ES8608887A1 - Procedimiento para la obtencion de preparados combinados antihipertensores y antianginicos a base de dihidropiridina y bloquear beta. - Google Patents

Procedimiento para la obtencion de preparados combinados antihipertensores y antianginicos a base de dihidropiridina y bloquear beta.

Info

Publication number
ES8608887A1
ES8608887A1 ES545522A ES545522A ES8608887A1 ES 8608887 A1 ES8608887 A1 ES 8608887A1 ES 545522 A ES545522 A ES 545522A ES 545522 A ES545522 A ES 545522A ES 8608887 A1 ES8608887 A1 ES 8608887A1
Authority
ES
Spain
Prior art keywords
mixture
drug
application
manufacturing process
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES545522A
Other languages
English (en)
Other versions
ES545522A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6241524&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8608887(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES545522A0 publication Critical patent/ES545522A0/es
Publication of ES8608887A1 publication Critical patent/ES8608887A1/es
Expired legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

METODO DE PREPARACION DE COMPOSICIONES A BASE DE DIHIDROPIRIDINA Y BLOQUEADOR BETA, QUE TIENEN APLICACIONES FARMACOLOGICAS POR SU EFECTO ANTIHIPERTENSOR Y ANTIANGINICO. COMPRENDE LA REACCION DE UN ACIDO CETOCARBOXILICO DE FORMULA (I) O (II), CON UN ALDEHIDO DE FORMULA (III), EN PRESENCIA DE SALES DE ACETATO DE AMINAS COMO CATALIZADOR, FORMULAS EN LAS QUE R1-R5 PUEDEN SER VARIOS TIPOS DE RADICALES; TRATAMIENTO DEL ILIDEN-COMPUESTO FORMADO CON UNA ENAMINA ADECUADA PARA FORMAR UNA DIHIDROPIRIDINA; COMBINACION DE ESTA CON UN BLOQUEADOR BETA SIN EFECTO ANESTESICO LOCAL, Y TRANSFORMACION DE AMBOS COMPONENTES EN UNA FORMA DE APLICACION ADECUADA.
ES545522A 1984-07-25 1985-07-24 Procedimiento para la obtencion de preparados combinados antihipertensores y antianginicos a base de dihidropiridina y bloquear beta. Expired ES8608887A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843427402 DE3427402A1 (de) 1984-07-25 1984-07-25 Neues kombinationspraeparat, verfahren zu seiner herstellung und seine verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
ES545522A0 ES545522A0 (es) 1986-07-16
ES8608887A1 true ES8608887A1 (es) 1986-07-16

Family

ID=6241524

Family Applications (1)

Application Number Title Priority Date Filing Date
ES545522A Expired ES8608887A1 (es) 1984-07-25 1985-07-24 Procedimiento para la obtencion de preparados combinados antihipertensores y antianginicos a base de dihidropiridina y bloquear beta.

Country Status (12)

Country Link
EP (1) EP0169470A3 (es)
JP (1) JPS6144816A (es)
KR (1) KR860000870A (es)
AU (1) AU576608B2 (es)
CA (1) CA1255596A (es)
DE (1) DE3427402A1 (es)
DK (1) DK338185A (es)
ES (1) ES8608887A1 (es)
GR (1) GR851823B (es)
IL (1) IL75873A (es)
PT (1) PT80852B (es)
ZA (1) ZA855584B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3424553A1 (de) * 1984-07-04 1986-01-09 Bayer Ag, 5090 Leverkusen Feste arzneizubereitungen mit dihydropyridinen und verfahren zu ihrer herstellung
DE3447170A1 (de) * 1984-12-22 1986-07-03 Bayer Ag, 5090 Leverkusen Mischung unterschiedlicher dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
DE3610037A1 (de) * 1986-03-21 1987-09-24 Schering Ag Nifedipinkombinationspraeparat
IE59540B1 (en) * 1987-01-09 1994-03-09 Elan Corp Sustained release capsule or tablet formulation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2084017B (en) * 1980-09-18 1984-08-22 Sandoz Ltd Pharmaceutical compositions effective against coronary heat disease and hypertension
DE3419130A1 (de) * 1984-05-23 1985-11-28 Bayer Ag, 5090 Leverkusen Nifedipinkombinationspraeparate und verfahren zu ihrer herstellung
DE3419131A1 (de) * 1984-05-23 1985-11-28 Bayer Ag, 5090 Leverkusen Dihydropyridinkombinationspraeparate und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
DK338185D0 (da) 1985-07-24
CA1255596A (en) 1989-06-13
IL75873A0 (en) 1985-11-29
JPS6144816A (ja) 1986-03-04
ES545522A0 (es) 1986-07-16
DK338185A (da) 1986-01-26
ZA855584B (en) 1986-03-26
DE3427402A1 (de) 1986-01-30
EP0169470A3 (de) 1988-11-02
EP0169470A2 (de) 1986-01-29
AU4528585A (en) 1986-01-30
IL75873A (en) 1988-11-30
PT80852A (en) 1985-08-01
KR860000870A (ko) 1986-02-20
GR851823B (es) 1985-11-26
PT80852B (pt) 1987-11-30
AU576608B2 (en) 1988-09-01

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Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960506