ES8506735A1 - Antibacterial 3-imino:acetamido-azetidinone-1-sulphonic acid derivs. p - Google Patents

Antibacterial 3-imino:acetamido-azetidinone-1-sulphonic acid derivs. p

Info

Publication number
ES8506735A1
ES8506735A1 ES529773A ES529773A ES8506735A1 ES 8506735 A1 ES8506735 A1 ES 8506735A1 ES 529773 A ES529773 A ES 529773A ES 529773 A ES529773 A ES 529773A ES 8506735 A1 ES8506735 A1 ES 8506735A1
Authority
ES
Spain
Prior art keywords
opt
substd
alkyl
derivs
acetamido
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES529773A
Other languages
Spanish (es)
Other versions
ES529773A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES8506735A1 publication Critical patent/ES8506735A1/en
Publication of ES529773A0 publication Critical patent/ES529773A0/en
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Prodn. of 1-sulphoazetidine derivs. of formula (I) in racemic and 35 enantiomeric form, and their easily hydrolysed esters or pharmaceutically acceptable salts comprises reacting the 3-aminoazetidine derivs. (II) with thioesters (III). (Het is an opt. amino substd., 5 or 6 membered aromatic heterocycle, contg. 1 or 2N and opt. also an O or S atom. R1 is H, alkyl (opt. substd. by phenyl, alkenyl, alkoxycarbonyl, phenylalkoxycarbonyl, nitrophenylalkoxycarbonyl or carboxy), alkanoyl or alkoxy carbonyl. R2 is H, alkyl (opt. substd. by alkanoyloxy or carbamoyloxy), alkenyl (opt. substd. by alkoxycarbonyl or carbamoyl), alkynyl, or hydroxy- or alkoxy-iminomethyl, and =NOR1 exists at least partly in the syn-form. R20 is as R2 or also 2,2-dimethyl-1,3-dioxolan-4-yl. R3 is H or sulpho. R10 is as R1 but not carboxyalkyl, or can also be trialkylsilyl-alkoxycarbonylalkyl or an easily hydrolysed esterified carboxyalkyl. All alkyl etc. have upto 7C). The reaction prod. having R3 as H is sulphonated and if necessary R20 and R10 converted conventionally. (I) have broad-spectrum antimicrobial activity and are esp. useful against gram negative species such as E. coli, Proteus and Serratia spp. and Pseudomonas aeruginosa. The usual daily dose is 10-600 mg per kg. Specifically claimed are 11 cpds. (I) and 7 cpds. (III), e.g. 3-((Z)-2-(2A4T)-2-(methoxyimino) acetamido- 4-((E)-carbamoylvinyl or methoxyiminomethyl)- 2-oxo-1-azetidine sulphonic acid and benzothiazol-2-ylthio 2-(2A4T)--2-((Z)- (p-nitrobenzyloxy- or tert. butoxy-carbonyl) methoxyimino)acetate (2A4T is 2-amino-4-thiazolyl).
ES529773A 1983-04-25 1984-02-16 PROCEDURE FOR THE PRODUCTION OF CARBOXYL ACIDS Granted ES529773A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH220183 1983-04-25

Publications (2)

Publication Number Publication Date
ES8506735A1 true ES8506735A1 (en) 1985-08-01
ES529773A0 ES529773A0 (en) 1985-08-01

Family

ID=4228255

Family Applications (2)

Application Number Title Priority Date Filing Date
ES529773A Granted ES529773A0 (en) 1983-04-25 1984-02-16 PROCEDURE FOR THE PRODUCTION OF CARBOXYL ACIDS
ES529775A Expired ES8506585A1 (en) 1983-04-25 1984-02-16 Antibacterial 3-imino:acetamido-azetidinone-1-sulphonic acid derivs. p

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES529775A Expired ES8506585A1 (en) 1983-04-25 1984-02-16 Antibacterial 3-imino:acetamido-azetidinone-1-sulphonic acid derivs. p

Country Status (2)

Country Link
ES (2) ES529773A0 (en)
HU (1) HU194844B (en)

Also Published As

Publication number Publication date
HU194844B (en) 1988-03-28
ES529775A0 (en) 1985-08-01
ES8506585A1 (en) 1985-08-01
ES529773A0 (en) 1985-08-01

Similar Documents

Publication Publication Date Title
ATE207922T1 (en) CARBAPENEM DERIVATIVES
NZ329363A (en) 3-[2-oxo-pyrrolidinyl-3-ylidene]methylene substituted 7-[2-(5-amino-[1,2,4]thiadiazol-3-yl)2-hydroxyimino-acetylamino ]-cephalosporin derivatives and medicaments
GB1526978A (en) 3-thiosubstituted cephalosporin antibiotics
AU7263991A (en) 3-tetrazolylthiomethyl cephalosporin antibiotics
AU5232190A (en) Novel compounds
GB1456144A (en) Ureido-aryl cephalosporin compounds
AU6889294A (en) Novel intermediates useful in the preparation of heteroaroyl derivatives of monocyclic beta-lactam antibiotics
ES476856A1 (en) Penicillins, per se and for use as antibacterially active antibiotics and their production.
AU1312292A (en) New thiazolidinone and oxazolidinone derivatives, their preparation and their use as vasodilators
ES8506735A1 (en) Antibacterial 3-imino:acetamido-azetidinone-1-sulphonic acid derivs. p
ES8800237A1 (en) Alkeneamidocephalosporin esters
AU6731100A (en) Integrase inhibitors containing aromatic heterocycle derivatives
ES429864A1 (en) 1,4-Dihydro-4-oxo-pyridylacetamido cephalosporins and their utilization as medicinal agents for combating bacterial infections
ES8506026A1 (en) Beta-lactam antibacterial agents.
BG100551A (en) 2-(pyrazol-3-yl)carbapenem derivatives
IE41420L (en) Cephalosporin derivatives
EP0280240A3 (en) Cephalosporin derivatives, process for their preparation and antibacterial agents
KR950014111A (en) New carbapenem derivatives and preparation method thereof
AU532634B2 (en) Thiazolyl derivatives
ES441744A1 (en) Cephalosporin derivatives, and compositions containing them
FR2305185A2 (en) 7-Acylamino cephalosporin derivs - antibacterials active against Gram positive and Gram negative bacteria
AU606701B2 (en) Antipsychotic compositions containing dioxopiperidine derivatives
KR930012766A (en) Antibiotic C-3 dithioacetal-substituted carbapenem compounds, compositions, preparations and uses thereof
ES8506294A1 (en) 3-Imino-acetamido-azetidinone-1-sulphonic acid derivs.
FR2269348A1 (en) 7-Acylamino cephalosporin derivs - antibacterials active against Gram positive and Gram negative bacteria