ES8601995A1 - Un procedimiento para preparar s-triazolo(3, 4-a)ftalazinas - Google Patents

Un procedimiento para preparar s-triazolo(3, 4-a)ftalazinas

Info

Publication number
ES8601995A1
ES8601995A1 ES531458A ES531458A ES8601995A1 ES 8601995 A1 ES8601995 A1 ES 8601995A1 ES 531458 A ES531458 A ES 531458A ES 531458 A ES531458 A ES 531458A ES 8601995 A1 ES8601995 A1 ES 8601995A1
Authority
ES
Spain
Prior art keywords
substd
opt
alkyl
alkoxy
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES531458A
Other languages
English (en)
Other versions
ES531458A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruppo Lepetit SpA
Original Assignee
Gruppo Lepetit SpA
Lepetit SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruppo Lepetit SpA, Lepetit SpA filed Critical Gruppo Lepetit SpA
Publication of ES8601995A1 publication Critical patent/ES8601995A1/es
Publication of ES531458A0 publication Critical patent/ES531458A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/34—Phthalazines with nitrogen atoms directly attached to carbon atoms of the nitrogen-containing ring, e.g. hydrazine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Anesthesiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE S-TRIAZOLO 3,4-A FTALAZINAS, DE FORMULA (I), EN LA QUE R, R1, R2 Y R3 PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA CICLACION DEL CORRESPONDIENTE DERIVADO DE 4-SUSTITUIDA-1-HIDRAZINOFTALAZINA CON DISULFURO DE CARBONO; REACCION DE CLORACION OXIDANTE DE LA TRIAZOLO 3,4-A FTALAZINA OBTENIDA, DE FORMULA (I), EN LA QUE R Y TAMBIEN R1 PUEDEN SER MERCAPTO; Y DESPLAZAMIENTO DEL SUSTITUYENTE 3-CLORO Y/O 6-CLORO INTRODUCIDO, POR REACCION CON UNA AMINA. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SUS PROPIEDADES ANTIHIPERTENSORAS, ANTIINFLAMATORIAS, BRONCODILATADORA Y ANTICANCEROSA.
ES531458A 1982-01-18 1984-04-10 Un procedimiento para preparar s-triazolo(3, 4-a)ftalazinas Granted ES531458A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8201273 1982-01-18

Publications (2)

Publication Number Publication Date
ES8601995A1 true ES8601995A1 (es) 1985-11-01
ES531458A0 ES531458A0 (es) 1985-11-01

Family

ID=10527683

Family Applications (1)

Application Number Title Priority Date Filing Date
ES531458A Granted ES531458A0 (es) 1982-01-18 1984-04-10 Un procedimiento para preparar s-triazolo(3, 4-a)ftalazinas

Country Status (20)

