FR2269348A1 - 7-Acylamino cephalosporin derivs - antibacterials active against Gram positive and Gram negative bacteria - Google Patents

7-Acylamino cephalosporin derivs - antibacterials active against Gram positive and Gram negative bacteria

Info

Publication number
FR2269348A1
FR2269348A1 FR7415226A FR7415226A FR2269348A1 FR 2269348 A1 FR2269348 A1 FR 2269348A1 FR 7415226 A FR7415226 A FR 7415226A FR 7415226 A FR7415226 A FR 7415226A FR 2269348 A1 FR2269348 A1 FR 2269348A1
Authority
FR
France
Prior art keywords
alkyl
negative bacteria
active against
phenylalkyl
gram negative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7415226A
Other languages
French (fr)
Other versions
FR2269348B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Industries SA
Original Assignee
Rhone Poulenc Industries SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Industries SA filed Critical Rhone Poulenc Industries SA
Priority to FR7415226A priority Critical patent/FR2269348A1/en
Priority to AR258603A priority patent/AR207148A1/en
Priority to AR261526A priority patent/AR207604A1/en
Priority to NL7504869A priority patent/NL7504869A/en
Priority to DK188375A priority patent/DK188375A/en
Priority to NO751551A priority patent/NO751551L/no
Priority to LU72391A priority patent/LU72391A1/xx
Priority to BE155993A priority patent/BE828631A/en
Priority to CS753027A priority patent/CS188226B2/en
Priority to SU752133307A priority patent/SU589920A3/en
Priority to US05/573,110 priority patent/US4034088A/en
Priority to SE7505066A priority patent/SE7505066L/en
Priority to ZA00752798A priority patent/ZA752798B/en
Priority to FI751296A priority patent/FI751296A/fi
Priority to IL47212A priority patent/IL47212A0/en
Priority to HU75RO00000839A priority patent/HU171666B/en
Priority to GB1830575A priority patent/GB1459370A/en
Priority to CH993677A priority patent/CH601318A5/xx
Priority to CA226,045A priority patent/CA1032157A/en
Priority to CH559575A priority patent/CH602753A5/xx
Priority to JP50052628A priority patent/JPS50154283A/ja
Priority to DE19752519503 priority patent/DE2519503A1/en
Priority to AU80790/75A priority patent/AU497840B2/en
Priority to ES437383A priority patent/ES437383A1/en
Priority to AT337575A priority patent/AT336791B/en
Priority to ES441744A priority patent/ES441744A1/en
Priority to ES75441745A priority patent/ES441745A1/en
Publication of FR2269348A1 publication Critical patent/FR2269348A1/en
Priority to AR208736A priority patent/AR208736A1/en
Priority to SU762335245A priority patent/SU593668A3/en
Priority to SU7602335246A priority patent/SU578890A3/en
Priority to AT397576A priority patent/AT337365B/en
Priority to AT397676A priority patent/AT337366B/en
Priority to CS774354A priority patent/CS188246B2/en
Application granted granted Critical
Publication of FR2269348B1 publication Critical patent/FR2269348B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids

Abstract

Cpds. of formula (I) and metal salts and addition salts with nitrogen bases are new (where R is 1-4C alkyl or phenylalkyl with 1-4C in the alkyl part; n is 0, 1 or 2; R1 is H, acetoxy, (5-methyl-1,3,4-thia-diazol-2-yl)thio or (1-methyl-1,2,3,4-tetrazol-5-yl)-thio; R2 is carboxy or CO2CH(R3)OCOR4 in which CH(R3)OCOR4 is a gp. easily removed enzy maticallmatically; R3 is H, 1-4C alkyl, phenyl or phenylalkyl in which the alkyl part contains 1-2; R4 is 1-4C alkyl, 1-4C alkoxy, cyclohexyl, phenyl or phenylalkyl in which the alkyl part contains 1-2C; or R1 is pyridino and R2 is carboxylato ion, provided that when R is alkyl, R1 is H or acetoxy and R2 is carboxy or R1 is pyridino and R2 is carboxylato ion, n must be 1 or 2). (I) are antibacterials active against Gram positive and Gram negative bacteria in vitro and in vivo. Dosages are 1-12g/day for adults.
FR7415226A 1974-05-02 1974-05-02 7-Acylamino cephalosporin derivs - antibacterials active against Gram positive and Gram negative bacteria Granted FR2269348A1 (en)

Priority Applications (33)

