ES2058596T3 - Empleo de derivados de l-carnitina en el tratamiento terapeutico de alteraciones degenerativas del sistema nervioso. - Google Patents
Empleo de derivados de l-carnitina en el tratamiento terapeutico de alteraciones degenerativas del sistema nervioso.Info
- Publication number
- ES2058596T3 ES2058596T3 ES89830544T ES89830544T ES2058596T3 ES 2058596 T3 ES2058596 T3 ES 2058596T3 ES 89830544 T ES89830544 T ES 89830544T ES 89830544 T ES89830544 T ES 89830544T ES 2058596 T3 ES2058596 T3 ES 2058596T3
- Authority
- ES
- Spain
- Prior art keywords
- nervous system
- therapeutic treatment
- carnitine derivatives
- degenerative alterations
- degenerative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000004075 alteration Effects 0.000 title abstract 2
- 230000003412 degenerative effect Effects 0.000 title abstract 2
- 210000000653 nervous system Anatomy 0.000 title abstract 2
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical class C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- -1 AMINO Chemical class 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical class C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- HFHZKZSRXITVMK-UHFFFAOYSA-N oxyphenbutazone Chemical compound O=C1C(CCCC)C(=O)N(C=2C=CC=CC=2)N1C1=CC=C(O)C=C1 HFHZKZSRXITVMK-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
SE REVELA EL USO DE COMPONENTES DE FORMULA GENERAL: DONDE : Y ES HIDROGENO, METRIL O AMINO, Y R ES UN GRUPO ALQUIL SUSTITUIDO O NO SUSTITUIDO ELEGIDO ENTRE METIL, ETIL, 1-METILPROPIL, ISOBUTIL, MERCAPTOMETIL Y 3-GUANIDINOPROPIL Y LAS SALES FARMACEUTICAMENTE ACEPTABLES DE LO MISMO, PARA EL TRATAMIENTO DE LAS ALTERACIONES DEGENERATIVAS DEL SISTEMA NERVIOSO. LOS COMPUESTOS PUEDEN SER ADMINISTRADOS ORAL O PARENTERALMENTE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT8848717A IT1224842B (it) | 1988-12-27 | 1988-12-27 | Uso di derivati della l-carnitina nel trattamento terapeutico delle alterazioni degenerative del sistema nervoso |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2058596T3 true ES2058596T3 (es) | 1994-11-01 |
Family
ID=11268228
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES89830544T Expired - Lifetime ES2058596T3 (es) | 1988-12-27 | 1989-12-13 | Empleo de derivados de l-carnitina en el tratamiento terapeutico de alteraciones degenerativas del sistema nervioso. |
Country Status (9)
Country | Link |
---|---|
US (1) | US5043355A (es) |
EP (1) | EP0376899B1 (es) |
JP (1) | JP2828293B2 (es) |
AT (1) | ATE92316T1 (es) |
DE (1) | DE68908145T2 (es) |
ES (1) | ES2058596T3 (es) |
HK (1) | HK1005849A1 (es) |
IT (1) | IT1224842B (es) |
ZA (1) | ZA899802B (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1245699B (it) * | 1991-05-29 | 1994-10-14 | Sigma Tau Ind Farmaceuti | Derivati della l-carnitina quali agenti terapeutici per il trattamento delle miopatie, della degenarazione neuronale e per inibire la proteolisi |
IT1254314B (it) * | 1992-03-27 | 1995-09-14 | Sigma Tau Ind Farmaceuti | Composizioni farmaceutiche conyenenti l-carnitina e acil- carnitine inassociazione con ace-inibitori per il trattamento di patologie cardiovascolari. |
IT1263004B (it) * | 1992-10-08 | 1996-07-23 | Sigma Tau Ind Farmaceuti | Impiego della l-carnitina e acil l-carnitine nel trattamento a lungo termine di pazienti diabetici non insulino-dipendenti. |
IT1277898B1 (it) * | 1995-08-03 | 1997-11-12 | Mendes Srl | Uso di amminoacidi basici, di acil derivati di amminoacidi basici e di loro sali farmaceuticamente accettabili per la profilassi di malattie |
IT1276225B1 (it) * | 1995-10-17 | 1997-10-27 | Sigma Tau Ind Farmaceuti | Composizioni farmaceutiche contenenti l-carnitina e alcanoil l- carnitine in associazione con resveratrolo o suoi derivati utili per |
IT1276253B1 (it) | 1995-12-15 | 1997-10-27 | Sigma Tau Ind Farmaceuti | Composizione farmaceutica contenente l-carnitina o alcanoil l-carnitine per la prevenzione ed il trattamento di stati morbosi |
IT1283951B1 (it) * | 1996-03-15 | 1998-05-07 | Mendes Srl | Uso della acetil l-carnitina o dei suoi sali farmacologicamente accettabili per il trattamento terapeutico o la profilassi di |
IT1291113B1 (it) * | 1997-03-20 | 1998-12-29 | Sigma Tau Ind Farmaceuti | Composizione nutritiva terapeutica per soggetti affetti da diabete mellito |
