ES376555A1 - Novel process for producing antibiotics bleomycin - Google Patents
Novel process for producing antibiotics bleomycinInfo
- Publication number
- ES376555A1 ES376555A1 ES376555A ES376555A ES376555A1 ES 376555 A1 ES376555 A1 ES 376555A1 ES 376555 A ES376555 A ES 376555A ES 376555 A ES376555 A ES 376555A ES 376555 A1 ES376555 A1 ES 376555A1
- Authority
- ES
- Spain
- Prior art keywords
- bleomycin
- compound
- amino compound
- amino
- culture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
- C07K9/003—Peptides being substituted by heterocyclic radicals, e.g. bleomycin, phleomycin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Procedure to produce antibiotic bleomycin by aerobically inoculating and cultivating, in a medium containing a nutrient source, a bleomycin-producing strain belonging to the actinomycetes, where the culture is carried out in the presence of an amino compound having at least one group (see formula) and at least one basic group chosen from the amino, imino, guanidino, amidino and sulfonium groups, and cyclic nitrogen-containing compounds, or in the presence of a convertible compound, in the culture liquid, into such an amino compound as above, thereby selectively producing a known or new bleomycin component, corresponding to said amino compound or to an amino compound derived from the aforementioned compound, and then known or new bleomycin is recovered from the culture medium by known means. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1077469A JPS4832354B1 (en) | 1969-02-15 | 1969-02-15 | |
| JP44087589A JPS4832355B1 (en) | 1969-11-04 | 1969-11-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES376555A1 true ES376555A1 (en) | 1972-06-16 |
Family
ID=26346103
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES376555A Expired ES376555A1 (en) | 1969-02-15 | 1970-02-13 | Novel process for producing antibiotics bleomycin |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | USRE30451E (en) |
| AT (1) | AT295743B (en) |
| BE (1) | BE745926A (en) |
| BG (1) | BG17632A3 (en) |
| CA (1) | CA923055A (en) |
| CH (1) | CH545343A (en) |
| CS (1) | CS150904B2 (en) |
| DE (1) | DE2006446C3 (en) |
| DK (1) | DK123605B (en) |
| ES (1) | ES376555A1 (en) |
| FI (1) | FI46178C (en) |
| FR (1) | FR2034552B1 (en) |
| GB (1) | GB1292081A (en) |
| IL (1) | IL33879A (en) |
| NL (1) | NL147187B (en) |
| NO (1) | NO132875C (en) |
| PL (1) | PL80837B1 (en) |
| RO (1) | RO54829A (en) |
| SE (1) | SE360677B (en) |
| YU (1) | YU36389B (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1292081A (en) | 1969-02-15 | 1972-10-11 | Zaidan Hojin Biseibutsu | Process for producing bleomycin antibiotics |
| US3846400A (en) * | 1969-02-15 | 1974-11-05 | Microbial Chem Res Found | Novel process for producing antibiotics bleomycin |
| JPS5739751B2 (en) * | 1972-03-03 | 1982-08-23 | ||
| FR2199456A2 (en) * | 1972-09-20 | 1974-04-12 | Microbial Chem Res Found | Bleomycin derivs |
| FR2199455A2 (en) * | 1972-09-20 | 1974-04-12 | Nippon Kayaku Kk | Bleomycin derivs |
| GB1540466A (en) * | 1975-10-29 | 1979-02-14 | Meiji Seika Kaisha | Antibiotic polypeptides sf-1771 and sf-1881-b and production thereof |
