ES8407050A1 - Un derivado de trifluormetil-espiro(imidazolidina-4,3'-indolina)-2,2'5-triona. - Google Patents

Un derivado de trifluormetil-espiro(imidazolidina-4,3'-indolina)-2,2'5-triona.

Info

Publication number
ES8407050A1
ES8407050A1 ES522295A ES522295A ES8407050A1 ES 8407050 A1 ES8407050 A1 ES 8407050A1 ES 522295 A ES522295 A ES 522295A ES 522295 A ES522295 A ES 522295A ES 8407050 A1 ES8407050 A1 ES 8407050A1
Authority
ES
Spain
Prior art keywords
derivatives
fluoroalkyl
pharmaceutical use
indoline derivatives
indoline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES522295A
Other languages
English (en)
Other versions
ES522295A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Publication of ES522295A0 publication Critical patent/ES522295A0/es
Publication of ES8407050A1 publication Critical patent/ES8407050A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE FLUORALQUILO.CONSISTE EN HACER REACCIONAR UNA INDOLINA-2,3-DIONA DE FORMULA (II) O UN COMPUESTO DE FORMULA (III), CON UN CIANURO DE METAL ALCALINO O CARBONATO DE AMONIO PARA OBTENER UN COMPUESTO DE FORMULA (I), REALIZANDO LA REACCION EN PRESENCIA DE UN DISOLVENTE TAL COMO ALCANOL 1 - 4C, ETILENGLICOL Y DIETILENGLICOL CON AGUA, Y A UNA TEMPERATURA DE 20 A 100JC, DONDE EL SUSTITUYENTE DEL ANILLO BENCENO A ESTA EN POSICION 5 O 7; EL ANILLO BENCENO B ES DIHALOGENOFENILO; RA ES FLUOR O CLORO; RB ES HIDROGENO;RC ES CLORO, BROMO O YODO; Y RF ES ACILO O TRI-(ALQUILO 1-4C) SILILO.TIENE PROPIEDADES FARMACEUTICAS POR SER UN POTENTE INHIBIDOR DEL ENZIMA ALDOSA REDUCTASA.
ES522295A 1982-05-11 1983-05-11 Un derivado de trifluormetil-espiro(imidazolidina-4,3'-indolina)-2,2'5-triona. Expired ES8407050A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8213651 1982-05-11
GB8231129 1982-11-01

Publications (2)

Publication Number Publication Date
ES522295A0 ES522295A0 (es) 1984-08-16
ES8407050A1 true ES8407050A1 (es) 1984-08-16

Family

ID=26282800

Family Applications (1)

Application Number Title Priority Date Filing Date
ES522295A Expired ES8407050A1 (es) 1982-05-11 1983-05-11 Un derivado de trifluormetil-espiro(imidazolidina-4,3'-indolina)-2,2'5-triona.

Country Status (12)

Country Link
US (1) US4539329A (es)
EP (1) EP0101149A1 (es)
AU (1) AU566869B2 (es)
CA (1) CA1201124A (es)
DK (1) DK190683A (es)
ES (1) ES8407050A1 (es)
FI (1) FI831439L (es)
GR (1) GR78145B (es)
IL (1) IL68572A (es)
NO (1) NO831654L (es)
NZ (1) NZ204189A (es)
PT (1) PT76652B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63132889A (ja) * 1986-11-21 1988-06-04 Tanabe Seiyaku Co Ltd キナゾリノン誘導体
US20030014951A1 (en) * 2001-07-20 2003-01-23 Ingersoll-Rand Company Horizontal separator tank for oil-flooded air compressor
US20090076049A1 (en) * 2006-02-07 2009-03-19 Astrazeneca Ab Novel Spiro [Imidazolidine-4, 3' -Indole] 2, 2', 5' (1H) Triones for Treatment of Conditions Associated with Vanilloid Receptor 1

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3767653A (en) * 1971-06-28 1973-10-23 Squibb & Sons Inc Thiazines
US4053613A (en) * 1975-09-17 1977-10-11 E. R. Squibb & Sons, Inc. 1,3,thiazolinyl and 1,3 thiazinyl substituted indolinones
AU532110B2 (en) * 1979-11-13 1983-09-15 Ici Ltd. Spiro(imidazolidine-4,3:-indoline)-2,2:5-trione derivatives
IE52879B1 (en) * 1981-05-12 1988-03-30 Ici Plc Pharmaceutical spiro-hydantoin derivatives
GB2098212B (en) * 1981-05-12 1984-11-14 Ici Plc Process for preparing 1'-substituted-spiro(imidazolidine)-4,3'-indoline-2,2',5-triones
IE53102B1 (en) * 1981-05-12 1988-06-22 Ici Plc Pharmaceutical spiro-succinimide derivatives
GB8312379D0 (en) * 1983-05-05 1983-06-08 Ici Plc Heterocyclic compounds

Also Published As

Publication number Publication date
DK190683A (da) 1983-11-12
ES522295A0 (es) 1984-08-16
IL68572A (en) 1986-01-31
NZ204189A (en) 1985-08-30
DK190683D0 (da) 1983-04-28
PT76652B (en) 1986-02-04
US4539329A (en) 1985-09-03
FI831439A0 (fi) 1983-04-27
IL68572A0 (en) 1983-09-30
CA1201124A (en) 1986-02-25
AU1383883A (en) 1983-11-17
GR78145B (es) 1984-09-26
AU566869B2 (en) 1987-11-05
PT76652A (en) 1983-06-01
EP0101149A1 (en) 1984-02-22
NO831654L (no) 1983-11-14
FI831439L (fi) 1983-11-12

Similar Documents

Publication Publication Date Title
ES8801790A1 (es) Un procedimiento para la preparacion de derivados de indol
GB9319938D0 (en) Heterocyclic derivatives
JPS57192314A (en) Cyclic imide, manufacture, nontoxic biodegradable precursor and pharmaceutical composition for treating or preventing diabetes or complication of galactosemia
MX9403088A (es) Composiciones farmaceuticas que contienen deriva- dos de indol y metodos de uso.
ES8407050A1 (es) Un derivado de trifluormetil-espiro(imidazolidina-4,3'-indolina)-2,2'5-triona.
GR3018711T3 (en) (p-Carbonylaminophenyl)-sulphonyl-nitromethane derivatives
ES8604843A1 (es) Un metodo para la preparacion de un derivado de acetileno
ES8500955A1 (es) Procedimiento para la preparacion de furobenzoisoxazoles.
AU576473B2 (en) Spiro(2h-1,4-benzodioxepin-3(5h)4'-piperidine and 3'- pyrrolidino) compounds
IE820237L (en) Imidazo-triazine derivatives
PL334188A1 (en) Derivatives of nitromethylthiobenzene as inhibitors of aldosic reductase
GB9016980D0 (en) Amidobenzenes
ES2150400A6 (es) Una composicion para el tratamiento de desordenes ulcerosos del tracto gastrointestinal.