MX9803455A - Derivados de indolalquilo de benzodioxanmetilamina como ligandos del receptor 5-ht1a. - Google Patents

Derivados de indolalquilo de benzodioxanmetilamina como ligandos del receptor 5-ht1a.

Info

Publication number
MX9803455A
MX9803455A MX9803455A MX9803455A MX9803455A MX 9803455 A MX9803455 A MX 9803455A MX 9803455 A MX9803455 A MX 9803455A MX 9803455 A MX9803455 A MX 9803455A MX 9803455 A MX9803455 A MX 9803455A
Authority
MX
Mexico
Prior art keywords
benzodioxanmethylamine
receptor ligands
ht1a receptor
indolealkyl
derivatives
Prior art date
Application number
MX9803455A
Other languages
English (en)
Inventor
Young Hee Kang
Gary Paul Stack
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of MX9803455A publication Critical patent/MX9803455A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Los compuestos de la formula (I), en donde R1, R4 y R5 son, independientemente, hidrogeno, alquilo, alcoxi, aralcoxi, alcanoiloxi, hidroxi, halo, trifluorometilo, amino, mono-o di-alquilamino, alcanamido, o alcansulfonamido; o, R1 se define como anteriormente y R4 y R5 tomados conjuntamente, son metilendioxi, etilendioxi, o propilendioxi, substituidos en otro; R2 y R3 son, independientemente, hidrogeno o alquilo; n es 3 o 4; o sales de los mismos farmacéuticamente aceptables, sonutiles en el tratamiento de la depresion y desordenes relacionados.
MX9803455A 1995-11-06 1998-04-30 Derivados de indolalquilo de benzodioxanmetilamina como ligandos del receptor 5-ht1a. MX9803455A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US728495P 1995-11-06 1995-11-06

Publications (1)

Publication Number Publication Date
MX9803455A true MX9803455A (es) 1998-09-30

Family

ID=21725271

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9803455A MX9803455A (es) 1995-11-06 1998-04-30 Derivados de indolalquilo de benzodioxanmetilamina como ligandos del receptor 5-ht1a.

Country Status (21)

