EP0375726A4 - Melatonin analogues - Google Patents

Melatonin analogues

Info

Publication number
EP0375726A4
EP0375726A4 EP19880907911 EP88907911A EP0375726A4 EP 0375726 A4 EP0375726 A4 EP 0375726A4 EP 19880907911 EP19880907911 EP 19880907911 EP 88907911 A EP88907911 A EP 88907911A EP 0375726 A4 EP0375726 A4 EP 0375726A4
Authority
EP
European Patent Office
Prior art keywords
melatonin analogues
melatonin
analogues
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP19880907911
Other versions
EP0375726A1 (en
Inventor
Margarita L. Dubocovich
James V. Peck
Atef A. Helmy
Vithal J. Rajadhyaksha
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Whitby Research Inc
Original Assignee
Whitby Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Whitby Research Inc filed Critical Whitby Research Inc
Publication of EP0375726A1 publication Critical patent/EP0375726A1/en
Publication of EP0375726A4 publication Critical patent/EP0375726A4/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
EP19880907911 1987-08-17 1988-05-20 Melatonin analogues Ceased EP0375726A4 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US8629087A 1987-08-17 1987-08-17
US8606287A 1987-08-17 1987-08-17
US86290 1987-08-17
US86062 1987-08-17

Publications (2)

Publication Number Publication Date
EP0375726A1 EP0375726A1 (en) 1990-07-04
EP0375726A4 true EP0375726A4 (en) 1991-01-30

Family

ID=26774333

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19880907911 Ceased EP0375726A4 (en) 1987-08-17 1988-05-20 Melatonin analogues

Country Status (7)

Country Link
EP (1) EP0375726A4 (en)
KR (1) KR910006124B1 (en)
AU (1) AU616907B2 (en)
DK (1) DK42490A (en)
FI (1) FI900801A0 (en)
NO (1) NO173732C (en)
WO (1) WO1989001472A1 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK108022C (en) * 1964-10-15 1967-07-31 Svend Anton Hansen Wexel Method for fully or partially cutting the backbone of cut carcases, in particular pig carcasses, and plants for carrying out this method.
AU644367B2 (en) * 1989-05-17 1993-12-09 Applied Medical Research Ltd Use of melatonin derivatives for effecting contraception
US5071875A (en) * 1989-09-25 1991-12-10 Northwestern University Substituted 2-amidotetralins as melatonin agonists and antagonists
IT1251544B (en) * 1991-05-13 1995-05-17 Gabriele Biella PHARMACEUTICAL COMPOSITIONS ACTIVE IN THE THERAPY OF SLEEP DISORDERS INCLUDING MELATONIN OR A DERIVATIVE IN ASSOCIATION WITH A BENZODIAZEPINE DERIVATIVE
FR2680366B1 (en) * 1991-08-13 1995-01-20 Adir NOVEL ARYLETHYLAMINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
JPH07503232A (en) * 1991-10-18 1995-04-06 アルザ・コーポレーション Controlled transdermal administration of melatonin
US5206377A (en) * 1991-12-05 1993-04-27 Whitby Research, Inc. Compounds useful as antiproliferative agents
IT1255199B (en) * 1992-07-01 1995-10-20 Franco Fraschini SYNTHESIZED DRUG ANALOG OF MELATONIN PARTICULARLY EFFECTIVE IN THE PATHOLOGIES THAT INTERFER WITH CIRCADIAN RHYTHMS
US5300481A (en) * 1993-05-05 1994-04-05 The Regents Of The University Of California Methods for controlling flowering in plants
US6180657B1 (en) 1993-11-18 2001-01-30 Eli Lilly And Company Melatonin derivatives for use in treating desynchronization disorders
US5654325A (en) * 1993-11-18 1997-08-05 Eli Lilly And Company Melatonin derivatives for use in treating sleep disorders
FR2713636B1 (en) * 1993-12-07 1996-01-05 Adir New naphthalene derivatives, process for their preparation, and pharmaceutical compositions containing them.
US5403851A (en) * 1994-04-05 1995-04-04 Interneuron Pharmaceuticals, Inc. Substituted tryptamines, phenalkylamines and related compounds
EP0754183A1 (en) * 1994-04-07 1997-01-22 Cemaf Novel spiro[indole-pyrrolidine] derivatives as melatoninergic agonists, method for preparing same and use thereof as a drug
FR2718445B1 (en) * 1994-04-07 1996-06-28 Cemaf New derivatives of spiro [indole-pyrrolidine] melatonin agonists, process for their preparation and their use as medicaments.
FR2724170B1 (en) * 1994-09-02 1997-05-30 Cemaf NOVEL SPIRO (INDOLE-PYRROLIDINE) DERIVATIVES OF MELATONIN AGONISTS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS
ES2172415B2 (en) * 2000-07-28 2003-11-16 Univ Madrid Complutense TREATMENT OF GLAUCOMA AND OCULAR HYPERTENSION THROUGH A MELATONINE ANALOG.
AR035651A1 (en) * 2000-07-28 2004-06-23 Univ Madrid Complutense USE OF INDOL DERIVATIVES FOR THE MANUFACTURE OF A MEDICINAL PRODUCT TO REDUCE INTRAOCULAR PRESSURE AND A COMPOSITION
CA2440374A1 (en) 2001-03-14 2002-09-19 Takayuki Maruyama A pharmaceutical composition for the treatment of depression comprising the ep1 antagonist as active ingredient
FR2874611B1 (en) * 2004-08-31 2006-11-17 Servier Lab NOVEL IMIDAZOPYRIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
RU2011107443A (en) 2008-07-30 2012-09-10 Феррер Интернасионал С.А. (ES) INDACENE COMPOUNDS, PHARMACEUTICAL COMPOSITION AND A MEDICINE BASED ON THEM, A METHOD FOR PRODUCING THERE AND A METHOD FOR TREATING OR PREVENTING CONDITIONS CONCERNING SYSTEM RESEARCH,
KR101534523B1 (en) * 2013-04-30 2015-07-09 경희대학교 산학협력단 Cosmetic Composition for Skin Whitening Comprising 1,2,3,4-Tetrahydro-6-methoxy-1-oxo-beta-carboline
FR3065225B1 (en) 2017-04-12 2024-04-05 Patrick Choay Sas ADJUVANTS FREE OF CYTOKINES FOR CELL CULTURE MEDIA, PARTICULARLY FOR IN VITRO FERTILIZATION, OR FOR THE CULTURE OF FOLLICLES, MALE GERM CELLS OR EMBRYOS

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3370063A (en) * 1964-10-05 1968-02-20 Mcneilab Inc Substituted dimethoxy indoles and method of making the same
US3915990A (en) * 1973-03-13 1975-10-28 Nelson Res & Dev Tryptamines
US4087444A (en) * 1976-09-08 1978-05-02 Eli Lilly And Company Amides as ovulation inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO8901472A1 *

Also Published As

Publication number Publication date
KR910006124B1 (en) 1991-08-13
FI900801A0 (en) 1990-02-16
AU2309788A (en) 1989-03-09
DK42490A (en) 1990-04-17
NO900790D0 (en) 1990-02-19
DK42490D0 (en) 1990-02-16
AU616907B2 (en) 1991-11-14
NO173732B (en) 1993-10-18
NO900790L (en) 1990-03-26
EP0375726A1 (en) 1990-07-04
KR890701558A (en) 1989-12-20
WO1989001472A1 (en) 1989-02-23
NO173732C (en) 1994-01-26

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 19890814

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A4 Supplementary search report drawn up and despatched

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18R Application refused

Effective date: 19950710