MXPA02011426A - Derivados de b-carbolina utiles como inhibidores de fosfodiesterasa. - Google Patents
Derivados de b-carbolina utiles como inhibidores de fosfodiesterasa.Info
- Publication number
- MXPA02011426A MXPA02011426A MXPA02011426A MXPA02011426A MXPA02011426A MX PA02011426 A MXPA02011426 A MX PA02011426A MX PA02011426 A MXPA02011426 A MX PA02011426A MX PA02011426 A MXPA02011426 A MX PA02011426A MX PA02011426 A MXPA02011426 A MX PA02011426A
- Authority
- MX
- Mexico
- Prior art keywords
- bgr
- phosphodiesterase
- inhibitors
- derivatives useful
- carboline derivatives
- Prior art date
Links
- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 title 1
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 208000010228 Erectile Dysfunction Diseases 0.000 abstract 1
- 229940082638 cardiac stimulant phosphodiesterase inhibitors Drugs 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 201000001881 impotence Diseases 0.000 abstract 1
- 239000002571 phosphodiesterase inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Abstract
La presente invencion se refiere a derivados de ??-carbolina novedosos, de la formula general (l), (ver formula) en donde todas las variables son como se describe dentro de la especificacion, utiles como inhibidores de fosfodiesterasa; la presente invencion se refiere ademas al uso de los derivados descritos para el tratamiento de enfermedades y condiciones relacionadas con PDE, por ejemplo, disfuncion erectil masculina.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20466700P | 2000-05-17 | 2000-05-17 | |
PCT/US2001/014357 WO2001087038A2 (en) | 2000-05-17 | 2001-05-03 | β-CARBOLINE DERIVATIVES USEFUL AS INHIBITORS OF PHOSPHODIESTERASE |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA02011426A true MXPA02011426A (es) | 2004-09-06 |
Family
ID=22758909
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA02011426A MXPA02011426A (es) | 2000-05-17 | 2001-05-03 | Derivados de b-carbolina utiles como inhibidores de fosfodiesterasa. |
Country Status (32)
Country | Link |
---|---|
US (2) | US6492358B2 (es) |
EP (1) | EP1289985B1 (es) |
JP (1) | JP5014551B2 (es) |
KR (1) | KR20030031482A (es) |
CN (1) | CN1255403C (es) |
AR (1) | AR028576A1 (es) |
AT (1) | ATE256127T1 (es) |
AU (2) | AU2001261167B2 (es) |
BG (1) | BG66141B1 (es) |
CA (1) | CA2409715C (es) |
CZ (1) | CZ20023934A3 (es) |
DE (1) | DE60101479T2 (es) |
DK (1) | DK1289985T3 (es) |
ES (1) | ES2211806T3 (es) |
GE (1) | GEP20053511B (es) |
HK (1) | HK1051368A1 (es) |
HR (1) | HRP20020910B1 (es) |
HU (1) | HUP0302412A3 (es) |
IL (2) | IL152873A0 (es) |
MX (1) | MXPA02011426A (es) |
MY (1) | MY128479A (es) |
NO (1) | NO324251B1 (es) |
NZ (1) | NZ522731A (es) |
PL (1) | PL205507B1 (es) |
PT (1) | PT1289985E (es) |
RU (1) | RU2271358C2 (es) |
SK (1) | SK16972002A3 (es) |
TR (1) | TR200302309T4 (es) |
TW (1) | TWI286553B (es) |
UA (1) | UA74826C2 (es) |
WO (1) | WO2001087038A2 (es) |
ZA (1) | ZA200210111B (es) |
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US6900220B2 (en) * | 2001-01-02 | 2005-05-31 | Syntex (U.S.A.) Llc | Quinazolone derivatives as alpha 1A/B adrenergic receptor antagonists |
WO2002064591A2 (en) * | 2001-02-12 | 2002-08-22 | Lilly Icos Llc | Carboline derivatives |
ATE302775T1 (de) * | 2001-02-12 | 2005-09-15 | Lilly Icos Llc | Carbolinderivate |
CA2441792C (en) * | 2001-04-25 | 2010-08-03 | Lilly Icos Llc | Carboline derivatives as inhibitors of phosphodiesterase 5 (pdes) for the treatment of cardiovascular diseases and erectile dysfunction |
JP2004536816A (ja) | 2001-06-05 | 2004-12-09 | リリー アイコス リミテッド ライアビリティ カンパニー | Pde5阻害剤としてのカルボリン誘導体 |
ES2269679T3 (es) * | 2001-06-21 | 2007-04-01 | Lilly Icos Llc | Derivados de carbolina como inhibidores de pdev. |
PT1448562E (pt) | 2001-11-14 | 2007-08-31 | Ortho Mcneil Pharm Inc | Derivados da pirroloquinolona tetracíclica substituídos, úteis como inibidores da fosfodiesterase |
CN101732298B (zh) * | 2002-02-07 | 2012-09-19 | 田纳西大学研究基金会 | 用sarms治疗良性前列腺增生 |
EP1534707B9 (en) * | 2002-06-19 | 2008-11-26 | Janssen Pharmaceutica N.V. | Substituted 2,4-dihydro-pyrrolo (3, 4-b) -quinolin-9-one derivatives useful as phosphodiesterase inhibitors |
JP4671123B2 (ja) * | 2003-06-23 | 2011-04-13 | 小野薬品工業株式会社 | 新規三環性複素環化合物 |
CN1910183A (zh) | 2004-01-23 | 2007-02-07 | 希龙公司 | 四氢咔啉化合物作为抗癌药 |
US8076352B2 (en) | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Administration of carboline derivatives useful in the treatment of cancer and other diseases |
US7767689B2 (en) | 2004-03-15 | 2010-08-03 | Ptc Therapeutics, Inc. | Carboline derivatives useful in the treatment of cancer |
US8076353B2 (en) | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Inhibition of VEGF translation |
