ES8602816A1 - Un procedimiento para la preparacion de nuevos antibioticos de cefalosporina. - Google Patents

Un procedimiento para la preparacion de nuevos antibioticos de cefalosporina.

Info

Publication number
ES8602816A1
ES8602816A1 ES536728A ES536728A ES8602816A1 ES 8602816 A1 ES8602816 A1 ES 8602816A1 ES 536728 A ES536728 A ES 536728A ES 536728 A ES536728 A ES 536728A ES 8602816 A1 ES8602816 A1 ES 8602816A1
Authority
ES
Spain
Prior art keywords
alkyl
hydrogen
sec
formula
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES536728A
Other languages
English (en)
Other versions
ES536728A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of ES8602816A1 publication Critical patent/ES8602816A1/es
Publication of ES536728A0 publication Critical patent/ES536728A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/48—Methylene radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE NUEVOS ANTIBIOTICOS DE CEFALOSPORINA. COMPRENDE: A) CONDENSAR EL COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III) PARA OBTENER UN COMPUESTO DE FORMULA (I); B) ACILAR EL COMPUESTO DE FORMULA (I), DONDE R, ES H, UNASAL, O UN 4-ESTER DEL MISMO, CON UN ACIDO DE FORMULA (IV); O C) DESACILAR EL COMPUESTO DE FORMULA (I) CUANDO R NO ES H, O 4-ESTER DEL MISMO, PARA OBTENER UNA SAL FARMACEUTICAMENTE ACEPTABLE O UN ESTER BIOLOGICAMENTE ESCINDIBLE. SIENDO: L, GRUPO SALIENTE; R, H, FORMILO Y OTROS; R1, H, ALQUILO C 1 A 4 Y OTROS; R3, H, O GRUPOS CARBOXI; X, UN ATOMO DE OXIGENO O AZUFRE O N-R2; R2, H, O ALQUILO C 1 A 4; M E Y, SON 0,1.2 O 3, SIEMPRE Y M 3. SE UTILIZA EN FARMACOLOGIA POR SU AMPLIO ESPECTRO ANTIBACTERIANO, EN ANIMALES.
ES536728A 1983-10-17 1984-10-11 Un procedimiento para la preparacion de nuevos antibioticos de cefalosporina. Granted ES536728A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US54261983A 1983-10-17 1983-10-17

Publications (2)

Publication Number Publication Date
ES8602816A1 true ES8602816A1 (es) 1985-11-16
ES536728A0 ES536728A0 (es) 1985-11-16

Family

ID=24164603

Family Applications (1)

Application Number Title Priority Date Filing Date
ES536728A Granted ES536728A0 (es) 1983-10-17 1984-10-11 Un procedimiento para la preparacion de nuevos antibioticos de cefalosporina.

Country Status (17)

Country Link
EP (1) EP0138552A3 (es)
JP (1) JPS60105685A (es)
KR (1) KR850002992A (es)
AU (1) AU574107B2 (es)
CA (1) CA1225390A (es)
DK (1) DK489184A (es)
ES (1) ES536728A0 (es)
FI (1) FI844000L (es)
GB (2) GB2148289B (es)
GR (1) GR80670B (es)
HU (1) HU195512B (es)
IL (1) IL73230A0 (es)
NZ (1) NZ209833A (es)
PH (1) PH21040A (es)
PT (1) PT79357B (es)
SU (1) SU1360587A3 (es)
ZA (1) ZA847926B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH22107A (en) * 1984-06-07 1988-06-01 Takeda Chemical Industries Ltd 3-pyrazolo(1,5-a)pyrdinium cephem compounds
US4734408A (en) * 1986-12-17 1988-03-29 Eli Lilly And Company Crystalline cephalosporin antibiotic salts and solvates
EP0304858A3 (en) * 1987-08-25 1989-12-20 Takeda Chemical Industries, Ltd. Cephem compounds, their production and use
TW526202B (en) * 1998-11-27 2003-04-01 Shionogi & Amp Co Broad spectrum cephem having benzo[4,5-b]pyridium methyl group of antibiotic activity
AT412214B (de) * 1999-05-05 2004-11-25 Sandoz Ag Verfahren zur herstellung des dinatrium-hemiheptahydratsalzes von ceftriaxon
GB0215293D0 (en) 2002-07-03 2002-08-14 Rega Foundation Viral inhibitors
US20050222198A1 (en) 2003-12-22 2005-10-06 K.U. Leuven Research & Development, Gerhard Puerstinger And Gilead Sciences, Inc. Imidazo[4,5-c]pyridine compounds and methods of antiviral treatment
EP1841765B1 (en) 2004-12-21 2009-03-25 Gilead Sciences, Inc. Imidazo[4,5-c]pyridine compound and method of antiviral treatment
US7754720B2 (en) 2006-07-07 2010-07-13 Gilead Sciences, Inc. Pyridazine compound and use thereof
UA99466C2 (en) 2007-07-06 2012-08-27 Гилиад Сайенсиз, Инк. Crystalline pyridazine compound
US20140274996A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Tazobactam and ceftolozane antibiotic compositions
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
US20140274994A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Stabilizing ceftolozane
EP3043797B1 (en) 2013-09-09 2020-04-08 Merck Sharp & Dohme Corp. Treating infections with ceftolozane/tazobactam in subjects having impaired renal function
US20150094293A1 (en) 2013-09-27 2015-04-02 Calixa Therapeutics, Inc. Solid forms of ceftolozane
WO2019236884A1 (en) * 2018-06-07 2019-12-12 Disarm Therapeutics, Inc. Inhibitors of sarm1

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3118732A1 (de) * 1981-05-12 1982-12-02 Hoechst Ag, 6000 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
GR76701B (es) * 1981-09-08 1984-08-29 Lilly Co Eli
DE3207840A1 (de) * 1982-03-04 1983-09-15 Hoechst Ag, 6230 Frankfurt "cephalosporinderivate und verfahren zu ihrer herstellung"
JPS5910593A (ja) * 1982-06-28 1984-01-20 Bristol Mayers Kenkyusho Kk セフアロスポリン誘導体
US4500526A (en) * 1982-06-28 1985-02-19 Bristol-Myers Company Cephalosporin derivatives

Also Published As

Publication number Publication date
IL73230A0 (en) 1985-01-31
PT79357A (en) 1984-11-01
EP0138552A2 (en) 1985-04-24
FI844000A0 (fi) 1984-10-11
GB8627171D0 (en) 1986-12-10
CA1225390A (en) 1987-08-11
GB2148289B (en) 1987-09-23
JPS60105685A (ja) 1985-06-11
SU1360587A3 (ru) 1987-12-15
ZA847926B (en) 1986-05-28
ES536728A0 (es) 1985-11-16
PT79357B (en) 1986-11-20
NZ209833A (en) 1988-04-29
GR80670B (en) 1985-02-18
DK489184A (da) 1985-04-18
EP0138552A3 (en) 1986-03-19
FI844000L (fi) 1985-04-18
PH21040A (en) 1987-07-03
AU574107B2 (en) 1988-06-30
AU3418984A (en) 1985-04-26
GB2181136A (en) 1987-04-15
DK489184D0 (da) 1984-10-12
HUT35687A (en) 1985-07-29
HU195512B (en) 1988-05-30
KR850002992A (ko) 1985-05-28
GB2148289A (en) 1985-05-30
GB2181136B (en) 1988-05-25
GB8425453D0 (en) 1984-11-14

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