ES8706680A1 - Procedimiento para preparar derivados de carbapenem - Google Patents

Procedimiento para preparar derivados de carbapenem

Info

Publication number
ES8706680A1
ES8706680A1 ES536443A ES536443A ES8706680A1 ES 8706680 A1 ES8706680 A1 ES 8706680A1 ES 536443 A ES536443 A ES 536443A ES 536443 A ES536443 A ES 536443A ES 8706680 A1 ES8706680 A1 ES 8706680A1
Authority
ES
Spain
Prior art keywords
mono
alkyl
image
formula
represents hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES536443A
Other languages
English (en)
Other versions
ES536443A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanraku Inc
Original Assignee
Sanraku Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanraku Inc filed Critical Sanraku Inc
Publication of ES8706680A1 publication Critical patent/ES8706680A1/es
Publication of ES536443A0 publication Critical patent/ES536443A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

METODO DE PREPARAR DERIVADOS DE CARBAPENEM. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II), EN UN DISOLVENTE INERTE, CON UN COMPUESTO DE FORMULA H-S-R2, A TEMPERATURA ENTRE -50GC Y LA TEMPERATURA AMBIENTE, SEGUIDO DE LA ELIMINACION DE CUALQUIER GRUPO PROTECTOR RESULTANTE, PARA OBTENER DERIVADOS DE CARBAPENEM DE FORMULA (I) DONDE R1 ES H O METILO; R2 ES H O ALQUILO INFERIOR, ALQUENILO INFERIOR, ALQUINILO INFERIOR O CICLOALQUILO Y OTROS; R3 REPRESENTA HIDROGENO O ALQUILO INFERIOR; Y R4 ES ALQUILO INFERIOR. TIENEN APLICACIONES FARMACEUTICAS POR SU ACTIVIDAD ANTIMICROBIAL. *FORMULA*
ES536443A 1983-10-03 1984-10-02 Procedimiento para preparar derivados de carbapenem Expired ES8706680A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH5363/83A CH660736A5 (de) 1983-10-03 1983-10-03 Carbapenemderivate.

Publications (2)

Publication Number Publication Date
ES8706680A1 true ES8706680A1 (es) 1987-07-01
ES536443A0 ES536443A0 (es) 1987-07-01

Family

ID=4292307

Family Applications (1)

Application Number Title Priority Date Filing Date
ES536443A Expired ES8706680A1 (es) 1983-10-03 1984-10-02 Procedimiento para preparar derivados de carbapenem

Country Status (24)

Country Link
US (1) US4720491A (es)
JP (2) JPS60105676A (es)
KR (1) KR910009290B1 (es)
AT (1) AT386204B (es)
AU (1) AU3376084A (es)
BE (1) BE900718A (es)
CA (1) CA1241656A (es)
CH (2) CH660736A5 (es)
DE (1) DE3434504A1 (es)
DK (1) DK470684A (es)
ES (1) ES8706680A1 (es)
FI (1) FI843847L (es)
FR (1) FR2552763B1 (es)
GB (1) GB2147298B (es)
GR (1) GR80515B (es)
HU (1) HUT36478A (es)
IL (1) IL73127A0 (es)
IT (1) IT1199203B (es)
LU (1) LU85570A1 (es)
NL (1) NL8402936A (es)
PL (1) PL249834A1 (es)
PT (1) PT79293B (es)
SE (1) SE462493B (es)
ZA (1) ZA847781B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60202886A (ja) * 1984-03-27 1985-10-14 Sankyo Co Ltd １―置換カルバペネム―３―カルボン酸誘導体
EP0234484B1 (en) * 1986-02-19 1993-10-20 Sanraku Incorporated Novel azetidinone derivatives
EP0464900A3 (en) 1990-06-26 1992-07-22 Merck & Co. Inc. 2-biphenyl-carbapenems
CA2052730A1 (en) 1990-10-11 1992-04-12 Frank P. Dininno 2-(substituted-dibenzofuranyl and dibenzothienyl) carbapenem antibacterial agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4312871A (en) * 1979-12-03 1982-01-26 Merck & Co., Inc. 6-, 1- And 2-substituted-1-carbadethiapen-2-em-3-carboxylic acids
PT73791B (en) * 1980-10-17 1983-10-14 Merck & Co Inc Process for preparing 2-carbamimidoyl-6-substituted-1- -carbadethiapen-2-em-3-carboxylic acids
ES8404184A1 (es) * 1981-08-03 1984-04-16 Merck & Co Inc Un procedimiento para la prepracion de nuevos derivados de acidos 2-carbamimidoil-1-,carbadestiapen-2-en-3-carboxilados.
FI832619A (fi) * 1982-07-26 1984-01-27 Sandoz Ag Fluoralkylerade karbapenemderivat

Also Published As

Publication number Publication date
JPH04364183A (ja) 1992-12-16
ZA847781B (en) 1986-05-28
SE462493B (sv) 1990-07-02
PT79293A (en) 1984-11-01
DK470684D0 (da) 1984-10-01
CH662117A5 (de) 1987-09-15
PT79293B (en) 1986-09-10
DK470684A (da) 1985-04-04
SE8404906D0 (sv) 1984-10-01
IT8448934A1 (it) 1986-04-02
GB2147298B (en) 1988-01-13
FI843847L (fi) 1985-04-04
PL249834A1 (en) 1985-12-03
IT1199203B (it) 1988-12-30
GB8424708D0 (en) 1984-11-07
FR2552763A1 (fr) 1985-04-05
JPS60105676A (ja) 1985-06-11
JPH0564153B2 (es) 1993-09-14
GB2147298A (en) 1985-05-09
AU3376084A (en) 1985-04-18
JPH0670059B2 (ja) 1994-09-07
ATA311584A (de) 1987-12-15
CA1241656A (en) 1988-09-06
GR80515B (en) 1985-01-28
DE3434504A1 (de) 1985-04-18
HUT36478A (en) 1985-09-30
KR850002983A (ko) 1985-05-28
BE900718A (fr) 1985-04-01
US4720491A (en) 1988-01-19
KR910009290B1 (ko) 1991-11-09
SE8404906L (sv) 1985-04-04
AT386204B (de) 1988-07-25
CH660736A5 (de) 1987-06-15
NL8402936A (nl) 1985-05-01
IT8448934A0 (it) 1984-10-02
LU85570A1 (fr) 1985-06-19
FR2552763B1 (fr) 1987-01-09
ES536443A0 (es) 1987-07-01
IL73127A0 (en) 1984-12-31
FI843847A0 (fi) 1984-10-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970203