DE60021194D1 - Phenylpiperazin-derivate als inhibitoren der serotonin-wiederaufnahme - Google Patents

Phenylpiperazin-derivate als inhibitoren der serotonin-wiederaufnahme

Info

Publication number
DE60021194D1
DE60021194D1 DE60021194T DE60021194T DE60021194D1 DE 60021194 D1 DE60021194 D1 DE 60021194D1 DE 60021194 T DE60021194 T DE 60021194T DE 60021194 T DE60021194 T DE 60021194T DE 60021194 D1 DE60021194 D1 DE 60021194D1
Authority
DE
Germany
Prior art keywords
inhibitors
phenylpiperazine derivatives
serotonin
recovery
serotonin recovery
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60021194T
Other languages
English (en)
Other versions
DE60021194T2 (de
Inventor
Roelof Van Hes
Johannes A M Van Der Heijden
Cornelis G Kruse
Jacobus Tipker
Martinus T M Tulp
Gerben M Visser
Bernard J Van Vliet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Healthcare Products BV
Original Assignee
Solvay Pharmaceuticals BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharmaceuticals BV filed Critical Solvay Pharmaceuticals BV
Publication of DE60021194D1 publication Critical patent/DE60021194D1/de
Application granted granted Critical
Publication of DE60021194T2 publication Critical patent/DE60021194T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE60021194T 1999-08-23 2000-08-22 Phenylpiperazin-derivate als inhibitoren der serotonin-wiederaufnahme Expired - Lifetime DE60021194T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP99202710 1999-08-23
EP99202710 1999-08-23
NL1012888 1999-08-23
NL1012888 1999-08-23
PCT/EP2000/008190 WO2001014330A2 (en) 1999-08-23 2000-08-22 Phenylpiperazines as serotonin reuptake inhibitors

Publications (2)

Publication Number Publication Date
DE60021194D1 true DE60021194D1 (de) 2005-08-11
DE60021194T2 DE60021194T2 (de) 2005-12-22

Family

ID=26153354

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60021194T Expired - Lifetime DE60021194T2 (de) 1999-08-23 2000-08-22 Phenylpiperazin-derivate als inhibitoren der serotonin-wiederaufnahme

Country Status (30)

