ES8604571A1 - Un derivado de indol-3-carboxamida - Google Patents

Un derivado de indol-3-carboxamida

Info

Publication number
ES8604571A1
ES8604571A1 ES538418A ES538418A ES8604571A1 ES 8604571 A1 ES8604571 A1 ES 8604571A1 ES 538418 A ES538418 A ES 538418A ES 538418 A ES538418 A ES 538418A ES 8604571 A1 ES8604571 A1 ES 8604571A1
Authority
ES
Spain
Prior art keywords
alkyl
indole
halogen
carboxamide derivatives
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES538418A
Other languages
English (en)
Other versions
ES538418A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Welfide Corp
Original Assignee
Welfide Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Welfide Corp filed Critical Welfide Corp
Publication of ES538418A0 publication Critical patent/ES538418A0/es
Publication of ES8604571A1 publication Critical patent/ES8604571A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S47/00—Plant husbandry
    • Y10S47/01—Methods of plant-breeding and including chromosome multiplication

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

METODO PARA LA PREPARACION DE UN DERIVADO DE INDOL-3-CARBOXAMIDA. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), EN UN DISOLVENTE INERTE, A LA TEMPERATURA AMBIENTE Y EN PRESENCIA D EUN AGENTE CONDENSANTE COMO UNA CARBOIIMIDA, DIFENILDOSFORILAZIDA O UN SAL DE PIRIDINIO CUATERNARIA, CUANDO LOS COMPUESTOS (II) CON ACIDOS CARBOXILICOS, PARA OBTENER COMPUESTOS DE FORMULA (I) Y OPCIONALMENTE SUS SALES DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLES. SIENDO: R1, H, UN GRUPO ALQUILO DE C1-4 O UN GRUPO FENILO OPCIONALMENTE SUSTITUIDO; R2, H O UN GRUPO ALQUILO C1-4; R3, H, UN ATOMO DE HALOGENO U OTROS; R4, H, GRUPO ALQUILO C1-4, UN GRUPO CICLOALQUILO C3-7, UN GRUPO ALILO O UN GRUPO BENCILO OPCIONALMENTE SUSTITUIDO; R5, H O UN GRUPO ALQUILO C1-4; M ES 0 O 1; Y N, 1, 2 O 3. SE UTILIZAN COMO FARMACOS PARA EL TRATAMIENTO DE LA ULCERA GASTRICA.
ES538418A 1983-12-08 1984-12-07 Un derivado de indol-3-carboxamida Expired ES8604571A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP58232514A JPS60123485A (ja) 1983-12-08 1983-12-08 インド−ル−３−カルボキサミド誘導体

Publications (2)

Publication Number Publication Date
ES538418A0 ES538418A0 (es) 1986-02-01
ES8604571A1 true ES8604571A1 (es) 1986-02-01

Family

ID=16940520

Family Applications (1)

Application Number Title Priority Date Filing Date
ES538418A Expired ES8604571A1 (es) 1983-12-08 1984-12-07 Un derivado de indol-3-carboxamida

Country Status (8)

