AR004229A1 - Derivados indolalquilo de benzodioxanmetilamina y su uso para preparar medicamentos - Google Patents

Derivados indolalquilo de benzodioxanmetilamina y su uso para preparar medicamentos

Info

Publication number
AR004229A1
AR004229A1 ARP960104894A ARP960104894A AR004229A1 AR 004229 A1 AR004229 A1 AR 004229A1 AR P960104894 A ARP960104894 A AR P960104894A AR P960104894 A ARP960104894 A AR P960104894A AR 004229 A1 AR004229 A1 AR 004229A1
Authority
AR
Argentina
Prior art keywords
carbon atoms
derivatives
indolalkyl
benzodioxanmetilamina
alkyl
Prior art date
Application number
ARP960104894A
Other languages
English (en)
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of AR004229A1 publication Critical patent/AR004229A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Derivados de indolalquilo de benzodioxanmetilamina de fórmula (I), en la cual R1, R4 y R5 son, independientemente, hidrógeno, alquilo de 1-6 átomos decarbono, alcoxi de1-6 átomos de carbono, aralcoxi de 7 a 12 átomos de carbono, alcanoiloxi de2a 6 átomos de carbono, hidroxi, halo, trifluormetilo, amino,mono- ó di-alquilamino, en donde cada grupo alquilo tiene de 1 a 6 átomos de carbono, alcanamido de 2 a 6 átomos de carbono o alcansulfonamido de 1 a 6átomos de carbono; ó R1 es como sede fine precedentemente y R4 y R5, tomados juntos, son metilendioxi,etilendioxi o propilendioxi orto-sustituidos; R2 y R3son, independientemente, hidrógeno ó alquilo de 1 a 6 átomos de carbono; n es 3 ó 4; o sus sales farmacéuticamenteaceptables, út iles en el tratamiento de ladepresión y trastornos relacionados; y el uso de los mismos para la preparación de medicamentos.
ARP960104894A 1995-11-06 1996-10-24 Derivados indolalquilo de benzodioxanmetilamina y su uso para preparar medicamentos AR004229A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US728495P 1995-11-06 1995-11-06

Publications (1)

Publication Number Publication Date
AR004229A1 true AR004229A1 (es) 1998-11-04

Family

ID=21725271

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960104894A AR004229A1 (es) 1995-11-06 1996-10-24 Derivados indolalquilo de benzodioxanmetilamina y su uso para preparar medicamentos

Country Status (21)