Country Link
US (3) US7067513B1 (de)
EP (1) EP1212320B1 (de)
JP (1) JP4919565B2 (de)
KR (1) KR100634039B1 (de)
CN (1) CN1155596C (de)
AR (1) AR031526A1 (de)
AT (1) ATE299142T1 (de)
AU (1) AU772189B2 (de)
BR (1) BR0013498A (de)
CA (1) CA2379021C (de)
CZ (1) CZ298533B6 (de)
DE (1) DE60021194T2 (de)
DK (1) DK1212320T3 (de)
ES (1) ES2244469T3 (de)
HK (1) HK1051199A1 (de)
HU (1) HUP0203194A3 (de)
IL (2) IL148218A0 (de)
MX (1) MXPA02001919A (de)
NO (1) NO321887B1 (de)
NZ (1) NZ517900A (de)
PL (1) PL201178B1 (de)
PT (1) PT1212320E (de)
RU (1) RU2246494C2 (de)
SI (1) SI1212320T1 (de)
SK (1) SK287018B6 (de)
TR (1) TR200200460T2 (de)
TW (1) TWI286136B (de)
UA (1) UA74160C2 (de)
WO (1) WO2001014330A2 (de)
ZA (1) ZA200201829B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0203194A3 (en) 1999-08-23 2004-01-28 Solvay Pharm Bv Phenylpiperazines, pharmaceutical compositions containing them and their use
AR032712A1 (es) * 2001-02-21 2003-11-19 Solvay Pharm Bv Un mesilato de derivados de fenilpiperazina y composiciones farmaceuticas que lo contienen
AR032711A1 (es) 2001-02-21 2003-11-19 Solvay Pharm Bv Derivados de fenilpiperazina, un metodo para la preparacion de los mismos y una composicion farmaceutica que los contiene
US7041683B2 (en) 2001-04-24 2006-05-09 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1, 4-benzodiozan
EP1381600A1 (de) 2001-04-24 2004-01-21 Wyeth, A Corporation of the State of Delaware Azaheterocyclylmethyldeivate von 2,3-dihydro-1,4-benzodioxan als antidepressiva
US6656950B2 (en) 2001-04-25 2003-12-02 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 1,4-dioxino[2,3-b]pyridine
EP1336406A1 (de) * 2002-02-14 2003-08-20 Solvay Pharmaceuticals B.V. Partieller Dopamin-D2 Rezeptoragonist plus Substanzen mit Serotonin- und/oder Noradrenalin inhibitorischer Aktivität
ES2256744T3 (es) * 2002-05-13 2006-07-16 F. Hoffmann-La Roche Ag Derivados de benzoxazina como moduladores de 5-ht6 y usos de los mismos.
DE10233500A1 (de) * 2002-07-24 2004-02-19 Boehringer Ingelheim Pharma Gmbh & Co. Kg 3-Z-[1-(4-(N-((4-Methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylen]-6-methoxycarbonyl-2-indolinon-Monoethansulfonat und dessen Verwendung als Arzneimittel
DK1562918T3 (da) * 2002-11-08 2008-05-05 Hoffmann La Roche Substituerede benzoxazinoner og anvendelser deraf
US7276603B2 (en) 2003-05-02 2007-10-02 Wyeth Benzofuranyl-and benzothienyl-piperazinyl quinolines and methods of their use
WO2004108671A1 (en) * 2003-06-06 2004-12-16 Suven Life Sciences Limited Substituted indoles with serotonin receptor affinity, process for their preparation and pharmaceutical compositions containing them
CA2587940A1 (en) * 2004-12-07 2006-06-15 Solvay Pharmaceuticals B.V. Benzdioxane piperazine derivatives with a combination of affinity for dopamine-d2 receptors and serotonin reuptake sites
CN101072765A (zh) * 2004-12-07 2007-11-14 索尔瓦药物有限公司 同时对多巴胺－d2受体和5－羟色胺重摄取部位具有亲合力的苯基哌嗪
US7371769B2 (en) 2004-12-07 2008-05-13 Solvay Pharmaceuticals B.V. Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites
US8101619B2 (en) 2004-12-08 2012-01-24 Solvay Pharmaceuticals B.V. Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition
WO2006061377A1 (en) * 2004-12-08 2006-06-15 Solvay Pharmaceuticals B.V. Phenylpiperazine derivatives with a combination of partial dopamine-d2 receptor agonism and serotonin reuptake inhibition
AR055424A1 (es) 2005-09-12 2007-08-22 Wyeth Corp Formulacion de liberacion sostenida y usos de la misma
GT200600414A (es) * 2005-09-12 2007-09-20 Sal de glucuranato de compuesto de piperazine
GT200600416A (es) 2005-09-12 2007-09-20 Sales salicilato y gentisato de un compuesto de piperazina
US9066903B2 (en) 2006-02-28 2015-06-30 The United States Of America As Represented By The Department Of Veterans Affairs Pharmacological treatment of Parkinson's disease
FR2941946B1 (fr) * 2009-02-12 2011-03-25 Sanofi Aventis Derives de 3-benzofuranyl-indol-2-one-3-acetamidopiperazines substitues, leur preparation et leur application en therapeutique
JP5732453B2 (ja) * 2009-06-25 2015-06-10 アルカーメス ファーマ アイルランド リミテッド Ｎｈ酸性化合物のプロドラッグ
CN104337812B (zh) 2013-07-29 2018-09-14 广东东阳光药业有限公司 取代的杂芳基化合物及其使用方法和用途
US10316025B2 (en) 2015-06-03 2019-06-11 Sunshine Lake Pharma Co., Ltd. Substituted piperazine compounds and methods of use and use thereof

