PT656209E - Derivados de melatonina para uso no tratamento de perturbacoes de dessincronizacao - Google Patents

Derivados de melatonina para uso no tratamento de perturbacoes de dessincronizacao

Info

Publication number
PT656209E
PT656209E PT94308467T PT94308467T PT656209E PT 656209 E PT656209 E PT 656209E PT 94308467 T PT94308467 T PT 94308467T PT 94308467 T PT94308467 T PT 94308467T PT 656209 E PT656209 E PT 656209E
Authority
PT
Portugal
Prior art keywords
perturbaces
dessincronization
treatment
melatonin derivatives
melatonin
Prior art date
Application number
PT94308467T
Other languages
English (en)
Inventor
Michael Edward Flaugh
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PT656209E publication Critical patent/PT656209E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PT94308467T 1993-11-18 1994-11-16 Derivados de melatonina para uso no tratamento de perturbacoes de dessincronizacao PT656209E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/154,903 US6180657B1 (en) 1993-11-18 1993-11-18 Melatonin derivatives for use in treating desynchronization disorders

Publications (1)

Publication Number Publication Date
PT656209E true PT656209E (pt) 2003-09-30

Family

ID=22553300

Family Applications (1)

Application Number Title Priority Date Filing Date
PT94308467T PT656209E (pt) 1993-11-18 1994-11-16 Derivados de melatonina para uso no tratamento de perturbacoes de dessincronizacao

Country Status (21)

Country Link
US (1) US6180657B1 (pt)
EP (1) EP0656209B1 (pt)
JP (1) JPH07196504A (pt)
KR (1) KR950013509A (pt)
CN (1) CN1100533C (pt)
AT (1) ATE239470T1 (pt)
AU (1) AU7777694A (pt)
CA (1) CA2135710C (pt)
CZ (1) CZ288834B6 (pt)
DE (1) DE69432626T2 (pt)
DK (1) DK0656209T3 (pt)
ES (1) ES2197904T3 (pt)
HU (1) HUT72070A (pt)
IL (1) IL111579A (pt)
NO (1) NO307364B1 (pt)
NZ (1) NZ264893A (pt)
PT (1) PT656209E (pt)
RU (1) RU2160101C2 (pt)
SG (1) SG77569A1 (pt)
UA (1) UA35588C2 (pt)
ZA (1) ZA948928B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0748627A3 (en) * 1995-06-14 1997-05-21 Lilly Co Eli Melatonin agonists for the treatment of benign forms of hyperplasia of the prostate
US7674816B2 (en) * 2003-12-23 2010-03-09 Abraxis Bioscience, Llc Substituted melatonin derivatives, process for their preparation, and methods of use
TWI402261B (zh) * 2006-06-19 2013-07-21 Takeda Pharmaceutical 三環化合物及其醫藥組成物
WO2009140754A1 (en) * 2008-05-19 2009-11-26 F. Hoffmann-La Roche Ag An anti-cancer cytotoxic monoclonal antibody
KR102411809B1 (ko) 2012-01-26 2022-06-22 반다 파마슈티칼즈, 인코퍼레이티드. 일주기 리듬 장애의 치료
US11918557B2 (en) 2012-01-26 2024-03-05 Vanda Pharmaceuticals Inc. Treatment of circadian rhythm disorders
EP3767297A1 (en) 2012-12-18 2021-01-20 Vanda Pharmaceuticals Inc. Method of determining tau and thereby determining whether a patient has a free-running circadian rhythm
RU2533965C1 (ru) * 2013-07-04 2014-11-27 Государственное бюджетное учреждение здравоохранения "Самарский областной гериатрический центр" Способ нормализации циркадианных ритмов человека
US11090285B2 (en) 2013-11-12 2021-08-17 Vanda Pharmaceuticals Inc Treatment of circadian rhythm disorders
US10376487B2 (en) 2013-11-12 2019-08-13 Vanda Pharmaceuticals Inc. Method of treatment
RU2655813C1 (ru) * 2017-06-09 2018-05-29 Федеральное государственное бюджетное учреждение науки "Институт токсикологии Федерального медико-биологического агентства" Средство коррекции и профилактики состояний, вызванных нарушением суточных ритмов

