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Otsuka Pharmaceutical Co Ltd
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Otsuka Pharmaceutical Co Ltd
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Priority claimed from JP22107084Aexternal-prioritypatent/JPS61100568A/ja
Application filed by Otsuka Pharmaceutical Co LtdfiledCriticalOtsuka Pharmaceutical Co Ltd
Publication of ES548040A0publicationCriticalpatent/ES548040A0/es
Publication of ES8706121A1publicationCriticalpatent/ES8706121A1/es
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR DERIVADOS ACIDO 1-FENIL SUSTITUIDO-4-OXOQUINOLIN-2-CARBOXILICO. CONSISTE EN HACER REACCIONAR A UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (H-R1), EN DICLOROMETANO, EN PRESENCIA DE UN ACEPTOR DE ACIDO, ENTRE 100 Y 250JC, A UNA PRESION ENTRE 1 Y 20 ATMOSFERAS Y DURANTE 1 A 20 HORAS, PARA PRODUCIR UN COMPUESTO DE FORMULA (I) Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. SIENDO: R1, UN GRUPO DE FORMULA (IV); R2, UN GRUPO DE FORMULA (IV); R3, H O ALQUILO DE C 1 A 2; R4, HIDROXI O ALCARBOXI DE C 1 A 6; R4A, HIDROXI, ALCOXI DE C 1 A 6 Y OTROS; Y R5 Y X, H O F. SE UTILIZAN COMO ANTIMICROBIANOS.
ES548040A1984-10-191985-10-18Un procedimiento para la preparacion de derivados de acido-1-fenil sustituido-4-oxoquinolin-2-carboxilico.
ExpiredES8706121A1
(es)