ATE22562T1 - 6-substituierte s-triazolo(3,4-a)phthalazinderivate. - Google Patents

6-substituierte s-triazolo(3,4-a)phthalazinderivate.

Info

Publication number
ATE22562T1
ATE22562T1 AT83100232T AT83100232T ATE22562T1 AT E22562 T1 ATE22562 T1 AT E22562T1 AT 83100232 T AT83100232 T AT 83100232T AT 83100232 T AT83100232 T AT 83100232T AT E22562 T1 ATE22562 T1 AT E22562T1
Authority
AT
Austria
Prior art keywords
triazolo
substitute
phthalazine derivatives
phthalazine
derivatives
Prior art date
Application number
AT83100232T
Other languages
English (en)
Inventor
Emilio Occelli
Domenico Barone
Giorgio Tarzia
Adele Giunta
Original Assignee
Lepetit Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lepetit Spa filed Critical Lepetit Spa
Application granted granted Critical
Publication of ATE22562T1 publication Critical patent/ATE22562T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/34—Phthalazines with nitrogen atoms directly attached to carbon atoms of the nitrogen-containing ring, e.g. hydrazine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Anesthesiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AT83100232T 1982-01-18 1983-01-13 6-substituierte s-triazolo(3,4-a)phthalazinderivate. ATE22562T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8201273 1982-01-18
EP83100232A EP0085840B1 (de) 1982-01-18 1983-01-13 6-Substituierte s-Triazolo(3,4-a)phthalazin-Derivate

Publications (1)

Publication Number Publication Date
ATE22562T1 true ATE22562T1 (de) 1986-10-15

Family

ID=10527683

Family Applications (1)

Application Number Title Priority Date Filing Date
AT83100232T ATE22562T1 (de) 1982-01-18 1983-01-13 6-substituierte s-triazolo(3,4-a)phthalazinderivate.

Country Status (20)