| CA1090728A (en) * | 1976-02-04 | 1980-12-02 | Eli Lilly And Company | Antibiotic a-7413 mixture comprising factors a,b,c and d and a process for producing it |
| US4246400A (en) * | 1979-07-13 | 1981-01-20 | Bristol-Myers Company | Tallysomycin compounds |
| JPS58116496A (en) | 1981-12-29 | 1983-07-11 | Nippon Kayaku Co Ltd | Amide n-substituted bleomycins |
| JPS58116497A (en) * | 1981-12-29 | 1983-07-11 | Microbial Chem Res Found | Aminopropylaminobleomycin derivative and its preparation |
| JPS606698A (en) | 1983-06-27 | 1985-01-14 | Microbial Chem Res Found | Novel 3-(4'-aminobutylamino)propylamino-bleomycin derivative and its preparation |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1292081A (en) | 1969-02-15 | 1972-10-11 | Zaidan Hojin Biseibutsu | Process for producing bleomycin antibiotics |
| US3846400A (en) * | 1969-02-15 | 1974-11-05 | Microbial Chem Res Found | Novel process for producing antibiotics bleomycin |
-
1970
- 1970-02-05 GB GB5666/70A patent/GB1292081A/en not_active Expired
- 1970-02-10 IL IL33879A patent/IL33879A/en unknown
- 1970-02-10 FR FR7004581A patent/FR2034552B1/fr not_active Expired
- 1970-02-11 CA CA074574A patent/CA923055A/en not_active Expired
- 1970-02-12 DK DK70170AA patent/DK123605B/en not_active IP Right Cessation
- 1970-02-12 DE DE2006446A patent/DE2006446C3/en not_active Expired
- 1970-02-13 CH CH207470A patent/CH545343A/en not_active IP Right Cessation
- 1970-02-13 YU YU00358/70A patent/YU36389B/en unknown
- 1970-02-13 BE BE745926D patent/BE745926A/en not_active IP Right Cessation
- 1970-02-13 AT AT133070A patent/AT295743B/en not_active IP Right Cessation
- 1970-02-13 ES ES376555A patent/ES376555A1/en not_active Expired
- 1970-02-13 NL NL707002104A patent/NL147187B/en not_active IP Right Cessation
- 1970-02-13 CS CS1037A patent/CS150904B2/cs unknown
- 1970-02-13 FI FI700399A patent/FI46178C/en active
- 1970-02-13 SE SE01858/70A patent/SE360677B/xx unknown
- 1970-02-14 NO NO526/70A patent/NO132875C/no unknown
- 1970-02-14 BG BG013968A patent/BG17632A3/en unknown
- 1970-02-14 PL PL1970138814A patent/PL80837B1/en unknown
- 1970-02-16 RO RO62478A patent/RO54829A/ro unknown
-
1979
- 1979-05-24 US US06/041,996 patent/USRE30451E/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| BE745926A (en) | 1970-07-16 |
| FI46178C (en) | 1973-01-10 |
| GB1292081A (en) | 1972-10-11 |
| NO132875B (en) | 1975-10-13 |
| RO54829A (en) | 1973-07-20 |
| NO132875C (en) | 1976-01-21 |
| DE2006446B2 (en) | 1977-09-29 |
| FR2034552B1 (en) | 1974-01-11 |
| YU35870A (en) | 1981-11-13 |
| NL147187B (en) | 1975-09-15 |
| DK123605B (en) | 1972-07-10 |
| CH545343A (en) | 1973-12-15 |
| YU36389B (en) | 1983-06-30 |
| FR2034552A1 (en) | 1970-12-11 |
| NL7002104A (en) | 1970-08-18 |
| DE2006446A1 (en) | 1970-10-22 |
| DE2006446C3 (en) | 1978-08-31 |
| USRE30451E (en) | 1980-12-16 |
| BG17632A3 (en) | 1973-11-10 |
| CS150904B2 (en) | 1973-09-17 |
| IL33879A0 (en) | 1970-04-20 |
| FI46178B (en) | 1972-10-02 |
| PL80837B1 (en) | 1975-08-30 |
| AT295743B (en) | 1972-01-10 |
| IL33879A (en) | 1973-05-31 |
| CA923055A (en) | 1973-03-20 |
| SE360677B (en) | 1973-10-01 |
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