ES8606375A1 - Un procedimiento para preparar un derivado de aminoprpilaminobleomicina - Google Patents
Un procedimiento para preparar un derivado de aminoprpilaminobleomicinaInfo
- Publication number
- ES8606375A1 ES8606375A1 ES533688A ES533688A ES8606375A1 ES 8606375 A1 ES8606375 A1 ES 8606375A1 ES 533688 A ES533688 A ES 533688A ES 533688 A ES533688 A ES 533688A ES 8606375 A1 ES8606375 A1 ES 8606375A1
- Authority
- ES
- Spain
- Prior art keywords
- aminobutylamino
- propylamino
- medicaments
- novel
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
- C07K9/003—Peptides being substituted by heterocyclic radicals, e.g. bleomycin, phleomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR UN DERIVADO DE AMINOPROPILAMINOBLEOMICINA. CONSISTE EN SOMETER A UN COMPUESTO DE FORMULA (II) A UNA CONDENSACION REDCUCTORA CON UN COMPUESTO DE CARBONILO DE FORMULA (III) EN METANOL, AGUA Y OTROS, A UNA TEMPERATURA ENTRE 0 Y 50JC Y DURANTE 3 A 70 HORAS, PARA OBTENER UN COMPUESTO DE FORMULA (I) SIENDO: A UN GRUPO DE FORMULA (IV); AK UN GRUPO DE FORMULA (VI); B UN GRUPO DE FORMULA (V); BX RADICAL QUE QUEDA DESPUES DE SEPARAR UN GRUPO HIDROXILO DEL GRUPO CARBOXILO DEL ACIDO BLEOMICINICO; R1 ES H, GRUPO ALQUILO DE C 1 A 10, Y OTROS; R2 ES UN GRUPO ALQUILO INFERIOR O UN GRUPO BENCILO; R3 Y R4, SON H, GRUPO ALQUILO CON C 5 A 10, Y OTROS; R5 Y R6 SON H, GRUPO ALQUILO DE C 4 A 9, Y OTROS, Y R1K ES H, GRUPO ALQUILO INFERIOR, Y OTROS. SE UTILIZA PARA TRATAR EL CARCINOMA CELULAR ESCAMOSO Y OTROS TIPOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP58114257A JPS606698A (ja) | 1983-06-27 | 1983-06-27 | 新規な3−(4′−アミノブチルアミノ)プロピルアミノブレオマイシン誘導体及びその製造法 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8606375A1 true ES8606375A1 (es) | 1986-04-01 |
ES533688A0 ES533688A0 (es) | 1986-04-01 |
Family
ID=14633251
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES533688A Expired ES8606375A1 (es) | 1983-06-27 | 1984-06-25 | Un procedimiento para preparar un derivado de aminoprpilaminobleomicina |
Country Status (10)
Country | Link |
---|---|
US (1) | US4808703A (es) |
EP (1) | EP0135675B1 (es) |
JP (1) | JPS606698A (es) |
AT (1) | ATE32514T1 (es) |
CA (1) | CA1270600A (es) |
DE (1) | DE3469358D1 (es) |
DK (1) | DK311284A (es) |
ES (1) | ES8606375A1 (es) |
GR (1) | GR81639B (es) |
ZA (1) | ZA844850B (es) |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US30451A (en) * | 1860-10-23 | Clothes-squeezer | ||
GB1292081A (en) | 1969-02-15 | 1972-10-11 | Zaidan Hojin Biseibutsu | Process for producing bleomycin antibiotics |
US3922262A (en) * | 1971-04-28 | 1975-11-25 | Nippon Kayaku Kk | N-Substituted derivatives of bleomycins |
-
1983
- 1983-06-27 JP JP58114257A patent/JPS606698A/ja active Granted
-
1984
- 1984-06-21 EP EP84107138A patent/EP0135675B1/en not_active Expired
- 1984-06-21 US US06/622,884 patent/US4808703A/en not_active Expired - Fee Related
- 1984-06-21 AT AT84107138T patent/ATE32514T1/de not_active IP Right Cessation
- 1984-06-21 DE DE8484107138T patent/DE3469358D1/de not_active Expired
- 1984-06-25 ES ES533688A patent/ES8606375A1/es not_active Expired
- 1984-06-26 CA CA000457427A patent/CA1270600A/en not_active Expired - Fee Related
- 1984-06-26 GR GR75112A patent/GR81639B/el unknown
- 1984-06-26 ZA ZA844850A patent/ZA844850B/xx unknown
- 1984-06-26 DK DK311284A patent/DK311284A/da not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
ATE32514T1 (de) | 1988-03-15 |
DK311284A (da) | 1984-12-28 |
ZA844850B (en) | 1985-02-27 |
JPH03880B2 (es) | 1991-01-09 |
CA1270600A (en) | 1990-06-19 |
EP0135675A1 (en) | 1985-04-03 |
DK311284D0 (da) | 1984-06-26 |
GR81639B (es) | 1984-12-11 |
JPS606698A (ja) | 1985-01-14 |
DE3469358D1 (en) | 1988-03-24 |
ES533688A0 (es) | 1986-04-01 |
EP0135675B1 (en) | 1988-02-17 |
US4808703A (en) | 1989-02-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970203 |