WO1998051667A1 - Indole derivatives and mono- and diazaindole derivatives - Google Patents

Indole derivatives and mono- and diazaindole derivatives Download PDF

Info

Publication number
WO1998051667A1
WO1998051667A1 PCT/JP1998/002139 JP9802139W WO9851667A1 WO 1998051667 A1 WO1998051667 A1 WO 1998051667A1 JP 9802139 W JP9802139 W JP 9802139W WO 9851667 A1 WO9851667 A1 WO 9851667A1
Authority
WO
WIPO (PCT)
Prior art keywords
derivatives
mono
diazaindole
indole
compounds
Prior art date
Application number
PCT/JP1998/002139
Other languages
French (fr)
Japanese (ja)
Inventor
Hiroharu Matsuoka
Noriaki Maruyama
Hirotaka Kashiwagi
Original Assignee
Chugai Seiyaku Kabushiki Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Seiyaku Kabushiki Kaisha filed Critical Chugai Seiyaku Kabushiki Kaisha
Priority to AU72379/98A priority Critical patent/AU7237998A/en
Publication of WO1998051667A1 publication Critical patent/WO1998051667A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring

Abstract

Compounds represented by general formula (I), wherein A1 represents =N-, etc.; A2 represents =N- or =CH-; R1 represents hydrogen, etc.; R3 represents an alkyl, etc.; R4 represents an optionally substituted aryl, etc., hydrates thereof, and pharmaceutically acceptable salts of both. These compounds have COX-2 inhibitory activities and are useful as medicines such as an antiphlogistic.
PCT/JP1998/002139 1997-05-16 1998-05-15 Indole derivatives and mono- and diazaindole derivatives WO1998051667A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU72379/98A AU7237998A (en) 1997-05-16 1998-05-15 Indole derivatives and mono- and diazaindole derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP12705997 1997-05-16
JP9/127059 1997-05-16

Publications (1)

Publication Number Publication Date
WO1998051667A1 true WO1998051667A1 (en) 1998-11-19

Family

ID=14950582

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1998/002139 WO1998051667A1 (en) 1997-05-16 1998-05-15 Indole derivatives and mono- and diazaindole derivatives

Country Status (2)

Country Link
AU (1) AU7237998A (en)
WO (1) WO1998051667A1 (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001012187A2 (en) * 1999-08-18 2001-02-22 Astrazeneca Ab Benzoic acid derivatives and their use as ppar receptor agonists
WO2003029212A1 (en) * 2001-09-27 2003-04-10 F. Hoffmann-La Roche Ag Indole derivatives as cox ii inhibitors
US7442805B2 (en) 2003-09-25 2008-10-28 Wyeth Substituted sulfonamide-indoles
US7683091B2 (en) 2005-08-17 2010-03-23 Wyeth Substituted indoles and methods of their use
WO2011013624A1 (en) * 2009-07-27 2011-02-03 キッセイ薬品工業株式会社 Indole derivative and pharmacologically acceptable salt thereof
CN102498097A (en) * 2009-07-27 2012-06-13 橘生药品工业株式会社 Indole derivative and pharmacologically acceptable salt thereof
JP2012167085A (en) * 2011-01-25 2012-09-06 Kissei Pharmaceutical Co Ltd Medical application of indole derivative or pharmaceutically acceptable salt thereof
WO2022195579A1 (en) 2021-03-15 2022-09-22 Saul Yedgar Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory diseases

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995018799A1 (en) * 1994-01-10 1995-07-13 Merck Frosst Canada Inc. Phenyl heterocycles as cox-2 inhibitors
JPH08504408A (en) * 1992-12-11 1996-05-14 メルク フロスト カナダ インコーポレーテツド 5-Methanesulfonamide-1-indanone as a cyclooxygenase-2 inhibitor
JPH08157631A (en) * 1994-10-05 1996-06-18 Sekisui Chem Co Ltd Crosslinked and foamed polyolefin and its production
JPH08325249A (en) * 1994-12-20 1996-12-10 Japan Tobacco Inc Oxazole derivative
JPH0952882A (en) * 1994-12-20 1997-02-25 Japan Tobacco Inc Oxazole heterocyclic aromatic compound
JPH0977664A (en) * 1995-09-13 1997-03-25 Yakult Honsha Co Ltd Specific inhibitor of cyclooxygenase-2 and anti-inflammatory agent

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08504408A (en) * 1992-12-11 1996-05-14 メルク フロスト カナダ インコーポレーテツド 5-Methanesulfonamide-1-indanone as a cyclooxygenase-2 inhibitor
WO1995018799A1 (en) * 1994-01-10 1995-07-13 Merck Frosst Canada Inc. Phenyl heterocycles as cox-2 inhibitors
JPH08157631A (en) * 1994-10-05 1996-06-18 Sekisui Chem Co Ltd Crosslinked and foamed polyolefin and its production
JPH08325249A (en) * 1994-12-20 1996-12-10 Japan Tobacco Inc Oxazole derivative
JPH0952882A (en) * 1994-12-20 1997-02-25 Japan Tobacco Inc Oxazole heterocyclic aromatic compound
JPH0977664A (en) * 1995-09-13 1997-03-25 Yakult Honsha Co Ltd Specific inhibitor of cyclooxygenase-2 and anti-inflammatory agent