Application Number Priority Date Filing Date Title
FR7415226A FR2269348A1 (en) 1974-05-02 1974-05-02 7-Acylamino cephalosporin derivs - antibacterials active against Gram positive and Gram negative bacteria
AR258603A AR207148A1 (en) 1974-05-02 1975-01-01 PROCEDURE FOR THE PREPARATION OF A NEW DERIVATIVE OF CEPHALOSPORIN
AR261526A AR207604A1 (en) 1974-05-02 1975-01-01 PROCEDURE FOR THE PREPARATION OF A NEW DERIVATIVE OF CEPHALOSPORIN
NL7504869A NL7504869A (en) 1974-05-02 1975-04-24 PROCEDURE FOR THE PREPARATION OF CEPHALOSPORINE DIVATIVES AND THEIR SALTS, PROCEDURE FOR THE PREPARATION OF PREPARATIONS WITH PHARMACOLOGICAL ACTION AND THE PREPARATIONS FORMED.
NO751551A NO751551L (en) 1974-05-02 1975-04-30
LU72391A LU72391A1 (en) 1974-05-02 1975-04-30
DK188375A DK188375A (en) 1974-05-02 1975-04-30 PROCEDURE FOR THE PREPARATION OF CEPHALOSPORINE DERIVATIVES
CS753027A CS188226B2 (en) 1974-05-02 1975-04-30 Method of producing new derivative of cephalosporine
SU752133307A SU589920A3 (en) 1974-05-02 1975-04-30 Method of preparing cephalosporin derivatives or salts thereof
US05/573,110 US4034088A (en) 1974-05-02 1975-04-30 Cephalosporin derivatives, and compositions containing them
SE7505066A SE7505066L (en) 1974-05-02 1975-04-30 PROCEDURE FOR THE PREPARATION OF CEFALSPORIN DERIVATIVES.
ZA00752798A ZA752798B (en) 1974-05-02 1975-04-30 Cephalosporin derivatives, their preparation and compositions containing them
FI751296A FI751296A (en) 1974-05-02 1975-04-30
IL47212A IL47212A0 (en) 1974-05-02 1975-04-30 Cephalosporin derivatives,process for their preparation and pharmaceutical compositions containing them
HU75RO00000839A HU171666B (en) 1974-05-02 1975-04-30 Process for producing new 7-square bracket-2-bracket-1-imidasolyl-bracket closed-acethylamino-square bracket closed-3-methyl-ceph-3-eme-4-carboxylic acid derivatives
BE155993A BE828631A (en) 1974-05-02 1975-04-30 NEW DERIVATIVES OF CEPHALOSPORIN
GB1830575A GB1459370A (en) 1974-05-02 1975-05-01 Cephalosporin derivatives their preparation and compositions containing them
CH993677A CH601318A5 (en) 1974-05-02 1975-05-01
CA226,045A CA1032157A (en) 1974-05-02 1975-05-01 Cephalosporin derivatives, preparation thereof and pharmaceutical compounds containing same
CH559575A CH602753A5 (en) 1974-05-02 1975-05-01
DE19752519503 DE2519503A1 (en) 1974-05-02 1975-05-02 NEW DERIVATIVES OF CEPHALOSPORIN, THEIR PRODUCTION AND THE PHARMACEUTICAL PREPARATIONS CONTAINING THEM
AU80790/75A AU497840B2 (en) 1974-05-02 1975-05-02 Cephalosporins
ES437383A ES437383A1 (en) 1974-05-02 1975-05-02 Cephalosporin derivatives, and compositions containing them
AT337575A AT336791B (en) 1974-05-02 1975-05-02 PROCESS FOR THE PREPARATION OF NEW DERIVATIVES OF CEPHALOSPORINE AND THEIR SALT
JP50052628A JPS50154283A (en) 1974-05-02 1975-05-02
ES75441745A ES441745A1 (en) 1974-05-02 1975-10-13 Procedure for the preparation of a new derivative of cefalosporine. (Machine-translation by Google Translate, not legally binding)
ES441744A ES441744A1 (en) 1974-05-02 1975-10-13 Cephalosporin derivatives, and compositions containing them
AR208736A AR208736A1 (en) 1974-05-02 1975-12-09 PROCEDURE FOR THE PREPARATION OF A NEW DERIVATIVE OF CEAPHALOSPORIN
SU762335245A SU593668A3 (en) 1974-05-02 1976-03-25 Method of preparing cephalosporin derivatives or salts thereof
SU7602335246A SU578890A3 (en) 1974-05-02 1976-03-25 Method of preparing cephalosporin or salts thereof
AT397576A AT337365B (en) 1974-05-02 1976-05-31 PROCESS FOR THE PREPARATION OF NEW DERIVATIVES OF CEPHALOSPORINE AND THEIR SALT
AT397676A AT337366B (en) 1974-05-02 1976-05-31 PROCESS FOR THE PREPARATION OF NEW DERIVATIVES OF CEPHALOSPORINE AND THEIR SALT
CS774354A CS188246B2 (en) 1974-05-02 1977-06-30 Method of producing new derivatives of cephalosporine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7415226A FR2269348A1 (en) 1974-05-02 1974-05-02 7-Acylamino cephalosporin derivs - antibacterials active against Gram positive and Gram negative bacteria

Publications (2)

Publication Number Publication Date
FR2269348A1 true FR2269348A1 (en) 1975-11-28
FR2269348B1 FR2269348B1 (en) 1977-11-10

Family

ID=9138377

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7415226A Granted FR2269348A1 (en) 1974-05-02 1974-05-02 7-Acylamino cephalosporin derivs - antibacterials active against Gram positive and Gram negative bacteria

Country Status (9)

Country Link
AR (1) AR207604A1 (en)
AT (1) AT336791B (en)
BE (1) BE828631A (en)
CH (1) CH601318A5 (en)
CS (1) CS188226B2 (en)
ES (1) ES441745A1 (en)
FR (1) FR2269348A1 (en)
SU (2) SU578890A3 (en)
ZA (1) ZA752798B (en)

Also Published As

Publication number Publication date
SU593668A3 (en) 1978-02-15
AR207604A1 (en) 1976-10-15
SU578890A3 (en) 1977-10-30
ATA337575A (en) 1976-09-15
CS188226B2 (en) 1979-02-28
ZA752798B (en) 1976-04-28
ES441745A1 (en) 1977-03-16
CH601318A5 (en) 1978-07-14
FR2269348B1 (en) 1977-11-10
AT336791B (en) 1977-05-25
BE828631A (en) 1975-10-30

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