ES2166470T3 - Derivados de indolalquilo de la benzodioxanmetilamina como ligandos de los receptores 5-ht1a. - Google Patents

Derivados de indolalquilo de la benzodioxanmetilamina como ligandos de los receptores 5-ht1a.

Info

Publication number
ES2166470T3
ES2166470T3 ES96937782T ES96937782T ES2166470T3 ES 2166470 T3 ES2166470 T3 ES 2166470T3 ES 96937782 T ES96937782 T ES 96937782T ES 96937782 T ES96937782 T ES 96937782T ES 2166470 T3 ES2166470 T3 ES 2166470T3
Authority
ES
Spain
Prior art keywords
indolalquilo
benzodioxanmetilamine
ligands
derivatives
ht1a receptors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96937782T
Other languages
English (en)
Inventor
Young Hee Kang
Gary Paul Stack
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp filed Critical American Home Products Corp
Application granted granted Critical
Publication of ES2166470T3 publication Critical patent/ES2166470T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

LOS COMPUESTOS DE LA FORMULA (I), EN LA QUE R 1 , R SUP,4 Y R 5 SON, INDEPENDIENTEMENTE, HIDROGENO, ALQUILO, ALCOXILO, ARALCOXILO, ALCANOILOXILO, HIDROXILO, HALO, TRIFLUOROMETILO, AMINO, MONO O DIALQUILAMINO, ALCANAMIDO O ALCANOSULFONAMIDO; O, R 1 SE DEFINE COMO LO ANTERIOR Y R 4 Y R SUP,5 , JUNTOS, SON METILENDIOXILO, ETILENDIOXILO O PROPILENDIOXILO ORTOSUSTITUIDOS; R 2 Y R 3 SON, INDEPENDIENTEM ENTE, HIDROGENO O ALQUILO; N ES 3 O 4; O SUS SALES FARMACEUTICAMENTE ACEPTABLES, SON UTILES EN EL TRATAMIENTO DE LA DEPRESION Y DE TRASTORNOS RELACIONADOS.
ES96937782T 1995-11-06 1996-10-29 Derivados de indolalquilo de la benzodioxanmetilamina como ligandos de los receptores 5-ht1a. Expired - Lifetime ES2166470T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US728495P 1995-11-06 1995-11-06

Publications (1)

Publication Number Publication Date
ES2166470T3 true ES2166470T3 (es) 2002-04-16

Family

ID=21725271

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96937782T Expired - Lifetime ES2166470T3 (es) 1995-11-06 1996-10-29 Derivados de indolalquilo de la benzodioxanmetilamina como ligandos de los receptores 5-ht1a.

Country Status (20)

