GB1292081A - Process for producing bleomycin antibiotics - Google Patents

Process for producing bleomycin antibiotics

Info

Publication number
GB1292081A
GB1292081A GB5666/70A GB566670A GB1292081A GB 1292081 A GB1292081 A GB 1292081A GB 5666/70 A GB5666/70 A GB 5666/70A GB 566670 A GB566670 A GB 566670A GB 1292081 A GB1292081 A GB 1292081A
Authority
GB
United Kingdom
Prior art keywords
bleomycin
group
antibiotics
compound
partial formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5666/70A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP1077469A external-priority patent/JPS4832354B1/ja
Priority claimed from JP44087589A external-priority patent/JPS4832355B1/ja
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Publication of GB1292081A publication Critical patent/GB1292081A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • C07K9/003—Peptides being substituted by heterocyclic radicals, e.g. bleomycin, phleomycin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Abstract

1292081 Bleomycin antibiotics ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI 5 Feb 1970 [15 Feb 1969 4 Nov 1969] 5666/70 Heading C2A Novel bleomycin antibiotics having antitumour and microbicidal activity and characterized by having an ultra-violet absorption peak at 243 to 244 mÁ and an ultra-violet absorption maximum at 290 to 295 mÁ and a partial Formula (I) wherein R is one of the following groups and also known bleomycin antibiotics A 2 , A<SP>1</SP> 2 , A 5 , A 6 , B 2 and B 4 , which have a partial Formula (I) as above, wherein R is respectively are prepared by aerobically cultivating a bleomycin-producing strain of Streptomyces verticillus in a nutrient medium in the presence of an amino compound having at least one group of structure and in addition at least one amino, imino, guanidino, amidino, sulphonium or nitrogencontaining heterocyclic group, or in the presence of a compound which is convertible during the cultivation to such an amino compound, to produce a bleomycin compound containing a side chain R in the partial Formula (I) above, derived from the said amino compound by removal of a, hydrogen atom from the amine group of the group.
GB5666/70A 1969-02-15 1970-02-05 Process for producing bleomycin antibiotics Expired GB1292081A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP1077469A JPS4832354B1 (en) 1969-02-15 1969-02-15
JP44087589A JPS4832355B1 (en) 1969-11-04 1969-11-04

Publications (1)

Publication Number Publication Date
GB1292081A true GB1292081A (en) 1972-10-11

Family

ID=26346103

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5666/70A Expired GB1292081A (en) 1969-02-15 1970-02-05 Process for producing bleomycin antibiotics

Country Status (20)

Country Link
US (1) USRE30451E (en)
AT (1) AT295743B (en)
BE (1) BE745926A (en)
BG (1) BG17632A3 (en)
CA (1) CA923055A (en)
CH (1) CH545343A (en)
CS (1) CS150904B2 (en)
DE (1) DE2006446C3 (en)
DK (1) DK123605B (en)
ES (1) ES376555A1 (en)
FI (1) FI46178C (en)
FR (1) FR2034552B1 (en)
GB (1) GB1292081A (en)
IL (1) IL33879A (en)
NL (1) NL147187B (en)
NO (1) NO132875C (en)
PL (1) PL80837B1 (en)
RO (1) RO54829A (en)
SE (1) SE360677B (en)
YU (1) YU36389B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3846400A (en) * 1969-02-15 1974-11-05 Microbial Chem Res Found Novel process for producing antibiotics bleomycin
GB1292081A (en) 1969-02-15 1972-10-11 Zaidan Hojin Biseibutsu Process for producing bleomycin antibiotics
JPS5739751B2 (en) * 1972-03-03 1982-08-23
FR2199456A2 (en) * 1972-09-20 1974-04-12 Microbial Chem Res Found Bleomycin derivs
FR2199455A2 (en) * 1972-09-20 1974-04-12 Nippon Kayaku Kk Bleomycin derivs
GB1540466A (en) * 1975-10-29 1979-02-14 Meiji Seika Kaisha Antibiotic polypeptides sf-1771 and sf-1881-b and production thereof
CA1090728A (en) * 1976-02-04 1980-12-02 Eli Lilly And Company Antibiotic a-7413 mixture comprising factors a,b,c and d and a process for producing it
US4246400A (en) * 1979-07-13 1981-01-20 Bristol-Myers Company Tallysomycin compounds
JPS58116496A (en) 1981-12-29 1983-07-11 Nippon Kayaku Co Ltd Amide n-substituted bleomycins
JPS58116497A (en) * 1981-12-29 1983-07-11 Microbial Chem Res Found Aminopropylaminobleomycin derivative and its preparation
JPS606698A (en) 1983-06-27 1985-01-14 Microbial Chem Res Found Novel 3-(4'-aminobutylamino)propylamino-bleomycin derivative and its preparation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3846400A (en) * 1969-02-15 1974-11-05 Microbial Chem Res Found Novel process for producing antibiotics bleomycin
GB1292081A (en) 1969-02-15 1972-10-11 Zaidan Hojin Biseibutsu Process for producing bleomycin antibiotics

Also Published As

Publication number Publication date
CA923055A (en) 1973-03-20
BG17632A3 (en) 1973-11-10
SE360677B (en) 1973-10-01
NO132875B (en) 1975-10-13
RO54829A (en) 1973-07-20
BE745926A (en) 1970-07-16
DE2006446B2 (en) 1977-09-29
YU35870A (en) 1981-11-13
FI46178C (en) 1973-01-10
NL147187B (en) 1975-09-15
FR2034552B1 (en) 1974-01-11
NL7002104A (en) 1970-08-18
USRE30451E (en) 1980-12-16
PL80837B1 (en) 1975-08-30
FR2034552A1 (en) 1970-12-11
YU36389B (en) 1983-06-30
CH545343A (en) 1973-12-15
FI46178B (en) 1972-10-02
ES376555A1 (en) 1972-06-16
DK123605B (en) 1972-07-10
AT295743B (en) 1972-01-10
IL33879A (en) 1973-05-31
DE2006446C3 (en) 1978-08-31
DE2006446A1 (en) 1970-10-22
CS150904B2 (en) 1973-09-17
IL33879A0 (en) 1970-04-20
NO132875C (en) 1976-01-21

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PE20 Patent expired after termination of 20 years