US5863940A (en) | 1997-12-01 | 1999-01-26 | Sigma-Tau Healthscience S.P.A. | Medicament and therapeutical method for treating idiopathic asthenozoospermia |
US6090848A (en) * | 1997-12-01 | 2000-07-18 | Sigma-Tau Healthscience S.P.A. | Compositions and methods for increasing the concentration and/or motility of spermatozoa in humans |
ES2210705T5 (es) | 1998-03-19 | 2011-02-15 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Composición combinada que comprende una l-carnitina o una alcanoil-l-carnitina, un glucosaminoglucano y/o un constituyente del mismo. |
US8173618B2 (en) * | 2003-07-25 | 2012-05-08 | University Of Massachusetts | Formulations for reducing neuronal degeneration |
ITRM20040327A1 (it) * | 2004-07-01 | 2004-10-01 | Sigma Tau Ind Farmaceuti | Uso della acetil l-carnitina per la preparazione di un medicamento per il trattamento del dolore neuropatico in pazienti diabetici. |
US7842726B2 (en) * | 2005-09-30 | 2010-11-30 | Showa Denko K.K. | Carnitine derivative, salt thereof, external skin preparation and cosmetic material |
JP5047507B2 (ja) * | 2005-09-30 | 2012-10-10 | 昭和電工株式会社 | カルニチン誘導体及びその塩、皮膚外用剤ならびに化粧料 |
US8597640B2 (en) * | 2007-10-31 | 2013-12-03 | University Of Massachusetts Lowell | Over-the-counter vitamin/nutriceutical formulation that provides neuroprotection and maintains or improves cognitive performance in alzheimer's disease and normal aging |
WO2020092243A1 (en) * | 2018-10-29 | 2020-05-07 | Lonza Inc. | Method and composition for increasing the bioavailability of carnitine |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2903579A1 (de) * | 1978-02-03 | 1979-08-09 | Sigma Tau Ind Farmaceuti | Verwendung von acetylcarnitin und anderen acylderivaten des carnitins zur behandlung der hyperlipoproteinaemie und hyperlimpidaemie sowie arzneimittel |
IT1206954B (it) * | 1979-02-12 | 1989-05-17 | Sigma Tau Ind Farmaceuti | Agenti terapeutici a base di un acil derivato della carnitina per la cura di vasculopatie periferiche |
US4346107A (en) * | 1979-02-12 | 1982-08-24 | Claudio Cavazza | Pharmaceutical composition comprising acyl-carnitine for the treatment of impaired cerebral metabolism |
IT1116037B (it) * | 1979-04-23 | 1986-02-10 | Sigma Tau Ind Farmaceuti | Esteri e ammidi di acil carnitine loro procedimenti di preparazione e loro uso terapeutico |
IT1150396B (it) * | 1982-12-09 | 1986-12-10 | Sigma Tau Ind Farmaceuti | Impiego di alcanoil l-carnitine per il trattamento terapeutico di miopa tie e distrofie muscolari |
IT1181682B (it) * | 1985-06-11 | 1987-09-30 | Sigma Tau Ind Farmaceuti | Impiego di alcanoil l-carnitine per il trattamento terapeutico del parkinsonismo idiopatico o indotto |
IT1208753B (it) * | 1986-07-02 | 1989-07-10 | Sigma Tau Ind Farmaceuti | L-amminoacil derivati della l-carnitina, procedimento per la loro preparazione e composizioni farmaceutiche ad attivita' epatoprotettrice che li contengono |
IT1196564B (it) * | 1986-08-04 | 1988-11-16 | Sigma Tau Ind Farmaceuti | Impiego di acetil l-carnitina nel trattamento terapeutico delle neuropatie periferiche |
-
1988
- 1988-12-27 IT IT8848717A patent/IT1224842B/it active
-
1989
- 1989-12-13 AT AT89830544T patent/ATE92316T1/de not_active IP Right Cessation
- 1989-12-13 EP EP89830544A patent/EP0376899B1/en not_active Expired - Lifetime
- 1989-12-13 ES ES89830544T patent/ES2058596T3/es not_active Expired - Lifetime
- 1989-12-13 DE DE89830544T patent/DE68908145T2/de not_active Expired - Lifetime
- 1989-12-15 US US07/451,253 patent/US5043355A/en not_active Expired - Lifetime
- 1989-12-21 ZA ZA899802A patent/ZA899802B/xx unknown
- 1989-12-26 JP JP1338034A patent/JP2828293B2/ja not_active Expired - Lifetime
-
1998
- 1998-06-05 HK HK98104941A patent/HK1005849A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
IT8848717A0 (it) | 1988-12-27 |
EP0376899A2 (en) | 1990-07-04 |
US5043355A (en) | 1991-08-27 |
IT1224842B (it) | 1990-10-24 |
JPH02207020A (ja) | 1990-08-16 |
DE68908145T2 (de) | 1993-11-25 |
JP2828293B2 (ja) | 1998-11-25 |
EP0376899A3 (en) | 1991-09-18 |
ATE92316T1 (de) | 1993-08-15 |
HK1005849A1 (en) | 1999-01-29 |
EP0376899B1 (en) | 1993-08-04 |
ZA899802B (en) | 1990-11-28 |
DE68908145D1 (de) | 1993-09-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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