Country Link
US (1) US4616009A (es)
EP (1) EP0144986B1 (es)
JP (1) JPS60123485A (es)
KR (1) KR910006863B1 (es)
AT (1) ATE25682T1 (es)
CA (1) CA1279319C (es)
DE (1) DE3462504D1 (es)
ES (1) ES8604571A1 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8814277D0 (en) * 1988-06-16 1988-07-20 Glaxo Group Ltd Chemical compounds
NZ230068A (en) * 1988-07-29 1991-07-26 Dainippon Pharmaceutical Co Indazole-3-carboxylic acid esters and amides of diaza compounds having 6,7, or 8 ring members: preparatory processes and pharmaceutical compositions
US5166341A (en) * 1988-07-29 1992-11-24 Dainippon Pharmaceutical Co., Ltd. 6-amino-1,4-hexahydro-1H-diazepine derivatives
JPH0255357U (es) * 1988-10-07 1990-04-20
CA2030051C (en) * 1989-11-17 2001-08-07 Haruhiko Kikuchi Indole derivatives
JPH03206584A (ja) * 1990-01-09 1991-09-09 Nec Home Electron Ltd Ｉｃカードのロック機構
US5189054A (en) * 1990-11-02 1993-02-23 Merrell Dow Pharmaceuticals Inc. 3-amidoindolyl derivatives and pharmaceutical compositions thereof
CA2054339C (en) * 1990-11-02 2002-12-24 Francesco G. Salituro 3-amidoindolyl derivatives
GB9103862D0 (en) * 1991-02-25 1991-04-10 Glaxo Group Ltd Chemical compounds
US5852014A (en) * 1992-03-12 1998-12-22 Smithkline Beecham P.L.C. Condensed indole derivatives as 5HT4 -receptor antagonists
US5998409A (en) * 1992-03-12 1999-12-07 Smithkline Beecham Plc Condensed indole derivatives as 5HT4 -receptor antagonists
JP3037108U (ja) * 1996-10-22 1997-05-06 カシオ計算機株式会社 電子機器におけるロック機構
US7247729B2 (en) * 2001-09-10 2007-07-24 Mercian Corporation Method for producing pipecolamide derivative
CA2529622A1 (en) * 2003-07-02 2005-01-20 Sugen, Inc. Indolinone hydrazides as c-met inhibitors
US20070219206A1 (en) * 2005-11-04 2007-09-20 Amira Pharmaceuticals, Inc. 5-lipoxygenase-activating protein (flap) inhibitors
US8399666B2 (en) * 2005-11-04 2013-03-19 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
UA95084C2 (en) * 2005-11-04 2011-07-11 Амира Фармасутикалз, Инк. 5-lipoxygenase-activating protein (flap) inhibitors
US20070244128A1 (en) * 2005-11-04 2007-10-18 Amira Pharmaceuticals, Inc. 5-lipoxygenase-activating protein (flap) inhibitors
US7977359B2 (en) * 2005-11-04 2011-07-12 Amira Pharmaceuticals, Inc. 5-lipdxygenase-activating protein (FLAP) inhibitors
US20070225285A1 (en) * 2005-11-04 2007-09-27 Amira Pharmaceuticals, Inc. 5-lipoxygenase-activating protein (flap) inhibitors
GB2431927B (en) * 2005-11-04 2010-03-17 Amira Pharmaceuticals Inc 5-Lipoxygenase-activating protein (FLAP) inhibitors
TW200920369A (en) * 2007-10-26 2009-05-16 Amira Pharmaceuticals Inc 5-lipoxygenase activating protein (flap) inhibitor
KR20160129109A (ko) * 2008-05-23 2016-11-08 아미라 파마슈티칼스 인코포레이티드 5-리폭시게나아제 활성화 단백질 억제제
US8546431B2 (en) 2008-10-01 2013-10-01 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
ES2750868T3 (es) 2015-09-10 2020-03-27 Suven Life Sciences Ltd Derivados de fluoroindol como moduladores alostéricos positivos del receptor muscarínico M1

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1173148A (fr) * 1956-03-19 1959-02-20 Rhone Poulenc Sa Nouveaux dérivés de l'indole et leur préparation
US3136770A (en) * 1960-04-01 1964-06-09 Neisler Lab Inc Indolyl substituted piperidines
US3238215A (en) * 1963-10-17 1966-03-01 Sterling Drug Inc 1-[(3-, 2-, and 1-indolyl)-lower-alkyl-, lower-alkenyl-, and lower-alkynyl]piperidines
GB1273563A (en) * 1968-07-24 1972-05-10 Wyeth John & Brother Ltd Indoles
GB1345872A (en) * 1970-09-03 1974-02-06 Wyeth John & Brother Ltd Amino-and acylamino-pyridine and hydropyridine derivatives
GB1543619A (en) * 1976-03-12 1979-04-04 Wyeth John & Brother Ltd Process for preparing 3-(heterocycloalkyl)-indole derivatives

Also Published As

Publication number Publication date
DE3462504D1 (de) 1987-04-09
EP0144986A2 (en) 1985-06-19
ES538418A0 (es) 1986-02-01
CA1279319C (en) 1991-01-22
ATE25682T1 (de) 1987-03-15
JPS6348272B2 (es) 1988-09-28
JPS60123485A (ja) 1985-07-02
US4616009A (en) 1986-10-07
EP0144986B1 (en) 1987-03-04
EP0144986A3 (en) 1985-07-24
KR850004482A (ko) 1985-07-15
KR910006863B1 (ko) 1991-09-09

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19960603