Country Link
US (1) US4788186A (es)
EP (1) EP0085840B1 (es)
JP (1) JPS58124786A (es)
KR (1) KR890000184B1 (es)
AT (1) ATE22562T1 (es)
AU (1) AU564026B2 (es)
CA (1) CA1214168A (es)
DE (1) DE3366494D1 (es)
DK (1) DK163145C (es)
ES (1) ES531458A0 (es)
FI (1) FI81350C (es)
GR (1) GR78442B (es)
HU (1) HU193033B (es)
IE (1) IE55032B1 (es)
IL (1) IL67697A (es)
NO (1) NO161674C (es)
NZ (1) NZ203021A (es)
PH (1) PH21834A (es)
PT (1) PT76107A (es)
ZA (1) ZA83224B (es)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1194310B (it) * 1983-07-12 1988-09-14 Lepetit Spa Derivati triazolo (3,4-a) ftalazinici 3,6-disostituiti
US6465462B1 (en) 1996-07-25 2002-10-15 Merck Sharp & Dohme Ltd. Substituted triazolo pyridazine derivatives as inverse agonists of the GABAAα5 receptor subtype
AU723098B2 (en) * 1996-07-25 2000-08-17 Merck Sharp & Dohme Limited Substituted triazolo-pyridazine derivatives as ligands for GABA receptors
CA2288789C (en) 1997-05-08 2009-07-21 Merck Sharp & Dohme Limited Substituted 1,2,4-triazolo[3,4-a]phthalazine derivatives as gaba alpha 5 ligands
ES2137113B1 (es) * 1997-07-29 2000-09-16 Almirall Prodesfarma Sa Nuevos derivados de triazolo-piridazinas heterociclicos.
GB9715977D0 (en) 1997-07-29 1997-10-01 Merck Sharp & Dohme Therapeutic agents
GB9723999D0 (en) 1997-11-13 1998-01-14 Merck Sharp & Dohme Therapeutic use
GB9726702D0 (en) * 1997-12-18 1998-02-18 Merck Sharp & Dohme Therapeutic use
GB9726699D0 (en) * 1997-12-18 1998-02-18 Merck Sharp & Dohme Therapeutic use
GB9726701D0 (en) * 1997-12-18 1998-02-18 Merck Sharp & Dohme Therapeutic use
WO1999025353A1 (en) * 1997-11-13 1999-05-27 Merck Sharp & Dohme Limited Therapeutic uses of triazolo-pyridazine derivatives
US6110915A (en) * 1997-12-18 2000-08-29 Merck & Co., Inc. Antiemetic use of triazolo-pyridazine derivatives
JP2002509150A (ja) * 1998-01-14 2002-03-26 メルク シャープ エンド ドーム リミテッド Ｇａｂａ受容体のリガンドとしてのトリアゾロピリダジン誘導体
GB9801210D0 (en) * 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
NZ504870A (en) * 1998-01-21 2002-11-26 Merck Sharp & Dohme Triazolo-pyridazine derivatives as ligands for gaba receptors
GB9801208D0 (en) 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801202D0 (en) 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801234D0 (en) 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801397D0 (en) 1998-01-22 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801538D0 (en) 1998-01-23 1998-03-25 Merck Sharp & Dohme Pharmaceutical product
YU46500A (sh) 1998-02-25 2002-11-15 Merck Charp & Dohme Limited Substituisani 1,2,4-triazolo /3,4-a/piridazin
TR200002469T2 (tr) * 1998-02-25 2000-12-21 Merck Sharp & Dohme Limited İkameli 1,2,4-triazol [3,4-a]piridazin.
GB9824897D0 (en) 1998-11-12 1999-01-06 Merck Sharp & Dohme Therapeutic compounds
JP2002529468A (ja) 1998-11-12 2002-09-10 メルク エンド カムパニー インコーポレーテッド ＧＡＢＡ−Ａα−５逆活性薬の治療性多形およびそのパモエート組成物
GB9929569D0 (en) * 1999-12-14 2000-02-09 Merck Sharp & Dohme Therapeutic agents
GB0028583D0 (en) 2000-11-23 2001-01-10 Merck Sharp & Dohme Therapeutic compounds
WO2002083140A1 (en) * 2001-04-10 2002-10-24 Merck & Co., Inc. Inhibitors of akt activity
EP1379250A2 (en) * 2001-04-10 2004-01-14 Merck & Co., Inc. A method of treating cancer
EP1496981A2 (en) * 2002-04-08 2005-01-19 Merck & Co., Inc. Method of treating cancer
US20050054647A1 (en) * 2002-12-27 2005-03-10 Detlev Schuppan New pharmaceutical combination
ATE471324T1 (de) * 2004-09-02 2010-07-15 Nycomed Gmbh Triazolophthalazine
ES2397080T3 (es) * 2005-01-05 2013-03-04 Nycomed Gmbh Triazoloftalazinas como agentes inhibidores de la PDE2
AU2006204451C1 (en) * 2005-01-05 2012-05-24 Takeda Gmbh Triazolophthalazines as PDE2-inhibitors
CA2786002C (en) 2009-12-31 2018-10-02 Joaquin Pastor Fernandez Tricyclic compounds for use as kinase inhibitors
CN103694244B (zh) * 2014-01-09 2016-03-30 郑州大学 3,6位取代-1,2,4-三氮唑并[3,4-a]酞嗪类化合物及其制备和用途
CN104016986B (zh) * 2014-03-13 2016-02-03 郑州大学 3-取代-6-(1-取代哌嗪基)-1,2,4-三氮唑并[3,4-a]酞嗪类化合物、其制备方法和用途
EP4279074A1 (en) * 2022-05-19 2023-11-22 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin Azolo compounds for treatment of fibrotic diseases

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB629177A (en) * 1945-12-21 1949-09-14 Ciba Ltd Manufacture of new hydrazine compounds and derivatives thereof
US2484029A (en) * 1945-12-21 1949-10-11 Ciba Pharm Prod Inc Hydrazine derivatives of pyridazine compounds
JPS5132598A (en) * 1974-09-13 1976-03-19 Eisai Co Ltd Toriazoro * 3 44 ee * futarajinjudotai no goseiho
JPS603080B2 (ja) * 1976-08-10 1985-01-25 三菱化学株式会社 Ｓ―トリアゾロ〔３，４ ―α〕〔５，６，７，８〕テトラヒドロ フタラジン類
GR70309B (es) * 1979-10-29 1982-09-08 Dow Chemical Co

Also Published As

Publication number Publication date
IE55032B1 (en) 1990-05-09
GR78442B (es) 1984-09-27
FI830100L (fi) 1983-07-19
DK163145C (da) 1992-06-22
IL67697A0 (en) 1983-05-15
HU193033B (en) 1987-08-28
IL67697A (en) 1990-02-09
AU1055083A (en) 1983-07-28
DK163145B (da) 1992-01-27
PH21834A (en) 1988-03-17
ATE22562T1 (de) 1986-10-15
EP0085840A1 (en) 1983-08-17
NO161674B (no) 1989-06-05
US4788186A (en) 1988-11-29
FI81350B (fi) 1990-06-29
KR840003254A (ko) 1984-08-20
FI81350C (fi) 1990-10-10
KR890000184B1 (ko) 1989-03-09
NO830110L (no) 1983-07-19
NZ203021A (en) 1986-05-09
NO161674C (no) 1989-09-13
AU564026B2 (en) 1987-07-30
CA1214168A (en) 1986-11-18
PT76107A (en) 1983-02-01
ES531458A0 (es) 1985-11-01
EP0085840B1 (en) 1986-10-01
DK17983D0 (da) 1983-01-18
IE830082L (en) 1983-07-18
ZA83224B (en) 1983-10-26
FI830100A0 (fi) 1983-01-12
JPH048428B2 (es) 1992-02-17
JPS58124786A (ja) 1983-07-25
DE3366494D1 (de) 1986-11-06
DK17983A (da) 1983-07-19

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303