Country Link
US (1) US4788186A (de)
EP (1) EP0085840B1 (de)
JP (1) JPS58124786A (de)
KR (1) KR890000184B1 (de)
AT (1) ATE22562T1 (de)
AU (1) AU564026B2 (de)
CA (1) CA1214168A (de)
DE (1) DE3366494D1 (de)
DK (1) DK163145C (de)
ES (1) ES531458A0 (de)
FI (1) FI81350C (de)
GR (1) GR78442B (de)
HU (1) HU193033B (de)
IE (1) IE55032B1 (de)
IL (1) IL67697A (de)
NO (1) NO161674C (de)
NZ (1) NZ203021A (de)
PH (1) PH21834A (de)
PT (1) PT76107A (de)
ZA (1) ZA83224B (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1194310B (it) * 1983-07-12 1988-09-14 Lepetit Spa Derivati triazolo (3,4-a) ftalazinici 3,6-disostituiti
YU2899A (sh) 1996-07-25 2000-03-21 Merck Sharp & Dohme Limited Supstituisani triazolo-piridazin derivati kao ligandi za gaba receptore
AU724076B2 (en) 1996-07-25 2000-09-14 Merck Sharp & Dohme Limited Substituted triazolo pyridazine derivatives as inverse agonists of the GABAAalpha5 receptor subtype
US6200975B1 (en) * 1997-05-08 2001-03-13 Merck Sharp & Dohme Limited Substituted 1,2,4-triazolo[3,4-a]phthalazine derivatives as GABA alpha 5 ligands
ES2137113B1 (es) * 1997-07-29 2000-09-16 Almirall Prodesfarma Sa Nuevos derivados de triazolo-piridazinas heterociclicos.
GB9715977D0 (en) * 1997-07-29 1997-10-01 Merck Sharp & Dohme Therapeutic agents
GB9726699D0 (en) * 1997-12-18 1998-02-18 Merck Sharp & Dohme Therapeutic use
WO1999025353A1 (en) * 1997-11-13 1999-05-27 Merck Sharp & Dohme Limited Therapeutic uses of triazolo-pyridazine derivatives
GB9726701D0 (en) * 1997-12-18 1998-02-18 Merck Sharp & Dohme Therapeutic use
GB9723999D0 (en) 1997-11-13 1998-01-14 Merck Sharp & Dohme Therapeutic use
GB9726702D0 (en) * 1997-12-18 1998-02-18 Merck Sharp & Dohme Therapeutic use
US6110915A (en) * 1997-12-18 2000-08-29 Merck & Co., Inc. Antiemetic use of triazolo-pyridazine derivatives
CA2315219A1 (en) * 1998-01-14 1999-07-22 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for gaba receptors
GB9801234D0 (en) * 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801208D0 (en) 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801202D0 (en) 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801210D0 (en) * 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
US6579875B1 (en) 1998-01-21 2003-06-17 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for GABA receptors
GB9801397D0 (en) 1998-01-22 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801538D0 (en) 1998-01-23 1998-03-25 Merck Sharp & Dohme Pharmaceutical product
CA2317416A1 (en) * 1998-02-25 1999-09-02 Merck Sharp & Dohme Limited Substituted 1,2,4-triazolo[3,4-a]pyridazine
EE200000514A (et) 1998-02-25 2002-02-15 Merck Sharp & Dohme Limited Asendatud triasolopüridasiini derivaat, seda sisaldav farmatseutiline kompositsioon ning selle kasutamine kognitsioonivõimet suurendava ravimi valmistamiseks
GB9824897D0 (en) 1998-11-12 1999-01-06 Merck Sharp & Dohme Therapeutic compounds
EP1129094A2 (de) 1998-11-12 2001-09-05 Merck & Co., Inc. Therapeutische polymorphe von inverse agonisten des gaba-a alpha-5 rezeptor und pamoat-formulierungen
GB9929569D0 (en) * 1999-12-14 2000-02-09 Merck Sharp & Dohme Therapeutic agents
GB0028583D0 (en) 2000-11-23 2001-01-10 Merck Sharp & Dohme Therapeutic compounds
EP1379250A2 (de) * 2001-04-10 2004-01-14 Merck & Co., Inc. Verfahren zur behandlung von krebs
US6958334B2 (en) * 2001-04-10 2005-10-25 Merck & Co., Inc. Inhibitors of Akt activity
EP1496981A2 (de) * 2002-04-08 2005-01-19 Merck & Co., Inc. Verfahren zur behandlung von krebs
US20050054647A1 (en) * 2002-12-27 2005-03-10 Detlev Schuppan New pharmaceutical combination
DE602005021894D1 (de) 2004-09-02 2010-07-29 Nycomed Gmbh Triazolophthalazine
KR20070095986A (ko) 2005-01-05 2007-10-01 니코메드 게엠베하 Ｐｄｅ2 억제제로서의 트리아졸로프탈라진
EP1874775B1 (de) * 2005-01-05 2012-10-10 Nycomed GmbH Triazolophthalazine als pde2-inhibitoren
PH12012501361A1 (en) 2009-12-31 2012-10-22 Centro Nac De Investigaciones Oncologicas Cnio Tricyclic compounds for use as kinase inhibitors
CN103694244B (zh) * 2014-01-09 2016-03-30 郑州大学 3,6位取代-1,2,4-三氮唑并[3,4-a]酞嗪类化合物及其制备和用途
CN104016986B (zh) * 2014-03-13 2016-02-03 郑州大学 3-取代-6-(1-取代哌嗪基)-1,2,4-三氮唑并[3,4-a]酞嗪类化合物、其制备方法和用途
EP4279074A1 (de) * 2022-05-19 2023-11-22 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin Azoloverbindungen zur behandlung von fibrotischen erkrankungen

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2484029A (en) * 1945-12-21 1949-10-11 Ciba Pharm Prod Inc Hydrazine derivatives of pyridazine compounds
GB629177A (en) * 1945-12-21 1949-09-14 Ciba Ltd Manufacture of new hydrazine compounds and derivatives thereof
JPS5132598A (en) * 1974-09-13 1976-03-19 Eisai Co Ltd Toriazoro * 3 44 ee * futarajinjudotai no goseiho
JPS603080B2 (ja) * 1976-08-10 1985-01-25 三菱化学株式会社 Ｓ―トリアゾロ〔３，４ ―α〕〔５，６，７，８〕テトラヒドロ フタラジン類
GR70309B (de) * 1979-10-29 1982-09-08 Dow Chemical Co