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1075156A (en) 1963-08-27 1967-07-12 Luso Farmaco Inst Substituted piperazines
GB8830312D0 (en) * 1988-12-28 1989-02-22 Lundbeck & Co As H Heterocyclic compounds
DE4127849A1 (de) 1991-08-22 1993-02-25 Merck Patent Gmbh Benzodioxanderivate
US5314896A (en) 1991-11-20 1994-05-24 Warner-Lambert Company 1,3-substituted cycloalkenes and cycloalkanes as central nervous system agents
DE4333254A1 (de) 1993-09-30 1995-04-06 Merck Patent Gmbh Piperidine und Piperazine
DE4414113A1 (de) 1994-04-22 1995-10-26 Merck Patent Gmbh 3-Indolylpiperidine
US5576321A (en) 1995-01-17 1996-11-19 Eli Lilly And Company Compounds having effects on serotonin-related systems
AR004229A1 (es) 1995-11-06 1998-11-04 Wyeth Corp Derivados indolalquilo de benzodioxanmetilamina y su uso para preparar medicamentos
ZA9711376B (en) 1996-12-20 1998-07-21 Lundbeck & Co As H Indole or dihydroindole derivatives
DE19730989A1 (de) 1997-07-18 1999-01-21 Merck Patent Gmbh Piperazin-Derivate
CZ295937B6 (cs) * 1997-07-25 2005-12-14 H. Lundbeck A/S Indolové nebo 2,3-dihydroindolové deriváty
DE69819266T2 (de) * 1997-09-02 2004-07-29 Duphar International Research B.V. Piperidin- und Piperazin Derivate als 5-HT1-Rezeptor-Agonisten
EP0900792B1 (de) 1997-09-02 2003-10-29 Duphar International Research B.V Piperidin- und Piperazin Derivate als 5-HT1-Rezeptor-Agonisten
CA2335711A1 (en) 1998-06-19 1999-12-29 Ivan Mikkelsen 4,5,6 and 7-indole and indoline derivatives, their preparation and use
EA004248B1 (ru) * 1998-06-19 2004-02-26 Х.Лундбекк А/С Производные 4-, 5-, 6- и 7-замещенного индола и индолина, их получение и применение
AR020773A1 (es) 1998-10-16 2002-05-29 Duphar Int Res Compuesto derivados de 3-(tetrahidropiridin-4-il)indol, metodo para prepararlo, una composicion farmaceutica que los contiene, metodo para preparar dicha composicion y uso del compuesto
AR022303A1 (es) * 1999-01-22 2002-09-04 Lundbeck & Co As H Derivados de piperidina, tetrahidropiridina y piperazina, su preparacion y utilizacion
HUP0203194A3 (en) 1999-08-23 2004-01-28 Solvay Pharm Bv Phenylpiperazines, pharmaceutical compositions containing them and their use
AR032711A1 (es) 2001-02-21 2003-11-19 Solvay Pharm Bv Derivados de fenilpiperazina, un metodo para la preparacion de los mismos y una composicion farmaceutica que los contiene
AR032712A1 (es) * 2001-02-21 2003-11-19 Solvay Pharm Bv Un mesilato de derivados de fenilpiperazina y composiciones farmaceuticas que lo contienen
EP1336406A1 (de) 2002-02-14 2003-08-20 Solvay Pharmaceuticals B.V. Partieller Dopamin-D2 Rezeptoragonist plus Substanzen mit Serotonin- und/oder Noradrenalin inhibitorischer Aktivität

Also Published As

Publication number Publication date
RU2246494C2 (ru) 2005-02-20
AU772189B2 (en) 2004-04-08
TWI286136B (en) 2007-09-01
MXPA02001919A (es) 2003-07-21
PL364821A1 (en) 2004-12-13
US7605162B2 (en) 2009-10-20
SI1212320T1 (en) 2005-10-31
NO321887B1 (no) 2006-07-17
WO2001014330A2 (en) 2001-03-01
SK287018B6 (sk) 2009-09-07
EP1212320A2 (de) 2002-06-12
CN1390214A (zh) 2003-01-08
UA74160C2 (uk) 2005-11-15
US7456182B2 (en) 2008-11-25
PL201178B1 (pl) 2009-03-31
US20090143406A1 (en) 2009-06-04
KR20020057949A (ko) 2002-07-12
NZ517900A (en) 2003-08-29
CA2379021C (en) 2009-10-27
SK2492002A3 (en) 2002-09-10
CN1155596C (zh) 2004-06-30
NO20020810L (no) 2002-02-19
US20060293313A1 (en) 2006-12-28
NO20020810D0 (no) 2002-02-19
ATE299142T1 (de) 2005-07-15
JP4919565B2 (ja) 2012-04-18
IL148218A0 (en) 2002-09-12
CZ2002619A3 (cs) 2002-08-14
DE60021194T2 (de) 2005-12-22
ES2244469T3 (es) 2005-12-16
TR200200460T2 (tr) 2002-06-21
AR031526A1 (es) 2003-09-24
HK1051199A1 (en) 2003-07-25
AU7411800A (en) 2001-03-19
CZ298533B6 (cs) 2007-10-31
CA2379021A1 (en) 2001-03-01
IL148218A (en) 2007-05-15
US7067513B1 (en) 2006-06-27
BR0013498A (pt) 2002-05-14
DK1212320T3 (da) 2005-08-08
KR100634039B1 (ko) 2006-10-17
HUP0203194A3 (en) 2004-01-28
HUP0203194A2 (hu) 2003-01-28
WO2001014330A3 (en) 2001-08-02
PT1212320E (pt) 2005-11-30
EP1212320B1 (de) 2005-07-06
JP2003507454A (ja) 2003-02-25
ZA200201829B (en) 2003-08-27

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