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
GLAMKOWSKI E. J., REITANO P. A.: "SYNTHESIS AND EVALUATION FOR DIURETIC ACTIVITY OF 1-SUBSTITUTED 6- CHLORO-5-SULFAMYLINDOLINES.", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 22., no. 01., 1 January 1979 (1979-01-01), US, pages 106 - 109., XP002912309, ISSN: 0022-2623, DOI: 10.1021/jm00187a023 *

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001012187A2 (en) * 1999-08-18 2001-02-22 Astrazeneca Ab Benzoic acid derivatives and their use as ppar receptor agonists
WO2001012187A3 (en) * 1999-08-18 2001-06-07 Astrazeneca Ab Benzoic acid derivatives and their use as ppar receptor agonists
WO2003029212A1 (en) * 2001-09-27 2003-04-10 F. Hoffmann-La Roche Ag Indole derivatives as cox ii inhibitors
US7442805B2 (en) 2003-09-25 2008-10-28 Wyeth Substituted sulfonamide-indoles
US7683091B2 (en) 2005-08-17 2010-03-23 Wyeth Substituted indoles and methods of their use
CN102498097A (en) * 2009-07-27 2012-06-13 橘生药品工业株式会社 Indole derivative and pharmacologically acceptable salt thereof
WO2011013624A1 (en) * 2009-07-27 2011-02-03 キッセイ薬品工業株式会社 Indole derivative and pharmacologically acceptable salt thereof
CN102498096A (en) * 2009-07-27 2012-06-13 橘生药品工业株式会社 Indole derivative and pharmacologically acceptable salt thereof
EP2474530A1 (en) * 2009-07-27 2012-07-11 Kissei Pharmaceutical Co., Ltd. Indole derivative and pharmacologically acceptable salt thereof
EP2474530A4 (en) * 2009-07-27 2013-01-02 Kissei Pharmaceutical Indole derivative and pharmacologically acceptable salt thereof
JPWO2011013624A1 (en) * 2009-07-27 2013-01-07 キッセイ薬品工業株式会社 Indole derivatives or pharmacologically acceptable salts thereof
US8680120B2 (en) 2009-07-27 2014-03-25 Kissei Pharmaceutical Co., Ltd. Indole derivative or pharmaceutically acceptable salt thereof
JP2012167085A (en) * 2011-01-25 2012-09-06 Kissei Pharmaceutical Co Ltd Medical application of indole derivative or pharmaceutically acceptable salt thereof
WO2022195579A1 (en) 2021-03-15 2022-09-22 Saul Yedgar Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory diseases

Also Published As

Publication number Publication date
AU7237998A (en) 1998-12-08

Similar Documents

Publication Publication Date Title
AU3851199A (en) Heterocyclic indole derivatives and mono- or diazaindole derivatives
EP1243583A4 (en) Heterocyclic compounds having sulfonamide groups
PL327169A1 (en) Naphtyl-substituted derivatives of benzimidazole as anticoagulants
EP1156045A4 (en) Amide derivatives and drug compositions
CA2311742A1 (en) 6-amino-9-benzyl-8-hydroxypurine derivatives
AU695045B2 (en) Heteroaromatic oxazole compounds and use thereof
DK1104760T3 (en) Sulfamoyl heteroarylpyrazole compounds as anti-inflammatory / analgesic agents
AU1025795A (en) Prolineamide derivatives
EP1103552A4 (en) Benzothiepin derivatives, process for the preparation of the same and uses thereof
AU1200695A (en) 4,5-diaryloxazole derivatives
EP1097933A4 (en) Pyrimidine derivatives exhibiting antitumor activity
CA2277947A1 (en) Pyrrolidine derivatives having phospholipase a2 inhibitory activity
WO2001062705A3 (en) Aminoalcohol derivatives
WO1999000373A8 (en) Benzimidazole derivatives
WO1996004241A3 (en) Benzoylguanidine derivatives as medicaments
EP1243268A4 (en) Medicinal composition
WO2000005214A3 (en) Isoquinolines as urokinase inhibitors
CA2120028A1 (en) Indol Derivatives for the Treatment of Migrane
WO1998051667A1 (en) Indole derivatives and mono- and diazaindole derivatives
NZ332481A (en) 5-[2,4-diaminopyrimidinylmethyl]phenyl substituted propanone (or propenone) isoquinoline derivatives and medicaments
CA2307581A1 (en) Heterocyclic compounds having nos inhibiting action
WO1996005182A3 (en) Saccharin derivatives
CA2300069A1 (en) Naphthalimidobenzamide derivatives
EP1026162A4 (en) Antirheumatic
GC0000218A (en) New imidazole derivatives

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AL AU BA BB BG BR CA CN CU CZ EE GE GW HU ID IL IS KR LC LK LR LT LV MG MK MN MX NO NZ PL RO SG SI SK SL TR TT UA US UZ VN YU

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: CA