazole derivatives
US4372953A (en) * 1980-02-29 1983-02-08 Otsuka Pharmaceutical Company, Limited Tetrazole derivatives, and anti-ulcer composition containing the same
US4820625A (en) * 1986-09-19 1989-04-11 Fuji Photo Film Co., Ltd. Direct positive silver halide photographic material
WO1999002503A1 (fr) * 1997-07-07 1999-01-21 Basf Aktiengesellschaft Composes de triazole et leur utilisation comme ligands de la dopamine d¿3?

Cited By (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2862060A1 (fr) * 2003-11-06 2005-05-13 Galderma Res & Dev Procede de synthese en phase solide de composes de types sulfures de diaryle.
WO2005047237A1 (fr) * 2003-11-06 2005-05-26 Galderma Research & Development, S.N.C. Procede de synthese en phase solide de composes de types sulfures de diaryle
WO2007015809A2 (fr) * 2005-07-22 2007-02-08 Merck & Co., Inc. Inhibiteurs de la transcriptase inverse du vih
WO2007015809A3 (fr) * 2005-07-22 2007-03-29 Merck & Co Inc Inhibiteurs de la transcriptase inverse du vih
US7807684B2 (en) 2005-07-22 2010-10-05 Merck Sharp & Dohme Corp. HIV reverse transcriptase inhibitors
EP3939964A1 (fr) 2008-12-31 2022-01-19 Ardelyx, Inc. Combinaisons d'inhibition d'un antiport a mediation par nhe dans le traitement de troubles associes a une retention de fluide ou a une surcharge de sel et de troubles du tractus gastro-intestinal
EP3351248A1 (fr) 2008-12-31 2018-07-25 Ardelyx, Inc. Composés et procédés d'inhibition d'un antiport à médiation par nhe dans le traitement de troubles associés à une rétention de fluide ou à une surcharge de sel et de troubles du tractus gastro-intestinal
US9198923B2 (en) 2009-01-26 2015-12-01 Opko Ireland Global Holdings, Ltd. Phosphate management with small molecules
US10632118B2 (en) 2009-12-11 2020-04-28 Autifony Therapeutics Limited Imidazolidinedione derivatives
US9849131B2 (en) 2009-12-11 2017-12-26 Autifony Therapeutics Limited Imidazolidinedione derivatives
US8722695B2 (en) 2009-12-11 2014-05-13 Autifony Therapeutics Limited Imidazolidinedione derivatives
US10058551B2 (en) 2009-12-11 2018-08-28 Autifony Therapeutics Limited Imidazolidinedione derivatives
US9216967B2 (en) 2009-12-11 2015-12-22 Autifony Therapeutics Limited Imidazolidinedione derivatives
US8729068B2 (en) 2010-04-28 2014-05-20 Astellas Pharma Inc. Tetrahydrobenzothiophene compound
KR20130073908A (ko) 2010-04-28 2013-07-03 아스텔라스세이야쿠 가부시키가이샤 테트라하이드로벤조티오펜 화합물
JP5617919B2 (ja) * 2010-04-28 2014-11-05 アステラス製薬株式会社 テトラヒドロベンゾチオフェン化合物
CN102869656A (zh) * 2010-04-28 2013-01-09 安斯泰来制药株式会社 四氢苯并噻吩化合物
EA022521B1 (ru) * 2010-04-28 2016-01-29 Астеллас Фарма Инк. Соединения тетрагидробензотиофена, фармацевтическая композиция на их основе, их применение и способ лечения гиперфосфатемии
US9284295B2 (en) 2010-04-28 2016-03-15 Astellas Pharma Inc. Tetrahydrobenzothiophene compound
WO2011136269A1 (fr) 2010-04-28 2011-11-03 アステラス製薬株式会社 Composé de tétrahydrobenzothiophène
US9133175B2 (en) 2010-12-06 2015-09-15 Autifony Therapeutics Limited Compounds
US9346790B2 (en) 2010-12-06 2016-05-24 Autifony Therapeutics Limited Hydantoin derivatives useful as Kv3 inhibitors
US10835534B2 (en) 2010-12-06 2020-11-17 Autifony Therapeutics Limited Compounds
US9422272B2 (en) 2010-12-06 2016-08-23 Autifony Therapeutics Limited Compounds
US11197859B2 (en) 2010-12-06 2021-12-14 Autifony Therapeutics Limited Hydantoin derivatives useful as Kv3 inhibitors
