HUP9902091A2 - Benzodioxán-metil-amin indol-alkil-származékok és alkalmazásuk 5-HT1A receptor ligandumként - Google Patents

Benzodioxán-metil-amin indol-alkil-származékok és alkalmazásuk 5-HT1A receptor ligandumként

Info

Publication number
HUP9902091A2
HUP9902091A2 HU9902091A HUP9902091A HUP9902091A2 HU P9902091 A2 HUP9902091 A2 HU P9902091A2 HU 9902091 A HU9902091 A HU 9902091A HU P9902091 A HUP9902091 A HU P9902091A HU P9902091 A2 HUP9902091 A2 HU P9902091A2
Authority
HU
Hungary
Prior art keywords
benzodioxanmethylamine
receptor ligands
ht1a receptor
indolealkyl
derivatives
Prior art date
Application number
HU9902091A
Other languages
English (en)
Inventor
Young Hee Kang
Gary Paul Stack
Original Assignee
American Home Products Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corporation filed Critical American Home Products Corporation
Publication of HUP9902091A2 publication Critical patent/HUP9902091A2/hu
Publication of HUP9902091A3 publication Critical patent/HUP9902091A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

A találmány tárgya 5-HT1A receptőr ligandűmként alkalmazhatóbenződiőxán-metil-amin indől-alkil-származékai. Az (I) általánős képletű vegyületek, ahől R1, R4 és R5 egymástól függetlenül hidrőgén- vagy halőgénatőm, alkil-,alkőxi-, aralkőxi-, alkanőil-őxi-, hidrőxilcsőpőrt, triflűőr-metil-,aminő-, mőnő- vagy dialkil-aminő-, alkánamidő- vagyalkánszűlfőnamidőcsőpőrt, vagy R1 jelentése a fenti és R4 és R5 együtt őrtőszűbsztitűált metilén-diőxi-, etilén-diőxi- vagy prőpilén-diőxi-csőpőrtőt képez, R2 és R3 egymástól függetlenül hidrőgénatőm vagy alkilcsőpőrt, n értéke 3 vagy 4, vagy gyógyászatilag elfőgadható sói. A vegyületeket depresszió éshasőnló rendellenességek kezelésére lehet alkalmazni. ŕ
HU9902091A 1995-11-06 1996-10-29 Indolealkyl derivatives of benzodioxanmethylamine and their use as 5-ht1a receptor ligands HUP9902091A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US728495P 1995-11-06 1995-11-06
PCT/US1996/017275 WO1997017343A1 (en) 1995-11-06 1996-10-29 Indolealkyl derivatives of benzodioxanmethylamine as 5-ht1a receptor ligands

Publications (2)

Publication Number Publication Date
HUP9902091A2 true HUP9902091A2 (hu) 2000-02-28
HUP9902091A3 HUP9902091A3 (en) 2000-03-28

Family

ID=21725271

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9902091A HUP9902091A3 (en) 1995-11-06 1996-10-29 Indolealkyl derivatives of benzodioxanmethylamine and their use as 5-ht1a receptor ligands

Country Status (21)