EA016575B1 (ru) * | 2004-03-15 | 2012-06-29 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | Производные карболина, полезные в ингибировании ангиогенеза |
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ES2459742T3 (es) * | 2004-12-22 | 2014-05-12 | Ono Pharmaceutical Co., Ltd. | Compuesto tricíclico y uso del mismo |
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KR20080047375A (ko) * | 2005-07-29 | 2008-05-28 | 콘서트 파마슈티컬즈, 인크. | 약제 화합물 |
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US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
WO2007134136A2 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
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BRPI0716604A2 (pt) * | 2006-09-08 | 2013-04-09 | Braincells Inc | combinaÇÕes contendo um derivado de 4-acilaminopiridina |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
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JP5501251B2 (ja) | 2008-01-11 | 2014-05-21 | アルバニー モレキュラー リサーチ, インコーポレイテッド | Mch拮抗薬としての(1−アジノン)置換ピリドインドール類 |
CN104387382A (zh) | 2008-03-24 | 2015-03-04 | 梅迪维新技术公司 | 吡啶并[3,4-b]吲哚和应用方法 |
MD4009C2 (ro) * | 2008-07-15 | 2010-08-31 | Институт Химии Академии Наук Молдовы | Utilizarea 1-metil-4-(N-metilaminobutil-4)-β-carbolinei în calitate de remediu antituberculos |
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WO2010107485A1 (en) * | 2009-03-17 | 2010-09-23 | The Trustees Of Columbia University In The City Of New York | E3 ligase inhibitors |
US8629158B2 (en) | 2009-07-01 | 2014-01-14 | Albany Molecular Research, Inc. | Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof |
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WO1998040385A1 (en) | 1997-03-07 | 1998-09-17 | Novo Nordisk A/S | 4,5,6,7-TETRAHYDRO-THIENO[3,2-c]PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE |
US6043252A (en) | 1997-05-05 | 2000-03-28 | Icos Corporation | Carboline derivatives |
AU4919099A (en) | 1998-07-11 | 2000-02-01 | University Of Bristol, The | Compounds having activity at imidazoline receptors |
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-
2001
- 2001-03-05 UA UA2002119179A patent/UA74826C2/uk unknown
- 2001-05-02 US US09/847,767 patent/US6492358B2/en not_active Expired - Lifetime
- 2001-05-03 IL IL15287301A patent/IL152873A0/xx unknown
- 2001-05-03 AT AT01935038T patent/ATE256127T1/de active
- 2001-05-03 JP JP2001583517A patent/JP5014551B2/ja not_active Expired - Fee Related
- 2001-05-03 PL PL365445A patent/PL205507B1/pl unknown
- 2001-05-03 TR TR2003/02309T patent/TR200302309T4/xx unknown
- 2001-05-03 AU AU2001261167A patent/AU2001261167B2/en not_active Ceased
- 2001-05-03 AU AU6116701A patent/AU6116701A/xx active Pending
- 2001-05-03 EP EP01935038A patent/EP1289985B1/en not_active Expired - Lifetime
- 2001-05-03 GE GE5003A patent/GEP20053511B/en unknown
- 2001-05-03 CN CNB018128432A patent/CN1255403C/zh not_active Expired - Fee Related
- 2001-05-03 DE DE60101479T patent/DE60101479T2/de not_active Expired - Lifetime
- 2001-05-03 WO PCT/US2001/014357 patent/WO2001087038A2/en active IP Right Grant
- 2001-05-03 ES ES01935038T patent/ES2211806T3/es not_active Expired - Lifetime
- 2001-05-03 CA CA2409715A patent/CA2409715C/en not_active Expired - Fee Related
- 2001-05-03 DK DK01935038T patent/DK1289985T3/da active
- 2001-05-03 CZ CZ20023934A patent/CZ20023934A3/cs unknown
- 2001-05-03 NZ NZ522731A patent/NZ522731A/en not_active IP Right Cessation
- 2001-05-03 MX MXPA02011426A patent/MXPA02011426A/es active IP Right Grant
- 2001-05-03 SK SK1697-2002A patent/SK16972002A3/sk unknown
- 2001-05-03 PT PT01935038T patent/PT1289985E/pt unknown
- 2001-05-03 RU RU2002133867/04A patent/RU2271358C2/ru not_active IP Right Cessation
- 2001-05-03 KR KR1020027015581A patent/KR20030031482A/ko not_active Application Discontinuation
- 2001-05-03 HU HU0302412A patent/HUP0302412A3/hu unknown
- 2001-05-16 AR ARP010102326A patent/AR028576A1/es unknown
- 2001-05-16 MY MYPI20012323A patent/MY128479A/en unknown
-
2002
- 2002-01-21 TW TW091100842A patent/TWI286553B/zh not_active IP Right Cessation
- 2002-10-01 US US10/261,861 patent/US6864253B2/en not_active Expired - Lifetime
- 2002-11-15 IL IL152873A patent/IL152873A/en not_active IP Right Cessation
- 2002-11-15 HR HR20020910A patent/HRP20020910B1/xx not_active IP Right Cessation
- 2002-11-18 BG BG107285A patent/BG66141B1/bg unknown
- 2002-11-18 NO NO20025527A patent/NO324251B1/no not_active IP Right Cessation
- 2002-12-12 ZA ZA200210111A patent/ZA200210111B/en unknown
-
2003
- 2003-05-22 HK HK03103637A patent/HK1051368A1/xx not_active IP Right Cessation
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