Country Link
US (1) US5750724A (es)
EP (1) EP0861248B1 (es)
JP (1) JP2000500136A (es)
KR (1) KR19990067303A (es)
CN (1) CN1074414C (es)
AR (1) AR004229A1 (es)
AT (1) ATE210659T1 (es)
BR (1) BR9611406A (es)
CA (1) CA2236678A1 (es)
DE (1) DE69617995T2 (es)
DK (1) DK0861248T3 (es)
ES (1) ES2166470T3 (es)
HK (1) HK1015366A1 (es)
HU (1) HUP9902091A3 (es)
IL (1) IL124095A (es)
MX (1) MX9803455A (es)
NZ (1) NZ321821A (es)
PT (1) PT861248E (es)
TW (1) TW498075B (es)
WO (1) WO1997017343A1 (es)
ZA (1) ZA969221B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6231833B1 (en) 1999-08-05 2001-05-15 Pfizer Inc 2,7-substituted octahydro-1H-pyrido[1,2-A]pyrazine derivatives as ligands for serotonin receptors
US6121307A (en) 1998-04-08 2000-09-19 American Home Products Corp. N-aryloxyethyl-indoly-alkylamines for the treatment of depression
AU4552200A (en) * 1999-05-12 2000-12-05 Solvay Pharmaceuticals B.V. Method of treating psychotic disorders
SK287018B6 (sk) 1999-08-23 2009-09-07 Solvay Pharmaceuticals B. V. Deriváty fenylpiperazínov, spôsob ich prípravy, farmaceutická kompozícia s ich obsahom a ich použitie
FR2799463B1 (fr) * 1999-10-12 2004-04-16 Adir Nouveaux composes cyano-indoles inhibiteurs de recapture de serotonine, leur procede de preparation et ces compositions pharmaceutiques qui les contiennent
AR032712A1 (es) * 2001-02-21 2003-11-19 Solvay Pharm Bv Un mesilato de derivados de fenilpiperazina y composiciones farmaceuticas que lo contienen
US7041683B2 (en) * 2001-04-24 2006-05-09 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1, 4-benzodiozan
US6656951B2 (en) * 2001-04-24 2003-12-02 Wyeth 8-aza-bicyclo[3.2.1]octan-3-ol derivatives of 2,3-dihydro-1,4-benzodioxan as 5-HT1A antagonists
US6559169B2 (en) 2001-04-24 2003-05-06 Wyeth Antidepressant azaheterocyclymethyl derivatives of 2,3-dihydro-1,4-benzodioxan
US6656950B2 (en) 2001-04-25 2003-12-02 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 1,4-dioxino[2,3-b]pyridine
US8106074B2 (en) 2001-07-13 2012-01-31 Pierre Fabre Medicament Pyridin-2-yl-methylamine derivatives for treating opiate dependence
WO2003031439A1 (en) 2001-10-05 2003-04-17 Wyeth Antidepressant chroman and chromene derivatives of 3-(1,2,3,6-tetrahydro-4-pyridinyl)-1h-indole
US6800637B2 (en) * 2002-09-12 2004-10-05 Wyeth Antidepressant indolealkyl derivatives of heterocycle-fused benzodioxan methylamines
US6911445B2 (en) 2002-09-12 2005-06-28 Wyeth Antidepressant cycloalkylamine derivatives of heterocycle-fused benzodioxans
US7227023B2 (en) 2003-04-30 2007-06-05 Wyeth Quinoline 3-amino chroman derivatives
BRPI0608353A2 (pt) * 2005-02-17 2009-12-01 Wyeth Corp derivados de indol, benzotiofeno, benzofurano e indeno cicloalquilfundidos
MX2010011724A (es) 2008-04-29 2010-11-30 Nsab Af Neurosearch Sweden Ab Moduladores de neurotransmision de dopamina.
DK2271638T3 (da) 2008-04-29 2011-11-28 Nsab Af Neurosearch Sweden Ab Modulatorer af dopaminneurotransmission
JP2011519839A (ja) * 2008-04-29 2011-07-14 エヌエスエイビー、フィリアル アヴ ノイロサーチ スウェーデン エービー、スヴェーリエ ドーパミン神経伝達のモジュレーター
CN103965186B (zh) * 2013-01-25 2016-05-18 江苏恩华药业股份有限公司 苯并二噁烷-苯并噁（噻）唑哌啶衍生物及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL281245A (es) * 1962-07-20
JPS58219114A (ja) * 1982-06-15 1983-12-20 Mitsubishi Chem Ind Ltd 血圧降下剤
DE3419935A1 (de) * 1984-05-28 1985-11-28 Merck Patent Gmbh, 6100 Darmstadt Verwendung von hydroxyindolderivaten bei der senkung des blutdrucks
US4910302A (en) * 1988-12-19 1990-03-20 American Home Products Corporation Psychotropic polycyclic imides
CA2043709C (en) * 1990-06-29 2002-01-22 David W. Smith Antimigraine alkoxypyrimidine derivatives
DE4101686A1 (de) * 1991-01-22 1992-07-23 Merck Patent Gmbh Indolderivate
FR2707294B1 (fr) * 1993-07-06 1995-09-29 Pf Medicament Nouveaux dérivés de la 3,5-dioxo-(2H,4H)-1,2,4-triazine, leur préparation et leur application en thérapeutique humaine.
DE19512639A1 (de) * 1995-04-05 1996-10-10 Merck Patent Gmbh Benzonitrile und -fluoride

Also Published As

Publication number Publication date
BR9611406A (pt) 1999-01-05
JP2000500136A (ja) 2000-01-11
EP0861248A1 (en) 1998-09-02
DK0861248T3 (da) 2002-04-08
AU704216B2 (en) 1999-04-15
HUP9902091A3 (en) 2000-03-28
US5750724A (en) 1998-05-12
CN1074414C (zh) 2001-11-07
HK1015366A1 (en) 1999-10-15
DE69617995T2 (de) 2002-05-16
PT861248E (pt) 2002-05-31
EP0861248B1 (en) 2001-12-12
HUP9902091A2 (hu) 2000-02-28
KR19990067303A (ko) 1999-08-16
CA2236678A1 (en) 1997-05-15
NZ321821A (en) 1999-07-29
ATE210659T1 (de) 2001-12-15
AU7524596A (en) 1997-05-29
WO1997017343A1 (en) 1997-05-15
DE69617995D1 (de) 2002-01-24
AR004229A1 (es) 1998-11-04
IL124095A (en) 2001-10-31
ZA969221B (en) 1998-05-04
ES2166470T3 (es) 2002-04-16
TW498075B (en) 2002-08-11
CN1205700A (zh) 1999-01-20

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Legal Events

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FG Grant or registration
HC Change of company name or juridical status

Owner name: PUROLATOR FILTERS NA LLC.*

MM Annulment or lapse due to non-payment of fees