Country Link
US (1) US5750724A (es)
EP (1) EP0861248B1 (es)
JP (1) JP2000500136A (es)
KR (1) KR19990067303A (es)
CN (1) CN1074414C (es)
AR (1) AR004229A1 (es)
AT (1) ATE210659T1 (es)
BR (1) BR9611406A (es)
CA (1) CA2236678A1 (es)
DE (1) DE69617995T2 (es)
DK (1) DK0861248T3 (es)
ES (1) ES2166470T3 (es)
HK (1) HK1015366A1 (es)
HU (1) HUP9902091A3 (es)
IL (1) IL124095A (es)
MX (1) MX9803455A (es)
NZ (1) NZ321821A (es)
PT (1) PT861248E (es)
TW (1) TW498075B (es)
WO (1) WO1997017343A1 (es)
ZA (1) ZA969221B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6231833B1 (en) 1999-08-05 2001-05-15 Pfizer Inc 2,7-substituted octahydro-1H-pyrido[1,2-A]pyrazine derivatives as ligands for serotonin receptors
US6121307A (en) * 1998-04-08 2000-09-19 American Home Products Corp. N-aryloxyethyl-indoly-alkylamines for the treatment of depression
EP1200072A2 (en) * 1999-05-12 2002-05-02 Solvay Pharmaceuticals B.V. Method of treating psychotic disorders
IL148218A0 (en) 1999-08-23 2002-09-12 Solvay Pharm Bv New phenylpiperazines
FR2799463B1 (fr) * 1999-10-12 2004-04-16 Adir Nouveaux composes cyano-indoles inhibiteurs de recapture de serotonine, leur procede de preparation et ces compositions pharmaceutiques qui les contiennent
AR032712A1 (es) 2001-02-21 2003-11-19 Solvay Pharm Bv Un mesilato de derivados de fenilpiperazina y composiciones farmaceuticas que lo contienen
US6656951B2 (en) * 2001-04-24 2003-12-02 Wyeth 8-aza-bicyclo[3.2.1]octan-3-ol derivatives of 2,3-dihydro-1,4-benzodioxan as 5-HT1A antagonists
US6559169B2 (en) 2001-04-24 2003-05-06 Wyeth Antidepressant azaheterocyclymethyl derivatives of 2,3-dihydro-1,4-benzodioxan
US7041683B2 (en) * 2001-04-24 2006-05-09 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1, 4-benzodiozan
US6656950B2 (en) 2001-04-25 2003-12-02 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 1,4-dioxino[2,3-b]pyridine
US8106074B2 (en) 2001-07-13 2012-01-31 Pierre Fabre Medicament Pyridin-2-yl-methylamine derivatives for treating opiate dependence
WO2003031439A1 (en) 2001-10-05 2003-04-17 Wyeth Antidepressant chroman and chromene derivatives of 3-(1,2,3,6-tetrahydro-4-pyridinyl)-1h-indole
US6800637B2 (en) * 2002-09-12 2004-10-05 Wyeth Antidepressant indolealkyl derivatives of heterocycle-fused benzodioxan methylamines
US6911445B2 (en) * 2002-09-12 2005-06-28 Wyeth Antidepressant cycloalkylamine derivatives of heterocycle-fused benzodioxans
US7227023B2 (en) * 2003-04-30 2007-06-05 Wyeth Quinoline 3-amino chroman derivatives
BRPI0608353A2 (pt) * 2005-02-17 2009-12-01 Wyeth Corp derivados de indol, benzotiofeno, benzofurano e indeno cicloalquilfundidos
JP5514804B2 (ja) 2008-04-29 2014-06-04 エヌエスエイビー、フィリアル アヴ ノイロサーチ スウェーデン エービー、スヴェーリエ ドーパミン神経伝達のモジュレーター
WO2009133110A1 (en) 2008-04-29 2009-11-05 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Modulators of dopamine neurotransmission
EP2271635A1 (en) * 2008-04-29 2011-01-12 NSAB, Filial af NeuroSearch Sweden AB, Sverige Modulators of dopamine neurotransmission
CN103965186B (zh) * 2013-01-25 2016-05-18 江苏恩华药业股份有限公司 苯并二噁烷-苯并噁（噻）唑哌啶衍生物及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE635203A (es) * 1962-07-20
JPS58219114A (ja) * 1982-06-15 1983-12-20 Mitsubishi Chem Ind Ltd 血圧降下剤
DE3419935A1 (de) * 1984-05-28 1985-11-28 Merck Patent Gmbh, 6100 Darmstadt Verwendung von hydroxyindolderivaten bei der senkung des blutdrucks
US4910302A (en) * 1988-12-19 1990-03-20 American Home Products Corporation Psychotropic polycyclic imides
CA2043709C (en) * 1990-06-29 2002-01-22 David W. Smith Antimigraine alkoxypyrimidine derivatives
DE4101686A1 (de) * 1991-01-22 1992-07-23 Merck Patent Gmbh Indolderivate
FR2707294B1 (fr) * 1993-07-06 1995-09-29 Pf Medicament Nouveaux dérivés de la 3,5-dioxo-(2H,4H)-1,2,4-triazine, leur préparation et leur application en thérapeutique humaine.
DE19512639A1 (de) * 1995-04-05 1996-10-10 Merck Patent Gmbh Benzonitrile und -fluoride

Also Published As

Publication number Publication date
DE69617995D1 (de) 2002-01-24
WO1997017343A1 (en) 1997-05-15
PT861248E (pt) 2002-05-31
IL124095A (en) 2001-10-31
JP2000500136A (ja) 2000-01-11
NZ321821A (en) 1999-07-29
AU7524596A (en) 1997-05-29
BR9611406A (pt) 1999-01-05
DK0861248T3 (da) 2002-04-08
CN1205700A (zh) 1999-01-20
AU704216B2 (en) 1999-04-15
DE69617995T2 (de) 2002-05-16
KR19990067303A (ko) 1999-08-16
EP0861248B1 (en) 2001-12-12
MX9803455A (es) 1998-09-30
CN1074414C (zh) 2001-11-07
HUP9902091A2 (hu) 2000-02-28
EP0861248A1 (en) 1998-09-02
HK1015366A1 (en) 1999-10-15
CA2236678A1 (en) 1997-05-15
ATE210659T1 (de) 2001-12-15
HUP9902091A3 (en) 2000-03-28
US5750724A (en) 1998-05-12
ES2166470T3 (es) 2002-04-16
ZA969221B (en) 1998-05-04
TW498075B (en) 2002-08-11

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