Country Link
US (1) US5750724A (hu)
EP (1) EP0861248B1 (hu)
JP (1) JP2000500136A (hu)
KR (1) KR19990067303A (hu)
CN (1) CN1074414C (hu)
AR (1) AR004229A1 (hu)
AT (1) ATE210659T1 (hu)
BR (1) BR9611406A (hu)
CA (1) CA2236678A1 (hu)
DE (1) DE69617995T2 (hu)
DK (1) DK0861248T3 (hu)
ES (1) ES2166470T3 (hu)
HK (1) HK1015366A1 (hu)
HU (1) HUP9902091A3 (hu)
IL (1) IL124095A (hu)
MX (1) MX9803455A (hu)
NZ (1) NZ321821A (hu)
PT (1) PT861248E (hu)
TW (1) TW498075B (hu)
WO (1) WO1997017343A1 (hu)
ZA (1) ZA969221B (hu)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6231833B1 (en) 1999-08-05 2001-05-15 Pfizer Inc 2,7-substituted octahydro-1H-pyrido[1,2-A]pyrazine derivatives as ligands for serotonin receptors
US6121307A (en) * 1998-04-08 2000-09-19 American Home Products Corp. N-aryloxyethyl-indoly-alkylamines for the treatment of depression
AU4552200A (en) * 1999-05-12 2000-12-05 Solvay Pharmaceuticals B.V. Method of treating psychotic disorders
JP4919565B2 (ja) 1999-08-23 2012-04-18 アボツト・ヘルスケア・プロダクツ・ベー・ブイ 新規なフェニルピペラジン
FR2799463B1 (fr) * 1999-10-12 2004-04-16 Adir Nouveaux composes cyano-indoles inhibiteurs de recapture de serotonine, leur procede de preparation et ces compositions pharmaceutiques qui les contiennent
AR032712A1 (es) 2001-02-21 2003-11-19 Solvay Pharm Bv Un mesilato de derivados de fenilpiperazina y composiciones farmaceuticas que lo contienen
US7041683B2 (en) * 2001-04-24 2006-05-09 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1, 4-benzodiozan
US6559169B2 (en) 2001-04-24 2003-05-06 Wyeth Antidepressant azaheterocyclymethyl derivatives of 2,3-dihydro-1,4-benzodioxan
US6656951B2 (en) 2001-04-24 2003-12-02 Wyeth 8-aza-bicyclo[3.2.1]octan-3-ol derivatives of 2,3-dihydro-1,4-benzodioxan as 5-HT1A antagonists
US6656950B2 (en) 2001-04-25 2003-12-02 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 1,4-dioxino[2,3-b]pyridine
US8106074B2 (en) 2001-07-13 2012-01-31 Pierre Fabre Medicament Pyridin-2-yl-methylamine derivatives for treating opiate dependence
US6667322B2 (en) 2001-10-05 2003-12-23 Wyeth Antidepressant chroman and chromene derivatives of 3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole
US6800637B2 (en) * 2002-09-12 2004-10-05 Wyeth Antidepressant indolealkyl derivatives of heterocycle-fused benzodioxan methylamines
US6911445B2 (en) * 2002-09-12 2005-06-28 Wyeth Antidepressant cycloalkylamine derivatives of heterocycle-fused benzodioxans
US7227023B2 (en) * 2003-04-30 2007-06-05 Wyeth Quinoline 3-amino chroman derivatives
JP2008530229A (ja) * 2005-02-17 2008-08-07 ワイス シクロアルキル縮合インドール、ベンゾチオフェン、ベンゾフランおよびインデン誘導体
CA2722978A1 (en) 2008-04-29 2009-11-05 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Modulators of dopamine neurotransmission
EP2271635A1 (en) * 2008-04-29 2011-01-12 NSAB, Filial af NeuroSearch Sweden AB, Sverige Modulators of dopamine neurotransmission
JP5548853B2 (ja) 2008-04-29 2014-07-16 インテグレイティブ・リサーチ・ラボラトリーズ・スウェーデン・アーベー ドーパミン神経伝達のモジュレーター
CN103965186B (zh) * 2013-01-25 2016-05-18 江苏恩华药业股份有限公司 苯并二噁烷-苯并噁（噻）唑哌啶衍生物及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE635203A (hu) * 1962-07-20
JPS58219114A (ja) * 1982-06-15 1983-12-20 Mitsubishi Chem Ind Ltd 血圧降下剤
DE3419935A1 (de) * 1984-05-28 1985-11-28 Merck Patent Gmbh, 6100 Darmstadt Verwendung von hydroxyindolderivaten bei der senkung des blutdrucks
US4910302A (en) * 1988-12-19 1990-03-20 American Home Products Corporation Psychotropic polycyclic imides
CA2043709C (en) * 1990-06-29 2002-01-22 David W. Smith Antimigraine alkoxypyrimidine derivatives
DE4101686A1 (de) * 1991-01-22 1992-07-23 Merck Patent Gmbh Indolderivate
FR2707294B1 (fr) * 1993-07-06 1995-09-29 Pf Medicament Nouveaux dérivés de la 3,5-dioxo-(2H,4H)-1,2,4-triazine, leur préparation et leur application en thérapeutique humaine.
DE19512639A1 (de) * 1995-04-05 1996-10-10 Merck Patent Gmbh Benzonitrile und -fluoride

Also Published As

Publication number Publication date
CN1205700A (zh) 1999-01-20
DK0861248T3 (da) 2002-04-08
NZ321821A (en) 1999-07-29
CA2236678A1 (en) 1997-05-15
DE69617995D1 (de) 2002-01-24
BR9611406A (pt) 1999-01-05
CN1074414C (zh) 2001-11-07
AU704216B2 (en) 1999-04-15
MX9803455A (es) 1998-09-30
TW498075B (en) 2002-08-11
ES2166470T3 (es) 2002-04-16
HK1015366A1 (en) 1999-10-15
KR19990067303A (ko) 1999-08-16
PT861248E (pt) 2002-05-31
US5750724A (en) 1998-05-12
ZA969221B (en) 1998-05-04
ATE210659T1 (de) 2001-12-15
IL124095A (en) 2001-10-31
EP0861248B1 (en) 2001-12-12
JP2000500136A (ja) 2000-01-11
WO1997017343A1 (en) 1997-05-15
EP0861248A1 (en) 1998-09-02
HUP9902091A3 (en) 2000-03-28
AU7524596A (en) 1997-05-29
DE69617995T2 (de) 2002-05-16
AR004229A1 (es) 1998-11-04

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