Also Published As

Publication number Publication date
PT76107A (en) 1983-02-01
JPS58124786A (ja) 1983-07-25
KR840003254A (ko) 1984-08-20
GR78442B (de) 1984-09-27
US4788186A (en) 1988-11-29
FI830100L (fi) 1983-07-19
AU1055083A (en) 1983-07-28
IL67697A (en) 1990-02-09
IE55032B1 (en) 1990-05-09
AU564026B2 (en) 1987-07-30
JPH048428B2 (de) 1992-02-17
PH21834A (en) 1988-03-17
ES8601995A1 (es) 1985-11-01
IL67697A0 (en) 1983-05-15
HU193033B (en) 1987-08-28
NO161674B (no) 1989-06-05
EP0085840A1 (de) 1983-08-17
EP0085840B1 (de) 1986-10-01
DK163145C (da) 1992-06-22
KR890000184B1 (ko) 1989-03-09
IE830082L (en) 1983-07-18
DE3366494D1 (de) 1986-11-06
ZA83224B (en) 1983-10-26
NO830110L (no) 1983-07-19
NO161674C (no) 1989-09-13
FI81350B (fi) 1990-06-29
FI81350C (fi) 1990-10-10
CA1214168A (en) 1986-11-18
FI830100A0 (fi) 1983-01-12
ES531458A0 (es) 1985-11-01
NZ203021A (en) 1986-05-09
DK17983D0 (da) 1983-01-18
DK17983A (da) 1983-07-19
DK163145B (da) 1992-01-27

Similar Documents

Publication Publication Date Title
ATE22562T1 (de) 6-substituierte s-triazolo(3,4-a)phthalazinderivate.
BG43866A3 (en) Method for preparing of derivatives of 2, 2'- imino- bis- ethanol
ATE26115T1 (de) Substituierte 8-phenylxanthine.
DE3571982D1 (en) Benzisoselenazolethiones,process for their preparation and pharmaceutical products containing these compounds
IL58775A (en) Hydroxyethyl-azole compounds,their production and pharmaceutical compositions containing them
IL58782A (en) Hydroxypropyl-triazole compounds,their production and pharmaceutical compositions containing them
FI832004A7 (fi) Menetelmä 1-sulfo-2-oksoatsetidiini- johdannaisten valmistamiseksi.
JO1406B1 (en) Chemical compounds
ES478048A1 (es) Procedimiento para la obtencion de difenil-imidazolil-meta- nos sustituidos.
FI831926A7 (fi) (+)-syanidan-3-olijohdannaisia sisältävät farmaseuttiset valmisteet ja niiden käyttö, uudet substituosubstituoidut (+)-syanidan-3-oli- johdannaiset ja menetelmät niiden vavalmistamiseksi.
FI831475A7 (fi) Uusia atsepiinoindoleja, niiden valmistus ja niitä sisältäviä farmaseuttisia yhdistelmiä.
FI791424A7 (fi) Substituoidut 8-hydroksi-1-fenyyli-2,3,4,5-tetrahydro-1H-3- bentsatsepiinit, menetelmä niiden valmistamiseksi jniitä sisältävät farmaseuttiset seokset.
ES483662A1 (es) Un procedimiento para la produccion de una 2-aminoetil-1-fe-nilindolina
ES8305783A1 (es) Procedimiento para la obtencion de derivados de aminociclitol saturados.
ES473316A1 (es) Procedimiento para la obtencion de 1,4-dihidropiridazinas.
ES8604731A1 (es) Un metodo de preparar derivados de 6,11-dihidrodibenz (b,e) oxepina
DE3168544D1 (en) 6,7,8,9-tetrahydro-3h-benz(e)indolamine derivatives, processes for their preparation and intermediates used therein, and pharmaceutical compositions containing the indolamine derivatives
DE3368933D1 (en) Phosphate derivatives, process for preparation thereof and pharmaceutical compositions of the same
FI831008A7 (fi) Pyridoni-2- johdannaisia, menetelmiä niiden valmistamiseksi ja niitä sisältäviä lääkeaineita.
ES8606259A1 (es) Un metodo de producir una composicion farmaceutica que contiene isoxicamato de l-arginina como ingrediente activo.
FI883499A7 (fi) Menetelmä aryyli- tai heteroaryylimetyylisubstituoitujen 2.2'-bi-1H-imidatsolien valmistamiseksi
SE8401916D0 (sv) Condensed benzopyrone derivatives
SE8305361D0 (sv) New substituted phenylazacycloalkanes, processes for preparation and pharmaceutical preparations for such compounds
FI880080A7 (fi) Menetelmä 1,2,3,4-tetrahydro-5H-(1) bentsopyrano-(3,4-c)-pyridin-5-onin valmistamiseksi.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee