ES8200668A1 - Un procedimiento para la preparacion de nuevos derivados de oxazolina y tiazolina - Google Patents
Un procedimiento para la preparacion de nuevos derivados de oxazolina y tiazolinaInfo
- Publication number
- ES8200668A1 ES8200668A1 ES497560A ES497560A ES8200668A1 ES 8200668 A1 ES8200668 A1 ES 8200668A1 ES 497560 A ES497560 A ES 497560A ES 497560 A ES497560 A ES 497560A ES 8200668 A1 ES8200668 A1 ES 8200668A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- halogen
- optionally substituted
- alkoxy
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/48—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Developing Agents For Electrophotography (AREA)
- Peptides Or Proteins (AREA)
- Luminescent Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE OXAZOLINA Y TIAZOLINA, DE FORMULA ESTRUCTURAL (I), DONDE X REPRESENTA OXIGENO O AZUFRE, R1 Y R2 SON IGUALES O DIFERENTES Y REPRESENTAN HIDROGENO, HALOGENO, ALQUILO C1-6, FENILO O BENCILO, O BIEN R1 Y R2 REPRESENTAN LOS RESTANTES MIEMBROS DE UN ANULLO BENCENICO; R3 REPRESENTA HIDROGENO, ALQUILO C1-6, FENILO O BENCILO; R4 REPRESENTA HIDROGENO O ALQUILO C1-6; R5 REPRESENTA C1-6, FENILO O BENCILO, O BIEN R4 Y R5 UNIDOS REPRESENTAN LOS RESTANTES MIEMBROS DE UN ANILLO DE 5 A 6 MIEMBROS, Y R6 REPRESENTA ALQUILO C1-6, FENILO O BENCIDLO, Y LAS SALES DE ADICION FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II), DONDE R4, R5 Y R6 TIENEN LOS SIGNIFICADOS YA INDICADOS, CON UN IMINO-DERIVADO DE FORMULA (III), DONDE R1, R2, R3 Y X TIENEN LOS SIGNIFICADOS YA INDICADOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB7913864 | 1979-04-20 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8200668A1 true ES8200668A1 (es) | 1981-11-16 |
ES497560A0 ES497560A0 (es) | 1981-11-16 |
Family
ID=10504680
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES490675A Expired ES8105306A1 (es) | 1979-04-20 | 1980-04-17 | Un procedimiento para la preparacion de nuevos derivados de oxazolina y tiazolina |
ES497560A Granted ES497560A0 (es) | 1979-04-20 | 1980-12-09 | Un procedimiento para la preparacion de nuevos derivados de oxazolina y tiazolina |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES490675A Expired ES8105306A1 (es) | 1979-04-20 | 1980-04-17 | Un procedimiento para la preparacion de nuevos derivados de oxazolina y tiazolina |
Country Status (14)
Country | Link |
---|---|
US (1) | US4409216A (es) |
EP (1) | EP0018107B1 (es) |
JP (1) | JPS55141474A (es) |
AT (1) | ATE2075T1 (es) |
AU (1) | AU5758880A (es) |
DE (1) | DE3061396D1 (es) |
DK (1) | DK167580A (es) |
ES (2) | ES8105306A1 (es) |
FI (1) | FI801253A (es) |
GR (1) | GR67301B (es) |
IE (1) | IE49697B1 (es) |
IL (1) | IL59803A0 (es) |
NO (1) | NO801131L (es) |
ZA (1) | ZA801970B (es) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2075805A1 (es) * | 1993-12-30 | 1995-10-01 | Univ Murcia | Procedimiento para la obtencion de iminooxazolinas n-n'-sustituidas. |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102004008141A1 (de) * | 2004-02-19 | 2005-09-01 | Abbott Gmbh & Co. Kg | Guanidinverbindungen und ihre Verwendung als Bindungspartner für 5-HT5-Rezeptoren |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3023103A (en) * | 1960-08-02 | 1962-02-27 | Gen Aniline & Film Corp | Antifoggants and stabilizers for photographic silver halide emulsions |
DE2205744A1 (de) | 1972-02-08 | 1973-08-09 | Thomae Gmbh Dr K | Neue durch einen guanidinylidenrest substituierte heterocyclen und verfahren zu ihrer herstellung |
NZ183570A (en) * | 1976-03-19 | 1979-06-08 | Mcneilab Inc | Heterocyclic guanidine derivatives, having anti-secretory and hypogliycaemic activity |
CS225804B2 (cs) | 1976-03-19 | 1984-02-13 | Mcneilab Inc | Způsob výroby heterocyklických derivátů guanidinu |
US4089965A (en) * | 1976-03-26 | 1978-05-16 | American Cyanamid Company | Thiazolylphenylguanidines as antirhinovirus agents |
CA1201119A (en) * | 1978-09-18 | 1986-02-25 | Mcneilab, Inc. | Diaza-cyclic derivatives of guanidine |
AU5263779A (en) * | 1978-11-29 | 1980-05-29 | Beecham Group Limited | Derivatives of thiazolidin-2-ylidene and oxazolidin-2-ylidene with hypoglycaemic acitivity |
-
1980
- 1980-03-27 EP EP80300949A patent/EP0018107B1/en not_active Expired
- 1980-03-27 AT AT80300949T patent/ATE2075T1/de active
- 1980-03-27 DE DE8080300949T patent/DE3061396D1/de not_active Expired
- 1980-04-02 ZA ZA00801970A patent/ZA801970B/xx unknown
- 1980-04-10 IL IL59803A patent/IL59803A0/xx unknown
- 1980-04-11 US US06/139,284 patent/US4409216A/en not_active Expired - Lifetime
- 1980-04-15 GR GR61687A patent/GR67301B/el unknown
- 1980-04-17 ES ES490675A patent/ES8105306A1/es not_active Expired
- 1980-04-18 AU AU57588/80A patent/AU5758880A/en not_active Abandoned
- 1980-04-18 NO NO801131A patent/NO801131L/no unknown
- 1980-04-18 DK DK167580A patent/DK167580A/da active IP Right Grant
- 1980-04-18 FI FI801253A patent/FI801253A/fi not_active Application Discontinuation
- 1980-04-18 JP JP5155880A patent/JPS55141474A/ja active Pending
- 1980-04-18 IE IE787/80A patent/IE49697B1/en unknown
- 1980-12-09 ES ES497560A patent/ES497560A0/es active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2075805A1 (es) * | 1993-12-30 | 1995-10-01 | Univ Murcia | Procedimiento para la obtencion de iminooxazolinas n-n'-sustituidas. |
Also Published As
Publication number | Publication date |
---|---|
IE49697B1 (en) | 1985-11-27 |
US4409216A (en) | 1983-10-11 |
ES497560A0 (es) | 1981-11-16 |
GR67301B (es) | 1981-06-29 |
EP0018107B1 (en) | 1982-12-22 |
ZA801970B (en) | 1981-04-29 |
EP0018107A1 (en) | 1980-10-29 |
DK167580A (da) | 1980-10-21 |
JPS55141474A (en) | 1980-11-05 |
ES490675A0 (es) | 1981-05-16 |
IE800787L (en) | 1980-10-20 |
ATE2075T1 (de) | 1983-01-15 |
FI801253A (fi) | 1980-10-21 |
DE3061396D1 (en) | 1983-01-27 |
ES8105306A1 (es) | 1981-05-16 |
NO801131L (no) | 1980-10-21 |
AU5758880A (en) | 1980-10-23 |
IL59803A0 (en) | 1980-06-30 |
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