Country Link
US (1) US5750724A (es)
EP (1) EP0861248B1 (es)
JP (1) JP2000500136A (es)
KR (1) KR19990067303A (es)
CN (1) CN1074414C (es)
AR (1) AR004229A1 (es)
AT (1) ATE210659T1 (es)
BR (1) BR9611406A (es)
CA (1) CA2236678A1 (es)
DE (1) DE69617995T2 (es)
DK (1) DK0861248T3 (es)
ES (1) ES2166470T3 (es)
HU (1) HUP9902091A3 (es)
IL (1) IL124095A (es)
MX (1) MX9803455A (es)
NZ (1) NZ321821A (es)
PT (1) PT861248E (es)
TW (1) TW498075B (es)
WO (1) WO1997017343A1 (es)
ZA (1) ZA969221B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6231833B1 (en) 1999-08-05 2001-05-15 Pfizer Inc 2,7-substituted octahydro-1H-pyrido[1,2-A]pyrazine derivatives as ligands for serotonin receptors
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US6121307A (en) 1998-04-08 2000-09-19 American Home Products Corp. N-aryloxyethyl-indoly-alkylamines for the treatment of depression
JP2002544223A (ja) * 1999-05-12 2002-12-24 ソルベイ・フアーマシユーチカルズ・ベー・ブイ 精神病性障害の治療方法
ATE299142T1 (de) 1999-08-23 2005-07-15 Solvay Pharm Bv Phenylpiperazin-derivate als inhibitoren der serotonin-wiederaufnahme
FR2799463B1 (fr) * 1999-10-12 2004-04-16 Adir Nouveaux composes cyano-indoles inhibiteurs de recapture de serotonine, leur procede de preparation et ces compositions pharmaceutiques qui les contiennent
AR032712A1 (es) * 2001-02-21 2003-11-19 Solvay Pharm Bv Un mesilato de derivados de fenilpiperazina y composiciones farmaceuticas que lo contienen
US6656951B2 (en) 2001-04-24 2003-12-02 Wyeth 8-aza-bicyclo[3.2.1]octan-3-ol derivatives of 2,3-dihydro-1,4-benzodioxan as 5-HT1A antagonists
EP1381600A1 (en) 2001-04-24 2004-01-21 Wyeth, A Corporation of the State of Delaware Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-benzodioxan
US7041683B2 (en) * 2001-04-24 2006-05-09 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1, 4-benzodiozan
US6656950B2 (en) * 2001-04-25 2003-12-02 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 1,4-dioxino[2,3-b]pyridine
US8106074B2 (en) 2001-07-13 2012-01-31 Pierre Fabre Medicament Pyridin-2-yl-methylamine derivatives for treating opiate dependence
WO2003031439A1 (en) 2001-10-05 2003-04-17 Wyeth Antidepressant chroman and chromene derivatives of 3-(1,2,3,6-tetrahydro-4-pyridinyl)-1h-indole
US6911445B2 (en) 2002-09-12 2005-06-28 Wyeth Antidepressant cycloalkylamine derivatives of heterocycle-fused benzodioxans
US6800637B2 (en) * 2002-09-12 2004-10-05 Wyeth Antidepressant indolealkyl derivatives of heterocycle-fused benzodioxan methylamines
US7227023B2 (en) 2003-04-30 2007-06-05 Wyeth Quinoline 3-amino chroman derivatives
AU2006214233A1 (en) * 2005-02-17 2006-08-24 Wyeth Cycloalkylfused indole, benzothiophene, benzofuran and indene derivatives
KR20100135325A (ko) 2008-04-29 2010-12-24 엔에스아베 필리알 아프 뉴로서치 스웨덴 아베 스베리게 도파민 신경전달의 조절제
AU2009242095A1 (en) 2008-04-29 2009-11-05 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Modulators of dopamine neurotransmission
EP2271635A1 (en) * 2008-04-29 2011-01-12 NSAB, Filial af NeuroSearch Sweden AB, Sverige Modulators of dopamine neurotransmission
CN103965186B (zh) * 2013-01-25 2016-05-18 江苏恩华药业股份有限公司 苯并二噁烷-苯并噁（噻）唑哌啶衍生物及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1054104A (es) * 1962-07-20
JPS58219114A (ja) * 1982-06-15 1983-12-20 Mitsubishi Chem Ind Ltd 血圧降下剤
DE3419935A1 (de) * 1984-05-28 1985-11-28 Merck Patent Gmbh, 6100 Darmstadt Verwendung von hydroxyindolderivaten bei der senkung des blutdrucks
US4910302A (en) * 1988-12-19 1990-03-20 American Home Products Corporation Psychotropic polycyclic imides
CA2043709C (en) * 1990-06-29 2002-01-22 David W. Smith Antimigraine alkoxypyrimidine derivatives
DE4101686A1 (de) * 1991-01-22 1992-07-23 Merck Patent Gmbh Indolderivate
FR2707294B1 (fr) * 1993-07-06 1995-09-29 Pf Medicament Nouveaux dérivés de la 3,5-dioxo-(2H,4H)-1,2,4-triazine, leur préparation et leur application en thérapeutique humaine.
DE19512639A1 (de) * 1995-04-05 1996-10-10 Merck Patent Gmbh Benzonitrile und -fluoride

Also Published As

Publication number Publication date
AU704216B2 (en) 1999-04-15
EP0861248A1 (en) 1998-09-02
DE69617995T2 (de) 2002-05-16
BR9611406A (pt) 1999-01-05
HUP9902091A2 (hu) 2000-02-28
JP2000500136A (ja) 2000-01-11
IL124095A (en) 2001-10-31
WO1997017343A1 (en) 1997-05-15
EP0861248B1 (en) 2001-12-12
HUP9902091A3 (en) 2000-03-28
AU7524596A (en) 1997-05-29
TW498075B (en) 2002-08-11
CN1074414C (zh) 2001-11-07
NZ321821A (en) 1999-07-29
KR19990067303A (ko) 1999-08-16
MX9803455A (es) 1998-09-30
ATE210659T1 (de) 2001-12-15
DK0861248T3 (da) 2002-04-08
US5750724A (en) 1998-05-12
ZA969221B (en) 1998-05-04
PT861248E (pt) 2002-05-31
HK1015366A1 (en) 1999-10-15
CN1205700A (zh) 1999-01-20
DE69617995D1 (de) 2002-01-24
CA2236678A1 (en) 1997-05-15
AR004229A1 (es) 1998-11-04

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