ES8606259A1 - Un metodo de producir una composicion farmaceutica que contiene isoxicamato de l-arginina como ingrediente activo. - Google Patents

Un metodo de producir una composicion farmaceutica que contiene isoxicamato de l-arginina como ingrediente activo.

Info

Publication number
ES8606259A1
ES8606259A1 ES535408A ES535408A ES8606259A1 ES 8606259 A1 ES8606259 A1 ES 8606259A1 ES 535408 A ES535408 A ES 535408A ES 535408 A ES535408 A ES 535408A ES 8606259 A1 ES8606259 A1 ES 8606259A1
Authority
ES
Spain
Prior art keywords
isoxicamate
arginine
arginine isoxicamate
compound
disclosed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES535408A
Other languages
English (en)
Other versions
ES535408A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of ES535408A0 publication Critical patent/ES535408A0/es
Publication of ES8606259A1 publication Critical patent/ES8606259A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00—Preparation of quinones
    • C07C46/02—Preparation of quinones by oxidation giving rise to quinoid structures
    • C07C46/06—Preparation of quinones by oxidation giving rise to quinoid structures of at least one hydroxy group on a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/46—Phenazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/38—[b, e]-condensed with two six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • C07D279/34—[b, e]-condensed with two six-membered rings with hetero atoms directly attached to the ring sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/36—[b, e]-condensed, at least one with a further condensed benzene ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D293/00—Heterocyclic compounds containing rings having nitrogen and selenium or nitrogen and tellurium, with or without oxygen or sulfur atoms, as the ring hetero atoms
    • C07D293/10—Heterocyclic compounds containing rings having nitrogen and selenium or nitrogen and tellurium, with or without oxygen or sulfur atoms, as the ring hetero atoms condensed with carbocyclic rings or ring systems

Abstract

METODO PARA LA PRODUCCION DE UNA COMPOSICION FARMACEUTICA QUE CONTIENE ISIXICAMATO DE L-ARGININA COMO INGREDIENTE ACTIVO. CONSISTE EN HACER REACCIONAR, MEDIANTE CALENTAMIENTO, L-ARGININA CON 4-HIDROXI-2-METIL-N-(5-METIL-3-ISOXAZOLIL)-2H-1,2-BENZOTIAZINA-3-CARBOXAMIDA-1,1=DIOXIDO (ISOXICAM), Y A CONTINUACION SE MEZCLA UNA CANTIDAD EFICAZ DEL ISOXICAMATO DE L-ARGININA RESULTANTE DE LA OPERACION ANTERIOR CON UN VEHICULO INERTE FARMACEUTICAMENTE ACEPTABLE. DE APLICACION EN EL TRATAMIENTO DE LA ARTRITIS POR ADMINISTRACION PARENTERAL Y TAMBIEN EN EL TRATAMIENTO DEL DOLOR ASOCIADO CON LA ARTRITIS.
ES535408A 1983-09-28 1984-08-24 Un metodo de producir una composicion farmaceutica que contiene isoxicamato de l-arginina como ingrediente activo. Expired ES8606259A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53648183A 1983-09-28 1983-09-28

Publications (2)

Publication Number Publication Date
ES535408A0 ES535408A0 (es) 1986-04-01
ES8606259A1 true ES8606259A1 (es) 1986-04-01

Family

ID=24138678

Family Applications (1)

Application Number Title Priority Date Filing Date
ES535408A Expired ES8606259A1 (es) 1983-09-28 1984-08-24 Un metodo de producir una composicion farmaceutica que contiene isoxicamato de l-arginina como ingrediente activo.

Country Status (13)

Country Link
EP (1) EP0140492B1 (es)
JP (1) JPS6072890A (es)
AT (1) ATE39925T1 (es)
AU (1) AU557394B2 (es)
CA (1) CA1213888A (es)
DE (1) DE3476065D1 (es)
DK (1) DK435384A (es)
ES (1) ES8606259A1 (es)
GR (1) GR80337B (es)
IL (1) IL71989A (es)
NZ (1) NZ209701A (es)
PH (1) PH20151A (es)
ZA (1) ZA845244B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL83109A (en) * 1986-07-11 1992-06-21 Ciba Geigy Ag Guanidinium aspartates,their preparation and pharmaceutical compositions containing them
GB9200114D0 (en) * 1992-01-04 1992-02-26 Scras Dual inhibitors of no synthase and cyclooxygenase
AU2002220943A1 (en) * 2001-11-26 2003-06-10 Lean-Ex Ltd. Pharmaceutical composition for treating obesity

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4434163A (en) * 1981-06-01 1984-02-28 Pfizer Inc. Water-soluble benzothiazine dioxide salts

Also Published As

Publication number Publication date
DE3476065D1 (en) 1989-02-16
ZA845244B (en) 1985-02-27
PH20151A (en) 1986-10-08
DK435384D0 (da) 1984-09-12
CA1213888A (en) 1986-11-12
ATE39925T1 (de) 1989-01-15
IL71989A (en) 1987-10-30
DK435384A (da) 1985-03-29
AU557394B2 (en) 1986-12-18
GR80337B (en) 1985-01-14
EP0140492B1 (en) 1989-01-11
ES535408A0 (es) 1986-04-01
AU3003484A (en) 1985-04-04
EP0140492A1 (en) 1985-05-08
NZ209701A (en) 1986-12-05
JPS6072890A (ja) 1985-04-24
IL71989A0 (en) 1984-10-31

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