US9833452B2 (en) 2010-12-06 2017-12-05 Autifony Therapeutics Limited Compounds
US11541052B2 (en) 2010-12-06 2023-01-03 Autifony Therapeutics Limited Compounds
US10555945B2 (en) 2010-12-06 2020-02-11 Autifony Therapeutics Limited Compounds
US10265316B2 (en) 2010-12-06 2019-04-23 Autifony Therapeuctics Limited Hydantoin derivatives useful as Kv3 inhibitors
US10098881B2 (en) 2010-12-06 2018-10-16 Autifony Therapeutics Limited Compounds
US11583527B2 (en) 2010-12-06 2023-02-21 Autifony Therapeutics Limited Hydantoin derivatives useful as Kv3 inhibitors
US9193704B2 (en) 2011-06-07 2015-11-24 Autifony Therapeutics Limited Hydantoin derivatives as KV3 inhibitors
KR20140096322A (ko) 2011-10-27 2014-08-05 아스텔라스세이야쿠 가부시키가이샤 아미노 알킬 치환 n-티에닐벤즈아미드 유도체
US9062032B2 (en) 2011-10-27 2015-06-23 Astellas Pharma Inc. Aminoalkyl-substituted N-thienylbenzamide derivative
WO2013062065A1 (fr) 2011-10-27 2013-05-02 アステラス製薬株式会社 Dérivé de n-thiényl benzamide substitué avec un aminoalkyle
JPWO2013062065A1 (ja) * 2011-10-27 2015-04-02 アステラス製薬株式会社 アミノアルキル置換ｎ−チエニルベンズアミド誘導体
US11180461B2 (en) 2012-05-22 2021-11-23 Autifony Therapeutics Limited Triazoles as Kv3 inhibitors
US10160730B2 (en) 2012-05-22 2018-12-25 Autifony Therapeutics Limited Triazoles as KV3 inhibitors
US10611735B2 (en) 2012-05-22 2020-04-07 Autifony Therapeutics Limited Triazoles as Kv3 inhibitors
US9669030B2 (en) 2012-05-22 2017-06-06 Autifony Therapeutics Limited Hydantoin derivatives as Kv3 inhibitors
US9422252B2 (en) 2012-05-22 2016-08-23 Autifony Therapeutics Limited Triazoles as Kv3 inhibitors
US10376481B2 (en) 2012-08-21 2019-08-13 Ardelyx, Inc. Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
WO2014029983A1 (fr) 2012-08-21 2014-02-27 Ardelyx, Inc. Composés et procédés d'inhibition d'un antiport à médiation par nhe dans le traitement de troubles associés à une rétention de fluide ou à une surcharge de sel et de troubles du tractus gastro-intestinal
US10940146B2 (en) 2013-04-12 2021-03-09 Ardelyx, Inc. NHE3-binding compounds and methods for inhibiting phosphate transport
US10272079B2 (en) 2013-04-12 2019-04-30 Ardelyx, Inc. NHE3-binding compounds and methods for inhibiting phosphate transport
RU2662817C2 (ru) * 2013-04-24 2018-07-31 Дайити Санкио Компани, Лимитед Соединение дикарбоновой кислоты
US11147884B2 (en) 2017-01-09 2021-10-19 Ardelyx, Inc. Inhibitors of NHE-mediated antiport
WO2018129552A1 (fr) 2017-01-09 2018-07-12 Ardelyx, Inc. Composés utiles pour le traitement de troubles du tractus digestif
US11242337B2 (en) 2017-01-09 2022-02-08 Ardelyx, Inc. Compounds useful for treating gastrointestinal tract disorders
WO2018129557A1 (fr) 2017-01-09 2018-07-12 Ardelyx, Inc. Inhibiteurs d'antiport à médiation par nhe
WO2018129556A1 (fr) 2017-01-09 2018-07-12 Ardelyx, Inc. Composés et procédés pour l'inhibition d'un antiport à médiation par échangeur sodium/proton (nhe) dans le traitement de troubles associés à une rétention d'eau ou à une surcharge en sel et de troubles du tractus gastro-intestinal
WO2023219127A1 (fr) * 2022-05-11 2023-11-16 中外製薬株式会社 Composition pharmaceutique pour le traitement ou la prévention d'une maladie kystique

Also Published As

Publication number Publication date
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JPWO2003048134A1 (ja) 2005-04-14

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