ES8500955A1 - Procedimiento para la preparacion de furobenzoisoxazoles. - Google Patents

Procedimiento para la preparacion de furobenzoisoxazoles.

Info

Publication number
ES8500955A1
ES8500955A1 ES523990A ES523990A ES8500955A1 ES 8500955 A1 ES8500955 A1 ES 8500955A1 ES 523990 A ES523990 A ES 523990A ES 523990 A ES523990 A ES 523990A ES 8500955 A1 ES8500955 A1 ES 8500955A1
Authority
ES
Spain
Prior art keywords
loweralkyl
halo
hydrogen
carboxylic acids
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES523990A
Other languages
English (en)
Other versions
ES523990A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of ES8500955A1 publication Critical patent/ES8500955A1/es
Publication of ES523990A0 publication Critical patent/ES523990A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C07C45/513—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being an etherified hydroxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE FUROBENZOISOXAZOLES.CONSISTE EN LA PREPARACION DE COMPUESTOS DE FORMULA (I) DONDE X ES HIDROGENO, ALQUILO INFERIOR, HALOGENO, ALCOXI INFERIOR O TRIFLUORMETILO Y Z ES HIDROGENO, ALQUILO INFERIOR, HALOGENO, HIDROXI O ALCOXI, O SUS SALES FARMACEUTICAMENTE ACEPTABLES; PARA LO CUAL SE HACE REACCIONAR EL ACETATO DE LA OXIMA DEL 2,3-DIHIDRO-5-(O-FLUORBENZOIL)-6-HIDROXI-7-HALO-BENZOFURAN-2-CARBOXILATO DE ETILO CON HIDRURO SODICO EN UNA SOLUCION DE N.N-DIMETILFORMAMIDA.TIENE APLICACION COMO MEDICAMENTO POR SUS PROPIEDADES DIURETICAS.
ES523990A 1983-02-23 1983-07-08 Procedimiento para la preparacion de furobenzoisoxazoles. Granted ES523990A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/469,059 US4456612A (en) 1981-09-08 1983-02-23 Benzisoxazole carboxylic acids

Publications (2)

Publication Number Publication Date
ES8500955A1 true ES8500955A1 (es) 1984-11-01
ES523990A0 ES523990A0 (es) 1984-11-01

Family

ID=23862260

Family Applications (1)

Application Number Title Priority Date Filing Date
ES523990A Granted ES523990A0 (es) 1983-02-23 1983-07-08 Procedimiento para la preparacion de furobenzoisoxazoles.

Country Status (9)

Country Link
US (1) US4456612A (es)
EP (1) EP0119294B1 (es)
JP (1) JPS60500573A (es)
KR (1) KR850006389A (es)
AU (1) AU570642B2 (es)
CA (1) CA1205474A (es)
DE (1) DE3373656D1 (es)
ES (1) ES523990A0 (es)
WO (1) WO1984003199A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4490384A (en) * 1983-02-23 1984-12-25 Abbott Laboratories Benzisoxazole carboxylic acids
US4732906A (en) * 1985-04-08 1988-03-22 Chugai Seiyaki Kabushiki Kaisha Dioxolobenzizoxazole derivatives
US4791209A (en) * 1985-05-22 1988-12-13 Chugai Seiyako Kabushiki Kaisha Furobenzisoxazole derivatives
US20080250729A1 (en) * 2007-04-12 2008-10-16 Matthew Kriesel Acoustical and energy absorbent flooring underlayment
CN102267964B (zh) * 2011-06-15 2014-06-18 浙江师范大学 3-羟基-2,3-二氢苯并呋喃衍生物及其合成方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2178815A1 (en) * 1972-04-07 1973-11-16 Delalande Sa Furo-benzoxazole derivs - analgesics, vasodilators, diuretics, etc
US3878207A (en) * 1973-10-11 1975-04-15 Delalande Sa Novel amine derivatives of 4,8 dimethoxy furo (3{40 ,2{40 -f) benzoxazole
US4100294A (en) * 1976-12-06 1978-07-11 Merck & Co., Inc. 5-(Hydroxy (substituted) methyl)-2,3-dihydrobenzo furan-2-carboxylic acid and its derivatives

Also Published As

Publication number Publication date
CA1205474A (en) 1986-06-03
JPS60500573A (ja) 1985-04-25
DE3373656D1 (de) 1987-10-22
EP0119294A1 (en) 1984-09-26
AU570642B2 (en) 1988-03-24
AU1778883A (en) 1984-09-10
KR850006389A (ko) 1985-10-05
WO1984003199A1 (en) 1984-08-30
US4456612A (en) 1984-06-26
ES523990A0 (es) 1984-11-01
EP0119294B1 (en) 1987-09-16

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