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4087444A (en) 1976-09-08 1978-05-02 Eli Lilly And Company Amides as ovulation inhibitors
US4600723A (en) 1983-05-18 1986-07-15 Monash University Method for minimizing disturbances in circadian rhythms of bodily performance and function
EP0126630B1 (en) * 1983-05-18 1987-09-16 Monash University The use of melatonin for the manufacture of a medicament
US4614807A (en) 1984-10-04 1986-09-30 Eli Lilly And Company 6,7-dihalomelatonins
US4687763A (en) 1985-02-25 1987-08-18 Massachusetts Institute Of Technology Composition and method for increasing levels or release of brain serotonin
IL79264A0 (en) 1986-06-27 1986-09-30 Univ Ramot Tryptamine derivatives,pharmaceutical compositions containing them and their use in an assay for melatonin receptors
US4997845A (en) 1987-02-02 1991-03-05 Eli Lilly And Company β-alkylmelatonins as ovulation inhibitors
US5093352A (en) 1988-11-14 1992-03-03 Whitby Research, Inc. Antidepressant agents
EP0375726A4 (en) 1987-08-17 1991-01-30 Whitby Research Incorporated Melatonin analogues
JPH0418034A (ja) * 1990-05-11 1992-01-22 Kanegafuchi Chem Ind Co Ltd 点眼組成物
US5242941A (en) 1990-12-04 1993-09-07 State Of Oregon Methods of treating circadian rhythm disorders
IT1251544B (it) 1991-05-13 1995-05-17 Gabriele Biella Composizioni farmaceutiche attive nella terapia dei disturbi del sonno comprendenti melatonina o un suo derivato in associazione con un derivato benzodiazepinico
AU660336B2 (en) * 1991-10-18 1995-06-22 Alza Corporation Device for the transdermal administration of melatonin
US5196435A (en) 1991-11-21 1993-03-23 Eli Lilly And Company Melatonin derivatives and combinations with antiestrogen compounds for treating mammalian breast carcinoma
IT1255199B (it) * 1992-07-01 1995-10-20 Franco Fraschini Farmaco sintetizzato analogo della melatonina particolarmente efficacenelle patologie che interferiscono con i ritmi circadiani
IT1254995B (it) * 1992-06-24 1995-10-11 Farmaco contenente melatonina e/o agonisti, con somministrazione particolarmente efficace nelle patologie che interferiscono con i ritmi circandiani
US5449683A (en) * 1992-10-01 1995-09-12 Massachussetts Institute Of Technology Methods of inducing sleep using melatonin

Also Published As

Publication number Publication date
ZA948928B (en) 1996-05-10
IL111579A (en) 1999-10-28
CN1100533C (zh) 2003-02-05
EP0656209A3 (en) 1995-10-11
CA2135710A1 (en) 1995-05-19
NO944340D0 (no) 1994-11-14
ES2197904T3 (es) 2004-01-16
RU94041028A (ru) 1996-09-20
IL111579A0 (en) 1995-01-24
ATE239470T1 (de) 2003-05-15
EP0656209B1 (en) 2003-05-07
NO944340L (no) 1995-05-19
CZ288834B6 (cs) 2001-09-12
EP0656209A2 (en) 1995-06-07
CN1107700A (zh) 1995-09-06
AU7777694A (en) 1995-05-25
HU9403299D0 (en) 1995-01-30
HUT72070A (en) 1996-03-28
JPH07196504A (ja) 1995-08-01
NO307364B1 (no) 2000-03-27
CA2135710C (en) 2007-07-10
DE69432626D1 (de) 2003-06-12
SG77569A1 (en) 2001-01-16
NZ264893A (en) 1997-06-24
RU2160101C2 (ru) 2000-12-10
DE69432626T2 (de) 2004-04-08
KR950013509A (ko) 1995-06-15
DK0656209T3 (da) 2003-09-01
US6180657B1 (en) 2001-01-30
CZ276494A3 (en) 1995-07-12
UA35588C2 (uk) 2001-04-16

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